Efficacy of the HLA-B∗58:01 screening test in preventing allopurinol-induced severe cutaneous adverse reactions in patients with chronic renal insufficiency- a prospective study

Publication date: Available online 21 December 2018

Source: The Journal of Allergy and Clinical Immunology: In Practice

Author(s): Heung-Woo Park, Dong Ki Kim, Sae-Hoon Kim, Sejoong Kim, Dong-Wan Chae, Min-Suk Yang, Yun Kyu Oh, Jung Pyo Lee, Jae-Woo Jung, Jungho Shin, Jin Ho Hwang, Min-Gyu Kang, Sun Moon Kim, Soon Kil Kwon, Hye-Young Kim, Min-Hye Kim, Seung-Jung Kim, Dong-Ryeol Ryu, Young-Joo Cho, Young-Koo Jee

Abstract

Background

Thus far, human leukocyte antigen (HLA)-B^∗58:01 has been recognized as the most important risk factor for allopurinol induced severe cutaneous adverse reactions (SCARs).

Objective

To determine the usefulness of prospective screening for the HLA-B^∗58:01 allele to identify Korean individuals at risk for SCARs induced by allopurinol treatment

Methods

We prospectively enrolled 542 patients with chronic renal insufficiency (CRI) from 10 hospitals nationwide and performed DNA genotyping to determine whether they carried the HLA-B^∗58:01 allele. Of these, 503 HLA-B^∗58:01-negative patients (92.8% of total) were treated with allopurinol, and 39 HLA-B^∗58:01-positive patients (7.2%) were treated with febuxostat, an alternative drug. The patients then were followed up bi-weekly for 90 days using a telephone survey to monitor symptoms of adverse drug reactions, including SCARs. As a control, we used the historical incidence rate of allopurinol induced SCARs in 4,002 patients with CRI from the same hospitals who were enrolled retrospectively.

Results

Nineteen patients in the prospective cohort developed mild and transient adverse reactions but none showed allopurinol-induced SCARs. By contrast, we identified 38 patients with allopurinol-induced SCARs (0.95%) in the historical control. The difference in the incidence of allopurinol-induced SCARs between the prospective cohort and historical control was statistically significant (0 vs. 0.95%, respectively; P = 0.029).

Conclusion

The present study demonstrated the clinical usefulness of the HLA-B^∗58:01 screening test before allopurinol administration to prevent allopurinol-induced SCARs in patients with CRI.

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