A novel effector caspase (Caspase-3/7-1) involved in the regulation of immune homeostasis in Chinese mitten crab Eriocheir sinensis

Publication date: Available online 6 September 2018Source: Fish & Shellfish ImmunologyAuthor(s): Chen Qu, Wen Yang, Qingsong Xu, Jiejie Sun, Mengmeng Lu, Ying Wang, Chao Liu, Weilin Wang, Lingling Wang, Linsheng SongAbstractCaspases are a conserved family of cysteine proteases characterized by specificity for aspartic acid and play an essential role in cell apoptosis. In the present study, a novel effector caspase (designated as EsCaspase-3/7-1) was identified from Chinese mitten crab Eriocheir sinensis. The open reading frame of EsCaspase-3/7-1 cDNA was of 972 bp, encoding a polypeptide of 323 amino acids. EsCaspase-3/7-1 contained an N-terminal prodomain and a conservative C-terminal CASc domain, with the conserved active site "QACRG". The mRNA transcripts of EsCaspase-3/7-1 were con...

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