Zebrafish intelectin 1 (zITLN1) plays a role in the innate immune response

Publication date: Available online 6 September 2018Source: Fish & Shellfish ImmunologyAuthor(s): Lei Chen, Jie Yan, Jing Shi, Wenbo Sun, Zhi Chen, Jiang Yu, Jing Qi, Yijun Du, Haiqing Zhang, Lijun FengAbstractIntelectin displays carbohydrate binding capacity and has been demonstrated to agglutinate bacteria, suggesting its role in innate immunity. It has also been linked to many pathogenic conditions in human. After reporting two amphioxus orthologs and the zebrafish intelectin 2 (zITLN2), here we cloned and characterized zebrafish intelectin 1 (zITLN1). Like zITLN2, zITLN1 also contains a conserved fibrinogen-related domain (FReD) and a unique intelectin domain (ITLN-D), expresses in all the tissues tested, with the highest level in intestine, and responds to bacterial challenge in acute ...

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