The Editors' Choice

The forkhead box P3 (FOXP3) transcription factor controls the function of regulatory T (Treg) cells, which actively maintain immune peripheral tolerance. Accordingly, FOXP3 mutations cause immunodysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome, a fatal autoimmune syndrome. Although FOXP3 expression is not restricted to Treg cells in the human system, its role in effector T cells has not been fully addressed. In this issue, Santoni de Sio et  al (p 1909) found the following: (Source: Journal of Allergy and Clinical Immunology)

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