Activating mutations in PIK3CD disrupt the differentiation and function of human and murine CD4+ T cells

Gain of function mutations in PIK3CD cause multiple defects in CD4+ T cells including altered cytokine production and Tfh function which may contribute to the poor antibody responses in these patients.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UMYeDo