Investigating discordance between diagnostic tests for laboratory animal allergy

Laboratory animal allergy (LAA) is an important occupational disease and the intensity of exposure to laboratory animal allergens is considered a major risk factor for developing IgE sensitization and allergic symptoms. Identifying and monitoring sensitized workers is key for the prevention of disease progression; the clinical implications of a false negative result are significant. The large-scale SPIRAL (Safe Practice In Reducing Allergy in Laboratories) study recently found significant discordance between mouse allergy diagnostic tests.

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