Πέμπτη 28 Φεβρουαρίου 2019

Prediabetes and diabetes prevalence in the Workers’ Oral Health Study

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Abstract Objective To examine the association between periodontitis, diabetes, and prediabetes, assessed by fasting plasma glucose (FPG)...

Einstein Adds Curriculum on Adults with Intellectual and Developmental Disabilities

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BRONX, NY—(February 28, 2019)—Children with intellectual and developmental disabilities (IDD) have long benefited from the training pediatri...

Retrospective Assessment of the Efficacy of Modified Progressive Tinnitus Management Skills Education in a Military Medical Treatment Facility.

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CONCLUSIONS: The evidence supports the assumption that PTM is a flexible program of tinnitus management that even when modified to be suitab...

Hearing Preservation Surgery via Retrosigmoid Approach with Retrolabyrinthine Meatotomy in Small Vestibular Schwannoma

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Conclusions RLM via RS approach proved to be effective for HPS, enabling the full course of the facial and cochlear nerves through the IAC t...

Einstein Adds Curriculum on Adults with Intellectual and Developmental Disabilities

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BRONX, NY—(February 28, 2019)—Children with intellectual and developmental disabilities (IDD) have long benefited from the training pediatri...

Retrospective Assessment of the Efficacy of Modified Progressive Tinnitus Management Skills Education in a Military Medical Treatment Facility.

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CONCLUSIONS: The evidence supports the assumption that PTM is a flexible program of tinnitus management that even when modified to be suitab...

Hearing Preservation Surgery via Retrosigmoid Approach with Retrolabyrinthine Meatotomy in Small Vestibular Schwannoma

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Conclusions RLM via RS approach proved to be effective for HPS, enabling the full course of the facial and cochlear nerves through the IAC t...

Severe asthma ‐ A population study perspective

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Abstract Background Severe asthma is a considerable challenge for patients, health care professionals and society. Few studies have esti...

Severe asthma ‐ A population study perspective

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Abstract Background Severe asthma is a considerable challenge for patients, health care professionals and society. Few studies have esti...

Accurate Patient-Specific Machine Learning Models of Glioblastoma Invasion Using Transfer Learning [FUNCTIONAL]

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BACKGROUND AND PURPOSE: MR imaging–based modeling of tumor cell density can substantially improve targeted treatment of glioblastoma. Unf...

Preoperative MR Imaging to Differentiate Chordoid Meningiomas from Other Meningioma Histologic Subtypes [ADULT BRAIN]

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BACKGROUND AND PURPOSE: Chordoid meningiomas are uncommon WHO grade II primary intracranial neoplasms that possess unique chordoid histol...

Decubitus CT Myelography for Detecting Subtle CSF Leaks in Spontaneous Intracranial Hypotension [SPINE]

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SUMMARY: Spontaneous intracranial hypotension is caused by spinal CSF leaks, but the site of the leak is not always detected on spinal im...

A Serial 10-Year Follow-Up Study of Atrophied Brain Lesion Volume and Disability Progression in Patients with Relapsing-Remitting MS [ADULT BRAIN]

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BACKGROUND AND PURPOSE: Disappearance of T2 lesions into CSF spaces is frequently observed in patients with MS. Our aim was to investigat...

Evaluation of the Implementation of the Response Assessment in Neuro-Oncology Criteria in the HERBY Trial of Pediatric Patients with Newly Diagnosed High-Grade Gliomas [PEDIATRICS]

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BACKGROUND AND PURPOSE: HERBY was a Phase II multicenter trial setup to establish the efficacy and safety of adding bevacizumab to radiat...

Paranasal Sinus CT Is of Variable Value in Patients with Pediatric Cancer with Neutropenic Fever [LETTERS]

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2H5Eze4

Prevalence of Superior Semicircular Canal Dehiscence on High-Resolution CT Imaging in Patients without Vestibular or Auditory Abnormalities [HEAD & NECK]

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BACKGROUND AND PURPOSE: Prior studies of radiologic superior semicircular canal dehiscence have suggested that CT may overcall dehiscence...

Accurate Patient-Specific Machine Learning Models of Glioblastoma Invasion Using Transfer Learning [FUNCTIONAL]

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BACKGROUND AND PURPOSE: MR imaging–based modeling of tumor cell density can substantially improve targeted treatment of glioblastoma. Unf...

Preoperative MR Imaging to Differentiate Chordoid Meningiomas from Other Meningioma Histologic Subtypes [ADULT BRAIN]

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BACKGROUND AND PURPOSE: Chordoid meningiomas are uncommon WHO grade II primary intracranial neoplasms that possess unique chordoid histol...

Decubitus CT Myelography for Detecting Subtle CSF Leaks in Spontaneous Intracranial Hypotension [SPINE]

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SUMMARY: Spontaneous intracranial hypotension is caused by spinal CSF leaks, but the site of the leak is not always detected on spinal im...

Aneurysm Characteristics, Study Population, and Endovascular Techniques for the Treatment of Intracranial Aneurysms in a Large, Prospective, Multicenter Cohort: Results of the Analysis of Recanalization after Endovascular Treatment of Intracranial Aneurysm Study [INTERVENTIONAL]

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BACKGROUND AND PURPOSE: The Analysis of Recanalization after Endovascular Treatment of Intracranial Aneurysm (ARETA) prospective study ai...

A Serial 10-Year Follow-Up Study of Atrophied Brain Lesion Volume and Disability Progression in Patients with Relapsing-Remitting MS [ADULT BRAIN]

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BACKGROUND AND PURPOSE: Disappearance of T2 lesions into CSF spaces is frequently observed in patients with MS. Our aim was to investigat...

Evaluation of the Implementation of the Response Assessment in Neuro-Oncology Criteria in the HERBY Trial of Pediatric Patients with Newly Diagnosed High-Grade Gliomas [PEDIATRICS]

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BACKGROUND AND PURPOSE: HERBY was a Phase II multicenter trial setup to establish the efficacy and safety of adding bevacizumab to radiat...

Prevalence of Superior Semicircular Canal Dehiscence on High-Resolution CT Imaging in Patients without Vestibular or Auditory Abnormalities [HEAD & NECK]

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BACKGROUND AND PURPOSE: Prior studies of radiologic superior semicircular canal dehiscence have suggested that CT may overcall dehiscence...

AAAAI: Small Amounts of Dietary Peanuts Beneficial After Immunotherapy

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THURSDAY, Feb. 28, 2019 -- Most individuals who complete peanut immunotherapy trials continue peanut consumption with few reports of reactio...

Exosomes that fatten immune cells

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(Source: ScienceNOW) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2HafVJ9

Stressed gut epithelium gets some relief

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(Source: ScienceNOW) MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for ...

Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

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We report that IEC endoplasmic reticulum (ER) stress induces a polyreactive IgA response, which is protective against enteric inflammation. ...

A lipase-independent pathway of lipid release and immune modulation by adipocytes

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To meet systemic metabolic needs, adipocytes release fatty acids and glycerol through the action of neutral lipases. Here, we describe a sec...

Single Suture Synostosis and Isolated Cleft Palate in Non-Apert Syndrome Patients

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Conclusion: Examination of 6 patients with SSC and ICP suggests the presence of both conditions does not adversely impact management or outc...

AAAAI: Small Amounts of Dietary Peanuts Beneficial After Immunotherapy

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THURSDAY, Feb. 28, 2019 -- Most individuals who complete peanut immunotherapy trials continue peanut consumption with few reports of reactio...

Exosomes that fatten immune cells

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(Source: ScienceNOW) from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2HafVJ9

Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

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We report that IEC endoplasmic reticulum (ER) stress induces a polyreactive IgA response, which is protective against enteric inflammation. ...

A lipase-independent pathway of lipid release and immune modulation by adipocytes

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To meet systemic metabolic needs, adipocytes release fatty acids and glycerol through the action of neutral lipases. Here, we describe a sec...

Single Suture Synostosis and Isolated Cleft Palate in Non-Apert Syndrome Patients

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Conclusion: Examination of 6 patients with SSC and ICP suggests the presence of both conditions does not adversely impact management or outc...

AAAAI: Small Amounts of Dietary Peanuts Beneficial After Immunotherapy

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THURSDAY, Feb. 28, 2019 -- Most individuals who complete peanut immunotherapy trials continue peanut consumption with few reports of reactio...

Stressed gut epithelium gets some relief

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(Source: ScienceNOW) MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for ...

Epithelial endoplasmic reticulum stress orchestrates a protective IgA response

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We report that IEC endoplasmic reticulum (ER) stress induces a polyreactive IgA response, which is protective against enteric inflammation. ...

A lipase-independent pathway of lipid release and immune modulation by adipocytes

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To meet systemic metabolic needs, adipocytes release fatty acids and glycerol through the action of neutral lipases. Here, we describe a sec...

AAAAI: Small Amounts of Dietary Peanuts Beneficial After Immunotherapy

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THURSDAY, Feb. 28, 2019 -- Most individuals who complete peanut immunotherapy trials continue peanut consumption with few reports of reactio...

Stressed gut epithelium gets some relief

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(Source: ScienceNOW) MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for ...

A lipase-independent pathway of lipid release and immune modulation by adipocytes

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To meet systemic metabolic needs, adipocytes release fatty acids and glycerol through the action of neutral lipases. Here, we describe a sec...

Severe asthma in children: therapeutic considerations

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Purpose of review Children with poor asthma control despite maximal maintenance therapy have problematic severe asthma (PSA). A step-wise ap...

Diagnosis of occupational hypersensitivity pneumonitis

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Purpose of review To discuss the diagnostic methods currently used in the study of patients with hypersensitivity pneumonitis, with special ...

Symptom-based patient-reported outcomes in adults with eosinophilic esophagitis: value for treatment monitoring and randomized controlled trial design

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Purpose of review In adults with eosinophilic esophagitis (EoE), a chronic, inflammatory immune-mediated condition of the esophagus, both in...

The impact of exercise on asthma

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Purpose of review Asthma is one of the most common chronic diseases in children and adults in developed countries around the world. Despite ...

Preventing the development of asthma: stopping the allergic march

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Purpose of review To describe important precipitants of asthma and allergic disease, to highlight the links between these triggers and modif...

Basophil activation testing in occupational respiratory allergy to low molecular weight compounds

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Purpose of review There is an unmet need for better immunological tests in cases of suspected occupational asthma to many workplace chemical...

Management of acute loss of asthma control: yellow zone strategies

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This article reviews the evidence behind various recommended yellow zone intervention strategies. Recent findings There are many potential m...

Vitamin D and childhood asthma: causation and contribution to disease activity

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Purpose of review To review the literature of the past 18 months (April 2017 through September, 2018) relating to vitamin D and childhood as...

Single inhaler maintenance and reliever therapy in pediatric asthma

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Purpose of review Asthma affects more than 25 million people worldwide and continues to grow in prevalence. According to a center for diseas...

Precision medicine in childhood asthma

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Purpose of review Childhood asthma is a heterogeneous disease and many children have uncontrolled disease. Therefore an individualized appro...

Use of population data for assessing trends in work-related asthma mortality

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Purpose of review Work-related asthma has been associated with poorer asthma control and frequent unscheduled healthcare visits, and can be ...

Phenotypes of wheezing and asthma in preschool children

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Purpose of review The purpose of this review is to provide an overview of the identified phenotypes of preschool wheezing. Recent findings E...

Contributions of innate lymphocytes to allergic responses

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Purpose of review Allergic diseases represent a growing global health concern, especially among pediatric populations. Current strategies fo...

Symptom-based patient-reported outcomes in adults with eosinophilic esophagitis: value for treatment monitoring and randomized controlled trial design

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Purpose of review In adults with eosinophilic esophagitis (EoE), a chronic, inflammatory immune-mediated condition of the esophagus, both in...

The impact of exercise on asthma

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Purpose of review Asthma is one of the most common chronic diseases in children and adults in developed countries around the world. Despite ...

Preventing the development of asthma: stopping the allergic march

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Purpose of review To describe important precipitants of asthma and allergic disease, to highlight the links between these triggers and modif...

Basophil activation testing in occupational respiratory allergy to low molecular weight compounds

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Purpose of review There is an unmet need for better immunological tests in cases of suspected occupational asthma to many workplace chemical...

Management of acute loss of asthma control: yellow zone strategies

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This article reviews the evidence behind various recommended yellow zone intervention strategies. Recent findings There are many potential m...

Vitamin D and childhood asthma: causation and contribution to disease activity

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Purpose of review To review the literature of the past 18 months (April 2017 through September, 2018) relating to vitamin D and childhood as...

Precision medicine in childhood asthma

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Purpose of review Childhood asthma is a heterogeneous disease and many children have uncontrolled disease. Therefore an individualized appro...

Use of population data for assessing trends in work-related asthma mortality

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Purpose of review Work-related asthma has been associated with poorer asthma control and frequent unscheduled healthcare visits, and can be ...

Impact of occupational exposure on human microbiota

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Purpose of review Recent evidence suggests that environmental exposures change the adult human microbiome. Here, we review recent evidence o...

Editorial introductions

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No abstract available (Source: Current Opinion in Allergy and Clinical Immunology) from #Head and Neck by Sfakianakis via simeraentaxei ...

Neutrophil activation in occupational asthma

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Purpose of review The aim of this review is to emphasize the role of neutrophils in patients with occupational asthma. This review facilitat...

How guideline can shape clinical practice globally: the diagnosis and rationale for action against cow's milk allergy experience

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We report here the main international allergy guidelines with a more focused look on the Diagnosis and Rationale for Action against Cow'...

Neutrophil activation in occupational asthma

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Purpose of review The aim of this review is to emphasize the role of neutrophils in patients with occupational asthma. This review facilitat...

How guideline can shape clinical practice globally: the diagnosis and rationale for action against cow's milk allergy experience

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We report here the main international allergy guidelines with a more focused look on the Diagnosis and Rationale for Action against Cow'...

Repair of Cerebrospinal Fluid Leak in Cochlear Implantation

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Conclusion: Cerebrospinal fluid leakage may occur in cochlear implantation patients with inner ear anomalies postoperatively. Sealing of the...

Einstein Adds Curriculum on Adults with Intellectual and Developmental Disabilities

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BRONX, NY—(February 28, 2019)—Children with intellectual and developmental disabilities (IDD) have long benefited from the training pediatri...

Repair of Cerebrospinal Fluid Leak in Cochlear Implantation

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Conclusion: Cerebrospinal fluid leakage may occur in cochlear implantation patients with inner ear anomalies postoperatively. Sealing of the...

Einstein Adds Curriculum on Adults with Intellectual and Developmental Disabilities

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BRONX, NY—(February 28, 2019)—Children with intellectual and developmental disabilities (IDD) have long benefited from the training pediatri...

Exploring the “Preterm Behavioral Phenotype” in Children Born Extremely Preterm

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ABSTRACT: Objective: To examine whether difficulties in emotional, attention, and peer or social functioning (a proposed "preterm behav...

Exploring the “Preterm Behavioral Phenotype” in Children Born Extremely Preterm

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ABSTRACT: Objective: To examine whether difficulties in emotional, attention, and peer or social functioning (a proposed "preterm behav...

Mechanisms Underlying the Contribution of Sleep Disturbances to Pain (R21 Clinical Trial Optional)

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Funding Opportunity PA-19-201 from the NIH Guide for Grants and Contracts. The purpose of this FOAs are to encourage mechanistic research to...

Mechanisms Underlying the Contribution of Sleep Disturbances to Pain (R01 Clinical Trial Optional)

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Funding Opportunity PA-19-200 from the NIH Guide for Grants and Contracts. The purpose of this FOA is to encourage mechanistic research to i...

Microbial-based Cancer Therapy -Bugs as Drugs (R21 Clinical Trial Not Allowed)

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Funding Opportunity PAR-19-194 from the NIH Guide for Grants and Contracts. The overall purpose of this funding opportunity announcement (FO...

Microbial-based Cancer Therapy -Bugs as Drugs (R01 Clinical Trial Not Allowed)

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Funding Opportunity PAR-19-193 from the NIH Guide for Grants and Contracts. The overall purpose of this funding opportunity announcement (FO...

MicroRNA-1297 inhibits proliferation and promotes apoptosis in gastric cancer cells by downregulating CDC6 expression

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Gastric cancer (GC), one of the most common malignant tumors and the second most common leading cause of cancer-related death worldwide, is ...

Evaluation of the antileukemic effects of neurokinin-1 receptor antagonists, aprepitant, and L-733,060, in chronic and acute myeloid leukemic cells

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Neurokinin-1 receptor (NK1R) antagonists are known for their anxiolytic, antiemetic, anticancer, and anti-inflammatory effects. Aprepitant i...

Andrographolide sensitizes Hep-2 human laryngeal cancer cells to carboplatin-induced apoptosis by increasing reactive oxygen species levels

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Andrographolide is a natural diterpenoid from Andrographis paniculata that has been proposed as an anticancer agent as well as a chemosensit...

Talazoparib has no clinically relevant effect on QTc interval in patients with advanced solid tumors

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The aims of this study were (i) to evaluate the effect of talazoparib (1 mg once daily) on cardiac repolarization in patients with advanced ...

Microbial-based Cancer Therapy -Bugs as Drugs (R21 Clinical Trial Not Allowed)

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Funding Opportunity PAR-19-194 from the NIH Guide for Grants and Contracts. The overall purpose of this funding opportunity announcement (FO...

Microbial-based Cancer Therapy -Bugs as Drugs (R01 Clinical Trial Not Allowed)

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Funding Opportunity PAR-19-193 from the NIH Guide for Grants and Contracts. The overall purpose of this funding opportunity announcement (FO...

Evaluation of the antileukemic effects of neurokinin-1 receptor antagonists, aprepitant, and L-733,060, in chronic and acute myeloid leukemic cells

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Neurokinin-1 receptor (NK1R) antagonists are known for their anxiolytic, antiemetic, anticancer, and anti-inflammatory effects. Aprepitant i...

Andrographolide sensitizes Hep-2 human laryngeal cancer cells to carboplatin-induced apoptosis by increasing reactive oxygen species levels

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Andrographolide is a natural diterpenoid from Andrographis paniculata that has been proposed as an anticancer agent as well as a chemosensit...

A randomized phase II study to determine the efficacy and tolerability of two doses of eribulin plus lapatinib in trastuzumab-pretreated patients with HER-2-positive metastatic breast cancer (E-VITA)

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The E-VITA study evaluated the efficacy and tolerability of two schedules of eribulin and lapatinib in patients with trastuzumab-pretreated ...

Talazoparib has no clinically relevant effect on QTc interval in patients with advanced solid tumors

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The aims of this study were (i) to evaluate the effect of talazoparib (1 mg once daily) on cardiac repolarization in patients with advanced ...

A Rare Case of Vocal Cord Aspergillosis

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AbstractPrimary aspergillosis of larynx is very rare. Till now only 28 cases of isolated laryngeal aspergillosis are documented in the Engli...

A Rare Case of Vocal Cord Aspergillosis

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AbstractPrimary aspergillosis of larynx is very rare. Till now only 28 cases of isolated laryngeal aspergillosis are documented in the Engli...

Real-Time Ultrasound Improves Accuracy of Caudal Block in Children

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BACKGROUND: Caudal block, the most common regional anesthetic in children, is predominantly performed using palpation to determine placement...