Autophagy participates in innate immune defense in lamprey

Publication date: Available online 6 September 2018Source: Fish & Shellfish ImmunologyAuthor(s): Lingjie Luo, Juan Lu, Qin Wang, Shangwu Chen, Anlong Xu, Shaochun YuanAbstractAutophagy is a homeostatic process which degrades cytoplasmic constituents to maintain the balance of organs when they were challenged with nutrient stress. It also participates in cancer, neurodegenerative disorders, aging and innate immune defense. In order to reveal how autophagy participates in innate immune response when invertebrates evolved into vertebrates. Firstly, we performed a systematic analysis of Atg genes and found that they are highly conserved among lancelet, lamprey and zebrafish. Then, we observed autophagosomes upon starvation by TEM in lancelet, lamprey and zebrafish and found that the morphology...

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