Injury, dysbiosis and filaggrin deficiency drive skin inflammation via keratinocyte IL-1α release

Our data demonstrate that injury and dysbiosis drive intracellular IL-1α release from keratinocytes to mediate chronic inflammation in filaggrin-deficient mice. IL-1α and dysbiosis could represent therapeutic targets to reduce skin inflammation in atopic dermatitis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DgDOhQ