Intratumoral heterogeneity in recurrent metastatic squamous cell carcinoma of the oral cavity: New perspectives afforded by multiregion DNA sequencing and mtDNA analysis

Improvements in sequencing technologies have revealed that genetic differences among neoplastic cells may reflect clonal expansion. Intratumor heterogeneity (ITH) has been suggested to explain differences in prognosis and treatment response, indicating that personalized medicine is the goal of the future. Here, we evaluated ITH in five patients with recurrent metastatic oral squamous cell carcinoma (OSCC) and tracked the evolution from non-neoplastic tissue to neoplastic events developing after primary tumor formation.

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