Lack of Sprouty 1 and 2 enhances survival of effector CD8+ T cells and yields more protective memory cells [Immunology and Inflammation]

Identifying novel pathways that promote robust function and longevity of cytotoxic T cells has promising potential for immunotherapeutic strategies to combat cancer and chronic infections. We show that sprouty 1 and 2 (Spry1/2) molecules regulate the survival and function of memory CD8+ T cells. Spry1/2 double-knockout (DKO) ovalbumin (OVA)-specific CD8+... (Source: Proceedings of the National Academy of Sciences)

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