Molecular characterization and function analysis of a nucleotide excision repair gene Rad23 from Litopenaeus vannamei after Vibrio alginolyticus challenge

Publication date: Available online 6 September 2018Source: Fish & Shellfish ImmunologyAuthor(s): Di Huang, Xue-Li Qiao, Qing-jian Liang, Wei Wei, Jing-Rong Kong, Chang-sheng Zhao Huan-Kang, Yuan Liu, Wei-Na WangAbstractNucleotide excision repair (NER) removes many different types of DNA lesions, and NER related host factors are reported to aid recovery steps during viral integration. Here, we report the identification and characterization of a DNA repair gene Rad23 from Litopenaeus vannamei and explore its role in innate immunity of crustaceans. LvRad23 contains a1149 bp open reading frame (ORF) which encodes a 382 amino acids protein with predicted theoretical isoelectric point of 4.21. LvRad23 was ubiquitously expressed in the muscle, eyestalk, gill, stomach, heart, legs, intestine, and ...

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