RhoA/ROCK Signaling Modulates Lineage Commitment of Mesenchymal Stem Cells in Asthma through Lef1

MSCs are critical in airway repair/remodeling in asthma. RhoA/ROCK signaling functions as a molecular switch for the lineage fate of MSCs during airway repair/remodeling. Targeting RhoA/ROCK signaling might be an effective therapeutic strategy for asthma (Source: Journal of Allergy and Clinical Immunology)

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