Eosinophilia and reduced STAT3 signalling affect neutrophil cell death in autosomal-dominant Hyper-IgE syndrome.

This study was undertaken to functionally characterize neutrophils in STAT3-deficient HIES patients and to analyse whether the patients` eosinophilia affects the neutrophil phenotype in S. aureus infection. Neutrophil functions and cell death kinetics were studied in eight STAT3-deficient patients. Moreover, the response of STAT3-deficient neutrophils to S. aureus and the impact of autologous eosinophils on pathogen-induced cell death were analysed. No specific aberrations in neutrophil functions were detected within this cohort. However, the half-life of STAT3-deficient neutrophils ex vivo was reduced, which was partially attributable to the presence of eosinophils. Increased S. aureus-induced cell lysis, dependent on the staphylococcal virulence controlling agr-locus, was observed in STA...

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