GSE121818 Increased Hematopoietic Extracellular RNAs and Vesicles in the Lung during Allergic Airway Responses

Contributors : Heather H Pua ; Karl M AnselSeries Type : Non-coding RNA profiling by high throughput sequencingOrganism : Mus musculusExtracellular RNAs (exRNAs) can be released by numerous cell types in vitro, are often protected within vesicles, and can modify recipient cell function. To determine how the composition and cellular sources of exRNAs and the extracellular vesicles (EVs) that carry them change in vivo during tissue inflammation, we analyzed bronchoalveolar lavage fluid (BALF) from mice before and after lung allergen challenge. In the lung, extracellular microRNAs (ex-miRNAs) had a composition highly correlated with airway lining epithelium. Using cell-type specific membrane tagging and single vesicle flow, we also found that 80% of detected vesicles were of epithelial origin...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Dbppmj