Mucosal Bromodomain-Containing Protein 4 (BRD4) Mediates Aeroallergen-induced Inflammation and Remodeling

Allergen-induced exacerbations are associated with remodeling and loss of lung function. Repetitive exposure to cat dander activates TLR-NFκB signaling. Persistent activation results in epigenetic reprogramming, mesenchymal transition and myofibroblast expansion through the BRD4 histone acetyltransferase.

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