Upregulated P-Rex1 exacerbates human airway smooth muscle hyperplasia in asthma

P-Rex1, a Rac-selective activator is aberrantly upregulated in airway smooth muscle of subjects with asthma compared to non-asthmatics, and augments cell proliferation, thus contributing to airway smooth muscle hyperplasia and remodeling in severe asthma. (Source: Journal of Allergy and Clinical Immunology)

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