Engineering of structural variants of the major peanut allergens Ara h 2 and Ara h 6 for allergen-specific immunotherapy

Applying a novel way to design hypoallergens, we produced variants of the major peanut allergens Ara h 2 and Ara h 6 with significantly reduced IgE-binding and basophil activation capacities and preserved T-cell stimulatory activity. (Source: Journal of Allergy and Clinical Immunology)

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