Hepatic Cytochrome P450 Activity and Nitric Oxide Production During Multiple Ovalbumin Challenges

ConclusionsMultiple OVA challenges, unlike acute sensitization, greatly reduced serum NOx levels. The challenge-suppressed hepatic CYP metabolism was likely related to the increased serum NOx. Serum NOx may be an endogenous marker for CYP metabolism inhibition in type 1 allergic diseases. (Source: European Journal of Drug Metabolism and Pharmacokinetics)

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