Mast Cell CRF2 Suppresses Mast Cell Degranulation and Limits the Severity of Anaphylaxis and Stress-Induced Intestinal Permeability

Targeting CRF2 and (or) downstream pathways has potential as a new therapeutic approach to limit excessive MC activation and intestinal permeability which initiate and perpetuate highly prevalent and burdensome diseases including allergy, anaphylaxis and functional bowel disorders. (Source: Journal of Allergy and Clinical Immunology)

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