Characterization of Cysteinyl Leukotriene-Related Receptors and Their Interactions in a Mouse Model of Asthma

There is accumulating evidence for multifaceted roles of cysteinyl leukotrienes (CysLTs) and their receptors in allergic diseases. In asthma, CysLT C4, D4, and E4 are well known to modulate airway inflammation and airway remodeling [1, 2]. CysLTs exert their effects through interacting with receptors which belong to the G-protein-coupled receptor, termed CysLTR1 and CysLTR2 [3] to induce inflammatory responses, such as recruitment of inflammatory cells, cell-cell adhesion, vascular leakage, and platelet activation in asthma [4-7]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)

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