Defective glycosylation leads to defective gp130-dependent STAT3 signaling in PGM3-deficient patients

PGM3 deficient patients have impaired STAT3 signaling downstream of the highly glycosylated protein gp130, thereby constituting the mechanistic basis for the clinical features shared by STAT3-, gp130- and PGM3-deficient patients. (Source: Journal of Allergy and Clinical Immunology)

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