Fibrostenotic eosinophilic esophagitis may reflect epithelial lysyl oxidase induction by fibroblasts-derived tumor necrosis factor- α

Esophageal fibrosis is a long-term consequence of remodeling in eosinophilic esophagitis, but little is known about the pathophysiology of fibrosis. We now demonstrate that TNF α mediated lysyl oxidase production may be driving fibrostenotic phenotype. (Source: Journal of Allergy and Clinical Immunology)

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