Innate lymphoid cells in the upper airways: importance of CD117 and IL-1RI expression

We report that the CD117 and interleukin-receptor type I (IL-1RI) expression status of human ILC2s depends on the local tissue environment. Only CD117+ IL-1RI+ ILC2s, exclusively present in CRSwNP, possess an interrelationship with type 2 T-helper cell cytokine and eosinophil levels in human upper airway mucosa. In CRSsNP, mainly CD117–IL-1RI– ILC2s are increased, yielding lower eosinophilia in this disease despite the high levels of ILC2s. These data unveil that the CD117– and CD117+ fractions within the native human ILC2 population are not a random phenomenon, in contrast to what could be concluded from in vitro data, and that the IL-1RI expression is not ubiquitous in ILC2s in vivo in humans, which cannot be assessed via in vitro and murine experiments. (Source: Europe...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rnE1al