Intravenous immunoglobulin induces IL-4 in human basophils by signaling through surface-bound IgE

Therapeutic normal IgG (IVIG) activates human basophils through direct interaction with basophil surface-bound IgE, and by IL-3- and Syk-dependent mechanisms to promote Th2 responses in the context of therapy of autoimmune diseases. (Source: Journal of Allergy and Clinical Immunology)

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