Late thymic deficiency after HLA-haploidentical hematopoietic stem cell transplantation for severe combined immunodeficiency

In the absence of myelosuppressive conditioning, severe combined immunodeficiency patients transplanted with hematopoietic stem cell grafts from HLA-haploidentical donors were at risk of late loss of na ïve CD4+ T cells and restricted T-cell receptor repertoire. (Source: Journal of Allergy and Clinical Immunology)

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