Macrophage CD14 impacts immune defenses against influenza virus in allergic hosts

Publication date: Available online 5 December 2018Source: Microbial PathogenesisAuthor(s): Maneesha Palipane, John D. Snyder, Kim S. LeMessurier, Anna K. Schofield, Stacie N. Woolard, Amali E. SamarasingheAbstractAsthma and influenza are leading causes of worldwide morbidity and mortality. Although these two conditions can co-exist in the same patient, the immune parameters that impact disease outcomes are not fully elucidated. The importance of macrophages to both conditions suggested a role for CD14, a co-receptor for endotoxin, as a regulatory mechanism for innate immune responses during asthma and influenza co-morbidity. Herein, we hypothesized that parameters of influenza morbidity will be reduced in the absence of CD14. Age and gender matched wild-type (WT) and CD14 knock-out (KO) mi...

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