MARCH3 attenuates IL-1{beta}-triggered inflammation by mediating K48-linked polyubiquitination and degradation of IL-1RI [Immunology and Inflammation]

In this study, we identified the E3 ubiquitin ligase membrane-associated RING-CH-type finger 3 (MARCH3) as a critical negative regulator of IL-1β–triggered signaling. Overexpression of MARCH3 inhibited IL-1β–triggered activation... (Source: Proceedings of the National Academy of Sciences)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zLqNbY