Siglec-8 in eosinophilic disorders: receptor expression and targeting using chimeric antibodies

Siglec-8 levels are similar on blood eosinophils irrespective of eosinophil count or disease activity. Anti-Siglec-8 antibodies induce death of eosinophils from eosinophilic donors in vitro and in a humanized mouse model of IL-5-driven eosinophilia.

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