Synaptic reorganization response in the cochlear nucleus following intense noise exposure

Publication date: Available online 26 December 2018Source: NeuroscienceAuthor(s): S. Manohar, P.V. Ramchander, R. Salvi, G.M. SeigelAbstractThe cochlear nucleus, located in the brainstem, receives its afferent auditory input exclusively from the auditory nerve fibers of the ipsilateral cochlea. Noise-induced neurodegenerative changes occurring in the auditory nerve stimulate a cascade of neuroplastic changes in the cochlear nucleus resulting in major changes in synaptic structure and function. To identify some of the key molecular mechanisms mediating this synaptic reorganization, we unilaterally exposed rats to a high intensity noise that caused significant hearing loss and then measured the resulting changes in a synaptic plasticity gene array targeting neurogenesis and synaptic reorgani...

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