Hypoxia Enhances CD8+ Tc2 Dependent Airway Hyperresponsiveness and Inflammation Through Hypoxia Inducible Factor 1α

Hypoxia exposure amplifies CD8+ Tc2 differentiation with increased release of IL-13 in vitro and augmentation of lung allergic responses in vivo. The increases in Tc2 differentiation under hypoxia were shown to be dependent on HIF-1α.

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