In vitro detection of drug-induced granzyme B, interferon-gamma, and interleukin-22 releasing cells in different phenotypes of severe cutaneous adverse reactions

The measurement of drug-induced interferon-gamma releasing cells is another option to identify the culprit drug in severe cutaneous adverse reactions (SCARs) since drug provocation is contraindicated. However, its sensitivity is rather limited since other cytokines also play a role in pathogenesis of drug hypersensitivity. (Source: Journal of Allergy and Clinical Immunology)

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