Regulation of Ectodomain Shedding of ADAM33 In Vitro and In Vivo

TGF- β signaling regulates ectodomain shedding of ADAM33 mainly via an autocatalytic mechanism and is essential for shedding of catalytically-active ADAM33 in vivo. These mechanisms have implications for the genetic contribution of ADAM33 to asthma and BHR. (Source: Journal of Allergy and Clinical Immunology)

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