Siglec-8 Engagement Selectively Inhibits Allergen-Dependent Degranulation of Human Skin Mast Cells In Vitro

Mast cells (MCs) are well-known for their role in allergic responses. They can be activated through cross-linking of their high affinity IgE receptors (Fc εRI) by allergen, leading to the release of many pro-inflammatory mediators. Sialic acid-binding immunoglobulin-like (Siglec)-8 is a CD33-related receptor expressed on human MCs, though not yet described on skin MCs. A key feature of Siglec-8 is its inhibitory (ITIM) motif located within the cytopl asmic domain, suggesting that it may inhibit activating (ITAM) signaling. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TAsxwS