Persistent Nociception Facilitates the Extinction of Morphine-Induced Conditioned Place Preference

BACKGROUND: As opioid abuse and addiction have developed into a major national health crisis, prescription of opioids for pain management has become more controversial. However, opioids do help some patients by providing pain relief and improving the quality of life. To better understand the addictive properties of opioids under chronic pain conditions, we used a conditioned place preference (CPP) paradigm to examine the rewarding properties of morphine in rats with persistent nociception. METHODS: Spared nerve injury (SNI) model was used to induce persistent nociception in rats. Nociceptive behavior was assessed by von Frey test. CPP test was used to examine the rewarding properties of morphine. RESULTS: Our findings are as follows: (1) SNI rats did not show a difference compared with sham rats in magnitude of morphine-induced CPP 1 day after last morphine injection (2-way analysis of variance; for SNI versus sham, F[1,42] = 0.014, P = .91; and 95% confidence intervals for difference of means, −5.9 [−58 to 46], 0.76 [−51 to 53], and 0.90 [−51 to 53] for 2.5, 5, and 10 mg/kg, respectively); (2) increasing morphine dosage (2.5, 5, and 10 mg/kg) did not further increase the magnitude of CPP in both sham and SNI rats (for dosage: F[2,42] = 0.94, P = .40); and (3) morphine-induced CPP persisted in sham rats but extinguished in SNI rats when tested at 8 days after last morphine injection (for sham versus SNI: Bonferroni correction, P

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Grade 3 Echocardiographic Diastolic Dysfunction Is Associated With Increased Risk of Major Adverse Cardiovascular Events After Surgery: A Retrospective Cohort Study

BACKGROUND: Diastolic dysfunction is common and may increase the risk of cardiovascular complications. This study investigated the hypothesis that, in patients with isolated left ventricular diastolic dysfunction, higher grade diastolic dysfunction was associated with greater risk of major adverse cardiovascular events (MACEs) after surgery. METHODS: This was a retrospective cohort study. Data of adult patients with isolated echocardiographic diastolic dysfunction (ejection fraction, ≥50%) who underwent noncardiac surgery from January 1, 2015 to December 31, 2015 were collected. The primary end point was the occurrence of postoperative MACEs during hospital stay, which included acute myocardial infarction, congestive heart failure, stroke, nonfatal cardiac arrest, and cardiac death. The association between the grade of diastolic dysfunction and the occurrence of MACEs was assessed with a multivariable logistic model. RESULTS: A total of 2976 patients were included in the final analysis. Of these, 297 (10.0%) developed MACEs after surgery. After correction for confounding factors, grade 3 diastolic dysfunction was associated with higher risk of postoperative MACEs (odds ratio, 1.71; 95% confidence interval, 1.28–2.27; P

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Clock Drawing Performance Slows for Older Adults After Total Knee Replacement Surgery

BACKGROUND: Clock drawing is a neurocognitive screening tool used in preoperative settings. This study examined hypothesized changes in clock drawing to command and copy test conditions 3 weeks and 3 months after total knee arthroplasty (TKA) with general anesthesia. METHODS: Participants included 67 surgery and 66 nonsurgery individuals >60 years who completed the digital clock drawing test before TKA (or a pseudosurgery date), and 3 weeks and 3 months postsurgery. Generalized linear mixed models assessed digital clock drawing test latency (ie, total time to completion, seconds between digit placement) and graphomotor output (ie, total number of strokes, clock size). Reliable change analyses examined the percent of participants showing change beyond differences found in nonsurgery peers. RESULTS: After adjusting for age, education, and baseline cognition, both digital clock drawing test latency measures were significantly different for surgery and nonsurgery groups, where the surgery group performed slower on both command and copy test conditions. Reliable change analyses 3 weeks after surgery found that total time to completion was slower among 25% of command and 21% of copy constructions in the surgery group. At 3 months, 18% of surgery participants were slower than nonsurgery peers. Neither graphomotor measure significantly changed over time. CONCLUSIONS: Clock drawing construction slowed for nearly one-quarter of patients after TKA surgery, whereas nonsurgery peers showed the expected practice effect, ie, speed increased from baseline to follow-up time points. Future research should investigate the neurobiological basis for these changes after TKA. Accepted for publication July 16, 2018. Funding: This work was supported by the National Institutes of Health (grant nos. R01 NR014181 to C.C.P.; R01AG055337 to C.C.P. and P.T.; UL1R001427 and P50AG047266) and the National Science Foundation (1404333 to R.D., D.L.P., and C.C.P.). Conflicts of Interest: See Disclosures at the end of the article. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (https://ift.tt/KegmMq). Clinical Trial number and registry URL: NCT01786577; clinicaltrials.gov. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institute on Aging or the National Institutes of Health. Reprints will not be available from the authors. Address correspondence to Catherine C. Price, PhD, Department of Clinical and Health Psychology, University of Florida, College of PHHP, PO Box 100165, Gainesville, FL 32605. Address e-mail to cep23@phhp.ufl.edu. © 2018 International Anesthesia Research Society

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The Washington Manual of Critical Care, 3rd ed

No abstract available

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Mechanical Ventilation in the Critically Ill Obese Patient

No abstract available

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Pilot Survey of Female Anesthesiologists’ Childbearing and Parental Leave Experiences

While the literature regarding physicians' childbearing experiences is growing, there are no studies documenting those of anesthesiologists. We surveyed a convenience sample of 72 female anesthesiologists to obtain pilot data. Sixty-six women completed the survey (91.7% response rate), reporting 113 total births from before 1990 to present. Of all birth experiences, proportions of respondents reporting parental leave, lactation facilities, and lactation duration as adequate were 52.3%, 45.2%, and 58.3%, respectively. Most mothers (51.8%) gave birth to their first child while they were trainees. The majority (94.9%) favored an official statement supporting parental leave. These results may serve as groundwork for larger studies. Accepted for publication August 15, 2018. Funding: None. Conflicts of Interest: See Disclosures at the end of the article. Supplemental digital content is available for this article. Direct URL citations appear in the printed text and are provided in the HTML and PDF versions of this article on the journal's website (https://ift.tt/KegmMq). Reprints will not be available from the authors. Address correspondence to Amy C. S. Pearson, MD, Department of Anesthesia, University of Iowa Carver College of Medicine, 200 Hawkins Dr, 6JCP, Iowa City, Iowa 52242. Address e-mail to amy-pearson@uiowa.edu. © 2018 International Anesthesia Research Society

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A bronchoprotective role for Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation

Asthma exacerbations are associated with the recruitment of neutrophils to the lungs. These cells release proteases and mediators, many of which act at G protein-coupled receptors (GPCRs) that couple via Gq to...

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A bronchoprotective role for Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation

Asthma exacerbations are associated with the recruitment of neutrophils to the lungs. These cells release proteases and mediators, many of which act at G protein-coupled receptors (GPCRs) that couple via Gq to...

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PET imaging of [ 11 C]PBR28 in Parkinson’s disease patients does not indicate increased binding to TSPO despite reduced dopamine transporter binding

Abstract

Purpose

To examine the hypothesis that cerebral binding to the 18 kDa translocator protein (TSPO), a marker of microglia activation, is elevated in Parkinson's disease (PD), and to assess the relationship between brain TSPO binding and dopaminergic pathology in PD.

Methods

The radioligand [¹¹C]PBR28 was used for quantitative assessment of brain TSPO in 16 control subjects and 16 PD patients. To analyse the relationship between dopaminergic pathology and brain TSPO binding, PET studies of the dopamine transporter (DAT) were undertaken in PD patients using the DAT radioligand [¹⁸F]FE-PE2I. The total distribution volume of [¹¹C]PBR28 was quantified in nigrostriatal regions, limbic cortices and thalamus, and the binding potential of [¹⁸F]FE-PE2I was quantified in nigrostriatal regions.

Results

Based on genotype analysis of the TSPO rs6971 polymorphism, 16 subjects (8 control subjects and 8 PD patients) were identified as high-affinity binders, and the remaining subjects were identified as mixed-affinity binders. A two-way ANOVA showed a strong main effect of TSPO genotype on the cerebral binding of [¹¹C]PBR28, whereas no statistically significant main effect of diagnostic group, or a group by genotype interaction was found for any of the regions analysed. [¹⁸F]FE-PE2I PET studies in patients indicated a marked reduction in nigrostriatal binding to DAT. However, no correlations between the binding parameters were found for [¹¹C]PBR28 and [¹⁸F]FE-PE2I.

Conclusion

The findings do not support the hypothesis of elevated cerebral TSPO binding or a relationship between TSPO binding and dopaminergic pathology in PD.

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PET imaging of [ 11 C]PBR28 in Parkinson’s disease patients does not indicate increased binding to TSPO despite reduced dopamine transporter binding

Abstract

Purpose

To examine the hypothesis that cerebral binding to the 18 kDa translocator protein (TSPO), a marker of microglia activation, is elevated in Parkinson's disease (PD), and to assess the relationship between brain TSPO binding and dopaminergic pathology in PD.

Methods

The radioligand [¹¹C]PBR28 was used for quantitative assessment of brain TSPO in 16 control subjects and 16 PD patients. To analyse the relationship between dopaminergic pathology and brain TSPO binding, PET studies of the dopamine transporter (DAT) were undertaken in PD patients using the DAT radioligand [¹⁸F]FE-PE2I. The total distribution volume of [¹¹C]PBR28 was quantified in nigrostriatal regions, limbic cortices and thalamus, and the binding potential of [¹⁸F]FE-PE2I was quantified in nigrostriatal regions.

Results

Based on genotype analysis of the TSPO rs6971 polymorphism, 16 subjects (8 control subjects and 8 PD patients) were identified as high-affinity binders, and the remaining subjects were identified as mixed-affinity binders. A two-way ANOVA showed a strong main effect of TSPO genotype on the cerebral binding of [¹¹C]PBR28, whereas no statistically significant main effect of diagnostic group, or a group by genotype interaction was found for any of the regions analysed. [¹⁸F]FE-PE2I PET studies in patients indicated a marked reduction in nigrostriatal binding to DAT. However, no correlations between the binding parameters were found for [¹¹C]PBR28 and [¹⁸F]FE-PE2I.

Conclusion

The findings do not support the hypothesis of elevated cerebral TSPO binding or a relationship between TSPO binding and dopaminergic pathology in PD.

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A bronchoprotective role for Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation

Abstract

Background

Asthma exacerbations are associated with the recruitment of neutrophils to the lungs. These cells release proteases and mediators, many of which act at G protein-coupled receptors (GPCRs) that couple via Gq to promote bronchoconstriction and inflammation. Common asthma therapeutics up-regulate expression of the regulator of G protein signalling (RGS), RGS2. As RGS2 reduces signaling from Gq-coupled GPCRs, we have defined role(s) for this GTPase-activating protein in an acute neutrophilic model of lung inflammation.

Methods

Wild type and Rgs2^−/− C57Bl6 mice were exposed to nebulized lipopolysaccharide (LPS). Lung function (respiratory system resistance and compliance) was measured using a SCIREQ flexivent small animal ventilator. Lung inflammation was assessed by histochemistry, cell counting and by cytokine and chemokine expression in bronchoalveolar lavage (BAL) fluid.

Results

Lipopolysaccharide inhalation induced transient airways hyperreactivity (AHR) and neutrophilic lung inflammation. While AHR and inflammation was greatest 3 h post-LPS exposure, BAL neutrophils persisted for 24 h. At 3 h post-LPS inhalation, multiple inflammatory cytokines (CSF2, CSF3, IL6, TNF) and chemokines (CCL3, CCL4, CXCL1, CXCL2) were highly expressed in the BAL fluid, prior to declining by 24 h. Compared to wild type counterparts, Rgs2^−/− mice developed significantly greater airflow resistance in response to inhaled methacholine (MCh) at 3 h post-LPS exposure. At 24 h post-LPS exposure, when lung function was recovering in the wild type animals, MCh-induced resistance was increased, and compliance decreased, in Rgs2^−/− mice. Thus, Rgs2^−/− mice show AHR and stiffer lungs 24 h post-LPS exposure. Histological markers of inflammation, total and differential cell counts, and major cytokine and chemokine expression in BAL fluid were similar between wild type and Rgs2^−/− mice. However, 3 and 24 h post-LPS exposure, IL12B expression was significantly elevated in BAL fluid from Rgs2^−/− mice compared to wild type animals.

Conclusions

While Rgs2 is bronchoprotective in acute neutrophilic inflammation, no clear anti-inflammatory effect was apparent. Nevertheless, elevated IL12B expression in Rgs2^−/− animals raises the possibility that RGS2 could dampen Th1 responses. These findings indicate that up-regulation of RGS2, as occurs in response to inhaled corticosteroids and long-acting β₂-adrenoceptor agonists, may be beneficial in acute neutrophilic exacerbations of airway disease, including asthma.

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A bronchoprotective role for Rgs2 in a murine model of lipopolysaccharide-induced airways inflammation

Abstract

Background

Asthma exacerbations are associated with the recruitment of neutrophils to the lungs. These cells release proteases and mediators, many of which act at G protein-coupled receptors (GPCRs) that couple via Gq to promote bronchoconstriction and inflammation. Common asthma therapeutics up-regulate expression of the regulator of G protein signalling (RGS), RGS2. As RGS2 reduces signaling from Gq-coupled GPCRs, we have defined role(s) for this GTPase-activating protein in an acute neutrophilic model of lung inflammation.

Methods

Wild type and Rgs2^−/− C57Bl6 mice were exposed to nebulized lipopolysaccharide (LPS). Lung function (respiratory system resistance and compliance) was measured using a SCIREQ flexivent small animal ventilator. Lung inflammation was assessed by histochemistry, cell counting and by cytokine and chemokine expression in bronchoalveolar lavage (BAL) fluid.

Results

Lipopolysaccharide inhalation induced transient airways hyperreactivity (AHR) and neutrophilic lung inflammation. While AHR and inflammation was greatest 3 h post-LPS exposure, BAL neutrophils persisted for 24 h. At 3 h post-LPS inhalation, multiple inflammatory cytokines (CSF2, CSF3, IL6, TNF) and chemokines (CCL3, CCL4, CXCL1, CXCL2) were highly expressed in the BAL fluid, prior to declining by 24 h. Compared to wild type counterparts, Rgs2^−/− mice developed significantly greater airflow resistance in response to inhaled methacholine (MCh) at 3 h post-LPS exposure. At 24 h post-LPS exposure, when lung function was recovering in the wild type animals, MCh-induced resistance was increased, and compliance decreased, in Rgs2^−/− mice. Thus, Rgs2^−/− mice show AHR and stiffer lungs 24 h post-LPS exposure. Histological markers of inflammation, total and differential cell counts, and major cytokine and chemokine expression in BAL fluid were similar between wild type and Rgs2^−/− mice. However, 3 and 24 h post-LPS exposure, IL12B expression was significantly elevated in BAL fluid from Rgs2^−/− mice compared to wild type animals.

Conclusions

While Rgs2 is bronchoprotective in acute neutrophilic inflammation, no clear anti-inflammatory effect was apparent. Nevertheless, elevated IL12B expression in Rgs2^−/− animals raises the possibility that RGS2 could dampen Th1 responses. These findings indicate that up-regulation of RGS2, as occurs in response to inhaled corticosteroids and long-acting β₂-adrenoceptor agonists, may be beneficial in acute neutrophilic exacerbations of airway disease, including asthma.

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Clinical efficacy of sublingual immunotherapy is associated with restoration of steady-state serum lipocalin 2 after SLIT: a pilot study

Abstract

Background

So far, only a few biomarkers in allergen immunotherapy exist that are associated with a clinical benefit. We thus investigated in a pilot study whether innate molecules such as the molecule lipocalin-2 (LCN2), with implications in immune tolerance demonstrated in other fields, may discriminate A) between allergic and non-allergic individuals, and B) between patients clinically responding or non-responding to sublingual allergen immunotherapy (SLIT) with house dust mite (HDM) extract. Moreover, we assessed haematological changes potentially correlating with allergic symptoms.

Methods

LCN2-concentrations were assessed in sera of healthy and allergic subjects (n = 126) as well as of house dust mite (HDM) allergics before and during HDM- sublingual immunotherapy (SLIT) in a randomized, double-blind, placebo-controlled trial for 24 weeks. Sera pre-SLIT (week 0), post-SLIT (week 24) and 9 months after SLIT were assessed for LCN2 levels and correlated with total nasal symptom scores (TNSS) obtained during chamber challenge at week 24 in patients receiving HDM- (n = 31) or placebo-SLIT (n = 10).

Results

Allergic individuals had significantly (p < 0.0001) lower LCN2-levels than healthy controls. HDM-allergic patients who received HDM-SLIT showed a significant increase in LCN2 9 months after termination of HDM-SLIT (p < 0.001), whereas in subjects receiving placebo no increase in LCN2 was observed. Among blood parameters a lower absolute rise in the lymphocyte population (p < 0.05) negatively correlated with symptom improvement (Pearson r 0.3395), and a lower relative increase in the neutrophils were associated with improvement in TNSS (p < 0.05). LCN2 levels 9 months after immunotherapy showed a low positive correlation with the relative improvement of symptoms (Pearson r 0.3293). LCN2-levels 9 months off-SLIT were significantly higher in patients whose symptoms improved during chamber challenge than in those whose symptoms aggravated (p < 0.01).

Conclusion

Serum LCN2 concentrations 9 months off-SLIT correlated with clinical reactivity in allergic patients. An increase in the LCN2 levels 9 months after HDM-SLIT was associated with a clinical benefit. Serum LCN2 may thus contribute to assess clinical reactivity in allergic patients.

Trial registration

Part of the data were generated from clinicaltrials.gov Identifier NCT01644617.

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2018 Sidney H. Ingbar Distinguished Lectureship Award to Be Given to Anthony N. Hollenberg, MD, at American Thyroid Association’s Annual Meeting

October 1, 2018—The American Thyroid Association (ATA) is pleased to announce that the 2018 Sidney H. Ingbar Distinguished Lectureship Award recipient will be Dr. Anthony N. Hollenberg, currently Professor and Chief of the Division of Endocrinology, Metabolism, and Diabetes at Beth Israel Hospital, Boston, as well as Physician in Endocrinology at Beth Israel Deaconess Medical Center (BIDMC).

The Ingbar Award recognizes an established investigator who has made outstanding contributions to thyroid-related research over many years. The award honors the memory of Dr. Sidney H. Ingbar, a brilliant innovator who was once Chief of the Beth Israel Thyroid Unit, a position Dr. Hollenberg now holds. The medal is conferred at the ATA Annual Meeting, held this year from October 3 to 7 in Washington, DC. On Friday, October 5, at 1 pm, Dr. Hollenberg will deliver the Sidney H. Ingbar Distinguished Award Lecture, titled "New Insights into Thyroid Hormone Action."

Dr. Hollenberg is recognized internationally for his consistent research contributions in studies of the molecular action of thyroid hormones. He was among the first to identify that thyrotropin-releasing hormone (TRH) neurons in the hypothalamus serve as integrators of metabolic input, setting thyroid hormone levels within the context of body weight. He was also among the first to identify the role of specific co-repressors in negative regulation by the thyroid and helped to establish the idea that hormone sensitivity is due to the quantity of co-repressors present. He has had an independent research laboratory at Beth Israel Hospital since 1993 and been funded continuously by the NIH since 1995. In addition, he founded the Thyroid Nodule Clinic at BIDMC 16 years ago to enable clinicians, radiologist, and cytologist to practice together, enhancing clinical care for patients with nodules.

In addition to groundbreaking research in thyroid hormone receptor action and function, Dr. Hollenberg has more recently begun a new program in his laboratory focused on the development of functioning thyroid follicular cells from embryonic stem cells, working in conjunction with the Kotton lab at Boston University School of Medicine.

Dr. Hollenberg received his MD from the Faculty of Medicine at the University of Calgary, Alberta, after earning his AB degree cum laude in biochemical sciences from Harvard College. He spent his internship and residency at BIDMC, after which he was Chief Medical Resident there for one year. Overlapping that appointment and continuing after it, he was Clinical and Research Fellow in Endocrinology as Massachusetts General Hospital (MGH). At the same time, he has risen from Instructor to Professor of Medicine at Harvard Medical School and has held—and continues to hold—numerous administrative positions at the local, national, and international levels. He has been a welcomed speaker at symposia, seminars, society meetings, and medical schools around the world for almost 20 years.

In addition to his research and academic activities, Dr. Hollenberg has served in an editorial capacity for the New England Journal of Medicine, Proceedings of the National Academy of Sciences, Endocrinology, Journal of Biological Chemistry, and many other journals and been on the editorial boards of Endocrinology and Molecular Endocrinology. Over 100 publications and book chapters have Dr. Hollenberg's signature and he has mentored and trained well over 100 graduate students and laboratory trainees. He received the ATA's Van Meter Award and the British Endocrine Society's Pitt Rivers Award, among others.

Through his sophisticated research, innovations, public speaking, and publications, Dr. Hollenberg has contributed significantly and continuously to the well-being of those with thyroid disease. That commitment, combined with his dedication to his patients and students, makes him a very worthy recipient for the highly sought after and prestigious, Sidney H. Ingbar Distinguished Award.

 ###

The American Thyroid Association (ATA) is the leading worldwide organization dedicated to the advancement, understanding, prevention, diagnosis, and treatment of thyroid disorders and thyroid cancer. ATA is an international membership medical society with over 1,700 members from 43 countries around the world. Celebrating its 95^th anniversary, the ATA continues to deliver its mission of being devoted to thyroid biology and to the prevention and treatment of thyroid disease through excellence in research, clinical care, education, and public health.  These efforts are carried out via several key endeavors:

•  The publication of the highly regarded professional journals Thyroid, Clinical Thyroidology, and VideoEndocrinology
• Annual scientific meetings
• Biennial clinical and research symposia
• Research grant programs for young investigators
• Support of online professional, public, and patient educational programs
• Development of guidelines for clinical management of thyroid disease and thyroid cancer

 The ATA promotes thyroid awareness and information online through Clinical Thyroidology for the Public and extensive, authoritative explanations of thyroid disease and thyroid cancer in both English and Spanish. The ATA website serves as the clinical resource for patients and the public who look for reliable information on the Internet. Every fifth year, the American Thyroid Association joins with the Latin American Thyroid Society, the European Thyroid Association, and the Asia and Oceania Thyroid Association to cosponsor the International Thyroid Congress (ITC).

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2018 Paul Starr Award to Be Given to Scott A. Rivkees, MD, at American Thyroid Association’s Annual Meeting

October 1, 2018—The American Thyroid Association (ATA) is pleased to announce that the 2018 Paul Starr Award recipient and lecturer will be Dr. Scott A. Rivkees, Professor and Chair, as well as Nemours Eminent Scholar, at the University of Florida Department of Pediatrics. Dr. Rivkees is also Physician-in-Chief at Shands Children's Hospital in Gainesville, Academic Chair of Pediatrics at Arnold Palmer Hospital in Orlando, and University of Florida Chair of Pediatrics at Studer Family Children's Hospital at Sacred Heart in Pensacola.

The Starr Award is presented to an outstanding contributor to clinical thyroidology. At the ATA Annual Meeting in Washington, DC, Dr. Rivkees will deliver the Paul Starr Award Lecture at 1:00 pm on October 4, 2018, on "Unmasking the Problems With Antithyroid Medication Safety."

Dr. Rivkees earned his BS in biochemistry from Cook College at Rutgers University and his MD from New Jersey Medical School. Thereafter, he was a Resident in Pediatrics at Massachusetts General Hospital (MGH) and Clinical Fellow in Pediatrics at Harvard Medical School (HMS), then a Clinical Fellow in Pediatric Endocrinology at both locations. While working as a Postdoctoral Fellow in Neuroscience—again at both locations—Dr. Rivkees was also a Research Fellow at MGH. After his postdoc, he was appointed Instructor in Pediatrics at HMS and Assistant in Pediatrics at MGH, followed by Assistant Professor of Pediatrics at HMS and Associate Professor Pediatrics at Indiana University and Yale University. After receiving tenure at Yale, he became director of the Yale Child Health Research Center, Professor of Pediatrics, Chief of the Section of Developmental Endocrinology and Biology, and Associate Chair of Yale Pediatrics for Research, all at the same time. From there he moved to his current appointments in Florida.

Dr. Rivkees's important contributions have focused on pediatric thyroidology, but also on thyroidology more generally. He made public the dangers—especially the onset of liver failure—associated with the use of the medicine propylthiouracil, which resulted in worldwide changes in the treatment of hyperthyroidism. Through his research, clinical work, and publications, he was responsible for changing the way children with juvenile-acquired hypothyroidism are treated. He wrote many papers concerning the risks and benefits of using radioactive iodine in children with thyroid disease, predating the ATA's own guidelines on treating pediatric thyroid cancer. And he started the first Pediatric Thyroid Cancer Program in the US, at Yale University.

Another area of Dr. Rivkees's research evaluated the risks of antithyroid medications to both mother and fetus, which led to findings that are now incorporated into the ATA guidelines for managing hypothyroidism during pregnancy.

Dr. Rivkees has written over 230 articles, chapters, and editorials. He is Editor-in-Chief of the International Journal of Pediatric Endocrinology and a member of the American Society for Clinical Investigation. He has been named "One of America's Best Doctors" and "One of America's Top Pediatricians," as well as "Physician of the Year" by the CARES Foundation. Dr. Rivkees has served on numerous panels, advisory boards, editorial boards, and symposia and in 2012 was named a Fellow of the American Academy for the Advancement of Science. He holds one patent, with three more pending.

Over the past three-plus decades, Dr. Rivkees has demonstrated repeatedly his dedication to clinical thyroidology, improving the care of infants, children, and adolescents worldwide. That commitment, combined with his dedication to his patients and students, makes him a very worthy recipient for the highly sought after and prestigious, 2018 Paul Starr Award, the first ever given to a pediatric endocrinologist.

 ###

The American Thyroid Association (ATA) is the leading worldwide organization dedicated to the advancement, understanding, prevention, diagnosis, and treatment of thyroid disorders and thyroid cancer. ATA is an international membership medical society with over 1,700 members from 43 countries around the world. Celebrating its 95^th anniversary, the ATA continues to deliver its mission of being devoted to thyroid biology and to the prevention and treatment of thyroid disease through excellence in research, clinical care, education, and public health.  These efforts are carried out via several key endeavors:

•  The publication of the highly regarded professional journals Thyroid, Clinical Thyroidology, and VideoEndocrinology
  
• Annual scientific meetings
• Biennial clinical and research symposia
• Research grant programs for young investigators
• Support of online professional, public, and patient educational programs
  
• Development of guidelines for clinical management of thyroid disease and thyroid cancer

 The ATA promotes thyroid awareness and information online through Clinical Thyroidology for the Public and extensive, authoritative explanations of thyroid disease and thyroid cancer in both English and Spanish. The ATA website serves as the clinical resource for patients and the public who look for reliable information on the Internet. Every fifth year, the American Thyroid Association joins with the Latin American Thyroid Society, the European Thyroid Association, and the Asia and Oceania Thyroid Association to cosponsor the International Thyroid Congress (ITC).

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2018 Lewis E. Braverman Distinguished Award to Be Presented to R. Michael Tuttle, MD, at American Thyroid Association’s Annual Meeting

October 1, 2018—The American Thyroid Association (ATA) announces with pleasure that the 2018 Lewis E. Braverman Distinguished Award recipient will be Dr. R. Michael Tuttle, currently Clinical Director of the Endocrinology Service and Attending Physician at Memorial Hospital for Cancer and Allied Diseases in New York City. Academic positions include Member, at Memorial Sloan Kettering Cancer Center (MSKCC) and Professor of Medicine at Weill Medical College of Cornell University, both in New York City.

The Braverman Distinguished Award is presented annually to an individual who: demonstrates excellence and passion for mentoring fellows, students, and junior faculty; has a long history of productive thyroid research; and is devoted to the ATA. Dr. Tuttle will give the Braverman Lecture, entitled "Common Clinical Thyroid Cancer Questions in Need of Better Answers" on October 6 at 10:45 am, during the ATA Annual Meeting, which is held this year from October 3 to 7 in Washington, DC.

Dr. Tuttle has demonstrated his teaching and mentoring excellence in training medical students, interns, residents, and fellows during his entire career. Many of his past fellows have gone on to national and international prominence in thyroid cancer research, treatment, and education. To quote one of his fellows, now an assistant professor from Saudi Arabia, he learned from Dr. Tuttle that "it is OK to change my practice and admit to do so if studies proved new evidence…. I learned how to communicate with colleagues and other working staff in a delightful way. He was always considerate and open to new ideas." Another cancer physician writes that after his fellowship with Dr. Tuttle he "gave multiple lectures around the country [Israel] that helped change the 'one size fits all' approach to a more risk-adapted, personalized approach." Through hundreds of invited lectures, meetings, and grand rounds, as well as his almost 300 publications, Dr. Tuttle has reached even more medical students, fellows, and peers with his emphasis on minimalism in treatment.

Dr. Tuttle's research has had major clinical impact over the years on the care of thyroid cancer patients. His laboratory's work confirmed that a recurrence staging system effectively predicts the risks of recurrence and persistent disease and that these risk assessments can be used productively to tailor follow-up recommendations for individual patients on a case-by-case basis, rather than using generalized treatment methods. Another of his mentees comments, "Thanks to everything learned with Dr. Mike Tuttle…the quality of life of patients with diagnosis and thyroid cancer in Chile is significantly higher."

An active member of the ATA since 1997, Dr. Tuttle has served on multiple committees, such as Clinical Affairs, Standards of Care, and Membership, among others. He was Program Chair of the 2014 Annual Meeting and a member of the Board of Directors from 2007 to 2011. He was key in drafting the ATA Guidelines on the Management of Thyroid Nodules and Thyroid Cancer and continues to be active on that committee, and he currently is Chair of the ATA's Medullary Thyroid Cancer Registry Consortium. In addition, Dr. Tuttle has been a reviewer for the ATA's journal Thyroid (as well as many other journals) and was Associate Editor of Thyroid from 2013 through 2015. He has attracted many new members to the ATA with his great enthusiasm for the study of thyroid disease.

Dr. Tuttle earned his BS in biology magna cum laude from Northern Kentucky University and his MD cum laude from the University of Louisville School of Medicine, KY. He spent his internship and residency in Internal Medicine at Dwight David Eisenhower Army Medical Center, Augusta, GA, where he was awarded "Outstanding Graduating Resident." He held a Clinical Fellowship in endocrinology, a Research Fellowship in endocrinology and molecular biology, and then was Staff Endocrinologist, all at Madigan Army Medical Center in Tacoma, WA. His hospital positions thereafter were at Walter Reed Army Medical Center and then the Department of Medicine, Memorial Hospital for Cancer and Allied Disease, NYC, where he is now Attending Physician and Clinical Director of the Endocrinology Service. At the same time, his teaching and research positions have led him through the professional ranks at Memorial Sloan Kettering Cancer Center and the Weill Medical College of Cornell University.

Dr. Tuttle continues to leave a significant impact in the thyroid cancer field through his valuable mentoring, research, and contributions to the ATA.  That commitment, combined with his dedication to his patients and students, makes him a very worthy recipient for the highly sought after and prestigious, 2018 Lewis E. Braverman Distinguished Award.

 ###

The American Thyroid Association (ATA) is the leading worldwide organization dedicated to the advancement, understanding, prevention, diagnosis, and treatment of thyroid disorders and thyroid cancer. ATA is an international membership medical society with over 1,700 members from 70 countries around the world. Celebrating its 95^th anniversary, the ATA delivers its mission of being devoted to thyroid biology and to the prevention and treatment of thyroid disease through excellence in research, clinical care, education, and public health. 

These efforts are carried out via several key endeavors:

• The publication of the highly regarded professional journals Thyroid^®, Clinical Thyroidology^®, and VideoEndocrinology
• Annual scientific meetings
• Biennial clinical and research symposia
• Research grant programs for young investigators
• Support of online professional, public, and patient educational programs
• Development of guidelines for clinical management of thyroid disease and thyroid cancer

 Further information about the ATA^® annual meeting can be found https://www.thyroid.org/88th-annual-meeting-ata/ and research grants program https://www.thyroid.org/media-main/ and patient information https://www.thyroid.org/thyroid-information/.  The ATA promotes thyroid awareness and information online through Clinical Thyroidology^® for the Public and extensive, authoritative explanations of thyroid disease and thyroid cancer in both English and Spanish. The ATA website serves as the clinical resource for patients and the public who look for reliable information on the Internet. Every fifth year, the American Thyroid Association joins with the Latin American Thyroid Society, the European Thyroid Association, and the Asia and Oceania Thyroid Association to cosponsor the International Thyroid Congress (ITC).

 

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The American Thyroid Association holds its 88th Annual Meeting at the Marriott Marquis, Washington DC from October 3-7, 2018

The 88^th Annual Meeting of the American Thyroid Association (ATA) is almost here!! On behalf of the program committee, we look forward to welcoming you and your guests to our ATA annual meeting to be held October 3-7, 2018 at the Marriott Marquis Washington DC. This year the program committee, comprised of experts of all thyroid disciplines, has worked tirelessly to develop a program featuring the latest advances in basic/ translational and clinical thyroidology (www.thyroid.org). Meeting registration is on track to generate the highest attendance we have ever had for an ATA meeting. Washington, DC is a world-class destination with many stellar cultural, musical and museum attractions (within walking distance of the headquarters' hotel) available to attendees and their families.

New Programs This Year

This year the program will feature a wide variety of primary lectures, symposia and discussion-debates/meet the professor workshops that have been highly rated in the past along with several new sessions we hope to be of great interest. The first is the very first ATA international symposium – the ATA Latin American Satellite Symposium from 1:00 PM to 4:00 PM on Wednesday, October 3. This will represent a gathering of Latin American and ATA leaders allowing for true international interaction, networking, collaboration, the renewal of old and hopefully the development of new friendships. The international representation of the annual meeting is reflected by the over 543 abstracts submitted representing more than 38 countries.

The other new addition to the 2018 program is the 1^st Annual Advanced Practice Providers (APP) Satellite Symposium from 1:00 to 6:00 PM on Saturday, October 6.  This symposium reflects the growing membership within the ATA of advanced practice providers.  Reflecting this, the APP symposium will bring together the spectrum of healthcare professionals comprising the clinical "thyroid team"; focusing on all aspects of clinical management of thyroid disease, including nurse practitioners, clinical nurse specialists, advanced degree nurses and physician assistants.

Opening Day

Of interest in our pre-meeting programming is the ATA Endocrine Neck Advanced Ultrasound Course co-chaired by Kevin Brumund and Susan Mandel on Wednesday, October 3 and the E. Chester Ridgway Trainee Conference, an extensive clinical and basic training program co-chaired by Jacqueline Kung and Jennifer Sipos (for both these pre-congress programs preregistration is required, and seating is limited). On the evening of October 3, the annual meeting will kick off with our traditional Year in Thyroidology review featuring three leaders to discuss and interpret the top recent literature published in basic, clinical and surgical thyroidology. Christine Spitzweg, Virginia Sarapura, and Amy Chen will present summaries of the most notable studies in each of their respective fields. This remains a highly anticipated opening session and will be followed by the

This year, we have two distinguished speakers who will be presenting timely and novel plenary lectures: Dr. Kevin Harold from Yale University speaking on The Role of the Microbiome in Thyroid Autoimmunity and Dr. Timothy Chan from MSKCC discussing Antitumor Immunology and Immune therapies for Advanced Thyroid Cancer. Notable symposia include: Clinical Symposium: Iodine and Health, chaired by Elizabeth Pearce with speakers Jonathan Gorstein, Sarah C. Bath and Angela M. Leung; Basic Symposium: Genetic Landscapes on Advanced Thyroid Cancers chaired by Laura Boucai, with speakers Mingzhao Xing, Matthew D. Ringel and James A. Fagin. The highly anticipated Arthur Bauman Clinical Symposium will focus on cytologically indeterminate thyroid nodules and the role (and controversies) of molecular markers in their management strategies.

Awards remain an important part of the meeting, with recognitions being held for the following:

• The ATA will announce the recipient of the Van Meter Award on Thursday, October 4^th in recognition of outstanding contributions to thyroid research.
• Scott A. Rivkees is the recipient of the Paul Starr Award, which recognizes outstanding contributions to clinical thyroidology, and will present Unmasking the Problems with Anti-Thyroid Medication Safety.
• The ATA Distinguished Service Award will be presented to David H. Sarne for his outstanding contributions to the society.
• The John B. Stanbury Thyroid Pathophysiology Medal will be awarded to Marvin C. Gershengorn.
• The Clark T. Sawin Historical Presentation on the Treatment of Hypothyroidism – from Animal Extracts to Current Controversies will be moderated by Peter Kopp, with panelists to include John Morris, Valerie Anne Galton, Jacqueline Jonklaas and Stephen LaFranchi.
• The Sidney H. Ingbar Distinguished Awardee, an established investigator who has made major contributions to thyroid-related research over many years, is Anthony Hollenberg who will speak on New Insights into Thyroid Hormone Action.
• The Lewis E. Braverman Distinguished Lectureship Award established in 2011 to recognize an individual who has demonstrated excellence and passion for mentoring fellows, students and junior faculty is being presented by R. Michael Tuttle on Common Clinical Thyroid Cancer Questions in Need of Better Answers.

Based on the success of last year's meeting, we are pleased to again offer the ATA Pediatric Thyroid Forum Satellite Symposium – Current state and Future Directions, co-chaired by Andrew Bauer and Catherine Dinauer taking place Saturday, October 6.

Mainstays of the Annual meeting, Discussion-Debates/Meet The Professor Workshops have shown high registration numbers thus far, including Locally Advanced Thyroid Cancer in the Era of TKIs, Endocrine and Nuclear Medicine – Controversies, Consensus and Collaboration in the use of RAI therapy in DTC, Understanding of Thyroid Pathology and Cytology for Endocrinologists and Surgeons, Thyroid Disease and Pregnancy, Medullary Thyroid Cancer – Updates on Detection, Management and Postoperative follow-up, RET translational symposium – 25 year anniversary of RET and Precision Medicine in Thyroid Cancer 2018.

Surgical programming

The surgical component of this year's annual meeting will be strong with participation of our many surgeon members representing numerous thyroid surgical societies. Sessions of interest to surgeons include the Role of molecular markers and evaluation of thyroid nodules chaired by Jennifer Sipos, a session on Medullary Thyroid Cancer chaired by Rich Wong, a session on Patient Reported Outcomes in Thyroid Cancer Treatment chaired by Megan Haymart and Jeffrey Garber and a special Surgical Symposium on Multidisciplinary Management of Graves' Disease 2018 chaired by Rosemary Metzger as well as a Thyroid Cancer Tumor Board session chaired by Catherine Sinclair and a session on Locally Advanced Thyroid Cancer Management in the Era of TKIs moderated by Wendy Sacks. We will again have a VideoEndocrinology session on Risk stratification of thyroid cancer chaired by William Barry Inabnet and David Terris.

ATA Governance and Constituency-building

The ATA annual meeting is a great time to work for the ATA within its committee structure and to get time to engage directly with colleagues and trainees over a poster or by discussion of an oral abstract presentation. Meet presenters and attendees with backgrounds in basic and clinical thyroid research, general endocrinology, otolaryngology, endocrine surgery, pediatric endocrinology, medical oncology, nuclear medicine, laboratory sciences, industry, pathology, cytology, advanced practice providers and allied health disciplines. Meet with pharmaceutical, device and technology sponsors and our patient support groups at the 2018 ATA Thyroid EXPO. ATA committee meetings will be held Wednesday, October 3, the Women in Thyroidology Networking Reception also Wednesday, October 3 the annual ATA Business Meeting will be held Thursday, October 4.

CME and MOC credits available

This year through meeting attendance one may earn a maximum of 23.50 AMA PRA Category 1 Credits™ and in addition through a new Maintenance of Certification (MOC) program attendees may earn up to 23.50 medical knowledge MOC points in the American Board of Internal Medicine MOC program through their program and activity reporting system and ACCME.

 

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2018 Distinguished Service Award to Be Given to David H. Sarne, MD, at American Thyroid Association’s Annual Meeting

October 1, 2018—The American Thyroid Association (ATA) is pleased to announce that the 2018 Distinguished Service Award recipient will be Dr. David H. Sarne, currently Clinical Associate in the Department of Medicine at the University of Chicago.

The Distinguished Service Award recognizes an ATA member who has made important and continuing contributions to the Association. The award will be conferred during the Presentation of Awards, beginning at 4:00 pm on October 4 during the ATA Annual Meeting, held this year from October 3 to 7 in Washington, DC.

Dr. Sarne received his MD with honors from the University of Michigan Medical School, after receiving his BS with highest distinction in Psychology and Zoology from the University of Michigan. He spent his internship and residency with the University of California Hospitals and Clinics in San Francisco and then became a Fellow in the Section of Endocrinology, Department of Medicine, at the University of Chicago. After three years as an Assistant Professor of Medicine at the University of Chicago, he moved to the University of Illinois Medical Center, where he rose to Professor. In 2012 he returned to the University of Chicago in his current position.

He has specialized in thyroid disorders, including hyperthyroidism, nodules, and thyroid cancer. As such, he has received regular funding for research efforts and has been an invited speaker at universities, association meetings, and conferences. Dr. Sarne has been the primary or a significant contributor to over 50 articles, book chapters, and other publications and has served as a manuscript reviewer for numerous medical journals, including JAMA, the New England Journal of Medicine, Thyroid, and Endocrinology, among others. He has repeatedly been named one of the "Best Doctors in America" and received scholarships, prizes, and awards throughout his academic and practice years.

Most important for the Distinguished Service Award, Dr. Sarne served on a variety of committees for the ATA between 1987 and 2017, including the Education Committee, the Distinguished Service Committee, the Awards Committee, the Annual Meeting Organizing Committee, and the Finance and Audit Committee—for the last of which he was Chair for 13 years. And he has twice served on the ATA's Board of Directors as Treasurer and member of the Executive Committee, first for a period of 7 years and most recently for 2 more years.

Dr. Sarne's tremendous commitment of time and energy to the Association over the past 30 years has helped to maintain our successful operation, particularly our financial health and stability. That commitment, combined with his dedication to his patients and students, makes him a very worthy recipient for the highly sought after and prestigious Distinguished Service Award.

 ###

The American Thyroid Association (ATA) is the leading worldwide organization dedicated to the advancement, understanding, prevention, diagnosis, and treatment of thyroid disorders and thyroid cancer. ATA is an international membership medical society with over 1,700 members from 70 countries around the world. Celebrating its 95^th anniversary, the ATA delivers its mission of being devoted to thyroid biology and to the prevention and treatment of thyroid disease through excellence in research, clinical care, education, and public health. 

These efforts are carried out via several key endeavors:

• The publication of the highly regarded professional journals Thyroid^®, Clinical Thyroidology^®, and VideoEndocrinology
• Annual scientific meetings
• Biennial clinical and research symposia
• Research grant programs for young investigators
• Support of online professional, public, and patient educational programs
• Development of guidelines for clinical management of thyroid disease and thyroid cancer

 Further information about the ATA^® annual meeting can be found https://www.thyroid.org/88th-annual-meeting-ata/ and research grants program https://www.thyroid.org/media-main/ and patient information https://www.thyroid.org/thyroid-information/.  The ATA promotes thyroid awareness and information online through Clinical Thyroidology^® for the Public and extensive, authoritative explanations of thyroid disease and thyroid cancer in both English and Spanish. The ATA website serves as the clinical resource for patients and the public who look for reliable information on the Internet. Every fifth year, the American Thyroid Association joins with the Latin American Thyroid Society, the European Thyroid Association, and the Asia and Oceania Thyroid Association to cosponsor the International Thyroid Congress (ITC).

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2018 John B. Stanbury Thyroid Pathophysiology Medal to Be Awarded to Marvin C. Gershengorn, MD, at American Thyroid Association’s Annual Meeting

October 1, 2018—The American Thyroid Association (ATA) announces with pleasure that the 2018 John B. Stanbury Thyroid Pathophysiology Medal will be awarded to Dr. Marvin C. Gershengorn at the ATA Annual Meeting this week. Dr. Gershengorn is Chief of the Clinical Endocrinology Branch (formerly the Laboratory of Endocrinology and Receptor Biology) at the National Institute of Diabetes & Digestive & Kidney Diseases (NIDDK), National Institutes of Health, Bethesda, Maryland.

The Stanbury Medal recognizes outstanding research contributions, either conceptual or technical, to the understanding of thyroid physiology or the pathophysiology of thyroid disease, that have had a major impact on research or clinical practice. The medal is traditionally conferred at the ATA Annual Meeting, held this year from October 3 to 7 in Washington, DC.

Dr. Gershengorn received his MD with honors in Biochemistry in 1971 from New York University School of Medicine after completing his BS magna cum laude at City College of the City University of New York (CUNY). He completed his internship and residency in Medicine at Strong Memorial Hospital of the University of Rochester School of Medicine and Dentistry. He became a Clinical Associate in the Clinical Endocrinology Branch of the National Institute of Arthritis, Metabolism, and Digestive Diseases at NIH, then returned to the NYU School of Medicine as Assistant Professor, then Director of the Honors Program, Associate Professor of Medicine, and Associate Professor in the Graduate School of Arts and Sciences. Moving to Cornell University Medical College and the New York Hospital, he was appointed in turn Professor of Medicine and Chief of the Division of Endocrinology and Metabolism, Professor of Physiology and Biophysics, the Abby Rockefeller Mauze Distinguished Professor of Endocrinology in Medicine, Professor of Cell Biology and Genetics, Professor of Medicine and Director of the Division of Molecular Medicine, and Director of the Molecular Medicine Training Program. At Weill Graduate School of Medical Sciences of Cornell University, Dr. Gershengorn was appointed Chair of the Program in Physiology, Biophysics, and Molecular Medicine. He joined the NIDDK in 2001 as Director of the Division of Intramural Research (Scientific Director) before his current appointment in 2008.

During his various research positions, Dr. Gershengorn has made groundbreaking scientific contributions that have increased our understanding of thyroid physiology, from the development of the first assays to measure T3 in human serum, to using lithium as an adjunct to radioiodine therapy in thyroid cancer, to fine-needle aspiration biopsy for the diagnosing thyroid nodules, to determining the gene sequence of the TRH receptor, among many others. His laboratory has been the leader in developing small-molecule, drug-like compounds that target the TSH receptors of the thyroid.

Dr. Gershengorn has received numerous awards, honors, and fellowships during his career, including both the Van Meter Award and the Sidney Ingbar Distinguished Lectureship for Outstanding Thyroid Research from the ATA, two awards from the Endocrine Society, and the NIDDK Director's Award for Translational Research. He has served on the editorial boards of journals dedicated to endocrinology, biological chemistry, and physiology and on advisory boards, review committees, and as a board director. From 1999 to 2001, Dr. Gershengorn was a Director of the ATA Board.

In addition to holding five patents, Dr. Gershengorn has shared in writing 280 journal articles since 1968.

His four decades of very productive research, teaching, writing, and continuous contributions to our understanding of the pathophysiology of thyroid disease make Dr. Gershengorn an extremely appropriate recipient of the 2018 John B. Stanbury Pathophysiology Medal.

 ###

The American Thyroid Association (ATA) is the leading worldwide organization dedicated to the advancement, understanding, prevention, diagnosis, and treatment of thyroid disorders and thyroid cancer. ATA is an international membership medical society with over 1,700 members from 43 countries around the world. Celebrating its 95^th anniversary, the ATA continues to deliver its mission of being devoted to thyroid biology and to the prevention and treatment of thyroid disease through excellence in research, clinical care, education, and public health.  These efforts are carried out via several key endeavors:

•  The publication of the highly regarded professional journals Thyroid^®, Clinical Thyroidology^®, and VideoEndocrinology
• Annual scientific meetings
  
• Biennial clinical and research symposia
• Research grant programs for young investigators
• Support of online professional, public, and patient educational programs
  
• Development of guidelines for clinical management of thyroid disease and thyroid cancer

 The ATA promotes thyroid awareness and information online through Clinical Thyroidology for the Public and extensive, authoritative explanations of thyroid disease and thyroid cancer in both English and Spanish. The ATA website serves as the clinical resource for patients and the public who look for reliable information on the Internet. Every fifth year, the American Thyroid Association joins with the Latin American Thyroid Society, the European Thyroid Association, and the Asia and Oceania Thyroid Association to cosponsor the International Thyroid Congress (ITC).

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Clinical efficacy of sublingual immunotherapy is associated with restoration of steady-state serum lipocalin 2 after SLIT: a pilot study

Abstract

Background

So far, only a few biomarkers in allergen immunotherapy exist that are associated with a clinical benefit. We thus investigated in a pilot study whether innate molecules such as the molecule lipocalin-2 (LCN2), with implications in immune tolerance demonstrated in other fields, may discriminate A) between allergic and non-allergic individuals, and B) between patients clinically responding or non-responding to sublingual allergen immunotherapy (SLIT) with house dust mite (HDM) extract. Moreover, we assessed haematological changes potentially correlating with allergic symptoms.

Methods

LCN2-concentrations were assessed in sera of healthy and allergic subjects (n = 126) as well as of house dust mite (HDM) allergics before and during HDM- sublingual immunotherapy (SLIT) in a randomized, double-blind, placebo-controlled trial for 24 weeks. Sera pre-SLIT (week 0), post-SLIT (week 24) and 9 months after SLIT were assessed for LCN2 levels and correlated with total nasal symptom scores (TNSS) obtained during chamber challenge at week 24 in patients receiving HDM- (n = 31) or placebo-SLIT (n = 10).

Results

Allergic individuals had significantly (p < 0.0001) lower LCN2-levels than healthy controls. HDM-allergic patients who received HDM-SLIT showed a significant increase in LCN2 9 months after termination of HDM-SLIT (p < 0.001), whereas in subjects receiving placebo no increase in LCN2 was observed. Among blood parameters a lower absolute rise in the lymphocyte population (p < 0.05) negatively correlated with symptom improvement (Pearson r 0.3395), and a lower relative increase in the neutrophils were associated with improvement in TNSS (p < 0.05). LCN2 levels 9 months after immunotherapy showed a low positive correlation with the relative improvement of symptoms (Pearson r 0.3293). LCN2-levels 9 months off-SLIT were significantly higher in patients whose symptoms improved during chamber challenge than in those whose symptoms aggravated (p < 0.01).

Conclusion

Serum LCN2 concentrations 9 months off-SLIT correlated with clinical reactivity in allergic patients. An increase in the LCN2 levels 9 months after HDM-SLIT was associated with a clinical benefit. Serum LCN2 may thus contribute to assess clinical reactivity in allergic patients.

Trial registration

Part of the data were generated from clinicaltrials.gov Identifier NCT01644617.

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2018 Sidney H. Ingbar Distinguished Lectureship Award to Be Given to Anthony N. Hollenberg, MD, at American Thyroid Association’s Annual Meeting

October 1, 2018—The American Thyroid Association (ATA) is pleased to announce that the 2018 Sidney H. Ingbar Distinguished Lectureship Award recipient will be Dr. Anthony N. Hollenberg, currently Professor and Chief of the Division of Endocrinology, Metabolism, and Diabetes at Beth Israel Hospital, Boston, as well as Physician in Endocrinology at Beth Israel Deaconess Medical Center (BIDMC).

The Ingbar Award recognizes an established investigator who has made outstanding contributions to thyroid-related research over many years. The award honors the memory of Dr. Sidney H. Ingbar, a brilliant innovator who was once Chief of the Beth Israel Thyroid Unit, a position Dr. Hollenberg now holds. The medal is conferred at the ATA Annual Meeting, held this year from October 3 to 7 in Washington, DC. On Friday, October 5, at 1 pm, Dr. Hollenberg will deliver the Sidney H. Ingbar Distinguished Award Lecture, titled "New Insights into Thyroid Hormone Action."

Dr. Hollenberg is recognized internationally for his consistent research contributions in studies of the molecular action of thyroid hormones. He was among the first to identify that thyrotropin-releasing hormone (TRH) neurons in the hypothalamus serve as integrators of metabolic input, setting thyroid hormone levels within the context of body weight. He was also among the first to identify the role of specific co-repressors in negative regulation by the thyroid and helped to establish the idea that hormone sensitivity is due to the quantity of co-repressors present. He has had an independent research laboratory at Beth Israel Hospital since 1993 and been funded continuously by the NIH since 1995. In addition, he founded the Thyroid Nodule Clinic at BIDMC 16 years ago to enable clinicians, radiologist, and cytologist to practice together, enhancing clinical care for patients with nodules.

In addition to groundbreaking research in thyroid hormone receptor action and function, Dr. Hollenberg has more recently begun a new program in his laboratory focused on the development of functioning thyroid follicular cells from embryonic stem cells, working in conjunction with the Kotton lab at Boston University School of Medicine.

Dr. Hollenberg received his MD from the Faculty of Medicine at the University of Calgary, Alberta, after earning his AB degree cum laude in biochemical sciences from Harvard College. He spent his internship and residency at BIDMC, after which he was Chief Medical Resident there for one year. Overlapping that appointment and continuing after it, he was Clinical and Research Fellow in Endocrinology as Massachusetts General Hospital (MGH). At the same time, he has risen from Instructor to Professor of Medicine at Harvard Medical School and has held—and continues to hold—numerous administrative positions at the local, national, and international levels. He has been a welcomed speaker at symposia, seminars, society meetings, and medical schools around the world for almost 20 years.

In addition to his research and academic activities, Dr. Hollenberg has served in an editorial capacity for the New England Journal of Medicine, Proceedings of the National Academy of Sciences, Endocrinology, Journal of Biological Chemistry, and many other journals and been on the editorial boards of Endocrinology and Molecular Endocrinology. Over 100 publications and book chapters have Dr. Hollenberg's signature and he has mentored and trained well over 100 graduate students and laboratory trainees. He received the ATA's Van Meter Award and the British Endocrine Society's Pitt Rivers Award, among others.

Through his sophisticated research, innovations, public speaking, and publications, Dr. Hollenberg has contributed significantly and continuously to the well-being of those with thyroid disease. That commitment, combined with his dedication to his patients and students, makes him a very worthy recipient for the highly sought after and prestigious, Sidney H. Ingbar Distinguished Award.

 ###

The American Thyroid Association (ATA) is the leading worldwide organization dedicated to the advancement, understanding, prevention, diagnosis, and treatment of thyroid disorders and thyroid cancer. ATA is an international membership medical society with over 1,700 members from 43 countries around the world. Celebrating its 95^th anniversary, the ATA continues to deliver its mission of being devoted to thyroid biology and to the prevention and treatment of thyroid disease through excellence in research, clinical care, education, and public health.  These efforts are carried out via several key endeavors:

•  The publication of the highly regarded professional journals Thyroid, Clinical Thyroidology, and VideoEndocrinology
• Annual scientific meetings
• Biennial clinical and research symposia
• Research grant programs for young investigators
• Support of online professional, public, and patient educational programs
• Development of guidelines for clinical management of thyroid disease and thyroid cancer

 The ATA promotes thyroid awareness and information online through Clinical Thyroidology for the Public and extensive, authoritative explanations of thyroid disease and thyroid cancer in both English and Spanish. The ATA website serves as the clinical resource for patients and the public who look for reliable information on the Internet. Every fifth year, the American Thyroid Association joins with the Latin American Thyroid Society, the European Thyroid Association, and the Asia and Oceania Thyroid Association to cosponsor the International Thyroid Congress (ITC).

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2018 Paul Starr Award to Be Given to Scott A. Rivkees, MD, at American Thyroid Association’s Annual Meeting

October 1, 2018—The American Thyroid Association (ATA) is pleased to announce that the 2018 Paul Starr Award recipient and lecturer will be Dr. Scott A. Rivkees, Professor and Chair, as well as Nemours Eminent Scholar, at the University of Florida Department of Pediatrics. Dr. Rivkees is also Physician-in-Chief at Shands Children's Hospital in Gainesville, Academic Chair of Pediatrics at Arnold Palmer Hospital in Orlando, and University of Florida Chair of Pediatrics at Studer Family Children's Hospital at Sacred Heart in Pensacola.

The Starr Award is presented to an outstanding contributor to clinical thyroidology. At the ATA Annual Meeting in Washington, DC, Dr. Rivkees will deliver the Paul Starr Award Lecture at 1:00 pm on October 4, 2018, on "Unmasking the Problems With Antithyroid Medication Safety."

Dr. Rivkees earned his BS in biochemistry from Cook College at Rutgers University and his MD from New Jersey Medical School. Thereafter, he was a Resident in Pediatrics at Massachusetts General Hospital (MGH) and Clinical Fellow in Pediatrics at Harvard Medical School (HMS), then a Clinical Fellow in Pediatric Endocrinology at both locations. While working as a Postdoctoral Fellow in Neuroscience—again at both locations—Dr. Rivkees was also a Research Fellow at MGH. After his postdoc, he was appointed Instructor in Pediatrics at HMS and Assistant in Pediatrics at MGH, followed by Assistant Professor of Pediatrics at HMS and Associate Professor Pediatrics at Indiana University and Yale University. After receiving tenure at Yale, he became director of the Yale Child Health Research Center, Professor of Pediatrics, Chief of the Section of Developmental Endocrinology and Biology, and Associate Chair of Yale Pediatrics for Research, all at the same time. From there he moved to his current appointments in Florida.

Dr. Rivkees's important contributions have focused on pediatric thyroidology, but also on thyroidology more generally. He made public the dangers—especially the onset of liver failure—associated with the use of the medicine propylthiouracil, which resulted in worldwide changes in the treatment of hyperthyroidism. Through his research, clinical work, and publications, he was responsible for changing the way children with juvenile-acquired hypothyroidism are treated. He wrote many papers concerning the risks and benefits of using radioactive iodine in children with thyroid disease, predating the ATA's own guidelines on treating pediatric thyroid cancer. And he started the first Pediatric Thyroid Cancer Program in the US, at Yale University.

Another area of Dr. Rivkees's research evaluated the risks of antithyroid medications to both mother and fetus, which led to findings that are now incorporated into the ATA guidelines for managing hypothyroidism during pregnancy.

Dr. Rivkees has written over 230 articles, chapters, and editorials. He is Editor-in-Chief of the International Journal of Pediatric Endocrinology and a member of the American Society for Clinical Investigation. He has been named "One of America's Best Doctors" and "One of America's Top Pediatricians," as well as "Physician of the Year" by the CARES Foundation. Dr. Rivkees has served on numerous panels, advisory boards, editorial boards, and symposia and in 2012 was named a Fellow of the American Academy for the Advancement of Science. He holds one patent, with three more pending.

Over the past three-plus decades, Dr. Rivkees has demonstrated repeatedly his dedication to clinical thyroidology, improving the care of infants, children, and adolescents worldwide. That commitment, combined with his dedication to his patients and students, makes him a very worthy recipient for the highly sought after and prestigious, 2018 Paul Starr Award, the first ever given to a pediatric endocrinologist.

 ###

The American Thyroid Association (ATA) is the leading worldwide organization dedicated to the advancement, understanding, prevention, diagnosis, and treatment of thyroid disorders and thyroid cancer. ATA is an international membership medical society with over 1,700 members from 43 countries around the world. Celebrating its 95^th anniversary, the ATA continues to deliver its mission of being devoted to thyroid biology and to the prevention and treatment of thyroid disease through excellence in research, clinical care, education, and public health.  These efforts are carried out via several key endeavors:

•  The publication of the highly regarded professional journals Thyroid, Clinical Thyroidology, and VideoEndocrinology
  
• Annual scientific meetings
• Biennial clinical and research symposia
• Research grant programs for young investigators
• Support of online professional, public, and patient educational programs
  
• Development of guidelines for clinical management of thyroid disease and thyroid cancer

 The ATA promotes thyroid awareness and information online through Clinical Thyroidology for the Public and extensive, authoritative explanations of thyroid disease and thyroid cancer in both English and Spanish. The ATA website serves as the clinical resource for patients and the public who look for reliable information on the Internet. Every fifth year, the American Thyroid Association joins with the Latin American Thyroid Society, the European Thyroid Association, and the Asia and Oceania Thyroid Association to cosponsor the International Thyroid Congress (ITC).

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2018 Lewis E. Braverman Distinguished Award to Be Presented to R. Michael Tuttle, MD, at American Thyroid Association’s Annual Meeting

October 1, 2018—The American Thyroid Association (ATA) announces with pleasure that the 2018 Lewis E. Braverman Distinguished Award recipient will be Dr. R. Michael Tuttle, currently Clinical Director of the Endocrinology Service and Attending Physician at Memorial Hospital for Cancer and Allied Diseases in New York City. Academic positions include Member, at Memorial Sloan Kettering Cancer Center (MSKCC) and Professor of Medicine at Weill Medical College of Cornell University, both in New York City.

The Braverman Distinguished Award is presented annually to an individual who: demonstrates excellence and passion for mentoring fellows, students, and junior faculty; has a long history of productive thyroid research; and is devoted to the ATA. Dr. Tuttle will give the Braverman Lecture, entitled "Common Clinical Thyroid Cancer Questions in Need of Better Answers" on October 6 at 10:45 am, during the ATA Annual Meeting, which is held this year from October 3 to 7 in Washington, DC.

Dr. Tuttle has demonstrated his teaching and mentoring excellence in training medical students, interns, residents, and fellows during his entire career. Many of his past fellows have gone on to national and international prominence in thyroid cancer research, treatment, and education. To quote one of his fellows, now an assistant professor from Saudi Arabia, he learned from Dr. Tuttle that "it is OK to change my practice and admit to do so if studies proved new evidence…. I learned how to communicate with colleagues and other working staff in a delightful way. He was always considerate and open to new ideas." Another cancer physician writes that after his fellowship with Dr. Tuttle he "gave multiple lectures around the country [Israel] that helped change the 'one size fits all' approach to a more risk-adapted, personalized approach." Through hundreds of invited lectures, meetings, and grand rounds, as well as his almost 300 publications, Dr. Tuttle has reached even more medical students, fellows, and peers with his emphasis on minimalism in treatment.

Dr. Tuttle's research has had major clinical impact over the years on the care of thyroid cancer patients. His laboratory's work confirmed that a recurrence staging system effectively predicts the risks of recurrence and persistent disease and that these risk assessments can be used productively to tailor follow-up recommendations for individual patients on a case-by-case basis, rather than using generalized treatment methods. Another of his mentees comments, "Thanks to everything learned with Dr. Mike Tuttle…the quality of life of patients with diagnosis and thyroid cancer in Chile is significantly higher."

An active member of the ATA since 1997, Dr. Tuttle has served on multiple committees, such as Clinical Affairs, Standards of Care, and Membership, among others. He was Program Chair of the 2014 Annual Meeting and a member of the Board of Directors from 2007 to 2011. He was key in drafting the ATA Guidelines on the Management of Thyroid Nodules and Thyroid Cancer and continues to be active on that committee, and he currently is Chair of the ATA's Medullary Thyroid Cancer Registry Consortium. In addition, Dr. Tuttle has been a reviewer for the ATA's journal Thyroid (as well as many other journals) and was Associate Editor of Thyroid from 2013 through 2015. He has attracted many new members to the ATA with his great enthusiasm for the study of thyroid disease.

Dr. Tuttle earned his BS in biology magna cum laude from Northern Kentucky University and his MD cum laude from the University of Louisville School of Medicine, KY. He spent his internship and residency in Internal Medicine at Dwight David Eisenhower Army Medical Center, Augusta, GA, where he was awarded "Outstanding Graduating Resident." He held a Clinical Fellowship in endocrinology, a Research Fellowship in endocrinology and molecular biology, and then was Staff Endocrinologist, all at Madigan Army Medical Center in Tacoma, WA. His hospital positions thereafter were at Walter Reed Army Medical Center and then the Department of Medicine, Memorial Hospital for Cancer and Allied Disease, NYC, where he is now Attending Physician and Clinical Director of the Endocrinology Service. At the same time, his teaching and research positions have led him through the professional ranks at Memorial Sloan Kettering Cancer Center and the Weill Medical College of Cornell University.

Dr. Tuttle continues to leave a significant impact in the thyroid cancer field through his valuable mentoring, research, and contributions to the ATA.  That commitment, combined with his dedication to his patients and students, makes him a very worthy recipient for the highly sought after and prestigious, 2018 Lewis E. Braverman Distinguished Award.

 ###

The American Thyroid Association (ATA) is the leading worldwide organization dedicated to the advancement, understanding, prevention, diagnosis, and treatment of thyroid disorders and thyroid cancer. ATA is an international membership medical society with over 1,700 members from 70 countries around the world. Celebrating its 95^th anniversary, the ATA delivers its mission of being devoted to thyroid biology and to the prevention and treatment of thyroid disease through excellence in research, clinical care, education, and public health. 

These efforts are carried out via several key endeavors:

• The publication of the highly regarded professional journals Thyroid^®, Clinical Thyroidology^®, and VideoEndocrinology
• Annual scientific meetings
• Biennial clinical and research symposia
• Research grant programs for young investigators
• Support of online professional, public, and patient educational programs
• Development of guidelines for clinical management of thyroid disease and thyroid cancer

 Further information about the ATA^® annual meeting can be found https://www.thyroid.org/88th-annual-meeting-ata/ and research grants program https://www.thyroid.org/media-main/ and patient information https://www.thyroid.org/thyroid-information/.  The ATA promotes thyroid awareness and information online through Clinical Thyroidology^® for the Public and extensive, authoritative explanations of thyroid disease and thyroid cancer in both English and Spanish. The ATA website serves as the clinical resource for patients and the public who look for reliable information on the Internet. Every fifth year, the American Thyroid Association joins with the Latin American Thyroid Society, the European Thyroid Association, and the Asia and Oceania Thyroid Association to cosponsor the International Thyroid Congress (ITC).

 

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The American Thyroid Association holds its 88th Annual Meeting at the Marriott Marquis, Washington DC from October 3-7, 2018

The 88^th Annual Meeting of the American Thyroid Association (ATA) is almost here!! On behalf of the program committee, we look forward to welcoming you and your guests to our ATA annual meeting to be held October 3-7, 2018 at the Marriott Marquis Washington DC. This year the program committee, comprised of experts of all thyroid disciplines, has worked tirelessly to develop a program featuring the latest advances in basic/ translational and clinical thyroidology (www.thyroid.org). Meeting registration is on track to generate the highest attendance we have ever had for an ATA meeting. Washington, DC is a world-class destination with many stellar cultural, musical and museum attractions (within walking distance of the headquarters' hotel) available to attendees and their families.

New Programs This Year

This year the program will feature a wide variety of primary lectures, symposia and discussion-debates/meet the professor workshops that have been highly rated in the past along with several new sessions we hope to be of great interest. The first is the very first ATA international symposium – the ATA Latin American Satellite Symposium from 1:00 PM to 4:00 PM on Wednesday, October 3. This will represent a gathering of Latin American and ATA leaders allowing for true international interaction, networking, collaboration, the renewal of old and hopefully the development of new friendships. The international representation of the annual meeting is reflected by the over 543 abstracts submitted representing more than 38 countries.

The other new addition to the 2018 program is the 1^st Annual Advanced Practice Providers (APP) Satellite Symposium from 1:00 to 6:00 PM on Saturday, October 6.  This symposium reflects the growing membership within the ATA of advanced practice providers.  Reflecting this, the APP symposium will bring together the spectrum of healthcare professionals comprising the clinical "thyroid team"; focusing on all aspects of clinical management of thyroid disease, including nurse practitioners, clinical nurse specialists, advanced degree nurses and physician assistants.

Opening Day

Of interest in our pre-meeting programming is the ATA Endocrine Neck Advanced Ultrasound Course co-chaired by Kevin Brumund and Susan Mandel on Wednesday, October 3 and the E. Chester Ridgway Trainee Conference, an extensive clinical and basic training program co-chaired by Jacqueline Kung and Jennifer Sipos (for both these pre-congress programs preregistration is required, and seating is limited). On the evening of October 3, the annual meeting will kick off with our traditional Year in Thyroidology review featuring three leaders to discuss and interpret the top recent literature published in basic, clinical and surgical thyroidology. Christine Spitzweg, Virginia Sarapura, and Amy Chen will present summaries of the most notable studies in each of their respective fields. This remains a highly anticipated opening session and will be followed by the

This year, we have two distinguished speakers who will be presenting timely and novel plenary lectures: Dr. Kevin Harold from Yale University speaking on The Role of the Microbiome in Thyroid Autoimmunity and Dr. Timothy Chan from MSKCC discussing Antitumor Immunology and Immune therapies for Advanced Thyroid Cancer. Notable symposia include: Clinical Symposium: Iodine and Health, chaired by Elizabeth Pearce with speakers Jonathan Gorstein, Sarah C. Bath and Angela M. Leung; Basic Symposium: Genetic Landscapes on Advanced Thyroid Cancers chaired by Laura Boucai, with speakers Mingzhao Xing, Matthew D. Ringel and James A. Fagin. The highly anticipated Arthur Bauman Clinical Symposium will focus on cytologically indeterminate thyroid nodules and the role (and controversies) of molecular markers in their management strategies.

Awards remain an important part of the meeting, with recognitions being held for the following:

• The ATA will announce the recipient of the Van Meter Award on Thursday, October 4^th in recognition of outstanding contributions to thyroid research.
• Scott A. Rivkees is the recipient of the Paul Starr Award, which recognizes outstanding contributions to clinical thyroidology, and will present Unmasking the Problems with Anti-Thyroid Medication Safety.
• The ATA Distinguished Service Award will be presented to David H. Sarne for his outstanding contributions to the society.
• The John B. Stanbury Thyroid Pathophysiology Medal will be awarded to Marvin C. Gershengorn.
• The Clark T. Sawin Historical Presentation on the Treatment of Hypothyroidism – from Animal Extracts to Current Controversies will be moderated by Peter Kopp, with panelists to include John Morris, Valerie Anne Galton, Jacqueline Jonklaas and Stephen LaFranchi.
• The Sidney H. Ingbar Distinguished Awardee, an established investigator who has made major contributions to thyroid-related research over many years, is Anthony Hollenberg who will speak on New Insights into Thyroid Hormone Action.
• The Lewis E. Braverman Distinguished Lectureship Award established in 2011 to recognize an individual who has demonstrated excellence and passion for mentoring fellows, students and junior faculty is being presented by R. Michael Tuttle on Common Clinical Thyroid Cancer Questions in Need of Better Answers.

Based on the success of last year's meeting, we are pleased to again offer the ATA Pediatric Thyroid Forum Satellite Symposium – Current state and Future Directions, co-chaired by Andrew Bauer and Catherine Dinauer taking place Saturday, October 6.

Mainstays of the Annual meeting, Discussion-Debates/Meet The Professor Workshops have shown high registration numbers thus far, including Locally Advanced Thyroid Cancer in the Era of TKIs, Endocrine and Nuclear Medicine – Controversies, Consensus and Collaboration in the use of RAI therapy in DTC, Understanding of Thyroid Pathology and Cytology for Endocrinologists and Surgeons, Thyroid Disease and Pregnancy, Medullary Thyroid Cancer – Updates on Detection, Management and Postoperative follow-up, RET translational symposium – 25 year anniversary of RET and Precision Medicine in Thyroid Cancer 2018.

Surgical programming

The surgical component of this year's annual meeting will be strong with participation of our many surgeon members representing numerous thyroid surgical societies. Sessions of interest to surgeons include the Role of molecular markers and evaluation of thyroid nodules chaired by Jennifer Sipos, a session on Medullary Thyroid Cancer chaired by Rich Wong, a session on Patient Reported Outcomes in Thyroid Cancer Treatment chaired by Megan Haymart and Jeffrey Garber and a special Surgical Symposium on Multidisciplinary Management of Graves' Disease 2018 chaired by Rosemary Metzger as well as a Thyroid Cancer Tumor Board session chaired by Catherine Sinclair and a session on Locally Advanced Thyroid Cancer Management in the Era of TKIs moderated by Wendy Sacks. We will again have a VideoEndocrinology session on Risk stratification of thyroid cancer chaired by William Barry Inabnet and David Terris.

ATA Governance and Constituency-building

The ATA annual meeting is a great time to work for the ATA within its committee structure and to get time to engage directly with colleagues and trainees over a poster or by discussion of an oral abstract presentation. Meet presenters and attendees with backgrounds in basic and clinical thyroid research, general endocrinology, otolaryngology, endocrine surgery, pediatric endocrinology, medical oncology, nuclear medicine, laboratory sciences, industry, pathology, cytology, advanced practice providers and allied health disciplines. Meet with pharmaceutical, device and technology sponsors and our patient support groups at the 2018 ATA Thyroid EXPO. ATA committee meetings will be held Wednesday, October 3, the Women in Thyroidology Networking Reception also Wednesday, October 3 the annual ATA Business Meeting will be held Thursday, October 4.

CME and MOC credits available

This year through meeting attendance one may earn a maximum of 23.50 AMA PRA Category 1 Credits™ and in addition through a new Maintenance of Certification (MOC) program attendees may earn up to 23.50 medical knowledge MOC points in the American Board of Internal Medicine MOC program through their program and activity reporting system and ACCME.

 

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2018 Distinguished Service Award to Be Given to David H. Sarne, MD, at American Thyroid Association’s Annual Meeting

October 1, 2018—The American Thyroid Association (ATA) is pleased to announce that the 2018 Distinguished Service Award recipient will be Dr. David H. Sarne, currently Clinical Associate in the Department of Medicine at the University of Chicago.

The Distinguished Service Award recognizes an ATA member who has made important and continuing contributions to the Association. The award will be conferred during the Presentation of Awards, beginning at 4:00 pm on October 4 during the ATA Annual Meeting, held this year from October 3 to 7 in Washington, DC.

Dr. Sarne received his MD with honors from the University of Michigan Medical School, after receiving his BS with highest distinction in Psychology and Zoology from the University of Michigan. He spent his internship and residency with the University of California Hospitals and Clinics in San Francisco and then became a Fellow in the Section of Endocrinology, Department of Medicine, at the University of Chicago. After three years as an Assistant Professor of Medicine at the University of Chicago, he moved to the University of Illinois Medical Center, where he rose to Professor. In 2012 he returned to the University of Chicago in his current position.

He has specialized in thyroid disorders, including hyperthyroidism, nodules, and thyroid cancer. As such, he has received regular funding for research efforts and has been an invited speaker at universities, association meetings, and conferences. Dr. Sarne has been the primary or a significant contributor to over 50 articles, book chapters, and other publications and has served as a manuscript reviewer for numerous medical journals, including JAMA, the New England Journal of Medicine, Thyroid, and Endocrinology, among others. He has repeatedly been named one of the "Best Doctors in America" and received scholarships, prizes, and awards throughout his academic and practice years.

Most important for the Distinguished Service Award, Dr. Sarne served on a variety of committees for the ATA between 1987 and 2017, including the Education Committee, the Distinguished Service Committee, the Awards Committee, the Annual Meeting Organizing Committee, and the Finance and Audit Committee—for the last of which he was Chair for 13 years. And he has twice served on the ATA's Board of Directors as Treasurer and member of the Executive Committee, first for a period of 7 years and most recently for 2 more years.

Dr. Sarne's tremendous commitment of time and energy to the Association over the past 30 years has helped to maintain our successful operation, particularly our financial health and stability. That commitment, combined with his dedication to his patients and students, makes him a very worthy recipient for the highly sought after and prestigious Distinguished Service Award.

 ###

The American Thyroid Association (ATA) is the leading worldwide organization dedicated to the advancement, understanding, prevention, diagnosis, and treatment of thyroid disorders and thyroid cancer. ATA is an international membership medical society with over 1,700 members from 70 countries around the world. Celebrating its 95^th anniversary, the ATA delivers its mission of being devoted to thyroid biology and to the prevention and treatment of thyroid disease through excellence in research, clinical care, education, and public health. 

These efforts are carried out via several key endeavors:

• The publication of the highly regarded professional journals Thyroid^®, Clinical Thyroidology^®, and VideoEndocrinology
• Annual scientific meetings
• Biennial clinical and research symposia
• Research grant programs for young investigators
• Support of online professional, public, and patient educational programs
• Development of guidelines for clinical management of thyroid disease and thyroid cancer

 Further information about the ATA^® annual meeting can be found https://www.thyroid.org/88th-annual-meeting-ata/ and research grants program https://www.thyroid.org/media-main/ and patient information https://www.thyroid.org/thyroid-information/.  The ATA promotes thyroid awareness and information online through Clinical Thyroidology^® for the Public and extensive, authoritative explanations of thyroid disease and thyroid cancer in both English and Spanish. The ATA website serves as the clinical resource for patients and the public who look for reliable information on the Internet. Every fifth year, the American Thyroid Association joins with the Latin American Thyroid Society, the European Thyroid Association, and the Asia and Oceania Thyroid Association to cosponsor the International Thyroid Congress (ITC).

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