Purpose of review Although the overall safety of blood transfusion is high, adverse events do still occur. Much research on transfusion reactions was done in nonperioperative patients. Fortunately, important contributions to the perioperative literature have been made in the last several years, specifically in the areas of transfusion-associated circulatory overload and transfusion-related acute lung injury (TRALI). Recent findings An unfavorable reaction occurs in as many as 1% of transfusions overall, although the risk of death with each unit given is between 0.002 and 0.0005%. Specific, modifiable factors exist, however, of which the anesthesiologist should be aware. A 2017 article by Clifford et al. is the first to examine risk factors and outcomes for transfusion-associated circulatory overload in a high-risk noncardiac surgery population undergoing anesthesia and surgery. In recent years, limiting plasma donors to males only resulted in an approximately 50% decrease in TRALI. Summary The current article explores new research on the topics of transfusion-associated circulatory overload and transfusion-related lung injury. Correspondence to Anna Clebone, MD, Department of Anesthesia and Critical Care, University of Chicago, 5841 S. Maryland Ave., MC4028, Chicago, IL 60637, USA. Tel: +1 773 702 6700; fax: +1 773 702 3535; e-mail: aclebone@gmail.com Copyright © 2019 YEAR Wolters Kluwer Health, Inc. All rights reserved.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CYk0Od
Τρίτη 8 Ιανουαρίου 2019
Transfusion reactions and cognitive aids
Purpose of review Although the overall safety of blood transfusion is high, adverse events do still occur. Much research on transfusion reactions was done in nonperioperative patients. Fortunately, important contributions to the perioperative literature have been made in the last several years, specifically in the areas of transfusion-associated circulatory overload and transfusion-related acute lung injury (TRALI). Recent findings An unfavorable reaction occurs in as many as 1% of transfusions overall, although the risk of death with each unit given is between 0.002 and 0.0005%. Specific, modifiable factors exist, however, of which the anesthesiologist should be aware. A 2017 article by Clifford et al. is the first to examine risk factors and outcomes for transfusion-associated circulatory overload in a high-risk noncardiac surgery population undergoing anesthesia and surgery. In recent years, limiting plasma donors to males only resulted in an approximately 50% decrease in TRALI. Summary The current article explores new research on the topics of transfusion-associated circulatory overload and transfusion-related lung injury. Correspondence to Anna Clebone, MD, Department of Anesthesia and Critical Care, University of Chicago, 5841 S. Maryland Ave., MC4028, Chicago, IL 60637, USA. Tel: +1 773 702 6700; fax: +1 773 702 3535; e-mail: aclebone@gmail.com Copyright © 2019 YEAR Wolters Kluwer Health, Inc. All rights reserved.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CYk0Od
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CYk0Od
Active Surveillance for T1bN0M0 Papillary Thyroid Carcinoma
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TB5LEr
Active Surveillance for T1bN0M0 Papillary Thyroid Carcinoma
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TB5LEr
Lower expression of prestin and MYO7A correlates with menopause-associated hearing loss.
CONCLUSION: Low estrogen levels may lead to reduced expression of prestin and MYO7A in cochlea, leading to a menopause-related hearing loss. PMID: 30612476 [PubMed - as supplied by publisher] (Source: Climacteric)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TEOqe0
Lower expression of prestin and MYO7A correlates with menopause-associated hearing loss.
CONCLUSION: Low estrogen levels may lead to reduced expression of prestin and MYO7A in cochlea, leading to a menopause-related hearing loss. PMID: 30612476 [PubMed - as supplied by publisher] (Source: Climacteric)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TEOqe0
Active Surveillance for T1bN0M0 Papillary Thyroid Carcinoma
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RlvrIR
Active Surveillance for T1bN0M0 Papillary Thyroid Carcinoma
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RlvrIR
Active Surveillance for T1bN0M0 Papillary Thyroid Carcinoma
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TB5LEr
Active Surveillance for T1bN0M0 Papillary Thyroid Carcinoma
Thyroid, Ahead of Print.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TB5LEr
Millions of People Wrongly Believe They Have Food Allergies
These days, it can seem like just about everybody has a food allergy. But according to a new study, about 11% of American adults actually do. Yet 19% of adults believe they have a food allergy, even though some don't have the diagnosis or symptoms to back it up, according to findings published in JAMA Network Open. This discrepancy suggests that quite a few adults are conflating allergies with less-severe food intolerances, which typically come with minimal digestion-related symptoms, the researchers write. If someone is truly allergic to a food, eating it can trigger a potentially life-threatening immune response. (People who are lactose intolerant, for example, may experience bloating, stomach pain and gas after eating dairy products, while those with a true milk allergy can experi...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RdCXoZ
Millions of People Wrongly Believe They Have Food Allergies
These days, it can seem like just about everybody has a food allergy. But according to a new study, about 11% of American adults actually do. Yet 19% of adults believe they have a food allergy, even though some don't have the diagnosis or symptoms to back it up, according to findings published in JAMA Network Open. This discrepancy suggests that quite a few adults are conflating allergies with less-severe food intolerances, which typically come with minimal digestion-related symptoms, the researchers write. If someone is truly allergic to a food, eating it can trigger a potentially life-threatening immune response. (People who are lactose intolerant, for example, may experience bloating, stomach pain and gas after eating dairy products, while those with a true milk allergy can experi...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RdCXoZ
Millions of People Wrongly Believe They Have Food Allergies
These days, it can seem like just about everybody has a food allergy. But according to a new study, about 11% of American adults actually do. Yet 19% of adults believe they have a food allergy, even though some don't have the diagnosis or symptoms to back it up, according to findings published in JAMA Network Open. This discrepancy suggests that quite a few adults are conflating allergies with less-severe food intolerances, which typically come with minimal digestion-related symptoms, the researchers write. If someone is truly allergic to a food, eating it can trigger a potentially life-threatening immune response. (People who are lactose intolerant, for example, may experience bloating, stomach pain and gas after eating dairy products, while those with a true milk allergy can experi...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RdCXoZ
Millions of People Wrongly Believe They Have Food Allergies
These days, it can seem like just about everybody has a food allergy. But according to a new study, about 11% of American adults actually do. Yet 19% of adults believe they have a food allergy, even though some don't have the diagnosis or symptoms to back it up, according to findings published in JAMA Network Open. This discrepancy suggests that quite a few adults are conflating allergies with less-severe food intolerances, which typically come with minimal digestion-related symptoms, the researchers write. If someone is truly allergic to a food, eating it can trigger a potentially life-threatening immune response. (People who are lactose intolerant, for example, may experience bloating, stomach pain and gas after eating dairy products, while those with a true milk allergy can experi...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RdCXoZ
Is the dentifrice containing calcium silicate, sodium phosphate, and fluoride able to protect enamel against chemical mechanical wear? An in situ / ex vivo study
Abstract
Objectives
The aim of this study was to investigate the effect of a dentifrice that contains calcium silicate, sodium phosphate, and fluoride on erosive-abrasive enamel wear.
Material and Methods
This randomized, single-blind in situ/ex vivo study was conducted with four crossover phases of 5 days (one group tested per phase). Bovine enamel blocks (n = 256) were allocated to 16 volunteers and 8 groups. The groups under study were test dentifrice, with calcium silicate, sodium phosphate, and 1450 ppm sodium monofluorophosphate; tin dentifrice, with 3500 ppm stannous chloride, 700 ppm amine fluoride, and 700 ppm sodium fluoride; conventional dentifrice, with 1450 ppm sodium monofluorophosphate; and control (deionized water). Half of the enamel blocks were subjected to erosion and the other half to erosion plus abrasion. The daily extraoral protocol consisted in four citric acid exposures (2 min) and two applications of dentifrice slurry on all blocks for 30 s; after, half of the blocks were brushed for 15 s. The response variable was enamel loss. Data were analyzed by two-way ANOVA and Fisher's test (p < 0.05).
Results
For erosion, the test dentifrice promoted less enamel loss than water (4.7 ± 3.1 and 5.8 ± 2.5 μm, respectively, p < 0.05), and did not differ from tin (4.8 ± 2.5 μm) and conventional (4.8 ± 1.4 μm) dentifrices (p > 0.05). However, the test dentifrice (7.7 ± 3.8 μm) promoted higher wear after erosive plus abrasive procedures than tin (5.4 ± 1.5 μm) and conventional (6.2 ± 1.7 μm, p < 0.05) dentifrices, and did not differ from water (6.9 ± 2.0 μm).
Conclusions
The investigated dentifrice reduced enamel loss against acid challenge but had no effect against acid and brushing challenge.
Clinical Relevance
Little is known regarding the preventive effect of dentifrices indicated for dental erosion. The tested anti-erosive dentifrice was unable to protect enamel when erosion was associated to toothbrushing abrasion.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HaSnG2
Impact of Sports-Related Subconcussive Injuries in Soccer Players
Semin Speech Lang 2019; 40: 057-064 DOI: 10.1055/s-0038-1676365Sports-related subconcussive impacts to the head are receiving increased interest. Recent evidence indicates that subconcussive impacts will have greater relevance across time because of the number of repetitive impacts. Soccer players are at risk of receiving at least one impact during a soccer game. The authors review the cognitive-communication functioning following subconcussive head injuries in youth and recommendations for baseline assessments and cognitive-communication dysfunctions after subconcussive impacts in youth. The review is followed by a description and discussion of a study that assessed the cognitive-communicative dysfunction in young soccer players prior to and following a series of soccer matches and recomm...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2LWrBj6
Clinical Assessments of Balance in Adults with Concussion: An Update
Semin Speech Lang 2019; 40: 048-056 DOI: 10.1055/s-0038-1676451Postural instability is a cardinal indicator of concussion. Assessments of the postural control system range from clinical to laboratory tests that assess the balance of the individual. In a previous article regarding clinical assessment of balance in adults with concussion, we reviewed the importance of balance as a component in concussion evaluations. The purpose of this review article is to update the information previously published in 2014. Since 2014, research has provided evidence for the incorporation of dynamic methods for evaluating balance postconcussion with particular emphasis on sensory system integration and dual tasking. Therefore, this review will examine the current state of knowledge on how concussion injurie...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2sjczuZ
Concussions: Activity Avoidance and Rest Recommendation
Semin Speech Lang 2019; 40: 027-035 DOI: 10.1055/s-0038-1676450Research surrounding rest recommendations for the concussed population is discussed. Rest is compared with activity avoidance, which is common in several chronic disease and traumatic injury types. The case is made for rest recommendations tailored to each head-injured individual. Research is presented which suggests that activity in the initial stages of concussion recovery may be beneficial in reducing postconcussion symptom duration and severity. Furthermore, a gradual increase in activity may potentially aid in returning to normal daily activity sooner than those who avoid both physical and cognitive activity during the acute stage of a traumatic brain injury. Finally, the current state of rest recommendations is reviewed a...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2LWKbYq
Disorders of Emotional Communication in Traumatic Brain Injury
This article summarizes the current evidence for evaluation and treatment of affective processing disorders in TBI. [...] Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Abstract | Full text (Source: Seminars in Speech and Language)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2sfgXex
Multidisciplinary Management of Collegiate Sports-Related Concussions
Conclusion Management of the complex sequelae of sports-related concussion for the varsity collegiate athlete necessitates implementation of a multidisciplinary, collaborative approach. Speech-language pathologists' training in the assessment and treatment of brain injury provides the team with an objective perspective in the evaluation and postinjury management of the injured student athlete. While our understanding of concussions has improved greatly over the past two decades, researchers and clinicians on the front lines of care recognize that continued voids exist in our knowledge, with the need to continually explore new methods to identify and manage the complex immediate and potentially long-term ramifications of concussion. [...] Thieme Medical Publishers 333 Seventh Avenue, New ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tyzq12
Concussions: Interdisciplinary Management
Semin Speech Lang 2019; 40: 001-002 DOI: 10.1055/s-0038-1676366 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Full text (Source: Seminars in Speech and Language)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2siEQlc
Self-Assessment Questions
Semin Speech Lang 2019; 40: C1-C10 DOI: 10.1055/s-0038-1676546 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Full text (Source: Seminars in Speech and Language)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2M0tlrJ
The Role of Speech-Language Pathology in an Interdisciplinary Care Model for Persistent Symptomatology of Mild Traumatic Brain Injury
Semin Speech Lang 2019; 40: 065-078 DOI: 10.1055/s-0038-1676452The Marcus Institute for Brain Health (MIBH) provides interdisciplinary care for adults struggling with persistent effects of mild traumatic brain injury and accompanying changes in behavioral health, with specific emphases on Veterans and retired elite athletes. The cognitive, physical, and behavioral symptoms associated with mild traumatic brain injury are interrelated, with neurobiopsychosocial modeling encompassing the factors related to recovery from a traumatic brain injury. The diffuse impacts of chronic concussive injuries require multiple clinical providers to address the breadth of symptoms, facilitating both interdisciplinary and transdisciplinary care models. By implementing integrated practice units, patients recei...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CVFhIe
Is the dentifrice containing calcium silicate, sodium phosphate, and fluoride able to protect enamel against chemical mechanical wear? An in situ / ex vivo study
Abstract
Objectives
The aim of this study was to investigate the effect of a dentifrice that contains calcium silicate, sodium phosphate, and fluoride on erosive-abrasive enamel wear.
Material and Methods
This randomized, single-blind in situ/ex vivo study was conducted with four crossover phases of 5 days (one group tested per phase). Bovine enamel blocks (n = 256) were allocated to 16 volunteers and 8 groups. The groups under study were test dentifrice, with calcium silicate, sodium phosphate, and 1450 ppm sodium monofluorophosphate; tin dentifrice, with 3500 ppm stannous chloride, 700 ppm amine fluoride, and 700 ppm sodium fluoride; conventional dentifrice, with 1450 ppm sodium monofluorophosphate; and control (deionized water). Half of the enamel blocks were subjected to erosion and the other half to erosion plus abrasion. The daily extraoral protocol consisted in four citric acid exposures (2 min) and two applications of dentifrice slurry on all blocks for 30 s; after, half of the blocks were brushed for 15 s. The response variable was enamel loss. Data were analyzed by two-way ANOVA and Fisher's test (p < 0.05).
Results
For erosion, the test dentifrice promoted less enamel loss than water (4.7 ± 3.1 and 5.8 ± 2.5 μm, respectively, p < 0.05), and did not differ from tin (4.8 ± 2.5 μm) and conventional (4.8 ± 1.4 μm) dentifrices (p > 0.05). However, the test dentifrice (7.7 ± 3.8 μm) promoted higher wear after erosive plus abrasive procedures than tin (5.4 ± 1.5 μm) and conventional (6.2 ± 1.7 μm, p < 0.05) dentifrices, and did not differ from water (6.9 ± 2.0 μm).
Conclusions
The investigated dentifrice reduced enamel loss against acid challenge but had no effect against acid and brushing challenge.
Clinical Relevance
Little is known regarding the preventive effect of dentifrices indicated for dental erosion. The tested anti-erosive dentifrice was unable to protect enamel when erosion was associated to toothbrushing abrasion.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HaSnG2
Physical Therapy Management of Adults with Mild Traumatic Brain Injury
Semin Speech Lang 2019; 40: 036-047 DOI: 10.1055/s-0038-1676652Rehabilitation for individuals after mild traumatic brain injury (mTBI) or concussion requires emphasis on both cognitive and physical rest, with a gradual return to activity including sports. As the client becomes more active, the rehabilitation professional should pay close attention to symptoms associated with mTBI, such as headache, dizziness, nausea, and difficulty concentrating. The systematic approach to return to play provided by the Berlin Consensus Statement on Concussion in Sport can apply to adults with mTBI. This protocol calls for gradually increasing the intensity of physical activity while attending to postconcussion symptoms. During the incident that led to an mTBI, the injured individual may incur injuries to ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2sgAFXl
Impact of Sports-Related Subconcussive Injuries in Soccer Players
Semin Speech Lang 2019; 40: 057-064 DOI: 10.1055/s-0038-1676365Sports-related subconcussive impacts to the head are receiving increased interest. Recent evidence indicates that subconcussive impacts will have greater relevance across time because of the number of repetitive impacts. Soccer players are at risk of receiving at least one impact during a soccer game. The authors review the cognitive-communication functioning following subconcussive head injuries in youth and recommendations for baseline assessments and cognitive-communication dysfunctions after subconcussive impacts in youth. The review is followed by a description and discussion of a study that assessed the cognitive-communicative dysfunction in young soccer players prior to and following a series of soccer matches and recomm...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2LWrBj6
Clinical Assessments of Balance in Adults with Concussion: An Update
Semin Speech Lang 2019; 40: 048-056 DOI: 10.1055/s-0038-1676451Postural instability is a cardinal indicator of concussion. Assessments of the postural control system range from clinical to laboratory tests that assess the balance of the individual. In a previous article regarding clinical assessment of balance in adults with concussion, we reviewed the importance of balance as a component in concussion evaluations. The purpose of this review article is to update the information previously published in 2014. Since 2014, research has provided evidence for the incorporation of dynamic methods for evaluating balance postconcussion with particular emphasis on sensory system integration and dual tasking. Therefore, this review will examine the current state of knowledge on how concussion injurie...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2sjczuZ
Concussions: Activity Avoidance and Rest Recommendation
Semin Speech Lang 2019; 40: 027-035 DOI: 10.1055/s-0038-1676450Research surrounding rest recommendations for the concussed population is discussed. Rest is compared with activity avoidance, which is common in several chronic disease and traumatic injury types. The case is made for rest recommendations tailored to each head-injured individual. Research is presented which suggests that activity in the initial stages of concussion recovery may be beneficial in reducing postconcussion symptom duration and severity. Furthermore, a gradual increase in activity may potentially aid in returning to normal daily activity sooner than those who avoid both physical and cognitive activity during the acute stage of a traumatic brain injury. Finally, the current state of rest recommendations is reviewed a...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2LWKbYq
Multidisciplinary Management of Collegiate Sports-Related Concussions
Conclusion Management of the complex sequelae of sports-related concussion for the varsity collegiate athlete necessitates implementation of a multidisciplinary, collaborative approach. Speech-language pathologists' training in the assessment and treatment of brain injury provides the team with an objective perspective in the evaluation and postinjury management of the injured student athlete. While our understanding of concussions has improved greatly over the past two decades, researchers and clinicians on the front lines of care recognize that continued voids exist in our knowledge, with the need to continually explore new methods to identify and manage the complex immediate and potentially long-term ramifications of concussion. [...] Thieme Medical Publishers 333 Seventh Avenue, New ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tyzq12
Concussions: Interdisciplinary Management
Semin Speech Lang 2019; 40: 001-002 DOI: 10.1055/s-0038-1676366 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Full text (Source: Seminars in Speech and Language)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2siEQlc
Self-Assessment Questions
Semin Speech Lang 2019; 40: C1-C10 DOI: 10.1055/s-0038-1676546 Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.Article in Thieme eJournals: Table of contents | Full text (Source: Seminars in Speech and Language)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2M0tlrJ
The Role of Speech-Language Pathology in an Interdisciplinary Care Model for Persistent Symptomatology of Mild Traumatic Brain Injury
Semin Speech Lang 2019; 40: 065-078 DOI: 10.1055/s-0038-1676452The Marcus Institute for Brain Health (MIBH) provides interdisciplinary care for adults struggling with persistent effects of mild traumatic brain injury and accompanying changes in behavioral health, with specific emphases on Veterans and retired elite athletes. The cognitive, physical, and behavioral symptoms associated with mild traumatic brain injury are interrelated, with neurobiopsychosocial modeling encompassing the factors related to recovery from a traumatic brain injury. The diffuse impacts of chronic concussive injuries require multiple clinical providers to address the breadth of symptoms, facilitating both interdisciplinary and transdisciplinary care models. By implementing integrated practice units, patients recei...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CVFhIe
Structural and Functional Aberrations of the Auditory Brainstem in Autism Spectrum Disorder.
Authors: Smith A, Storti S, Lukose R, Kulesza RJ Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition associated with difficulties in the social, communicative, and behavioral domains. Most cases of ASD arise from an unknown etiologic process, but there are numerous risk factors, including comorbidities and maternal exposures. Although it is not part of the diagnostic criteria, hearing difficulties ranging from deafness to hyperacusis are present in the majority of persons with ASD. High-functioning children with ASD have been found to have significantly slower and asymmetric auditory brainstem reflexes. Additionally, histopathological studies of postmortem brainstems in decedents who had ASD have consistently revealed significantly fewer neurons in auditory nu...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QyEmkA
The Harm Done by Senescent T Cells
Senescent cells accumulate with age in all tissues, and their presence is one of the root causes of aging. Cells become senescent in large numbers at all ages, and under a variety of circumstances: toxins, wound healing, ordinary somatic cells reaching the Hayflick limit, random mutational damage to important genes, and so forth. Senescence irreversibly shuts down cellular replication, making it a useful defense against cancer. Near all newly senescent cells are destroyed quickly. They either self-destruct or they are destroyed by the immune system, but both paths to a reliable natural clearance of senescent cells falter with the damage and dysfunction of aging. Lingering senescent cells that have evaded destruction never rise to more than a few percent of all cells by number, even ...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RG6erG
ClearUP Electronic Gadget for Relieving Sinus Pain from Hay Fever
Tivic Health, based outside of San Francisco, won FDA clearance for its ClearUP device for treating allergy-related sinus pain. ClearUP is used to deliver electric current to the nose, the user sliding the device along the outside of the nasal passages while therapy is administered. The device delivers only a small electric current using a proprietary signal pattern that has shown to be effective in clinical practice. There's only one button to push and the device can deliver three levels of therapy intensity, depending on the patient's needs. It only takes about five minutes to use the device and it helps the user to go through the treatment points accurately. The ClearUP should be available for purchase toward the middle of this year and is expected to cost $149. Here's...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HaVaiu
Structural and Functional Aberrations of the Auditory Brainstem in Autism Spectrum Disorder.
Authors: Smith A, Storti S, Lukose R, Kulesza RJ Abstract Autism spectrum disorder (ASD) is a neurodevelopmental condition associated with difficulties in the social, communicative, and behavioral domains. Most cases of ASD arise from an unknown etiologic process, but there are numerous risk factors, including comorbidities and maternal exposures. Although it is not part of the diagnostic criteria, hearing difficulties ranging from deafness to hyperacusis are present in the majority of persons with ASD. High-functioning children with ASD have been found to have significantly slower and asymmetric auditory brainstem reflexes. Additionally, histopathological studies of postmortem brainstems in decedents who had ASD have consistently revealed significantly fewer neurons in auditory nu...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QyEmkA
The Harm Done by Senescent T Cells
Senescent cells accumulate with age in all tissues, and their presence is one of the root causes of aging. Cells become senescent in large numbers at all ages, and under a variety of circumstances: toxins, wound healing, ordinary somatic cells reaching the Hayflick limit, random mutational damage to important genes, and so forth. Senescence irreversibly shuts down cellular replication, making it a useful defense against cancer. Near all newly senescent cells are destroyed quickly. They either self-destruct or they are destroyed by the immune system, but both paths to a reliable natural clearance of senescent cells falter with the damage and dysfunction of aging. Lingering senescent cells that have evaded destruction never rise to more than a few percent of all cells by number, even ...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RG6erG
ClearUP Electronic Gadget for Relieving Sinus Pain from Hay Fever
Tivic Health, based outside of San Francisco, won FDA clearance for its ClearUP device for treating allergy-related sinus pain. ClearUP is used to deliver electric current to the nose, the user sliding the device along the outside of the nasal passages while therapy is administered. The device delivers only a small electric current using a proprietary signal pattern that has shown to be effective in clinical practice. There's only one button to push and the device can deliver three levels of therapy intensity, depending on the patient's needs. It only takes about five minutes to use the device and it helps the user to go through the treatment points accurately. The ClearUP should be available for purchase toward the middle of this year and is expected to cost $149. Here's...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HaVaiu
Theoretical insight into the photophysical properties of five phosphorescent heteroleptic iridium(III) complexes bearing oxadiazol-substituted amide ligands
Photochem. Photobiol. Sci., 2019, Accepted Manuscript
DOI: 10.1039/C8PP00511G, Paper
DOI: 10.1039/C8PP00511G, Paper
Xiaohong Shang, Deming Han, Lihui Zhao, Leijiao Li, Shuhui Lv
A DFT/TDDFT (density functional theory/time-dependent density functional theory) investigation on the geometries in the ground and lowest triplet excited states, the frontier molecular orbitals, the absorption spectra and phosphorescent emission...
The content of this RSS Feed (c) The Royal Society of Chemistry
A DFT/TDDFT (density functional theory/time-dependent density functional theory) investigation on the geometries in the ground and lowest triplet excited states, the frontier molecular orbitals, the absorption spectra and phosphorescent emission...
The content of this RSS Feed (c) The Royal Society of Chemistry
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://rsc.li/2FkDoqu
In situ intravenous photodynamic therapy for the systemic eradication of blood stream infections
Photochem. Photobiol. Sci., 2019, Advance Article
DOI: 10.1039/C8PP00267C, Communication
DOI: 10.1039/C8PP00267C, Communication
Michael Raschpichler, Michael R. Agel, Shashank Reddy Pinnapireddy, Lili Duse, Elias Baghdan, Jens Schäfer, Udo Bakowsky
Scheme representing in situ photodynamic therapy within a blood vessel following intravenous administration of a photosensitiser.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Scheme representing in situ photodynamic therapy within a blood vessel following intravenous administration of a photosensitiser.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://rsc.li/2ReJUpz
In situ intravenous photodynamic therapy for the systemic eradication of blood stream infections
Photochem. Photobiol. Sci., 2019, Advance Article
DOI: 10.1039/C8PP00267C, Communication
DOI: 10.1039/C8PP00267C, Communication
Michael Raschpichler, Michael R. Agel, Shashank Reddy Pinnapireddy, Lili Duse, Elias Baghdan, Jens Schäfer, Udo Bakowsky
Scheme representing in situ photodynamic therapy within a blood vessel following intravenous administration of a photosensitiser.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
Scheme representing in situ photodynamic therapy within a blood vessel following intravenous administration of a photosensitiser.
To cite this article before page numbers are assigned, use the DOI form of citation above.
The content of this RSS Feed (c) The Royal Society of Chemistry
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://rsc.li/2ReJUpz
Chronischer Husten – Neue diagnostische Perspektiven?
Laryngo-Rhino-Otol 2019; 98: 14-20
DOI: 10.1055/a-0790-0777
Chronischer Husten wird bisher größtenteils über rein subjektive Mittel erfasst und beurteilt – zum Beispiel mithilfe von Fragebögen und/oder Tagebüchern. Die subjektive Beurteilung stimmt jedoch oft nicht mit den objektiven Messdaten überein. Bei Patienten mit chronischem Husten sollte daher die Basisdiagnostik und Verlaufskontrolle jedweder medikamentösen Therapie einer Kombination aus objektiven und subjektiven Kriterien unterzogen werden.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FeV1bS
Dank an die Gutachter
Laryngo-Rhino-Otol 2019; 98: 7-7
DOI: 10.1055/a-0817-7859
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fek7aJ
Parapharyngeale Kalzifikationen als Zufallsbefunde in der Panoramaschichtaufnahme und der dentalen digitalen Volumentomografie
Laryngo-Rhino-Otol 2019; 98: 44-45
DOI: 10.1055/a-0747-7012
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FhilVI
Parotidektomie: Komplikationen analysiert
Laryngo-Rhino-Otol 2019; 98: 8-9
DOI: 10.1055/a-0677-5554
Fiacchini G et al. Frey Syndrome, First Bite Syndrome, great auricular nerve morbidity, and quality of life following parotidectomy. Eur Arch Otorhinolaryngol 2018; 275: 1893–1902 Eine Parotidektomie kann zu zahlreichen Komplikationen führen, die die Lebensqualität einschränken. Zu diesen Komplikationen zählen Verletzungen des Nervus facialis, Asymmetrie des Gesichtsprofils, Keloide, Speicheldrüsenfistel, Frey-Syndrom (FS), First Bite Syndrom (FBS) und Hypästhesie der Haut. Ärzte der Universität von Pisa untersuchten die Inzidenz von Komplikationen nach Parotidektomie und deren Auswirkungen auf die Lebensqualität.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fhmd9Y
Kinder- und Erwachsenen-Cholesteatom im Vergleich
Laryngo-Rhino-Otol 2019; 98: 9-10
DOI: 10.1055/a-0677-5415
Jackson R et al. Cholesteatoma in children and adults: are there really any differences? J Laryngol Otol 2018; 132: 575–578 Das Cholesteatom gilt bei Kindern als aggressivere Läsion als bei Erwachsenen. Allerdings existieren nur wenige Studien, die die operativen Befunde und chirurgischen Ergebnisse zwischen diesen beiden Gruppen direkt verglichen haben. Britische Fachärzte für Otorhinolaryngologie bewerteten Unterschiede zwischen dem kindlichen- und dem Erwachsenen-Cholesteatom.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FcRRFH
Antikoagulation bei onkologischen Patienten
Laryngo-Rhino-Otol 2019; 98: 21-26
DOI: 10.1055/a-0790-0834
Tumorpatienten zeigen im Vergleich zur Normalbevölkerung ein erhöhtes Risiko für venöse Thromboembolien, welche erhebliche Auswirkungen auf Morbidität und Mortalität haben. Daher sind adäquate prophylaktische Maßnahmen sowie eine frühzeitige Diagnose und Therapie essenziell. Allerdings ist eine Antikoagulation bei Tumorpatienten mit einem gehäuften Auftreten von Blutungen und auch von Rezidiven verbunden. Angesichts dieser besonderen Herausforderungen haben mehrere Fachgesellschaften und Arbeitsgruppen spezifische Leitlinien und Empfehlungen zur Thromboseprophylaxe und -therapie bei Tumorpatienten veröffentlicht. Über diese soll im Folgenden ein Überblick gegeben werden.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FkkFeE
Alternative Schmerztherapien nach Tonsillektomie untersucht und bewertet
Laryngo-Rhino-Otol 2019; 98: 10-11
DOI: 10.1055/a-0651-4052
Keefe KR et al. Treating pediatric post-tonsillectomy pain and nausea with complementary and alternative medicine. Laryngoscope 2018 doi: 10.1002/lary.27231 Die Tonsillektomie ist ein sicheres Verfahren, wird allerdings durch postoperative Schmerzen verkompliziert. Eine Schmerztherapie bei Kindern wird kontrovers diskutiert. Eine geeignete Analgesie wird durch eine oft geringe Adhärenz von Eltern und Kindern erschwert. Zur Schmerzvermeidung wählen Eltern oft komplementäre und alternative Therapien. Amerikanische Wissenschaftler untersuchten, ob diese Methoden helfen.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fhmb1Q
Aus der Gutachtenpraxis: Ohrmuschel-perichondritis oder Herpes zoster oticus?
Laryngo-Rhino-Otol 2019; 98: 46-47
DOI: 10.1055/a-0784-9537
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fhingi
Fehlbildungschirurgie von Nase und Lippe
Laryngo-Rhino-Otol 2019; 98: 62-63
DOI: 10.1055/a-0784-9612
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FfSU7x
Kommentar der Schriftleitung
Laryngo-Rhino-Otol 2019; 98: 4-5
DOI: 10.1055/a-0784-9482
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fm1lxE
Nonincisional Shortening of the Posterior Lamellae: A Transconjunctival Approach
Facial plast Surg 2018; 34: 665-666
DOI: 10.1055/s-0038-1675636
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CZXlkN
Chronischer Husten – Neue diagnostische Perspektiven?
Laryngo-Rhino-Otol 2019; 98: 14-20
DOI: 10.1055/a-0790-0777
Chronischer Husten wird bisher größtenteils über rein subjektive Mittel erfasst und beurteilt – zum Beispiel mithilfe von Fragebögen und/oder Tagebüchern. Die subjektive Beurteilung stimmt jedoch oft nicht mit den objektiven Messdaten überein. Bei Patienten mit chronischem Husten sollte daher die Basisdiagnostik und Verlaufskontrolle jedweder medikamentösen Therapie einer Kombination aus objektiven und subjektiven Kriterien unterzogen werden.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FeV1bS
Dank an die Gutachter
Laryngo-Rhino-Otol 2019; 98: 7-7
DOI: 10.1055/a-0817-7859
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fek7aJ
Parapharyngeale Kalzifikationen als Zufallsbefunde in der Panoramaschichtaufnahme und der dentalen digitalen Volumentomografie
Laryngo-Rhino-Otol 2019; 98: 44-45
DOI: 10.1055/a-0747-7012
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FhilVI
Parotidektomie: Komplikationen analysiert
Laryngo-Rhino-Otol 2019; 98: 8-9
DOI: 10.1055/a-0677-5554
Fiacchini G et al. Frey Syndrome, First Bite Syndrome, great auricular nerve morbidity, and quality of life following parotidectomy. Eur Arch Otorhinolaryngol 2018; 275: 1893–1902 Eine Parotidektomie kann zu zahlreichen Komplikationen führen, die die Lebensqualität einschränken. Zu diesen Komplikationen zählen Verletzungen des Nervus facialis, Asymmetrie des Gesichtsprofils, Keloide, Speicheldrüsenfistel, Frey-Syndrom (FS), First Bite Syndrom (FBS) und Hypästhesie der Haut. Ärzte der Universität von Pisa untersuchten die Inzidenz von Komplikationen nach Parotidektomie und deren Auswirkungen auf die Lebensqualität.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fhmd9Y
„Direkte“ Defektdeckung der Radialislappenentnahmestelle
Laryngo-Rhino-Otol 2019; 98: 12-13
DOI: 10.1055/a-0784-9515
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FhiloG
Kinder- und Erwachsenen-Cholesteatom im Vergleich
Laryngo-Rhino-Otol 2019; 98: 9-10
DOI: 10.1055/a-0677-5415
Jackson R et al. Cholesteatoma in children and adults: are there really any differences? J Laryngol Otol 2018; 132: 575–578 Das Cholesteatom gilt bei Kindern als aggressivere Läsion als bei Erwachsenen. Allerdings existieren nur wenige Studien, die die operativen Befunde und chirurgischen Ergebnisse zwischen diesen beiden Gruppen direkt verglichen haben. Britische Fachärzte für Otorhinolaryngologie bewerteten Unterschiede zwischen dem kindlichen- und dem Erwachsenen-Cholesteatom.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FcRRFH
Antikoagulation bei onkologischen Patienten
Laryngo-Rhino-Otol 2019; 98: 21-26
DOI: 10.1055/a-0790-0834
Tumorpatienten zeigen im Vergleich zur Normalbevölkerung ein erhöhtes Risiko für venöse Thromboembolien, welche erhebliche Auswirkungen auf Morbidität und Mortalität haben. Daher sind adäquate prophylaktische Maßnahmen sowie eine frühzeitige Diagnose und Therapie essenziell. Allerdings ist eine Antikoagulation bei Tumorpatienten mit einem gehäuften Auftreten von Blutungen und auch von Rezidiven verbunden. Angesichts dieser besonderen Herausforderungen haben mehrere Fachgesellschaften und Arbeitsgruppen spezifische Leitlinien und Empfehlungen zur Thromboseprophylaxe und -therapie bei Tumorpatienten veröffentlicht. Über diese soll im Folgenden ein Überblick gegeben werden.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FkkFeE
Alternative Schmerztherapien nach Tonsillektomie untersucht und bewertet
Laryngo-Rhino-Otol 2019; 98: 10-11
DOI: 10.1055/a-0651-4052
Keefe KR et al. Treating pediatric post-tonsillectomy pain and nausea with complementary and alternative medicine. Laryngoscope 2018 doi: 10.1002/lary.27231 Die Tonsillektomie ist ein sicheres Verfahren, wird allerdings durch postoperative Schmerzen verkompliziert. Eine Schmerztherapie bei Kindern wird kontrovers diskutiert. Eine geeignete Analgesie wird durch eine oft geringe Adhärenz von Eltern und Kindern erschwert. Zur Schmerzvermeidung wählen Eltern oft komplementäre und alternative Therapien. Amerikanische Wissenschaftler untersuchten, ob diese Methoden helfen.
[...]
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Abstract | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fhmb1Q
Aus der Gutachtenpraxis: Ohrmuschel-perichondritis oder Herpes zoster oticus?
Laryngo-Rhino-Otol 2019; 98: 46-47
DOI: 10.1055/a-0784-9537
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fhingi
Fehlbildungschirurgie von Nase und Lippe
Laryngo-Rhino-Otol 2019; 98: 62-63
DOI: 10.1055/a-0784-9612
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FfSU7x
Kommentar der Schriftleitung
Laryngo-Rhino-Otol 2019; 98: 4-5
DOI: 10.1055/a-0784-9482
© Georg Thieme Verlag KG Stuttgart · New York
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Fm1lxE
Nonincisional Shortening of the Posterior Lamellae: A Transconjunctival Approach
Facial plast Surg 2018; 34: 665-666
DOI: 10.1055/s-0038-1675636
Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.
Article in Thieme eJournals:
Table of contents | Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CZXlkN
Threatened Preterm Birth and Time of Subsequent Delivery -a Prediction Model
Conditions: Preterm Birth; Immunologic Activity Alteration Intervention: Sponsor: Linkoeping University Completed (Source: ClinicalTrials.gov)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RE6Ein
Clinical and Immunological Long-term Follow-up of Patients With Pemphigus Included in the " RITUXIMAB 3 " Trial
Condition: Autoimmune Diseases Interventions: Drug: Rituximab; Drug: corticosteroids'therapy Sponsor: University Hospital, Rouen Not yet recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2H33dxL
Exploring Disease Immunogenicity and the Immunological Effects of Hypomethylating Agents in Acute Myeloid Leukemia
Condition: Acute Myeloid Leukemia Intervention: Genetic: Immunogenic profile Sponsor: Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori Not yet recruiting (Source: ClinicalTrials.gov)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RE6E1R
Intestinal Microbiota on Allergy, Growth and Development
Condition: Pregnancy Intervention: Sponsor: Chinese University of Hong Kong Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Hc5NBg
Multiple Drug Hypersensitivity Syndrome
Condition: Drug Allergy Intervention: Sponsor: University Hospital, Montpellier Not yet recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RAKsWm
Dose, Safety, Tolerability, and Immunogenicity of an HIV-1 Vaccine, VRC-HIVRGP096-00-VP, With Alum in Healthy Adults < TAB >
Condition: Human Immunodeficiency Virus (HIV) Intervention: Biological: VRC-HIVRGP096-00-VP Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GZxEob
Threatened Preterm Birth and Time of Subsequent Delivery -a Prediction Model
Conditions: Preterm Birth; Immunologic Activity Alteration Intervention: Sponsor: Linkoeping University Completed (Source: ClinicalTrials.gov)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RE6Ein
Clinical and Immunological Long-term Follow-up of Patients With Pemphigus Included in the " RITUXIMAB 3 " Trial
Condition: Autoimmune Diseases Interventions: Drug: Rituximab; Drug: corticosteroids'therapy Sponsor: University Hospital, Rouen Not yet recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2H33dxL
Exploring Disease Immunogenicity and the Immunological Effects of Hypomethylating Agents in Acute Myeloid Leukemia
Condition: Acute Myeloid Leukemia Intervention: Genetic: Immunogenic profile Sponsor: Istituto Scientifico Romagnolo per lo Studio e la cura dei Tumori Not yet recruiting (Source: ClinicalTrials.gov)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RE6E1R
Intestinal Microbiota on Allergy, Growth and Development
Condition: Pregnancy Intervention: Sponsor: Chinese University of Hong Kong Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Hc5NBg
Multiple Drug Hypersensitivity Syndrome
Condition: Drug Allergy Intervention: Sponsor: University Hospital, Montpellier Not yet recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RAKsWm
Dose, Safety, Tolerability, and Immunogenicity of an HIV-1 Vaccine, VRC-HIVRGP096-00-VP, With Alum in Healthy Adults < TAB >
Condition: Human Immunodeficiency Virus (HIV) Intervention: Biological: VRC-HIVRGP096-00-VP Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GZxEob
Value of dedicated small-field-of-view sacroiliac versus large-field-of-view pelvic magnetic resonance imaging for evaluating pediatric sacroiliitis
Abstract
Background
Optimized MRI parameters can be leveraged to improve signal intensity, accelerate imaging acquisition and increase resolution. Higher-resolution imaging with a small field of view (FOV) has been proposed as standard practice for investigating sacroiliac (SI) joints, but the improvement in disease detection and characterization over pelvic imaging with large FOV has not been established.
Objective
The purpose of this study was to compare dedicated MR images of the SI joints with survey imaging (large-FOV pelvic MRI) for detecting sacroiliitis.
Materials and methods
Fifty-eight pediatric patients suspected of having sacroiliitis underwent dedicated sacroiliac joint and survey pelvic imaging at the same imaging session. We independently evaluated the small- and large-FOV image data sets for presence or absence of sacroiliitis, e.g., bone marrow edema, erosions and synovitis. We used nonparametric statistical tests to compare lesion scores for severity of inflammation. We created test characteristics for the survey pelvic images (low-resolution images of the sacroiliac joints) using dedicated sacroiliac images (small-FOV, high-resolution images) as the gold standard.
Results
Dedicated sacroiliac small-FOV MRI detected more sacroiliitis compared to survey pelvic imaging with large FOV (χ2=6.125, P=0.013). Readers detected significantly more features of inflammation on small- compared to large-FOV images, e.g., erosions (P=0.039), synovitis (P=0.009), sclerosis (P=0.017) and osteitis (P=0.001). Test characteristics for pelvic large-FOV imaging were sensitivity=0.76, specificity=1.00, positive predictive value = 1.00 and negative predictive value = 0.75.
Conclusion
This study provides test characteristics for survey pelvic MRI with lower-resolution large-field-of-view images as a screening tool for detecting sacroiliitis. Pelvic screening studies with large FOV have lower sensitivity, and dedicated sacroiliac MRI with small FOV is superior in detecting sacroiliitis when compared to pelvic screening MRI.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AzGyU4
Value of dedicated small-field-of-view sacroiliac versus large-field-of-view pelvic magnetic resonance imaging for evaluating pediatric sacroiliitis
Abstract
Background
Optimized MRI parameters can be leveraged to improve signal intensity, accelerate imaging acquisition and increase resolution. Higher-resolution imaging with a small field of view (FOV) has been proposed as standard practice for investigating sacroiliac (SI) joints, but the improvement in disease detection and characterization over pelvic imaging with large FOV has not been established.
Objective
The purpose of this study was to compare dedicated MR images of the SI joints with survey imaging (large-FOV pelvic MRI) for detecting sacroiliitis.
Materials and methods
Fifty-eight pediatric patients suspected of having sacroiliitis underwent dedicated sacroiliac joint and survey pelvic imaging at the same imaging session. We independently evaluated the small- and large-FOV image data sets for presence or absence of sacroiliitis, e.g., bone marrow edema, erosions and synovitis. We used nonparametric statistical tests to compare lesion scores for severity of inflammation. We created test characteristics for the survey pelvic images (low-resolution images of the sacroiliac joints) using dedicated sacroiliac images (small-FOV, high-resolution images) as the gold standard.
Results
Dedicated sacroiliac small-FOV MRI detected more sacroiliitis compared to survey pelvic imaging with large FOV (χ2=6.125, P=0.013). Readers detected significantly more features of inflammation on small- compared to large-FOV images, e.g., erosions (P=0.039), synovitis (P=0.009), sclerosis (P=0.017) and osteitis (P=0.001). Test characteristics for pelvic large-FOV imaging were sensitivity=0.76, specificity=1.00, positive predictive value = 1.00 and negative predictive value = 0.75.
Conclusion
This study provides test characteristics for survey pelvic MRI with lower-resolution large-field-of-view images as a screening tool for detecting sacroiliitis. Pelvic screening studies with large FOV have lower sensitivity, and dedicated sacroiliac MRI with small FOV is superior in detecting sacroiliitis when compared to pelvic screening MRI.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AzGyU4
Association between perioperative oral care and postoperative pneumonia after cancer resection: conventional versus high-dimensional propensity score matching analysis
Abstract
Objectives
Perioperative oral care was reported to decrease postoperative pneumonia after cancer resections. However, the effect remains controversial because previous studies were limited due to their small sample sizes and lack of strict control for patient backgrounds. The present study evaluated the association between perioperative oral care and postoperative pneumonia using high-dimensional propensity score (hd-PS) matching to adjust for confounding factors.
Materials and methods
Using a Japanese health insurance claims database, we identified patients who underwent surgical treatment of cancer from April 2014 to March 2015. To compare outcomes (postoperative pneumonia and procedure-related complications) between patients with and without perioperative oral care, we performed hd-PS matching and conventional PS matching and chi-square test.
Results
We identified 621 patients with oral care and 4374 patients without oral care. The occurrences of postoperative pneumonia were not significantly different between patients with and without oral care in the unmatched (2.9% vs. 3.2%), conventional PS-matched (2.9% vs. 2.9%), or hd-PS-matched (2.9% vs. 3.3%) groups. The occurrences of procedure-related complication were not significantly different between patients with and without oral care in the unmatched (23.8% vs. 24.5%), conventional PS-matched (23.8% vs. 26.4%), or hd-PS-matched (24.4% vs. 27.7%) groups.
Conclusions
There was no significant difference in postoperative pneumonia or procedure-related complications between patients with and without perioperative oral care.
Clinical relevance
While maintaining optimal oral care in cancer patients is an important goal, the present study revealed no significant difference in postoperative outcomes. Further investigations would be needed to determine the effect of perioperative oral care.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Qu32uN
Use of Image-Based Analytics for Ultrasound Practice Management and Efficiency Improvement
Abstract
Our ultrasound practice is becoming even more focused on managing practice resources and improving our efficiency while maintaining practice quality. We often encounter questions related to issues such as equipment utilization and management, study type statistics, and productivity. We are developing an analytics system to allow more evidence-based management of our ultrasound practice. Our system collects information from tens of thousands of DICOM images produced during exams, including structured reporting, public and private DICOM headers, and text within the images via optical character recognition (OCR). Inventory/location information augments the data aggregation, and statistical analysis and metrics are computed such as median exam length (time from the first image to last), transducer models used in an exam, and exams performed in a particular room, practice location, or by a given sonographer. Additional reports detail the length of a scan room's operational day, the number and type of exams performed, the time between exams, and summary data such as exams per operational hour and time-based room utilization. Our findings have already helped guide practice decisions: two defective probes were not replaced (a savings of over $10,000) when utilization data showed that three or more of the shared probe model were always idle; neck exams are the most time-consuming individually, but abdomen exam volumes cause them to consume the most total scan time, making abdominal exams the better candidates for efficiency optimization efforts. A small subset of sonographers exhibit the greatest scanning and between-scan efficiency, making them good candidates for identifying best practices.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HeKW0z
Association between perioperative oral care and postoperative pneumonia after cancer resection: conventional versus high-dimensional propensity score matching analysis
Abstract
Objectives
Perioperative oral care was reported to decrease postoperative pneumonia after cancer resections. However, the effect remains controversial because previous studies were limited due to their small sample sizes and lack of strict control for patient backgrounds. The present study evaluated the association between perioperative oral care and postoperative pneumonia using high-dimensional propensity score (hd-PS) matching to adjust for confounding factors.
Materials and methods
Using a Japanese health insurance claims database, we identified patients who underwent surgical treatment of cancer from April 2014 to March 2015. To compare outcomes (postoperative pneumonia and procedure-related complications) between patients with and without perioperative oral care, we performed hd-PS matching and conventional PS matching and chi-square test.
Results
We identified 621 patients with oral care and 4374 patients without oral care. The occurrences of postoperative pneumonia were not significantly different between patients with and without oral care in the unmatched (2.9% vs. 3.2%), conventional PS-matched (2.9% vs. 2.9%), or hd-PS-matched (2.9% vs. 3.3%) groups. The occurrences of procedure-related complication were not significantly different between patients with and without oral care in the unmatched (23.8% vs. 24.5%), conventional PS-matched (23.8% vs. 26.4%), or hd-PS-matched (24.4% vs. 27.7%) groups.
Conclusions
There was no significant difference in postoperative pneumonia or procedure-related complications between patients with and without perioperative oral care.
Clinical relevance
While maintaining optimal oral care in cancer patients is an important goal, the present study revealed no significant difference in postoperative outcomes. Further investigations would be needed to determine the effect of perioperative oral care.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Qu32uN
Use of Image-Based Analytics for Ultrasound Practice Management and Efficiency Improvement
Abstract
Our ultrasound practice is becoming even more focused on managing practice resources and improving our efficiency while maintaining practice quality. We often encounter questions related to issues such as equipment utilization and management, study type statistics, and productivity. We are developing an analytics system to allow more evidence-based management of our ultrasound practice. Our system collects information from tens of thousands of DICOM images produced during exams, including structured reporting, public and private DICOM headers, and text within the images via optical character recognition (OCR). Inventory/location information augments the data aggregation, and statistical analysis and metrics are computed such as median exam length (time from the first image to last), transducer models used in an exam, and exams performed in a particular room, practice location, or by a given sonographer. Additional reports detail the length of a scan room's operational day, the number and type of exams performed, the time between exams, and summary data such as exams per operational hour and time-based room utilization. Our findings have already helped guide practice decisions: two defective probes were not replaced (a savings of over $10,000) when utilization data showed that three or more of the shared probe model were always idle; neck exams are the most time-consuming individually, but abdomen exam volumes cause them to consume the most total scan time, making abdominal exams the better candidates for efficiency optimization efforts. A small subset of sonographers exhibit the greatest scanning and between-scan efficiency, making them good candidates for identifying best practices.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HeKW0z
Analysis of Various Factors and Techniques to Improve Outcome of Surgical Management of 243 Cases of CSF Rhinorrhea
AbstractCerebrospinal fluid (CSF) rhinorrhea occurs when there is a communication between subarachnoid space and sinonasal mucosa due to meningeal, osseous and mucosal defects in the cranial base leading to discharge of CSF from the nose. The risk of developing meningitis after CSF rhinorrhea may vary from 5.6 (Leech and Paterson in Lancet 1:1013 –1016,1973) to 60% (Eljarnel and Foy in Br J Neurosurg 5:275 –279,1991). Hence surgical management of CSF rhinorrhea is highly recommended. Transnasal endoscopic approach first described by Wigand in 1981, has been proven to be the approach of choice in comparison to intracranial and external nasal approach (Jones and Becker in Br Med J 322:122 –123,2001) in most cases. The next defining milestone was the pedicled naso septal vascularized fl...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FgBg3J
Analysis of Various Factors and Techniques to Improve Outcome of Surgical Management of 243 Cases of CSF Rhinorrhea
AbstractCerebrospinal fluid (CSF) rhinorrhea occurs when there is a communication between subarachnoid space and sinonasal mucosa due to meningeal, osseous and mucosal defects in the cranial base leading to discharge of CSF from the nose. The risk of developing meningitis after CSF rhinorrhea may vary from 5.6 (Leech and Paterson in Lancet 1:1013 –1016,1973) to 60% (Eljarnel and Foy in Br J Neurosurg 5:275 –279,1991). Hence surgical management of CSF rhinorrhea is highly recommended. Transnasal endoscopic approach first described by Wigand in 1981, has been proven to be the approach of choice in comparison to intracranial and external nasal approach (Jones and Becker in Br Med J 322:122 –123,2001) in most cases. The next defining milestone was the pedicled naso septal vascularized fl...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FgBg3J
Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368
Abstract
Background
Reperfusion ventricular arrhythmia (RA) associated with hypothermic ischaemic storage is increasingly recognized as a substantial contributor to adverse consequences after heart transplantation. Ischemia- or hypothermia-induced gap junction (GJ) remodelling is closely linked to RA. Reducing GJ remodelling contributes to RA attenuation and is important in heart transplantation. However, sevoflurane has an antiarrhythmic effect associated with the connexin 43 (Cx43) protein that has not yet been fully established.
Methods
Hearts were divided into two groups according to a random number table: all hearts were arrested by an infusion of histidine-tryptophan-ketoglutarate (HTK) solution (4 °C) followed by (1) storage in HTK solution (4 °C) alone for 6 h (n = 8, Control group) or (2) storage in HTK solution supplemented with sevoflurane (2.5%) (4 °C) for 6 h (n = 8, Sevo-HTK group). First, the total Cx43 level and the phosphorylation of Cx43 at Ser368 (Cx43-pS368) were assessed by Western blotting, and the distribution of Cx43 was assessed by immunohistochemistry. Second, programmed electrical stimulation (PES) and monophasic action potential (MAP) recording were used to analyse the MAP duration (MAPD), conduction velocity (CV) and transmural repolarization dispersion (TDR). In addition, haematoxylin and eosin (HE) and terminal deoxynucleotidyl transferase-dUTP nick end labelling (TUNEL) staining were individually used to investigate the degree of myocardial pathological damage and cell apoptosis. Finally, bipolar electrograms were used to record the graft re-beating time and monitor RA during reperfusion for 15 to 30 min.
Results
Sevo-HTK solution relatively increased the total Cx43 (P < 0.01) and Cx43-pS368 (P < 0.01) levels and prevented Cx43 redistribution (P < 0.05) and CV slowing (P < 0.001) but did not change TDR (P > 0.05). Additionally, the Cx43-pS368/total Cx43 ratio (P>0.05) was similar in the two groups. However, with Sevo-HTK solution, the graft re-beating times were shortened, myocardial pathological damage was ameliorated, and the number of apoptotic cells was markedly decreased.
Conclusion
The reduction in hypothermia and ischaemia-induced reperfusion arrhythmias by the addition of sevoflurane to HTK solution may be related to the phosphorylation of Cx43 at serine 368.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ABMKux
Risk factors for early postoperative cognitive dysfunction after colorectal surgery
Abstract
Background
It has been reported that postoperative cognitive dysfunction (POCD) is correlated with the degeneration of the central nervous system, oxidative stress, inflammation, and endocrine and immune dysfunction. Increased age, predisposed comorbidity, long surgery time, and prolonged stay in the intensive care unit have been reported to be risk factors for developing POCD for cardiac surgery. In the present study, the risk factors of early POCD after colorectal surgery were investigated.
Methods
Eighty patients, who provided informed consents for their participation in this study, were enrolled and received colorectal surgery under general anesthesia. Neuropsychological tests were performed preoperatively and on postoperative day seven. The risk factors for POCD were analyzed using a multivariate logistic regression model.
Results
Nineteen patients were diagnosed with POCD (24.7%). Diabetes history (OR = 8.391 [2.208–31.882], P = 0.012), fasting over 3 days after surgery (OR = 5.236 [1.998–13.721], P = 0.001) and an SIRS score of > 3 on the second day after surgery (OR = 6.995 [1.948–25.111], P = 0.003) were risk factors for early POCD in colorectal cancer patients.
Conclusion
The risk factors for early POCD after colorectal surgery included diabetes history, fasting over 3 days, and an SIRS score of > 3 on the second day.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SOg3kU
Antiarrhythmic effect of sevoflurane as an additive to HTK solution on reperfusion arrhythmias induced by hypothermia and ischaemia is associated with the phosphorylation of connexin 43 at serine 368
Abstract
Background
Reperfusion ventricular arrhythmia (RA) associated with hypothermic ischaemic storage is increasingly recognized as a substantial contributor to adverse consequences after heart transplantation. Ischemia- or hypothermia-induced gap junction (GJ) remodelling is closely linked to RA. Reducing GJ remodelling contributes to RA attenuation and is important in heart transplantation. However, sevoflurane has an antiarrhythmic effect associated with the connexin 43 (Cx43) protein that has not yet been fully established.
Methods
Hearts were divided into two groups according to a random number table: all hearts were arrested by an infusion of histidine-tryptophan-ketoglutarate (HTK) solution (4 °C) followed by (1) storage in HTK solution (4 °C) alone for 6 h (n = 8, Control group) or (2) storage in HTK solution supplemented with sevoflurane (2.5%) (4 °C) for 6 h (n = 8, Sevo-HTK group). First, the total Cx43 level and the phosphorylation of Cx43 at Ser368 (Cx43-pS368) were assessed by Western blotting, and the distribution of Cx43 was assessed by immunohistochemistry. Second, programmed electrical stimulation (PES) and monophasic action potential (MAP) recording were used to analyse the MAP duration (MAPD), conduction velocity (CV) and transmural repolarization dispersion (TDR). In addition, haematoxylin and eosin (HE) and terminal deoxynucleotidyl transferase-dUTP nick end labelling (TUNEL) staining were individually used to investigate the degree of myocardial pathological damage and cell apoptosis. Finally, bipolar electrograms were used to record the graft re-beating time and monitor RA during reperfusion for 15 to 30 min.
Results
Sevo-HTK solution relatively increased the total Cx43 (P < 0.01) and Cx43-pS368 (P < 0.01) levels and prevented Cx43 redistribution (P < 0.05) and CV slowing (P < 0.001) but did not change TDR (P > 0.05). Additionally, the Cx43-pS368/total Cx43 ratio (P>0.05) was similar in the two groups. However, with Sevo-HTK solution, the graft re-beating times were shortened, myocardial pathological damage was ameliorated, and the number of apoptotic cells was markedly decreased.
Conclusion
The reduction in hypothermia and ischaemia-induced reperfusion arrhythmias by the addition of sevoflurane to HTK solution may be related to the phosphorylation of Cx43 at serine 368.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ABMKux
Risk factors for early postoperative cognitive dysfunction after colorectal surgery
Abstract
Background
It has been reported that postoperative cognitive dysfunction (POCD) is correlated with the degeneration of the central nervous system, oxidative stress, inflammation, and endocrine and immune dysfunction. Increased age, predisposed comorbidity, long surgery time, and prolonged stay in the intensive care unit have been reported to be risk factors for developing POCD for cardiac surgery. In the present study, the risk factors of early POCD after colorectal surgery were investigated.
Methods
Eighty patients, who provided informed consents for their participation in this study, were enrolled and received colorectal surgery under general anesthesia. Neuropsychological tests were performed preoperatively and on postoperative day seven. The risk factors for POCD were analyzed using a multivariate logistic regression model.
Results
Nineteen patients were diagnosed with POCD (24.7%). Diabetes history (OR = 8.391 [2.208–31.882], P = 0.012), fasting over 3 days after surgery (OR = 5.236 [1.998–13.721], P = 0.001) and an SIRS score of > 3 on the second day after surgery (OR = 6.995 [1.948–25.111], P = 0.003) were risk factors for early POCD in colorectal cancer patients.
Conclusion
The risk factors for early POCD after colorectal surgery included diabetes history, fasting over 3 days, and an SIRS score of > 3 on the second day.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SOg3kU
Interaural Pitch-Discrimination Range Effects for Bilateral and Single-Sided-Deafness Cochlear-Implant Users
AbstractBy allowing bilateral access to sound, bilateral cochlear implants (BI-CIs) or unilateral CIs for individuals with single-sided deafness (SSD; i.e., normal or near-normal hearing in one ear) can improve sound localization and speech understanding in noise. Spatial hearing in the horizontal plane is primarily conveyed by interaural time and level differences computed from neurons in the superior olivary complex that receive frequency-matched inputs. Because BI-CIs and SSD-CIs do not necessarily convey frequency-matched information, it is critical to understand how to align the inputs to CI users. Previous studies show that interaural pitch discrimination for SSD-CI listeners is highly susceptible to contextual biases, questioning its utility for establishing interaural frequency ali...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2VD4UVN
Neural ITD Sensitivity and Temporal Coding with Cochlear Implants in an Animal Model of Early-Onset Deafness
AbstractUsers of cochlear implant (CI) face challenges in everyday situations such as understanding conversations in noise, even with CIs in both ears. These challenges are related to difficulties with tasks that require fine temporal processing such as discrimination of pulse rates or interaural time differences (ITD), a major cue for sound localization. The degradation in temporal processing and ITD sensitivity are especially acute in those who lost hearing in early childhood. Here, we characterized temporal coding and ITD sensitivity of single neurons in a novel animal model of early-onset deafness. Rabbits were deafened as neonates and deprived of auditory stimulation until they reached adult age when single-unit recordings from the auditory midbrain were made chronically using an unan...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QwhjXJ
Interaural Pitch-Discrimination Range Effects for Bilateral and Single-Sided-Deafness Cochlear-Implant Users
AbstractBy allowing bilateral access to sound, bilateral cochlear implants (BI-CIs) or unilateral CIs for individuals with single-sided deafness (SSD; i.e., normal or near-normal hearing in one ear) can improve sound localization and speech understanding in noise. Spatial hearing in the horizontal plane is primarily conveyed by interaural time and level differences computed from neurons in the superior olivary complex that receive frequency-matched inputs. Because BI-CIs and SSD-CIs do not necessarily convey frequency-matched information, it is critical to understand how to align the inputs to CI users. Previous studies show that interaural pitch discrimination for SSD-CI listeners is highly susceptible to contextual biases, questioning its utility for establishing interaural frequency ali...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2VD4UVN
Neural ITD Sensitivity and Temporal Coding with Cochlear Implants in an Animal Model of Early-Onset Deafness
AbstractUsers of cochlear implant (CI) face challenges in everyday situations such as understanding conversations in noise, even with CIs in both ears. These challenges are related to difficulties with tasks that require fine temporal processing such as discrimination of pulse rates or interaural time differences (ITD), a major cue for sound localization. The degradation in temporal processing and ITD sensitivity are especially acute in those who lost hearing in early childhood. Here, we characterized temporal coding and ITD sensitivity of single neurons in a novel animal model of early-onset deafness. Rabbits were deafened as neonates and deprived of auditory stimulation until they reached adult age when single-unit recordings from the auditory midbrain were made chronically using an unan...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2QwhjXJ
Podcast: A Bipolar and a Schizophrenic Discuss Psychiatric Medications
Psychiatric medication gets a bad rap when it isn't deserved, while simultaneously being seen by some as the end-all treatment for people living with mental illness. Our hosts both need their prescribed medication to live well, and that makes people around them ask questions ― some of which are weirder than others. Tune in to this episode to hear what they have to say. SUBSCRIBE & REVIEW "It took me so much pride to get over that I needed psychiatric medication." – Michelle Hammer Highlights From 'Meds' Episode [1:00] What happens when Gabe and Michelle don't take their medications. [4:00] People just love to ask us for our medications. [8:00] Stigma from medical professionals. [14:00] Please don't buy pills from people to self-medicat...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RGgZtW
Breaking through: How sign language classes became 'a miracle' for this Newfoundland mom
As sign language classes spread along Newfoundland's west coast, the lessons aren't just benefiting the deaf and hard of hearing. (Source: CBC | Health)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CZuOM3
New peanut allergy treatments show promise. But for me, it still seems risky
Childhood peanut allergies are increasing in the U.S. (Source: ABC News: Health)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SEIwct
1 in 10 Adults Have Food Allergies, But Twice as Many Think They Do
Title: 1 in 10 Adults Have Food Allergies, But Twice as Many Think They DoCategory: Health NewsCreated: 1/4/2019 12:00:00 AMLast Editorial Review: 1/7/2019 12:00:00 AM (Source: MedicineNet Allergies General)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AB0vd0
Podcast: A Bipolar and a Schizophrenic Discuss Psychiatric Medications
Psychiatric medication gets a bad rap when it isn't deserved, while simultaneously being seen by some as the end-all treatment for people living with mental illness. Our hosts both need their prescribed medication to live well, and that makes people around them ask questions ― some of which are weirder than others. Tune in to this episode to hear what they have to say. SUBSCRIBE & REVIEW "It took me so much pride to get over that I needed psychiatric medication." – Michelle Hammer Highlights From 'Meds' Episode [1:00] What happens when Gabe and Michelle don't take their medications. [4:00] People just love to ask us for our medications. [8:00] Stigma from medical professionals. [14:00] Please don't buy pills from people to self-medicat...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RGgZtW
Breaking through: How sign language classes became 'a miracle' for this Newfoundland mom
As sign language classes spread along Newfoundland's west coast, the lessons aren't just benefiting the deaf and hard of hearing. (Source: CBC | Health)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CZuOM3
New peanut allergy treatments show promise. But for me, it still seems risky
Childhood peanut allergies are increasing in the U.S. (Source: ABC News: Health)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SEIwct
1 in 10 Adults Have Food Allergies, But Twice as Many Think They Do
Title: 1 in 10 Adults Have Food Allergies, But Twice as Many Think They DoCategory: Health NewsCreated: 1/4/2019 12:00:00 AMLast Editorial Review: 1/7/2019 12:00:00 AM (Source: MedicineNet Allergies General)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AB0vd0
New peanut allergy treatments show promise. But for me, it still seems risky
Childhood peanut allergies are increasing in the U.S. (Source: ABC News: Health)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SEIwct
1 in 10 Adults Have Food Allergies, But Twice as Many Think They Do
Title: 1 in 10 Adults Have Food Allergies, But Twice as Many Think They DoCategory: Health NewsCreated: 1/4/2019 12:00:00 AMLast Editorial Review: 1/7/2019 12:00:00 AM (Source: MedicineNet Allergies General)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AB0vd0
New peanut allergy treatments show promise. But for me, it still seems risky
Childhood peanut allergies are increasing in the U.S. (Source: ABC News: Health)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SEIwct
1 in 10 Adults Have Food Allergies, But Twice as Many Think They Do
Title: 1 in 10 Adults Have Food Allergies, But Twice as Many Think They DoCategory: Health NewsCreated: 1/4/2019 12:00:00 AMLast Editorial Review: 1/7/2019 12:00:00 AM (Source: MedicineNet Allergies General)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AB0vd0
Breaking through: How sign language classes became 'a miracle' for this Newfoundland mom
As sign language classes spread along Newfoundland's west coast, the lessons aren't just benefiting the deaf and hard of hearing. (Source: CBC | Health)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CZuOM3
Breaking through: How sign language classes became 'a miracle' for this Newfoundland mom
As sign language classes spread along Newfoundland's west coast, the lessons aren't just benefiting the deaf and hard of hearing. (Source: CBC | Health)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CZuOM3
Interaural Pitch-Discrimination Range Effects for Bilateral and Single-Sided-Deafness Cochlear-Implant Users
Abstract
By allowing bilateral access to sound, bilateral cochlear implants (BI-CIs) or unilateral CIs for individuals with single-sided deafness (SSD; i.e., normal or near-normal hearing in one ear) can improve sound localization and speech understanding in noise. Spatial hearing in the horizontal plane is primarily conveyed by interaural time and level differences computed from neurons in the superior olivary complex that receive frequency-matched inputs. Because BI-CIs and SSD-CIs do not necessarily convey frequency-matched information, it is critical to understand how to align the inputs to CI users. Previous studies show that interaural pitch discrimination for SSD-CI listeners is highly susceptible to contextual biases, questioning its utility for establishing interaural frequency alignment. Here, we replicate this finding for SSD-CI listeners and show that these biases also extend to BI-CI listeners. To assess the testing-range bias, three ranges of comparison electrodes (BI-CI) or pure-tone frequencies (SSD-CI) were tested: full range, apical/lower half, or basal/upper half. To assess the reference bias, the reference electrode was either held fixed throughout a testing block or randomly chosen from three electrodes (basal end, middle, or apical end of the array). Results showed no effect of reference electrode randomization, but a large testing range bias; changing the center of the testing-rage shifted the pitch match by an average 63 % (BI-CI) or 43 % (SSD-CI) of the change magnitude. This bias diminished pitch-match accuracy, with a change in reference electrode shifting the pitch match only an average 34 % (BI-CI) or 40 % (SSD-CI) of the expected amount. Because these effects extended to the relatively more symmetric BI-CI listeners, the results suggest that the bias cannot be attributed to interaural asymmetry. Unless the range effect can be minimized or accounted for, a pitch-discrimination task will produce interaural place-of-stimulation estimates that are highly influenced by the conditions tested, rather than reflecting a true interaural place-pitch comparison.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2segxFd
Neural ITD Sensitivity and Temporal Coding with Cochlear Implants in an Animal Model of Early-Onset Deafness
Abstract
Users of cochlear implant (CI) face challenges in everyday situations such as understanding conversations in noise, even with CIs in both ears. These challenges are related to difficulties with tasks that require fine temporal processing such as discrimination of pulse rates or interaural time differences (ITD), a major cue for sound localization. The degradation in temporal processing and ITD sensitivity are especially acute in those who lost hearing in early childhood. Here, we characterized temporal coding and ITD sensitivity of single neurons in a novel animal model of early-onset deafness. Rabbits were deafened as neonates and deprived of auditory stimulation until they reached adult age when single-unit recordings from the auditory midbrain were made chronically using an unanesthetized preparation. The results are compared to measurements from adult-deafened rabbits with normal auditory development to understand the effect of early-onset deafness on neural temporal coding and ITD sensitivity. Neurons in the inferior colliculus (IC) of early-deafened rabbits were less likely to show sustained, excitatory responses to pulse train stimulation and more likely to show suppressive responses compared to neurons in adult-deaf animals. Fewer neurons showed synchronized responses to pulse trains at any rate in the early-deaf group. In addition, fewer neurons showed significant ITD sensitivity in their overall firing rate in the early-deaf group compared to adult-deaf animals. Neural ITD discrimination thresholds in the early-deaf group were poorer than thresholds in adult-deaf group, especially at high pulse rates. The overall degradation in neural ITD sensitivity is consistent with the difficulties encountered by human CI users with early-onset hearing loss. These results lay the groundwork for investigating whether the degradations in temporal coding and ITD sensitivity observed in early-deaf animals can be reversed by appropriate CI stimulation during development.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2LZaI7I
Interaural Pitch-Discrimination Range Effects for Bilateral and Single-Sided-Deafness Cochlear-Implant Users
Abstract
By allowing bilateral access to sound, bilateral cochlear implants (BI-CIs) or unilateral CIs for individuals with single-sided deafness (SSD; i.e., normal or near-normal hearing in one ear) can improve sound localization and speech understanding in noise. Spatial hearing in the horizontal plane is primarily conveyed by interaural time and level differences computed from neurons in the superior olivary complex that receive frequency-matched inputs. Because BI-CIs and SSD-CIs do not necessarily convey frequency-matched information, it is critical to understand how to align the inputs to CI users. Previous studies show that interaural pitch discrimination for SSD-CI listeners is highly susceptible to contextual biases, questioning its utility for establishing interaural frequency alignment. Here, we replicate this finding for SSD-CI listeners and show that these biases also extend to BI-CI listeners. To assess the testing-range bias, three ranges of comparison electrodes (BI-CI) or pure-tone frequencies (SSD-CI) were tested: full range, apical/lower half, or basal/upper half. To assess the reference bias, the reference electrode was either held fixed throughout a testing block or randomly chosen from three electrodes (basal end, middle, or apical end of the array). Results showed no effect of reference electrode randomization, but a large testing range bias; changing the center of the testing-rage shifted the pitch match by an average 63 % (BI-CI) or 43 % (SSD-CI) of the change magnitude. This bias diminished pitch-match accuracy, with a change in reference electrode shifting the pitch match only an average 34 % (BI-CI) or 40 % (SSD-CI) of the expected amount. Because these effects extended to the relatively more symmetric BI-CI listeners, the results suggest that the bias cannot be attributed to interaural asymmetry. Unless the range effect can be minimized or accounted for, a pitch-discrimination task will produce interaural place-of-stimulation estimates that are highly influenced by the conditions tested, rather than reflecting a true interaural place-pitch comparison.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2segxFd
Neural ITD Sensitivity and Temporal Coding with Cochlear Implants in an Animal Model of Early-Onset Deafness
Abstract
Users of cochlear implant (CI) face challenges in everyday situations such as understanding conversations in noise, even with CIs in both ears. These challenges are related to difficulties with tasks that require fine temporal processing such as discrimination of pulse rates or interaural time differences (ITD), a major cue for sound localization. The degradation in temporal processing and ITD sensitivity are especially acute in those who lost hearing in early childhood. Here, we characterized temporal coding and ITD sensitivity of single neurons in a novel animal model of early-onset deafness. Rabbits were deafened as neonates and deprived of auditory stimulation until they reached adult age when single-unit recordings from the auditory midbrain were made chronically using an unanesthetized preparation. The results are compared to measurements from adult-deafened rabbits with normal auditory development to understand the effect of early-onset deafness on neural temporal coding and ITD sensitivity. Neurons in the inferior colliculus (IC) of early-deafened rabbits were less likely to show sustained, excitatory responses to pulse train stimulation and more likely to show suppressive responses compared to neurons in adult-deaf animals. Fewer neurons showed synchronized responses to pulse trains at any rate in the early-deaf group. In addition, fewer neurons showed significant ITD sensitivity in their overall firing rate in the early-deaf group compared to adult-deaf animals. Neural ITD discrimination thresholds in the early-deaf group were poorer than thresholds in adult-deaf group, especially at high pulse rates. The overall degradation in neural ITD sensitivity is consistent with the difficulties encountered by human CI users with early-onset hearing loss. These results lay the groundwork for investigating whether the degradations in temporal coding and ITD sensitivity observed in early-deaf animals can be reversed by appropriate CI stimulation during development.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2LZaI7I
ACA Coverage Gains Could Erode Without Individual Mandate
However, individual market in California not expected to destabilize because of mandate penalty (Source: The Doctors Lounge - Psychiatry)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2M03bW3
Εγγραφή σε:
Αναρτήσεις (Atom)