Conditions: Gingivitis; Mucositis Intervention: Behavioral: Experimentally induced plaque Sponsor: University of Campinas, Brazil Completed (Source: ClinicalTrials.gov)
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Condition: Conjunctivitis, Allergic Interventions: Drug: Reproxalap Ophthalmic Solution (0.25%); Drug: Reproxalap Ophthalmic Solution (0.5%); Drug: Vehicle Ophthalmic Solution Sponsor: Aldeyra Therapeutics, Inc. Recruiting (Source: ClinicalTrials.gov)
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Condition: HIV Interventions: Other: Digital Activity Tracker; Other: Smart Text Messaging; Other: Physical Activity Counseling Sponsors: Johns Hopkins University; National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Helicobacter Pylori Infection Interventions: Drug: Esomeprazole; Drug: Bismuth Potassium Citrate; Drug: Clarithromycin; Drug: Metronidazole; Drug: Levofloxacin; Drug: Tetracycline Sponsor: Shanghai Jiao Tong University School of Medicine Recruiting (Source: ClinicalTrials.gov)
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Condition: HIV Infection Interventions: Drug: ART; Biological: VRC01LS; Biological: 10-1074 Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Asthma Interventions: Drug: GSK2245035; Drug: Placebo; Drug: FP-DPI; Drug: Albuterol/Salbutamol; Other: eDairy; Other: ACQ-6 Sponsor: GlaxoSmithKline Withdrawn (Source: ClinicalTrials.gov)
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Condition: HIV-1-infection Interventions: Biological: SAR441236; Biological: Placebo; Drug: Antiretroviral treatment Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
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Conditions: Asthma; Asthma Attack; Asthma, Allergic Intervention: Device: VitalFlo spirometer Sponsors: VitalFlo Inc.; University of North Carolina, Chapel Hill Recruiting (Source: ClinicalTrials.gov)
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Condition: Penicillin Allergy Intervention: Other: Penicillin Allergic Risk Stratification Best Practice Alert Sponsors: Vanderbilt University Medical Center; Vanderbilt Institute for Clinical and Translational Research (Learning Healthcare System) Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Allergic Rhinitis Intervention: Other: Yoga training Sponsor: Chulalongkorn University Completed (Source: ClinicalTrials.gov)
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Conditions: Gingivitis; Mucositis Intervention: Behavioral: Experimentally induced plaque Sponsor: University of Campinas, Brazil Completed (Source: ClinicalTrials.gov)
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Condition: Conjunctivitis, Allergic Interventions: Drug: Reproxalap Ophthalmic Solution (0.25%); Drug: Reproxalap Ophthalmic Solution (0.5%); Drug: Vehicle Ophthalmic Solution Sponsor: Aldeyra Therapeutics, Inc. Recruiting (Source: ClinicalTrials.gov)
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Condition: HIV Interventions: Other: Digital Activity Tracker; Other: Smart Text Messaging; Other: Physical Activity Counseling Sponsors: Johns Hopkins University; National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Helicobacter Pylori Infection Interventions: Drug: Esomeprazole; Drug: Bismuth Potassium Citrate; Drug: Clarithromycin; Drug: Metronidazole; Drug: Levofloxacin; Drug: Tetracycline Sponsor: Shanghai Jiao Tong University School of Medicine Recruiting (Source: ClinicalTrials.gov)
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Condition: HIV Infection Interventions: Drug: ART; Biological: VRC01LS; Biological: 10-1074 Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
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Condition: Asthma Interventions: Drug: GSK2245035; Drug: Placebo; Drug: FP-DPI; Drug: Albuterol/Salbutamol; Other: eDairy; Other: ACQ-6 Sponsor: GlaxoSmithKline Withdrawn (Source: ClinicalTrials.gov)
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Condition: HIV-1-infection Interventions: Biological: SAR441236; Biological: Placebo; Drug: Antiretroviral treatment Sponsor: National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Conditions: Asthma; Asthma Attack; Asthma, Allergic Intervention: Device: VitalFlo spirometer Sponsors: VitalFlo Inc.; University of North Carolina, Chapel Hill Recruiting (Source: ClinicalTrials.gov)
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Condition: Penicillin Allergy Intervention: Other: Penicillin Allergic Risk Stratification Best Practice Alert Sponsors: Vanderbilt University Medical Center; Vanderbilt Institute for Clinical and Translational Research (Learning Healthcare System) Not yet recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CWXTZO
Condition: Allergic Rhinitis Intervention: Other: Yoga training Sponsor: Chulalongkorn University Completed (Source: ClinicalTrials.gov)
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Augmentation of the maxillary sinus floor with bone grafting is commonly used for successful treatment of edentulous posterior maxilla with dental implants, and it is essential to maintain good bone volume and quality for long-term success of dental implants. The aim of this experimental study was to investigate the local and systemic effects of boric acid on new bone formation after maxillary sinus floor augmentation (MSFA).
Twenty-four male, New Zealand rabbits were randomly divided into three groups with eight rabbits each, and bilateral MSFA was performed in each animal. An autogenous bone/xenograft mixture was used to augment the maxillary sinuses in each group. Group 1 was determined as control with no additional materials, whereas 3 mg/kg boric acid (BA) was added to the mixture in group 2, and 3 mg/kg boric acid solution added to drinking water daily in group 3.
The animals were sacrificed and also histologic, histomorphometric, and immunnohistochemical analyses were performed at weeks 4 and 8. At week 4, bone regeneration was better in the local BA group than in the control and systemic BA groups (p < 0.05). However, no significant difference was found among the groups in terms of bone regeneration at the end of week 8 (p > 0.05).
Significant higher new bone formation was revealed by BA at early healing especially with local application. BA may be a therapeutic option for improving the bone regeneration.
Augmentation of the maxillary sinus floor with bone grafting is commonly used for successful treatment of edentulous posterior maxilla with dental implants, and it is essential to maintain good bone volume and quality for long-term success of dental implants. The aim of this experimental study was to investigate the local and systemic effects of boric acid on new bone formation after maxillary sinus floor augmentation (MSFA).
Twenty-four male, New Zealand rabbits were randomly divided into three groups with eight rabbits each, and bilateral MSFA was performed in each animal. An autogenous bone/xenograft mixture was used to augment the maxillary sinuses in each group. Group 1 was determined as control with no additional materials, whereas 3 mg/kg boric acid (BA) was added to the mixture in group 2, and 3 mg/kg boric acid solution added to drinking water daily in group 3.
The animals were sacrificed and also histologic, histomorphometric, and immunnohistochemical analyses were performed at weeks 4 and 8. At week 4, bone regeneration was better in the local BA group than in the control and systemic BA groups (p < 0.05). However, no significant difference was found among the groups in terms of bone regeneration at the end of week 8 (p > 0.05).
Significant higher new bone formation was revealed by BA at early healing especially with local application. BA may be a therapeutic option for improving the bone regeneration.
In this study, we therefore determined changes in protein abundance in the liver and blood serum in response to S. Enteritidis infection using the unbiased approach of shotgun proteomics. Complement and coagulation cascades, TNF signalling, antigen processing and presentation was activated in the liver following infection with S. Enteritidis. Chicken proteins that decreased in the liver were involved in glycolysis, the citrate cycle, oxidative phosphorylation and fatty acid metabolism. No functional category was significantly activated or suppressed in the serum. Concerning individual proteins, VNN1, SAA, AVD, SERPINA3, SERPINB10, AGT, MRP126 or CP increased in abundance both in the liver and serum. MT4, MT3, PTGDS, GLRX and TGM4, though highly inducible in the liver, did not increase in t...
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In this study, we therefore determined changes in protein abundance in the liver and blood serum in response to S. Enteritidis infection using the unbiased approach of shotgun proteomics. Complement and coagulation cascades, TNF signalling, antigen processing and presentation was activated in the liver following infection with S. Enteritidis. Chicken proteins that decreased in the liver were involved in glycolysis, the citrate cycle, oxidative phosphorylation and fatty acid metabolism. No functional category was significantly activated or suppressed in the serum. Concerning individual proteins, VNN1, SAA, AVD, SERPINA3, SERPINB10, AGT, MRP126 or CP increased in abundance both in the liver and serum. MT4, MT3, PTGDS, GLRX and TGM4, though highly inducible in the liver, did not increase in t...
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Augmentation of the maxillary sinus floor with bone grafting is commonly used for successful treatment of edentulous posterior maxilla with dental implants, and it is essential to maintain good bone volume and quality for long-term success of dental implants. The aim of this experimental study was to investigate the local and systemic effects of boric acid on new bone formation after maxillary sinus floor augmentation (MSFA).
Twenty-four male, New Zealand rabbits were randomly divided into three groups with eight rabbits each, and bilateral MSFA was performed in each animal. An autogenous bone/xenograft mixture was used to augment the maxillary sinuses in each group. Group 1 was determined as control with no additional materials, whereas 3 mg/kg boric acid (BA) was added to the mixture in group 2, and 3 mg/kg boric acid solution added to drinking water daily in group 3.
The animals were sacrificed and also histologic, histomorphometric, and immunnohistochemical analyses were performed at weeks 4 and 8. At week 4, bone regeneration was better in the local BA group than in the control and systemic BA groups (p < 0.05). However, no significant difference was found among the groups in terms of bone regeneration at the end of week 8 (p > 0.05).
Significant higher new bone formation was revealed by BA at early healing especially with local application. BA may be a therapeutic option for improving the bone regeneration.
Augmentation of the maxillary sinus floor with bone grafting is commonly used for successful treatment of edentulous posterior maxilla with dental implants, and it is essential to maintain good bone volume and quality for long-term success of dental implants. The aim of this experimental study was to investigate the local and systemic effects of boric acid on new bone formation after maxillary sinus floor augmentation (MSFA).
Twenty-four male, New Zealand rabbits were randomly divided into three groups with eight rabbits each, and bilateral MSFA was performed in each animal. An autogenous bone/xenograft mixture was used to augment the maxillary sinuses in each group. Group 1 was determined as control with no additional materials, whereas 3 mg/kg boric acid (BA) was added to the mixture in group 2, and 3 mg/kg boric acid solution added to drinking water daily in group 3.
The animals were sacrificed and also histologic, histomorphometric, and immunnohistochemical analyses were performed at weeks 4 and 8. At week 4, bone regeneration was better in the local BA group than in the control and systemic BA groups (p < 0.05). However, no significant difference was found among the groups in terms of bone regeneration at the end of week 8 (p > 0.05).
Significant higher new bone formation was revealed by BA at early healing especially with local application. BA may be a therapeutic option for improving the bone regeneration.
Daclizumab is a humanized monoclonal antibody that blocks CD25, the high affinity alpha subunit of the interleukin-2 receptor. Daclizumab therapy targets T regulatory cell and activated effector T cell proliferation to suppress autoimmune disease activity, in inflammatory conditions like relapsing and remitting multiple sclerosis. Here, we present the first report of agranulocytosis with daclizumab therapy in a patient with relapsing and remitting multiple sclerosis.
Our patient was a 24-year-old Australian female with a clinical history of atopy, lymphocytic enteritis complicated by B12 deficiency, relapsing and remitting multiple sclerosis, recurrent lower respiratory tract infections, vulval/cervical intraepithelial neoplasia and melanoma. She was commenced on daclizumab therapy after failing several lines of treatment for relapsing and remitting multiple sclerosis. During a hospital admission for lymphocytic enteritis, she was incidentally diagnosed with combined immunodeficiency with hypogammaglobulinaemia and declined proposed regular intravenous immunoglobulin infusions. Following six months of daclizumab therapy, our patient presented to hospital with febrile neutropenia. No clear infective cause was found, despite numerous investigations. However, bone marrow biopsy revealed agranulocytosis with an apparent maturation block at the myeloblasts stage. Neustrophil recovery occurred following cessation of daclizumab and the initiation of T cell immunosuppressive agents including systemic corticosteroids and methotrexate. The patient was further investigated for combined immunodeficiency and whole exome sequencing revealed a novel heterozygous missense variant in cytotoxic T lymphocyte antigen 4 (CTLA4), leading to a diagnosis of CTLA-4 haploinsufficiency with autoimmune infiltration (CHAI).
This case demonstrates that autoimmune disease may be the presenting feature of primary immunodeficiency and should be appropriately investigated prior to the commencement of immunotherapy. Genetic clarification of underlying primary immunodeficiency may provide critical clinical information that alters the safety of the proposed treatment strategy.
There is ongoing controversy surrounding the appropriate standards and limits of accommodation of children with food allergies in schools. We identify and explain how relevant Canadian common law, legislation, constitutional law and human rights policy can inform future school policy around allergy, disability and food bans.
The Canadian Charter of Rights and Freedoms applies to governmental laws or policies, including the policies of schools, and grants every individual the right to freedom from discrimination based on, among other things, disability. Canadian constitutional and human rights law define disability broadly including perceived disabilities. Provincial human rights tribunals in both Ontario and BC have explicitly found allergy to be a disability requiring accommodation, even in cases not involving anaphylaxis risk. However, the cases most pertinent to the scenarios faced by schools have found that food bans may not be required, due to recent scientific evidence that they do not render allergy sufferers safer.
Anaphylaxis-level allergy constitutes a disability under both the Charter and human rights legislation, despite the fact that higher courts have not definitively ruled on the matter. Accordingly, schools must make careful decisions about how to deal with life-threatening allergies among their students. Food bans are generally not legally necessary, and, in the absence of new legislation, are only likely to become so if sufficient scientific evidence demonstrates that they increase safety for students. School policies should be substantially informed by evidence-based research in order to ensure ongoing congruence with human rights law.
Daclizumab is a humanized monoclonal antibody that blocks CD25, the high affinity alpha subunit of the interleukin-2 receptor. Daclizumab therapy targets T regulatory cell and activated effector T cell proliferation to suppress autoimmune disease activity, in inflammatory conditions like relapsing and remitting multiple sclerosis. Here, we present the first report of agranulocytosis with daclizumab therapy in a patient with relapsing and remitting multiple sclerosis.
Our patient was a 24-year-old Australian female with a clinical history of atopy, lymphocytic enteritis complicated by B12 deficiency, relapsing and remitting multiple sclerosis, recurrent lower respiratory tract infections, vulval/cervical intraepithelial neoplasia and melanoma. She was commenced on daclizumab therapy after failing several lines of treatment for relapsing and remitting multiple sclerosis. During a hospital admission for lymphocytic enteritis, she was incidentally diagnosed with combined immunodeficiency with hypogammaglobulinaemia and declined proposed regular intravenous immunoglobulin infusions. Following six months of daclizumab therapy, our patient presented to hospital with febrile neutropenia. No clear infective cause was found, despite numerous investigations. However, bone marrow biopsy revealed agranulocytosis with an apparent maturation block at the myeloblasts stage. Neustrophil recovery occurred following cessation of daclizumab and the initiation of T cell immunosuppressive agents including systemic corticosteroids and methotrexate. The patient was further investigated for combined immunodeficiency and whole exome sequencing revealed a novel heterozygous missense variant in cytotoxic T lymphocyte antigen 4 (CTLA4), leading to a diagnosis of CTLA-4 haploinsufficiency with autoimmune infiltration (CHAI).
This case demonstrates that autoimmune disease may be the presenting feature of primary immunodeficiency and should be appropriately investigated prior to the commencement of immunotherapy. Genetic clarification of underlying primary immunodeficiency may provide critical clinical information that alters the safety of the proposed treatment strategy.
There is ongoing controversy surrounding the appropriate standards and limits of accommodation of children with food allergies in schools. We identify and explain how relevant Canadian common law, legislation, constitutional law and human rights policy can inform future school policy around allergy, disability and food bans.
The Canadian Charter of Rights and Freedoms applies to governmental laws or policies, including the policies of schools, and grants every individual the right to freedom from discrimination based on, among other things, disability. Canadian constitutional and human rights law define disability broadly including perceived disabilities. Provincial human rights tribunals in both Ontario and BC have explicitly found allergy to be a disability requiring accommodation, even in cases not involving anaphylaxis risk. However, the cases most pertinent to the scenarios faced by schools have found that food bans may not be required, due to recent scientific evidence that they do not render allergy sufferers safer.
Anaphylaxis-level allergy constitutes a disability under both the Charter and human rights legislation, despite the fact that higher courts have not definitively ruled on the matter. Accordingly, schools must make careful decisions about how to deal with life-threatening allergies among their students. Food bans are generally not legally necessary, and, in the absence of new legislation, are only likely to become so if sufficient scientific evidence demonstrates that they increase safety for students. School policies should be substantially informed by evidence-based research in order to ensure ongoing congruence with human rights law.
Publication date: Available online 21 October 2018Source: Life SciencesAuthor(s): Ivan Mrkić, Rajna Minić, Dragan Popović, Irena Živković, Marija Gavrović-JankulovićAbstractAimTo investigate the immunomodulatory potential of a chimera composed of the receptor-binding domain of hemagglutinin 1 (H1s) from Influenza virus and Der p 2 (D2) allergen for allergen-specific immunotherapy of house-dust mite allergy (HDM).Main methodsH1sD2 chimera and D2 allergen were produced by genetic engineering in E. coli. Recombinant antigens were extracted from inclusion bodies by urea, then refolded and purified by immobilized- metal affinity chromatography (IMAC). Purity was verified by 2D-PAGE and secondary structures were assessed by CD spectroscopy. IgE reactivity of H1sD2 and D2 was tested in wes...
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Publication date: Available online 21 October 2018Source: Life SciencesAuthor(s): Ivan Mrkić, Rajna Minić, Dragan Popović, Irena Živković, Marija Gavrović-JankulovićAbstractAimTo investigate the immunomodulatory potential of a chimera composed of the receptor-binding domain of hemagglutinin 1 (H1s) from Influenza virus and Der p 2 (D2) allergen for allergen-specific immunotherapy of house-dust mite allergy (HDM).Main methodsH1sD2 chimera and D2 allergen were produced by genetic engineering in E. coli. Recombinant antigens were extracted from inclusion bodies by urea, then refolded and purified by immobilized- metal affinity chromatography (IMAC). Purity was verified by 2D-PAGE and secondary structures were assessed by CD spectroscopy. IgE reactivity of H1sD2 and D2 was tested in wes...
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18 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:
"Med Oral Patol Oral Cir Bucal"[jour]
These pubmed results were generated on 2018/10/21
PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
18 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:
"Med Oral Patol Oral Cir Bucal"[jour]
These pubmed results were generated on 2018/10/21
PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.
Authors: Ramos-Zayas Y, Franco-Molina MA, Hernádez-Granados AJ, Zárate-Triviño DG, Coronado-Cerda EE, Mendoza-Gamboa E, Zapata-Benavides P, Ramírez-Romero R, Santana-Krymskaya SE, Tamez-Guerra R, Rodríguez-Padilla C Abstract Exosomes secreted by tumor cells are a good source of cellular components that stimulate the immune response, such as alarmins (mRNA, tetraspanins (CD9, CD63, CD81), heat-shock proteins, major histocompatibility complex class I molecules) and tumor-associated antigens. These properties permit to pulsed dendritic cells in the immunotherapy for many cancers types. The aim of this study was to demonstrate the use of exosomes derived from canine transmissible venereal tumor (CTVT) as an antigen to pulsed dendritic cells and its administration in dogs with CTVT...
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Authors: Sharif K, Watad A, Coplan L, Amital H, Shoenfeld Y, Afek A Abstract INTRODUCTION: Type 1 diabetes mellitus (T1DM) is a chronic disease characterized by the destruction of insulin-producing β-cells of the pancreas. The current paradigm in this disease's etiopathogenesis points toward the interplay of genetic and environmental factors. Among the environmental variables, dietary factors, intestinal microbiota, toxins, and psychological stress have been implicated in disease onset. Areas covered: This review aims to investigate the relationship between psychological stress and T1DM by presenting evidence from epidemiological studies, animal models, and to provide the mechanism involved in this association. The literature search was conducted through PubMed to identify studies...
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Authors: Ocampo-Piraquive V, Nieto-Aristizábal I, Cañas CA, Tobón GJ Abstract INTRODUCTION: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by organ damage, flare-remission pattern and increased mortality when compared with the general population. SLE mortality depends on epidemiological, sociodemographic, genetic and clinical factors. Mortality causes have been mainly grouped in disease activity, infections and cardiovascular complications. Lupus nephritis and neuropsychiatric lupus are the main manifestations associated to mortality. Bacterial infection remains an important cause of death, and cardiovascular mortality is almost double when compared to age - and sex- matched comparisons. Characteristics such as time from onset to diagnosis > ...
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Authors: Romano C, Cuomo G, Ferrara R, Del Mastro A, Esposito S, Sellitto A, Adinolfi LE Abstract INTRODUCTION: Chronic hepatitis C virus (HCV) infection has been associated with myriad extrahepatic manifestations, often resulting from aberrant immune responses. Among the most common immune-mediated manifestations of HCV infection, mixed cryoglobulinemia is the best known extra-hepatic complication. Areas covered: Here we review less common extrahepatic manifestations of HCV infection, with ascertained or presumed immune pathogenesis and the role of the new all oral direct-acting antiviral agents. Rheumatologic, dermatologic, ophthalmologic, renal, pulmonary, hematologic, cardiovascular and neuropsychiatric manifestations of HCV infection have been considered. Expert commentary: Pa...
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Authors: Shen E, Xie K, Jwo K, Smith J, Mosaed S PMID: 30335586 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
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Authors: Cunningham ET, Zierhut M PMID: 30339504 [PubMed - in process] (Source: Ocular Immunology and Inflammation)
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CONCLUSION: There was high utilization of autoimmune tests such as ANA, anti-dsDNA, RF, and ANCA, despite its limited yield. Rationalization of investigations in patients with ocular inflammation via a stepladder approach may help optimize the use of limited resources. PMID: 30335550 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
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CONCLUSIONS: Ocular tuberculosis can be associated with Eales disease and often manifest later in the course of the disease. PMID: 30339475 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
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Conclusions: Cytological findings in CB specimens indicated similar histopathological characteristics of enucleated eyes. CB specimens obtained from vitreous waste diluted fluids may serve as effective materials for cytological diagnosis of VRL. PMID: 30335535 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
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In this study, we prepared bone marrow-derived mast cells from BALB/c and C57BL/6 mice and examined their cellular properties. Cellular response to IL-3 and the process of mast cell differentiation from bone marrow cells were different on the basis of cell surface marker molecules. BALB/c-derived cells more efficiently exhibited degranulation than did C57BL/6-derived cells following both calcium ionophore and receptor crosslinking. These functional differences persisted even after a longer cell culture for 8 weeks, suggesting a difference in cell-autonomous characteristics. These results support the concept that mast cells also have different cell types dependent on their genetic background. Abbreviations: Ab: antibody; BMMC: bone marrow-derived mast cell; DNP: dinitrophenyl; FACS: fluore...
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Authors: Ramos-Zayas Y, Franco-Molina MA, Hernádez-Granados AJ, Zárate-Triviño DG, Coronado-Cerda EE, Mendoza-Gamboa E, Zapata-Benavides P, Ramírez-Romero R, Santana-Krymskaya SE, Tamez-Guerra R, Rodríguez-Padilla C Abstract Exosomes secreted by tumor cells are a good source of cellular components that stimulate the immune response, such as alarmins (mRNA, tetraspanins (CD9, CD63, CD81), heat-shock proteins, major histocompatibility complex class I molecules) and tumor-associated antigens. These properties permit to pulsed dendritic cells in the immunotherapy for many cancers types. The aim of this study was to demonstrate the use of exosomes derived from canine transmissible venereal tumor (CTVT) as an antigen to pulsed dendritic cells and its administration in dogs with CTVT...
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Authors: Sharif K, Watad A, Coplan L, Amital H, Shoenfeld Y, Afek A Abstract INTRODUCTION: Type 1 diabetes mellitus (T1DM) is a chronic disease characterized by the destruction of insulin-producing β-cells of the pancreas. The current paradigm in this disease's etiopathogenesis points toward the interplay of genetic and environmental factors. Among the environmental variables, dietary factors, intestinal microbiota, toxins, and psychological stress have been implicated in disease onset. Areas covered: This review aims to investigate the relationship between psychological stress and T1DM by presenting evidence from epidemiological studies, animal models, and to provide the mechanism involved in this association. The literature search was conducted through PubMed to identify studies...
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Authors: Ocampo-Piraquive V, Nieto-Aristizábal I, Cañas CA, Tobón GJ Abstract INTRODUCTION: Systemic lupus erythematosus (SLE) is a chronic autoimmune disease characterized by organ damage, flare-remission pattern and increased mortality when compared with the general population. SLE mortality depends on epidemiological, sociodemographic, genetic and clinical factors. Mortality causes have been mainly grouped in disease activity, infections and cardiovascular complications. Lupus nephritis and neuropsychiatric lupus are the main manifestations associated to mortality. Bacterial infection remains an important cause of death, and cardiovascular mortality is almost double when compared to age - and sex- matched comparisons. Characteristics such as time from onset to diagnosis > ...
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Authors: Romano C, Cuomo G, Ferrara R, Del Mastro A, Esposito S, Sellitto A, Adinolfi LE Abstract INTRODUCTION: Chronic hepatitis C virus (HCV) infection has been associated with myriad extrahepatic manifestations, often resulting from aberrant immune responses. Among the most common immune-mediated manifestations of HCV infection, mixed cryoglobulinemia is the best known extra-hepatic complication. Areas covered: Here we review less common extrahepatic manifestations of HCV infection, with ascertained or presumed immune pathogenesis and the role of the new all oral direct-acting antiviral agents. Rheumatologic, dermatologic, ophthalmologic, renal, pulmonary, hematologic, cardiovascular and neuropsychiatric manifestations of HCV infection have been considered. Expert commentary: Pa...
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Authors: Shen E, Xie K, Jwo K, Smith J, Mosaed S PMID: 30335586 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
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Authors: Cunningham ET, Zierhut M PMID: 30339504 [PubMed - in process] (Source: Ocular Immunology and Inflammation)
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CONCLUSION: There was high utilization of autoimmune tests such as ANA, anti-dsDNA, RF, and ANCA, despite its limited yield. Rationalization of investigations in patients with ocular inflammation via a stepladder approach may help optimize the use of limited resources. PMID: 30335550 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
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CONCLUSIONS: Ocular tuberculosis can be associated with Eales disease and often manifest later in the course of the disease. PMID: 30339475 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
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Conclusions: Cytological findings in CB specimens indicated similar histopathological characteristics of enucleated eyes. CB specimens obtained from vitreous waste diluted fluids may serve as effective materials for cytological diagnosis of VRL. PMID: 30335535 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)
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In this study, we prepared bone marrow-derived mast cells from BALB/c and C57BL/6 mice and examined their cellular properties. Cellular response to IL-3 and the process of mast cell differentiation from bone marrow cells were different on the basis of cell surface marker molecules. BALB/c-derived cells more efficiently exhibited degranulation than did C57BL/6-derived cells following both calcium ionophore and receptor crosslinking. These functional differences persisted even after a longer cell culture for 8 weeks, suggesting a difference in cell-autonomous characteristics. These results support the concept that mast cells also have different cell types dependent on their genetic background. Abbreviations: Ab: antibody; BMMC: bone marrow-derived mast cell; DNP: dinitrophenyl; FACS: fluore...
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Publication date: Available online 21 October 2018
Source: Journal of Herbal Medicine
Author(s): Ahmad Saedisomeolia, Motahereh Makhdoomi Arzati, Mina Abdolahi, Mohsen Sedighiyan, Alejandra Rangel, Gerald Muench, Meysam Zarezadeh, Arash Jafarieh, Niyaz Mohammadzadeh Honarvar
Diabetes mellitus is considered a metabolic disorder characterized by high blood sugar. Active disease is associated with low grade chronic inflammation resulting from the enhanced release of inflammatory mediators such as interleukin (IL)-1 β, IL-6, induced nitric oxide synthase, and cyclooxygenase-2 enzymes that lead to insulin resistance and disease progression. Nuclear factor kappa-B (NF-κB) is a key mediator involved in the inflammatory process which plays an important role in the inflammatory pathogenesis of diabetes. Based on recent evidence, ginger—which contains many phytochemicals—is believed to exert anti-inflammatory properties through multiple mechanisms, such as probably inhibiting the activation of NF-κB signaling pathway. It can thus be a target agent in the treatment and control of diabetes. It appears that ginger may be a complementary agent in diabetes treatment by targeting the NF-κB cascade pathway and exerting antioxidant or anti-inflammatory actions. In this context, this review aims to present the recent evidence regarding the mechanisms of action of ginger in NF-κB signaling pathways in diabetes mellitus.
Conclusion: We demonstrated a strong association between the diagnoses of melanoma and RCC. These increased risks could not be attributed to either immune status or previous antineoplastic treatment. (Source: Cancer Epidemiology)
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Publication date: 15 March 2019Source: Food Chemistry, Volume 276Author(s): F. Francis, V. Doyen, F. Debaugnies, G. Mazzucchelli, R. Caparros, T. Alabi, C. Blecker, E. Haubruge, F. CorazzaAbstractInsects are seen as a solution to the increasing demand for protein sources for food. However, entomophagy has unfortunately been linked to allergic reactions in Europe with people with professional contacts. As mealworms (Tenebrio molitor) and crickets (Acheta domesticus) have recently become commercially available (both whole or in food formulation) in several European countries, this research assessed the cross allergenicity of arginine kinase (AK). Based on the collection of sera from a entomology laboratory staff, oven cooked insects but also purified AK fractions were tested. Immunoblotting ...
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Publication date: Available online 21 October 2018
Source: Journal of Herbal Medicine
Author(s): Ahmad Saedisomeolia, Motahereh Makhdoomi Arzati, Mina Abdolahi, Mohsen Sedighiyan, Alejandra Rangel, Gerald Muench, Meysam Zarezadeh, Arash Jafarieh, Niyaz Mohammadzadeh Honarvar
Diabetes mellitus is considered a metabolic disorder characterized by high blood sugar. Active disease is associated with low grade chronic inflammation resulting from the enhanced release of inflammatory mediators such as interleukin (IL)-1 β, IL-6, induced nitric oxide synthase, and cyclooxygenase-2 enzymes that lead to insulin resistance and disease progression. Nuclear factor kappa-B (NF-κB) is a key mediator involved in the inflammatory process which plays an important role in the inflammatory pathogenesis of diabetes. Based on recent evidence, ginger—which contains many phytochemicals—is believed to exert anti-inflammatory properties through multiple mechanisms, such as probably inhibiting the activation of NF-κB signaling pathway. It can thus be a target agent in the treatment and control of diabetes. It appears that ginger may be a complementary agent in diabetes treatment by targeting the NF-κB cascade pathway and exerting antioxidant or anti-inflammatory actions. In this context, this review aims to present the recent evidence regarding the mechanisms of action of ginger in NF-κB signaling pathways in diabetes mellitus.
Conclusion: We demonstrated a strong association between the diagnoses of melanoma and RCC. These increased risks could not be attributed to either immune status or previous antineoplastic treatment. (Source: Cancer Epidemiology)
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Publication date: 15 March 2019Source: Food Chemistry, Volume 276Author(s): F. Francis, V. Doyen, F. Debaugnies, G. Mazzucchelli, R. Caparros, T. Alabi, C. Blecker, E. Haubruge, F. CorazzaAbstractInsects are seen as a solution to the increasing demand for protein sources for food. However, entomophagy has unfortunately been linked to allergic reactions in Europe with people with professional contacts. As mealworms (Tenebrio molitor) and crickets (Acheta domesticus) have recently become commercially available (both whole or in food formulation) in several European countries, this research assessed the cross allergenicity of arginine kinase (AK). Based on the collection of sera from a entomology laboratory staff, oven cooked insects but also purified AK fractions were tested. Immunoblotting ...
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Conclusions: Our results confirm that the developed ICAR can be used to measure ICSP in acute experiments. The next generation of the ICAR will be used in chronic sheep experiments and in TICI. (Source: Sensors)
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Conclusions: Our results confirm that the developed ICAR can be used to measure ICSP in acute experiments. The next generation of the ICAR will be used in chronic sheep experiments and in TICI. (Source: Sensors)
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Publication date: Available online 21 October 2018
Source: Oral Oncology
Author(s): Enrico Cappelli, Paolo Degan, Carlo Dufour, Silvia Ravera
Publication date: Available online 21 October 2018
Source: American Journal of Preventive Medicine
Author(s): Soham Gupta, Alexander P. Cole, Maya Marchese, Ye Wang, Jacqueline M. Speed, Sean A. Fletcher, Junaid Nabi, Sebastian Berg, Stuart R. Lipsitz, Toni K. Choueiri, Steven L. Chang, Adam S. Kibel, Annemarie Uhlig, Quoc-Dien Trinh
With improvements in early detection and treatment, a growing proportion of the population now lives with a personal history of a cancer. Although many cancer survivors are in excellent health, the underlying risk factors and side effects of cancer treatment increase the risk of medical complications and secondary malignancies.
The 2013 National Health Interview Survey was utilized to assess the association between personal history of cancer and receipt of U.S. Preventive Services Task Force–recommended services, comprising three cancer screening tests (mammography, colonoscopy, and Pap smear) and six general medical preventive care services (aspirin for prevention of cardiovascular disease; blood pressure, cholesterol, and diabetes screening; diet/activity counseling; and tobacco use counseling). For each preventive service, patients with a history that would preclude that test were excluded. One to three matching of cancer survivors to controls was performed using propensity scores generated from patient-level demographic variables. Conditional logistic regression models were employed to compare odds of screening between matched cohorts of cancer survivors and controls. The years of analysis were 2015 and 2017.
A total of 2,639 cancer patients and 31,885 controls were extracted from the merged 2013 National Health Interview Survey. In the propensity score–matched cohorts of eligible adults, only one of the three cancer screening tests, colorectal, was more common in cancer survivors (OR=1.52, 95% CI=1.32, 1.75, p<0.001), whereas breast and cervical cancer screening were not more common in survivors. By contrast, all of the medical screening tests, with the exception of diabetes screening, were more common among cancer survivors.
The association between receipt of recommended preventive medical care and personal history of cancer varied, depending on the preventive service in question, but in the majority of preventive services assessed, cancer survivors had more frequent screening compared with non-cancer survivors.
Publication date: Available online 21 October 2018
Source: Oral Oncology
Author(s): Enrico Cappelli, Paolo Degan, Carlo Dufour, Silvia Ravera
Publication date: Available online 21 October 2018
Source: American Journal of Preventive Medicine
Author(s): Soham Gupta, Alexander P. Cole, Maya Marchese, Ye Wang, Jacqueline M. Speed, Sean A. Fletcher, Junaid Nabi, Sebastian Berg, Stuart R. Lipsitz, Toni K. Choueiri, Steven L. Chang, Adam S. Kibel, Annemarie Uhlig, Quoc-Dien Trinh
With improvements in early detection and treatment, a growing proportion of the population now lives with a personal history of a cancer. Although many cancer survivors are in excellent health, the underlying risk factors and side effects of cancer treatment increase the risk of medical complications and secondary malignancies.
The 2013 National Health Interview Survey was utilized to assess the association between personal history of cancer and receipt of U.S. Preventive Services Task Force–recommended services, comprising three cancer screening tests (mammography, colonoscopy, and Pap smear) and six general medical preventive care services (aspirin for prevention of cardiovascular disease; blood pressure, cholesterol, and diabetes screening; diet/activity counseling; and tobacco use counseling). For each preventive service, patients with a history that would preclude that test were excluded. One to three matching of cancer survivors to controls was performed using propensity scores generated from patient-level demographic variables. Conditional logistic regression models were employed to compare odds of screening between matched cohorts of cancer survivors and controls. The years of analysis were 2015 and 2017.
A total of 2,639 cancer patients and 31,885 controls were extracted from the merged 2013 National Health Interview Survey. In the propensity score–matched cohorts of eligible adults, only one of the three cancer screening tests, colorectal, was more common in cancer survivors (OR=1.52, 95% CI=1.32, 1.75, p<0.001), whereas breast and cervical cancer screening were not more common in survivors. By contrast, all of the medical screening tests, with the exception of diabetes screening, were more common among cancer survivors.
The association between receipt of recommended preventive medical care and personal history of cancer varied, depending on the preventive service in question, but in the majority of preventive services assessed, cancer survivors had more frequent screening compared with non-cancer survivors.
Publication date: 15 January 2019
Source: NeuroImage, Volume 185
Author(s): Jonathan F. O'Rawe, Jaime S. Ide, Hoi-Chung Leung
In accordance with the concept of topographic organization of neuroanatomical structures, there is an increased interest in estimating and delineating continuous changes in the functional connectivity patterns across neighboring voxels within a region of interest using resting-state fMRI data. Fundamental to this functional connectivity gradient analysis is the assumption that the functional organization is stable and uniform across the region of interest. To evaluate this assumption, we developed a statistical model testing procedure to arbitrate between overlapping, shifted, or different topographic connectivity gradients across subdivisions of a structure. We tested the procedure using the striatum, a subcortical structure consisting of the caudate nucleus and putamen, in which an extensive literature, primarily from rodents and non-human primates, suggest to have a shared topographic organization of a single diagonal gradient. We found, across multiple resting state fMRI data samples of different spatial resolutions in humans, and one macaque resting state fMRI data sample, that the models with different functional connectivity gradients across the caudate and putamen was the preferred model. The model selection procedure was validated in control conditions of checkerboard subdivisions, demonstrating the expected overlapping gradient. More specifically, while we replicated the diagonal organization of the functional connectivity gradients in both the caudate and putamen, our analysis also revealed a medial-lateral organization within the caudate. Not surprisingly, performing the same analysis assuming a unitary gradient obfuscates the medial-lateral organization of the caudate, producing only a diagonal gradient. These findings demonstrate the importance of testing basic assumptions and evaluating interpretations across species. The significance of differential topographic gradients across the putamen and caudate and the medial-lateral gradient of the caudate in humans should be tested in future studies.
Publication date: 15 January 2019
Source: NeuroImage, Volume 185
Author(s): Jonathan F. O'Rawe, Jaime S. Ide, Hoi-Chung Leung
In accordance with the concept of topographic organization of neuroanatomical structures, there is an increased interest in estimating and delineating continuous changes in the functional connectivity patterns across neighboring voxels within a region of interest using resting-state fMRI data. Fundamental to this functional connectivity gradient analysis is the assumption that the functional organization is stable and uniform across the region of interest. To evaluate this assumption, we developed a statistical model testing procedure to arbitrate between overlapping, shifted, or different topographic connectivity gradients across subdivisions of a structure. We tested the procedure using the striatum, a subcortical structure consisting of the caudate nucleus and putamen, in which an extensive literature, primarily from rodents and non-human primates, suggest to have a shared topographic organization of a single diagonal gradient. We found, across multiple resting state fMRI data samples of different spatial resolutions in humans, and one macaque resting state fMRI data sample, that the models with different functional connectivity gradients across the caudate and putamen was the preferred model. The model selection procedure was validated in control conditions of checkerboard subdivisions, demonstrating the expected overlapping gradient. More specifically, while we replicated the diagonal organization of the functional connectivity gradients in both the caudate and putamen, our analysis also revealed a medial-lateral organization within the caudate. Not surprisingly, performing the same analysis assuming a unitary gradient obfuscates the medial-lateral organization of the caudate, producing only a diagonal gradient. These findings demonstrate the importance of testing basic assumptions and evaluating interpretations across species. The significance of differential topographic gradients across the putamen and caudate and the medial-lateral gradient of the caudate in humans should be tested in future studies.
Publication date: Available online 21 October 2018
Source: Addictive Behaviors
Author(s): Jessica K. Pepper, Linda B. Squiers, Susana C. Peinado, Carla M. Bann, Suzanne D. Dolina, Molly M. Lynch, James M. Nonnemaker, Lauren A. McCormack
The science surrounding e-cigarettes and other electronic vaping products (EVPs) is rapidly evolving, and the health effects of vaping are unclear. Little research has explored how individuals respond to information acknowledging scientific uncertainty. The aim of the present study was to understand the impact of messages about scientific uncertainty regarding the health effects of vaping on risk perceptions and behavioral intentions.
Adults in an online experiment (n = 2508) were randomly exposed to view either a control message (a short factual statement about EVPs) or an uncertainty message (the control message plus additional information describing why EVP-related research is limited or inconclusive). Participants rated the risks of vaping and their intentions to try or stop vaping.
Individuals who viewed the uncertainty message rated vaping as less risky than those who viewed the control message. Message exposure did not impact intentions to try vaping soon or intentions to stop vaping in the next 6 months.
Acknowledging scientific uncertainty made EVP use seem less risky. Future research should explore possible drivers of this response, such as deeper message processing or emotional reactions. Researchers and practitioners designing public health campaigns about vaping might consider a cautious approach to presenting information about scientific uncertainty.
Publication date: Available online 21 October 2018
Source: Addictive Behaviors
Author(s): Jessica K. Pepper, Linda B. Squiers, Susana C. Peinado, Carla M. Bann, Suzanne D. Dolina, Molly M. Lynch, James M. Nonnemaker, Lauren A. McCormack
The science surrounding e-cigarettes and other electronic vaping products (EVPs) is rapidly evolving, and the health effects of vaping are unclear. Little research has explored how individuals respond to information acknowledging scientific uncertainty. The aim of the present study was to understand the impact of messages about scientific uncertainty regarding the health effects of vaping on risk perceptions and behavioral intentions.
Adults in an online experiment (n = 2508) were randomly exposed to view either a control message (a short factual statement about EVPs) or an uncertainty message (the control message plus additional information describing why EVP-related research is limited or inconclusive). Participants rated the risks of vaping and their intentions to try or stop vaping.
Individuals who viewed the uncertainty message rated vaping as less risky than those who viewed the control message. Message exposure did not impact intentions to try vaping soon or intentions to stop vaping in the next 6 months.
Acknowledging scientific uncertainty made EVP use seem less risky. Future research should explore possible drivers of this response, such as deeper message processing or emotional reactions. Researchers and practitioners designing public health campaigns about vaping might consider a cautious approach to presenting information about scientific uncertainty.
Publication date: Available online 19 October 2018Source: Speech CommunicationAuthor(s): Jinxi Guo, Ning Xu, Kailun Qian, Yang Shi, Kaiyuan Xu, Yingnian Wu, Abeer AlwanAbstractText-independent speaker recognition using short utterances is a highly challenging task due to the large variation and content mismatch between short utterances. I-vector and probabilistic linear discriminant analysis (PLDA) based systems have become the standard in speaker verification applications, but they are less effective with short utterances. In this paper, we first compare two state-of-the-art universal background model (UBM) training methods for i-vector modeling using full-length and short utterance evaluation tasks. The two methods are Gaussian mixture model (GMM) based (denoted I-vector_GMM) and deep ne...
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Publication date: Available online 19 October 2018Source: Speech CommunicationAuthor(s): Lorenzo Morales, Francis F. LiAbstractThe speech transmission index (STI) is one of the most widely used and standardized methods for objective prediction of speech intelligibility of transmission channels. The original verification of the relationship between the STI and the intelligibility for the English language was published in 1987. The methodology employed then for the listening tests and the different input spectrum recommended today by the current STI method suggest that the relationship STI vs speech intelligibility needs to be verified for the English language. This paper presents a new verification of the current STI for the English language with binaural listening and the speech materials ...
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Publication date: Available online 19 October 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Marina de M. Silva, Taís S. Macedo, Helena Mariana P. Teixeira, Diogo Rodrigo M. Moreira, Milena B.P. Soares, Ana Ligia da C. Pereira, Vanessa de L. Serafim, Francisco J.B. Mendonça-Júnior, Maria do Carmo A. de Lima, Ricardo O. de Moura, Edeildo F. da Silva-Júnior, João Xavier de Araújo-Júnior, Maria Dayanne de A. Dantas, Eduarda de O. O. Nascimento, Thamilla Maria S. Maciel, Thiago Mendonça de Aquino, Isis M. Figueiredo, Josué C.C. SantosAbstractAcridines are considered an important class of compounds due to their wide variety of biological activities. In this work, we synthesized four acridine derivatives (1–4) and evaluated their biological activity agains...
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In conclusion, increasing time in sound might facilitate vocal emotional expression, possibly requiring independently maturing emotion perception skills. PMID: 30334510 [PubMed - as supplied by publisher] (Source: Journal of Child Language)
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Publication date: Available online 19 October 2018Source: Speech CommunicationAuthor(s): Jinxi Guo, Ning Xu, Kailun Qian, Yang Shi, Kaiyuan Xu, Yingnian Wu, Abeer AlwanAbstractText-independent speaker recognition using short utterances is a highly challenging task due to the large variation and content mismatch between short utterances. I-vector and probabilistic linear discriminant analysis (PLDA) based systems have become the standard in speaker verification applications, but they are less effective with short utterances. In this paper, we first compare two state-of-the-art universal background model (UBM) training methods for i-vector modeling using full-length and short utterance evaluation tasks. The two methods are Gaussian mixture model (GMM) based (denoted I-vector_GMM) and deep ne...
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Publication date: Available online 19 October 2018Source: Speech CommunicationAuthor(s): Lorenzo Morales, Francis F. LiAbstractThe speech transmission index (STI) is one of the most widely used and standardized methods for objective prediction of speech intelligibility of transmission channels. The original verification of the relationship between the STI and the intelligibility for the English language was published in 1987. The methodology employed then for the listening tests and the different input spectrum recommended today by the current STI method suggest that the relationship STI vs speech intelligibility needs to be verified for the English language. This paper presents a new verification of the current STI for the English language with binaural listening and the speech materials ...
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Publication date: Available online 19 October 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Marina de M. Silva, Taís S. Macedo, Helena Mariana P. Teixeira, Diogo Rodrigo M. Moreira, Milena B.P. Soares, Ana Ligia da C. Pereira, Vanessa de L. Serafim, Francisco J.B. Mendonça-Júnior, Maria do Carmo A. de Lima, Ricardo O. de Moura, Edeildo F. da Silva-Júnior, João Xavier de Araújo-Júnior, Maria Dayanne de A. Dantas, Eduarda de O. O. Nascimento, Thamilla Maria S. Maciel, Thiago Mendonça de Aquino, Isis M. Figueiredo, Josué C.C. SantosAbstractAcridines are considered an important class of compounds due to their wide variety of biological activities. In this work, we synthesized four acridine derivatives (1–4) and evaluated their biological activity agains...
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In conclusion, increasing time in sound might facilitate vocal emotional expression, possibly requiring independently maturing emotion perception skills. PMID: 30334510 [PubMed - as supplied by publisher] (Source: Journal of Child Language)
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Publication date: Available online 21 October 2018
Source: British Journal of Oral and Maxillofacial Surgery
Author(s): J.V. Williams, P. Magennis, A.J. Graham
Publication date: Available online 21 October 2018
Source: British Journal of Oral and Maxillofacial Surgery
Author(s): J.V. Williams, P. Magennis, A.J. Graham
CONCLUSIONS: We found that the majority of human milk samples included beta-lactams or quinolones, even though the mothers did not receive these antibiotics during pregnancy and lactation. Antibiotic residues in human milk may affect early maintenance of the intestinal microbiota. Previous studies have shown that antimicrobials in food might increase the risks of allergies and could lead to the development of antibiotic-resistant bacterial strains. Effective policies on food safety and appropriate antibiotic use during pregnancy and lactation are needed. PMID: 30338827 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
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Publication date: Available online 21 October 2018
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): A. Jain, A. Saxena, R. Meher, N. Khurana
Synovial sarcoma is a malignant mesenchymal tumour typically occurring in the extremities. Its occurrence in the head and neck region, particularly in the paranasal sinuses is extremely rare.
Here, we report a case of primary synovial sarcoma of the ethmoid sinus in a 36-year-old female and review the literature of synovial sarcomas arising from the ethmoid sinus. Histopathology was essential in confirming the diagnosis. The patient underwent endoscopic excision of the tumour followed by postoperative radiotherapy.
As per our knowledge, only 2 cases of ethmoid sinus synovial sarcoma have been reported in the English literature till date. Although synovial sarcomas rarely involve the paranasal sinuses, they should be included in the differential diagnosis of paranasal sinus tumours. The accepted treatment modality is wide local excision followed by post operative radiotherapy.
CONCLUSIONS: We found that the majority of human milk samples included beta-lactams or quinolones, even though the mothers did not receive these antibiotics during pregnancy and lactation. Antibiotic residues in human milk may affect early maintenance of the intestinal microbiota. Previous studies have shown that antimicrobials in food might increase the risks of allergies and could lead to the development of antibiotic-resistant bacterial strains. Effective policies on food safety and appropriate antibiotic use during pregnancy and lactation are needed. PMID: 30338827 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)
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Publication date: Available online 21 October 2018
Source: European Annals of Otorhinolaryngology, Head and Neck Diseases
Author(s): A. Jain, A. Saxena, R. Meher, N. Khurana
Synovial sarcoma is a malignant mesenchymal tumour typically occurring in the extremities. Its occurrence in the head and neck region, particularly in the paranasal sinuses is extremely rare.
Here, we report a case of primary synovial sarcoma of the ethmoid sinus in a 36-year-old female and review the literature of synovial sarcomas arising from the ethmoid sinus. Histopathology was essential in confirming the diagnosis. The patient underwent endoscopic excision of the tumour followed by postoperative radiotherapy.
As per our knowledge, only 2 cases of ethmoid sinus synovial sarcoma have been reported in the English literature till date. Although synovial sarcomas rarely involve the paranasal sinuses, they should be included in the differential diagnosis of paranasal sinus tumours. The accepted treatment modality is wide local excision followed by post operative radiotherapy.
Publication date: Available online 21 October 2018
Source: European Journal of Radiology
Author(s): Karin Knešaurek, Abbas Tuli, Sara D Pasik, Sherif Heiba, Lale Kostakoglu
The aim of our study was to compare yttrium -90 (90Y) dosimetry obtained from pre-therapy 99mTc- macroaggregated albumin (MAA) SPECT/CT versus post-therapy PET/MRI imaging among patients with primary or metastatic hepatic tumors.
Prior to 90Y radioembolization (RE), 32 patients underwent a scan using MAA mimicking 90Y distribution. After RE with 90Y microspheres, the patients were imaged on a PET/MRI system. Reconstructed images were transferred to a common platform and used to calculate 90Y dosimetry. The Passing- Bablok regression scatter diagram and the Bland and Altman method were used to analyze the difference between dosimetry values.
For MAA and PET/MRI modalities, the mean liver doses for all 32 subjects were 43.0 ± 20.9 Gy and 46.5 ± 22.7 Gy, respectively, with a mean difference of 3.4 ± 6.2 Gy. The repeatibility coefficient was 12.1 (27.0% of the mean). The Spearman rank correlation coefficient was high (ρ = 0.92). Although, there was a substantial difference in the maximum doses to the liver between the modalities, the mean liver doses were relatively close, with a difference of 24.0 % or less.
The two main contributors to the difference between dosimetry calculations using MAA versus 90Y PET/MRI can be attributed to the changes in catheter positioning as well as the liver ROIs used for the calculations. In spite of these differences, our results demonstrate that the dosimetry values obtained from pre-therapy MAA SPECT/CT scans and PET/MRI post-therapy 90Y studies were not significantly different.
Publication date: Available online 21 October 2018
Source: European Journal of Radiology
Author(s): Karin Knešaurek, Abbas Tuli, Sara D Pasik, Sherif Heiba, Lale Kostakoglu
The aim of our study was to compare yttrium -90 (90Y) dosimetry obtained from pre-therapy 99mTc- macroaggregated albumin (MAA) SPECT/CT versus post-therapy PET/MRI imaging among patients with primary or metastatic hepatic tumors.
Prior to 90Y radioembolization (RE), 32 patients underwent a scan using MAA mimicking 90Y distribution. After RE with 90Y microspheres, the patients were imaged on a PET/MRI system. Reconstructed images were transferred to a common platform and used to calculate 90Y dosimetry. The Passing- Bablok regression scatter diagram and the Bland and Altman method were used to analyze the difference between dosimetry values.
For MAA and PET/MRI modalities, the mean liver doses for all 32 subjects were 43.0 ± 20.9 Gy and 46.5 ± 22.7 Gy, respectively, with a mean difference of 3.4 ± 6.2 Gy. The repeatibility coefficient was 12.1 (27.0% of the mean). The Spearman rank correlation coefficient was high (ρ = 0.92). Although, there was a substantial difference in the maximum doses to the liver between the modalities, the mean liver doses were relatively close, with a difference of 24.0 % or less.
The two main contributors to the difference between dosimetry calculations using MAA versus 90Y PET/MRI can be attributed to the changes in catheter positioning as well as the liver ROIs used for the calculations. In spite of these differences, our results demonstrate that the dosimetry values obtained from pre-therapy MAA SPECT/CT scans and PET/MRI post-therapy 90Y studies were not significantly different.
Publication date: Available online 21 October 2018
Source: American Journal of Otolaryngology
Author(s): Akina Tamaki, Claudia Cabrera, Clare Richardson, Nicole Maronian
Deficiencies in airway management knowledge can result in harm, especially in tracheostomy patients. Our objective is to assess the degree of knowledge in different medical specialties, before and after targeted airway education.
A lecture on tracheostomy management was prepared for Otolaryngology, Anesthesia, Emergency Medicine, General Surgery, Oral and Maxillofacial Surgery (OMFS), Internal Medicine (IM), and Family Medicine (FM). Before the lecture, a 12-question quiz on surgical airway knowledge was administered, and demographics from participants collected. Immediately following the lecture, participants were asked to retake the quiz. Performance was assessed. Baseline knowledge was assessed using variables of specialty, years of practice, and previous education.
A paired t-test evaluating pre- and post-lecture results showed a 34.2% improvement for all participants (n = 168) overall (2.7 points, p < 0.001). Providers with more years of practice performed better. Otolaryngology and OMFS performed the highest on the baseline test while FM and IM performed the lowest. The providers who reported previous standardized training from the hospital system, informal instruction on the ward, or had the topic covered in their degree program performed better compared to those without previous education (ANOVA model, 3.5 points, p < 0.01). Providers who underwent formal training in their degree program performed the best. A Likert scale with self-assessment of comfort with surgical airway correlated positively with the performance on the quiz.
Variability in tracheostomy knowledge based on specialty and years of training exists. We demonstrate that formal education on tracheostomy and surgical airways improved quantitative measures of knowledge.
Publication date: Available online 21 October 2018
Source: American Journal of Otolaryngology
Author(s): Fatma Caylakli
Publication date: Available online 21 October 2018
Source: American Journal of Otolaryngology
Author(s): Akina Tamaki, Claudia Cabrera, Clare Richardson, Nicole Maronian
Deficiencies in airway management knowledge can result in harm, especially in tracheostomy patients. Our objective is to assess the degree of knowledge in different medical specialties, before and after targeted airway education.
A lecture on tracheostomy management was prepared for Otolaryngology, Anesthesia, Emergency Medicine, General Surgery, Oral and Maxillofacial Surgery (OMFS), Internal Medicine (IM), and Family Medicine (FM). Before the lecture, a 12-question quiz on surgical airway knowledge was administered, and demographics from participants collected. Immediately following the lecture, participants were asked to retake the quiz. Performance was assessed. Baseline knowledge was assessed using variables of specialty, years of practice, and previous education.
A paired t-test evaluating pre- and post-lecture results showed a 34.2% improvement for all participants (n = 168) overall (2.7 points, p < 0.001). Providers with more years of practice performed better. Otolaryngology and OMFS performed the highest on the baseline test while FM and IM performed the lowest. The providers who reported previous standardized training from the hospital system, informal instruction on the ward, or had the topic covered in their degree program performed better compared to those without previous education (ANOVA model, 3.5 points, p < 0.01). Providers who underwent formal training in their degree program performed the best. A Likert scale with self-assessment of comfort with surgical airway correlated positively with the performance on the quiz.
Variability in tracheostomy knowledge based on specialty and years of training exists. We demonstrate that formal education on tracheostomy and surgical airways improved quantitative measures of knowledge.
Publication date: Available online 21 October 2018
Source: American Journal of Otolaryngology
Author(s): Fatma Caylakli
CONCLUSIONS: Genome sequencing and new biomarkers are also paving a novel pathway towards individualised immunotherapy for PCA. On-going research and clinical trials are exploring the question of which patients will benefit. PMID: 30341689 [PubMed - as supplied by publisher] (Source: Der Urologe. Ausg. A)
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CONCLUSIONS: Genome sequencing and new biomarkers are also paving a novel pathway towards individualised immunotherapy for PCA. On-going research and clinical trials are exploring the question of which patients will benefit. PMID: 30341689 [PubMed - as supplied by publisher] (Source: Der Urologe. Ausg. A)
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Publication date: Available online 21 October 2018
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Mark W. Lingen
Publication date: Available online 21 October 2018
Source: Oral Surgery, Oral Medicine, Oral Pathology and Oral Radiology
Author(s): Mark W. Lingen
Publication date: Available online 20 October 2018
Source: Annals of Allergy, Asthma & Immunology
Author(s): Marcus Shaker, Irene Yuan, Katie L. Kennedy, Peter Capucilli, Jonathan M. Spergel
Publication date: Available online 21 October 2018
Source: Journal of Allergy and Clinical Immunology
Author(s): Ricardo U. Sorensen, Luke A. Wall
Publication date: Available online 20 October 2018
Source: Annals of Allergy, Asthma & Immunology
Author(s): Marcus Shaker, Irene Yuan, Katie L. Kennedy, Peter Capucilli, Jonathan M. Spergel
Publication date: Available online 21 October 2018
Source: Journal of Allergy and Clinical Immunology
Author(s): Ricardo U. Sorensen, Luke A. Wall
European Journal of Oral Sciences, EarlyView.
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European Journal of Oral Sciences, EarlyView.
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European Journal of Oral Sciences, EarlyView.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R2x616
European Journal of Oral Sciences, EarlyView.
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Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)
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Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)
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Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)
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Conclusions: The methodology, suggestions, and comments that arose from our experience in implementing GCLP guidelines can be used by other laboratories to develop a quality system using GCLP guidelines to support medical research conducted to ensure the research data are reliable and can be easily reconstructed in other research settings. PMID: 30339188 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
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CONCLUSION: Quantification of preoperative CRP could identify patients at high risk for development of myopenia who will likely require individualized treatment plans, including postoperative nutrition intervention, rehabilitation, and oncological follow-up in patients with CRC. PMID: 30334265 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
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Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2R5l4Eh
Conclusions: The methodology, suggestions, and comments that arose from our experience in implementing GCLP guidelines can be used by other laboratories to develop a quality system using GCLP guidelines to support medical research conducted to ensure the research data are reliable and can be easily reconstructed in other research settings. PMID: 30339188 [PubMed - as supplied by publisher] (Source: American Journal of Clinical Pathology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2q5JRMN
CONCLUSION: Quantification of preoperative CRP could identify patients at high risk for development of myopenia who will likely require individualized treatment plans, including postoperative nutrition intervention, rehabilitation, and oncological follow-up in patients with CRC. PMID: 30334265 [PubMed - as supplied by publisher] (Source: JPEN Journal Of Parenteral And Enteral Nutrition)
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