No Significant Safety Concerns With Bivalent HPV Vaccine, Study Finds No Significant Safety Concerns With Bivalent HPV Vaccine, Study Finds

Reuters Health Information (Source: Medscape Allergy Headlines)

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The role of cancer stem cells in the modulation of anti-tumor immune responses

Publication date: Available online 24 September 2018Source: Seminars in Cancer BiologyAuthor(s): Cristina Maccalli, Kakil Ibrahim Rasul, Mamoun Elawad, Soldano FerroneAbstractTumor lesions comprise multiple subpopulations of cells including those endowed with "stemness" properties. The latter cells are responsible of tumor initiation, metastasis formation, resistance to conventional therapies and disease recurrence. These relatively rare cells denominated cancer stem cells (CSCs) or cancer initiating cells (CICs) are defined based on self-renewing, multipotency and tumorigenicity. These cells through their immunomodulating features can evade from immunesurveillance, persisting in the form of quiescence and dormancy. They can drive the neoplastic growth and recurrence, even after long l...

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To treat or not to treat: The minimally symptomatic EoE patient

Eosinophilic esophagitis (EoE) is a chronic immune-mediated disorder in which a mixed inflammatory cell infiltrate leads to symptoms of esophageal dysfunction. While great strides have been made to understand the pathophysiology and natural history of eosinophilic esophagitis over the last 30 years, there still does not exist an FDA-approved therapy. (Source: Annals of Allergy, Asthma and Immunology)

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Interferon-induced epithelial response to rhinovirus-16 in asthma relates to inflammation and FEV1

Bronchial epithelial cells from mild asthma patients in response to in vivo rhinovirus-16 challenge, display a marked interferon-induced response 6 days post-infection, which correlates with eosinophilic inflammation and virus-induced decline of lung function. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ph0iAT

Increased surface expression of NOTCH on memory T cells in peripheral blood from asthma patients

Using flow cytometry we found that circulating T cell subsets from asthma patients contained higher proportions of NOTCH receptor positive cells compared with healthy controls, suggesting enhanced NOTCH signaling in T cells from asthma patients. (Source: Journal of Allergy and Clinical Immunology)

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Human TBK1 is required for early autophagy induction upon HSV1 infection

(Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pEpVAM

Cholestenoic Acid is a Prognostic Biomarker in Acute Respiratory Distress Syndrome

Lower plasma levels of the oxysterol cholestenoic acid associate with increased mortality and organ failure in septic patients with acute respiratory distress syndrome (ARDS). Cholestenoic acid warrants further validation as a novel ARDS biomarker. (Source: Journal of Allergy and Clinical Immunology)

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Rethinking Morbidity and Mortality Conference

This article will discuss the importance of an effective morbidity and mortality (M&M) conference toward supporting a proactive and preventative approach to patient safety and quality improvement (PSQI). Key characteristics will be discussed that enhance this process for being a mechanism for driving positive PSQI culture change that permeates the department. The focus of this article will be on how to approach the structure and process of this conference for maximal benefit. (Source: Otolaryngologic clinics of North America)

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Management of Flaccid Facial Paralysis of Less Than Two Years ’ Duration

Flaccid facial paralysis results in disfiguring facial changes. The treatment of flaccid facial paralysis is complex and treatment approaches should be determined based on duration and the causes of paralysis, status and accessibility of the affected facial nerve, medical comorbidities, and patient-specific goals. Although primary nerve repair is the preferred treatment strategy when possible, nerve substitution procedures are the mainstay of treatment for patients with flaccid facial paralysis of less than 2 years duration. (Source: Otolaryngologic clinics of North America)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IHDoQU

Multidisciplinary Tracheostomy Care

There have been reports of successful quality-improvement initiatives surrounding tracheostomy care for more than a decade, but widespread adoption of best practices has not been universal. Five key drivers have been found to improve the quality of care for tracheostomy patients: multidisciplinary synchronous ward rounds, standardization of care protocols, appropriate interdisciplinary education and staff allocation, patient and family involvement, and use of data to drive improvement. The Global Tracheostomy Collaborative is a quality-improvement collaborative dedicated to improving the care of tracheostomy patients worldwide through communication, dissemination, and implementation of proven strategies based on these 5 key drivers. (Source: Otolaryngologic clinics of North America)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CxZbKy

Publicly Available Databases in Otolaryngology Quality Improvement

The historical context for quality improvement is provided. Important differences are described between the two overarching types of databases: clinical registries and administrative databases. The pros and cons of each are provided as are examples of their utilization in otolaryngology –head and neck surgery. (Source: Otolaryngologic clinics of North America)

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Delivering Otolaryngologic Care Safely and Successfully

In 2000, when the Institute of Medicine published To Err Is Human,1 the focus of the patient safety movement was on convincing both providers and patients that we had a safety problem. Currently, most people understand that patient safety is a real issue. Unfortunately, there are still an estimated 251,000 deaths2 and over 1,000,000 nonfatal injuries3 from medical errors annually in the United States. The focus now is on how to implement the best practices that we know exist. An additional challenge is creating a culture around safety, with leadership engagement. (Source: Otolaryngologic clinics of North America)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CrJaG9

Irritant Contact Dermatitis

Abstract

Contact dermatitis accounts for 95% of occupational skin disorders. Irritant contact dermatitis (ICD) is often caused by cumulative exposure to weak irritants, accounting for 80% of all cases of contact dermatitis. ICD can co-exist with atopic dermatitis (AD) and allergic contact dermatitis (ACD). Patients with AD and ACD may have a lower inflammatory threshold for developing ICD. Therefore, it needs to be distinguished from lesions of AD and ACD. ICD Patients report stinging and burning in excess of pruritus. Pruritus is classically reported by patients with AD and ACD. ICD lesions are typically well-demarcated unlike AD and ACD. ICD is diagnosed by exclusion. Patients undergo testing to rule out type I and type IV hypersensitivity. Negative results suggest a diagnosis of ICD. Management consists of irritant identification and avoidance with regular emollient use. Although ICD is more common in certain occupations, genetics and environment play significant roles in its development.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E3XXZc

Correction to: Passive blood anaphylaxis: subcutaneous immunoglobulins are a cause of ongoing passive anaphylactic reaction

Upon publication of the original article [1], the authors reported the following funding information was omitted: Publication supported by Wroclaw Centre of Biotechnology, programme The Leading National Resear...

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Emergency Department Approach to the Patient with Suspected Central Nervous System Infection

This article proposes an approach to the clinical evaluation of patients with suspected CNS infection and highlights methods of diagnosis, treatment, and complications associated with CNS infections. (Source: Emergency Medicine Clinics of North America)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pBxWGs

The role of cancer stem cells in the modulation of anti-tumor immune responses

Publication date: Available online 24 September 2018Source: Seminars in Cancer BiologyAuthor(s): Cristina Maccalli, Kakil Ibrahim Rasul, Mamoun Elawad, Soldano FerroneAbstractTumor lesions comprise multiple subpopulations of cells including those endowed with "stemness" properties. The latter cells are responsible of tumor initiation, metastasis formation, resistance to conventional therapies and disease recurrence. These relatively rare cells denominated cancer stem cells (CSCs) or cancer initiating cells (CICs) are defined based on self-renewing, multipotency and tumorigenicity. These cells through their immunomodulating features can evade from immunesurveillance, persisting in the form of quiescence and dormancy. They can drive the neoplastic growth and recurrence, even after long l...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PjF1XD

To treat or not to treat: The minimally symptomatic EoE patient

Eosinophilic esophagitis (EoE) is a chronic immune-mediated disorder in which a mixed inflammatory cell infiltrate leads to symptoms of esophageal dysfunction. While great strides have been made to understand the pathophysiology and natural history of eosinophilic esophagitis over the last 30 years, there still does not exist an FDA-approved therapy. (Source: Annals of Allergy, Asthma and Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pF7T1g

Interferon-induced epithelial response to rhinovirus-16 in asthma relates to inflammation and FEV1

Bronchial epithelial cells from mild asthma patients in response to in vivo rhinovirus-16 challenge, display a marked interferon-induced response 6 days post-infection, which correlates with eosinophilic inflammation and virus-induced decline of lung function. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ph0iAT

Increased surface expression of NOTCH on memory T cells in peripheral blood from asthma patients

Using flow cytometry we found that circulating T cell subsets from asthma patients contained higher proportions of NOTCH receptor positive cells compared with healthy controls, suggesting enhanced NOTCH signaling in T cells from asthma patients. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CvxqT5

Human TBK1 is required for early autophagy induction upon HSV1 infection

(Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pEpVAM

Cholestenoic Acid is a Prognostic Biomarker in Acute Respiratory Distress Syndrome

Lower plasma levels of the oxysterol cholestenoic acid associate with increased mortality and organ failure in septic patients with acute respiratory distress syndrome (ARDS). Cholestenoic acid warrants further validation as a novel ARDS biomarker. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Phg8vE

Medical Management of Acute Facial Paralysis

Acute facial paralysis (FP) describes acute onset of partial or complete weakness of the facial muscles innervated by the facial nerve. Acute FP occurs within a few hours to days. The differential diagnosis is broad; however, the most common cause is viral-associated Bell Palsy. A comprehensive history and physical examination are essential in arriving at a diagnosis. Medical treatment for acute FP depends on the specific diagnosis; however, corticosteroids and antiviral medications are the cornerstone of therapy. Lack of recovery after 4  months should prompt further diagnostic workup. (Source: Otolaryngologic clinics of North America)

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Rethinking Morbidity and Mortality Conference

This article will discuss the importance of an effective morbidity and mortality (M&M) conference toward supporting a proactive and preventative approach to patient safety and quality improvement (PSQI). Key characteristics will be discussed that enhance this process for being a mechanism for driving positive PSQI culture change that permeates the department. The focus of this article will be on how to approach the structure and process of this conference for maximal benefit. (Source: Otolaryngologic clinics of North America)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ct1Jtx

Management of Flaccid Facial Paralysis of Less Than Two Years ’ Duration

Flaccid facial paralysis results in disfiguring facial changes. The treatment of flaccid facial paralysis is complex and treatment approaches should be determined based on duration and the causes of paralysis, status and accessibility of the affected facial nerve, medical comorbidities, and patient-specific goals. Although primary nerve repair is the preferred treatment strategy when possible, nerve substitution procedures are the mainstay of treatment for patients with flaccid facial paralysis of less than 2 years duration. (Source: Otolaryngologic clinics of North America)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IHDoQU

Multidisciplinary Tracheostomy Care

There have been reports of successful quality-improvement initiatives surrounding tracheostomy care for more than a decade, but widespread adoption of best practices has not been universal. Five key drivers have been found to improve the quality of care for tracheostomy patients: multidisciplinary synchronous ward rounds, standardization of care protocols, appropriate interdisciplinary education and staff allocation, patient and family involvement, and use of data to drive improvement. The Global Tracheostomy Collaborative is a quality-improvement collaborative dedicated to improving the care of tracheostomy patients worldwide through communication, dissemination, and implementation of proven strategies based on these 5 key drivers. (Source: Otolaryngologic clinics of North America)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CxZbKy

Publicly Available Databases in Otolaryngology Quality Improvement

The historical context for quality improvement is provided. Important differences are described between the two overarching types of databases: clinical registries and administrative databases. The pros and cons of each are provided as are examples of their utilization in otolaryngology –head and neck surgery. (Source: Otolaryngologic clinics of North America)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IIgaKz

Delivering Otolaryngologic Care Safely and Successfully

In 2000, when the Institute of Medicine published To Err Is Human,1 the focus of the patient safety movement was on convincing both providers and patients that we had a safety problem. Currently, most people understand that patient safety is a real issue. Unfortunately, there are still an estimated 251,000 deaths2 and over 1,000,000 nonfatal injuries3 from medical errors annually in the United States. The focus now is on how to implement the best practices that we know exist. An additional challenge is creating a culture around safety, with leadership engagement. (Source: Otolaryngologic clinics of North America)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CrJaG9

Irritant Contact Dermatitis

Abstract

Contact dermatitis accounts for 95% of occupational skin disorders. Irritant contact dermatitis (ICD) is often caused by cumulative exposure to weak irritants, accounting for 80% of all cases of contact dermatitis. ICD can co-exist with atopic dermatitis (AD) and allergic contact dermatitis (ACD). Patients with AD and ACD may have a lower inflammatory threshold for developing ICD. Therefore, it needs to be distinguished from lesions of AD and ACD. ICD Patients report stinging and burning in excess of pruritus. Pruritus is classically reported by patients with AD and ACD. ICD lesions are typically well-demarcated unlike AD and ACD. ICD is diagnosed by exclusion. Patients undergo testing to rule out type I and type IV hypersensitivity. Negative results suggest a diagnosis of ICD. Management consists of irritant identification and avoidance with regular emollient use. Although ICD is more common in certain occupations, genetics and environment play significant roles in its development.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E3XXZc

Correction to: Passive blood anaphylaxis: subcutaneous immunoglobulins are a cause of ongoing passive anaphylactic reaction

Upon publication of the original article [1], the authors reported the following funding information was omitted: Publication supported by Wroclaw Centre of Biotechnology, programme The Leading National Resear...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CuXbmj

Irritant Contact Dermatitis

Abstract

Contact dermatitis accounts for 95% of occupational skin disorders. Irritant contact dermatitis (ICD) is often caused by cumulative exposure to weak irritants, accounting for 80% of all cases of contact dermatitis. ICD can co-exist with atopic dermatitis (AD) and allergic contact dermatitis (ACD). Patients with AD and ACD may have a lower inflammatory threshold for developing ICD. Therefore, it needs to be distinguished from lesions of AD and ACD. ICD Patients report stinging and burning in excess of pruritus. Pruritus is classically reported by patients with AD and ACD. ICD lesions are typically well-demarcated unlike AD and ACD. ICD is diagnosed by exclusion. Patients undergo testing to rule out type I and type IV hypersensitivity. Negative results suggest a diagnosis of ICD. Management consists of irritant identification and avoidance with regular emollient use. Although ICD is more common in certain occupations, genetics and environment play significant roles in its development.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E3XXZc

No Significant Safety Concerns With Bivalent HPV Vaccine, Study Finds No Significant Safety Concerns With Bivalent HPV Vaccine, Study Finds

Reuters Health Information (Source: Medscape Allergy Headlines)

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No Significant Safety Concerns With Bivalent HPV Vaccine, Study Finds No Significant Safety Concerns With Bivalent HPV Vaccine, Study Finds

Reuters Health Information (Source: Medscape Allergy Headlines)

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Extended analysis of parent and child confidence in recognizing anaphylaxis and using the epinephrine autoinjector during oral food challenges

Publication date: Available online 5 October 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Lianne Soller, Timothy Teoh, Ingrid Baerg, Tiffany Wong, Kyla J. Hildebrand, Victoria E. Cook, Catherine M. Biggs, Nicole Lee, Lindsay Yaworski, Scott B. Cameron, Edmond S. Chan (Source: The Journal of Allergy and Clinical Immunology: In Practice)

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Drug-induced Stevens–Johnson syndrome and toxic epidermal necrolysis: proportion and determinants of underreporting to pharmacovigilance

Publication date: Available online 5 October 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Guillaume Chaby, Bénédicte Lebrun-Vignes, Cynthia Haddad, Francois Hemery, Saskia Ingen-Housz-Oro, Nicolas de Prost, Pierre Wolkenstein, Olivier Chosidow, Laurence Fardet (Source: The Journal of Allergy and Clinical Immunology: In Practice)

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Does Changing Inhaler Device Impact Real-Life Asthma Outcomes? Clinical and Economic Evaluation

ConclusionChanging from a DPI to a pMDI for FDC ICS/LABA asthma treatment can be as effective and cost-effective as remaining on a DPI. (Source: The Journal of Allergy and Clinical Immunology: In Practice)

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Role of skin tests in the diagnosis of immediate hypersensitivity reactions to taxanes. Results of a multicenter study

ConclusionsSkin tests for taxanes seem useful and can be performed in the allergological work-up of subjects with HSRs to these agents, especially in cases of severe reactions with cutaneous involvement. (Source: The Journal of Allergy and Clinical Immunology: In Practice)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IHVMsP

Risk of postpartum depression among women with asthma

ConclusionOur findings suggest that women with asthma are more likely to suffer from postpartum depression. A close monitoring of signs of depression for pregnant women with asthma is indicated, allowing prompt and efficient interventions if needed. (Source: The Journal of Allergy and Clinical Immunology: In Practice)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CsAtuZ

"Desensitization to cross-reacting allergen in egg yolk and chicken meat"

Publication date: Available online 5 October 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Manuel Jorge Rial Prado, Marcela Valverde Monge, Aida Gómez Cardeñosa, Rosialzhira Vera Berríos, Carlos Pastor Vargas, Javier Cuesta Herranz (Source: The Journal of Allergy and Clinical Immunology: In Practice)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

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Tofacitinib for the treatment of ulcerative colitis.

Authors: Fernández-Clotet A, Castro-Poceiro J, Panés J Abstract INTRODUCTION: A new generations of small molecules are being developed for the treatment of ulcerative colitis. Among them, tofatinib (a Janus kinase (JAK) inhibitor) has demonstrated efficacy for inducing and maintaining remission and achieving mucosal healing with a reasonable safety profile. Oral administration is attractive for patients and lack of immunogenicity represents an advantage over biologic drugs. Areas covered: This review discusses the molecular aspects of the JAK-STAT pathway; the mechanism of action of tofacinitib pertinent to ulcerative colitis and the evidence on the efficacy of tofacitinib for achieving clinically relevant outcomes, including clinical remission, mucosal healing, and normalization...

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Choroidal Vascularity Index and Choroidal Thickness in Human Leukocyte Antigen-B27-Associated Uveitis.

CONCLUSION: Eyes with acute HLA-B27-associated uveitis exhibited choroidal thickening with increased choroidal vascularity that subsequently decreased after uveitis resolution. These were evident even in patients without posterior segment involvement. PMID: 30285514 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IHVodR

Increased surface expression of NOTCH on memory T cells in peripheral blood from asthma patients

Using flow cytometry we found that circulating T cell subsets from asthma patients contained higher proportions of NOTCH receptor positive cells compared with healthy controls, suggesting enhanced NOTCH signaling in T cells from asthma patients. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CvxqT5

Extended analysis of parent and child confidence in recognizing anaphylaxis and using the epinephrine autoinjector during oral food challenges

Publication date: Available online 5 October 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Lianne Soller, Timothy Teoh, Ingrid Baerg, Tiffany Wong, Kyla J. Hildebrand, Victoria E. Cook, Catherine M. Biggs, Nicole Lee, Lindsay Yaworski, Scott B. Cameron, Edmond S. Chan (Source: The Journal of Allergy and Clinical Immunology: In Practice)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CuVq8H

Drug-induced Stevens–Johnson syndrome and toxic epidermal necrolysis: proportion and determinants of underreporting to pharmacovigilance

Publication date: Available online 5 October 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Guillaume Chaby, Bénédicte Lebrun-Vignes, Cynthia Haddad, Francois Hemery, Saskia Ingen-Housz-Oro, Nicolas de Prost, Pierre Wolkenstein, Olivier Chosidow, Laurence Fardet (Source: The Journal of Allergy and Clinical Immunology: In Practice)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ILJpfz

Role of skin tests in the diagnosis of immediate hypersensitivity reactions to taxanes. Results of a multicenter study

ConclusionsSkin tests for taxanes seem useful and can be performed in the allergological work-up of subjects with HSRs to these agents, especially in cases of severe reactions with cutaneous involvement. (Source: The Journal of Allergy and Clinical Immunology: In Practice)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IHVMsP

Risk of postpartum depression among women with asthma

ConclusionOur findings suggest that women with asthma are more likely to suffer from postpartum depression. A close monitoring of signs of depression for pregnant women with asthma is indicated, allowing prompt and efficient interventions if needed. (Source: The Journal of Allergy and Clinical Immunology: In Practice)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CsAtuZ

"Desensitization to cross-reacting allergen in egg yolk and chicken meat"

Publication date: Available online 5 October 2018Source: The Journal of Allergy and Clinical Immunology: In PracticeAuthor(s): Manuel Jorge Rial Prado, Marcela Valverde Monge, Aida Gómez Cardeñosa, Rosialzhira Vera Berríos, Carlos Pastor Vargas, Javier Cuesta Herranz (Source: The Journal of Allergy and Clinical Immunology: In Practice)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IEWK9e

Tofacitinib for the treatment of ulcerative colitis.

Authors: Fernández-Clotet A, Castro-Poceiro J, Panés J Abstract INTRODUCTION: A new generations of small molecules are being developed for the treatment of ulcerative colitis. Among them, tofatinib (a Janus kinase (JAK) inhibitor) has demonstrated efficacy for inducing and maintaining remission and achieving mucosal healing with a reasonable safety profile. Oral administration is attractive for patients and lack of immunogenicity represents an advantage over biologic drugs. Areas covered: This review discusses the molecular aspects of the JAK-STAT pathway; the mechanism of action of tofacinitib pertinent to ulcerative colitis and the evidence on the efficacy of tofacitinib for achieving clinically relevant outcomes, including clinical remission, mucosal healing, and normalization...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CsXgHh

Choroidal Vascularity Index and Choroidal Thickness in Human Leukocyte Antigen-B27-Associated Uveitis.

CONCLUSION: Eyes with acute HLA-B27-associated uveitis exhibited choroidal thickening with increased choroidal vascularity that subsequently decreased after uveitis resolution. These were evident even in patients without posterior segment involvement. PMID: 30285514 [PubMed - as supplied by publisher] (Source: Ocular Immunology and Inflammation)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IHVodR

Increased surface expression of NOTCH on memory T cells in peripheral blood from asthma patients

Using flow cytometry we found that circulating T cell subsets from asthma patients contained higher proportions of NOTCH receptor positive cells compared with healthy controls, suggesting enhanced NOTCH signaling in T cells from asthma patients. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CvxqT5

No Significant Safety Concerns With Bivalent HPV Vaccine, Study Finds No Significant Safety Concerns With Bivalent HPV Vaccine, Study Finds

Reuters Health Information (Source: Medscape Allergy Headlines)

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No Significant Safety Concerns With Bivalent HPV Vaccine, Study Finds No Significant Safety Concerns With Bivalent HPV Vaccine, Study Finds

Reuters Health Information (Source: Medscape Allergy Headlines)

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Bilateral Globus Pallidus Internus Deep Brain Stimulation in a Case of Progressive Dystonia in Mohr-Tranebjaerg Syndrome with Bilateral Cochlear Implants

Conclusion DBS in MTS may be a viable option to treat debilitating dystonic symptoms. We describe successful DBS surgery, despite the presence of bilateral CIs, and stimulation therapy over 2 years. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part A: Central European Neurosurgery)

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Bilateral Globus Pallidus Internus Deep Brain Stimulation in a Case of Progressive Dystonia in Mohr-Tranebjaerg Syndrome with Bilateral Cochlear Implants

Conclusion DBS in MTS may be a viable option to treat debilitating dystonic symptoms. We describe successful DBS surgery, despite the presence of bilateral CIs, and stimulation therapy over 2 years. [...] Georg Thieme Verlag KG Stuttgart · New YorkArticle in Thieme eJournals: Table of contents  |  Abstract  |  Full text (Source: Journal of Neurological Surgery Part A: Central European Neurosurgery)

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Interactive Musical Created for Children With Autism

Adjusting live performances to fit the needs of audience members with autism or other sensory issues is nothing new. Creating an interactive show especially suited to a neurodiverse audience is less common. Staff and students from Michigan State University's (MSU) theater department created "Farm! A Musical Experience," to fit exactly that niche. According to articles published by ABC News, MSU theater faculty member and outreach coordinator Dionne O'Dell worked with a class of students last year to create "Farm." First, O'Dell visited and worked with theater companies specializing in shows for audiences with special needs. Then, after completing the script, the cast tested the show on students studying special education. Once she felt the show was ready, O'Dell took "Fa...

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Interactive Musical Created for Children With Autism

Adjusting live performances to fit the needs of audience members with autism or other sensory issues is nothing new. Creating an interactive show especially suited to a neurodiverse audience is less common. Staff and students from Michigan State University's (MSU) theater department created "Farm! A Musical Experience," to fit exactly that niche. According to articles published by ABC News, MSU theater faculty member and outreach coordinator Dionne O'Dell worked with a class of students last year to create "Farm." First, O'Dell visited and worked with theater companies specializing in shows for audiences with special needs. Then, after completing the script, the cast tested the show on students studying special education. Once she felt the show was ready, O'Dell took "Fa...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IHphei

Biogenic Au@ZnO core –shell nanocomposites kill Staphylococcus aureus without provoking nuclear damage and cytotoxicity in mouse fibroblasts cells under hyperglycemic condition with enhanced wound healing proficiency

AbstractThe aim of the present study is focused on the synthesis of Au@ZnO core –shell nanocomposites, where zinc oxide is overlaid on biogenic gold nanoparticles obtained fromHibiscus Sabdariffa plant extract. Optical property of nanocomposites is investigated using UV –visible spectroscopy and crystal structure has been determined using X-ray crystallography (XRD) technique. The presence of functional groups on the surface of Au@ZnO core–shell nanocomposites has been observed by Fourier transforms infrared (FTIR) spectroscopy. Electron microscopy studies reve aled the morphology of the above core–shell nanocomposites. The synthesized nanocomposite material has shown antimicrobial and anti-biofilm activity againstStaphylococcus aureus and Methicillin ResistantStaphylococcus haemol...

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Prevention of oral carcinogenesis in rats by Dracaena cinnabari resin extracts

Abstract

Objectives

In vivo study was performed to determine the chemopreventive efficacy of the DC resin methanol extract on a 4-nitroquinoline-1-oxide (4NQO) oral cancer animal model.

Materials and methods

This study involves administration of 4NQO solution for 8 weeks alone (cancer induction) or with Dracaena cinnabari (DC) extract at 100, 500, and 1000 mg/kg. DC extract administration started 1 week before exposure until 1 week after the carcinogen exposure was stopped. All rats were sacrificed after 22 weeks, and histological analysis was performed to assess any incidence of pathological changes. Immunohistochemical expressions of selected tumor marker antibodies were analyzed using an image analyzer computer system, and the expression of selected genes involved in apoptosis and proliferative mechanism related to oral cancer were evaluated using RT²-PCR.

Results

The incidence of OSCC decreased with the administration of DC extract at 100, 500, and 1000 mg/kg compared to the induced cancer group. The developed tumor was also observed to be smaller when compared to the induced cancer group. The DC 1000 mg/kg group inhibits the expression of Cyclin D1, Ki-67, Bcl-2, and p53 proteins. It was observed that DC 1000 mg/kg induced apoptosis by upregulation of Bax and Casp3 genes and downregulation of Tp53, Bcl-2, Cox-2, Cyclin D1, and EGFR genes when compared to the induced cancer group.

Conclusions

The data indicated that systemic administration of the DC resin methanol extract has anticarcinogenic potency on oral carcinogenesis.

Clinical relevance

Chemoprevention with DC resin methanol extract may significantly reduce morbidity and possibly mortality from OSCC.

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Effect of intermittent teriparatide (PTH 1-34) on the alveolar healing process in orchiectomized rats

Abstract

Objective

To evaluate intermittent teriparatide therapy's influence on the alveolar healing process in rats with induced osteoporosis.

Materials and methods

Fifty-four male rats were divided into three groups: fictitious surgery (SHAM), bilateral orchiectomy (ORQ NT), and bilateral orchiectomy treated with teriparatide (ORQ TERI). Right upper incisor extraction was performed. After 14 and 42 days, the rats were euthanized. Immunolabeling analysis was performed in order to characterize bone turnover through Wnt, alcaline phosphatase, osteocalcin, and TRAP presence in tissue; micro-CT analysis was performed in order to determine the bone volume fraction (BV/TV), trabecular thickness, separation, and number (Tb.Th, Tb.Sp, Tb.N). For the micro-CT data, statistical analysis was performed through one-way ANOVA and Tukey post-test, for parametrical data, with significance level adopted in p < 0.05. Days, Wnt, alkaline phosphatase, and osteocalcin revealed more labeling for ORQ TERI and less for TRAP. For the Tb.N in the ORQ NT group was 0.496 mm, a significant statistical difference was observed between the groups of ORQ NT and ORQ TERI (p < 0.05). For the BV/TV, Tb.Sp, and Tb.Th parameters, no significant statistical difference was observed among the three experimental groups (p > 0.05).

Conclusions

Treatment with intermittent teriparatide reverted impairment in the metabolism of repairing bone tissue in orchiectomized animals.

Clinical relevance

Cases of decreased bone density such as osteoporosis can lead to delayed alveolar repair process. PTH 1-34 has been shown to be a medication that improves this repair, making bone of low quality into one with normal features.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nr7PeM

Prevention of oral carcinogenesis in rats by Dracaena cinnabari resin extracts

Abstract

Objectives

In vivo study was performed to determine the chemopreventive efficacy of the DC resin methanol extract on a 4-nitroquinoline-1-oxide (4NQO) oral cancer animal model.

Materials and methods

This study involves administration of 4NQO solution for 8 weeks alone (cancer induction) or with Dracaena cinnabari (DC) extract at 100, 500, and 1000 mg/kg. DC extract administration started 1 week before exposure until 1 week after the carcinogen exposure was stopped. All rats were sacrificed after 22 weeks, and histological analysis was performed to assess any incidence of pathological changes. Immunohistochemical expressions of selected tumor marker antibodies were analyzed using an image analyzer computer system, and the expression of selected genes involved in apoptosis and proliferative mechanism related to oral cancer were evaluated using RT²-PCR.

Results

The incidence of OSCC decreased with the administration of DC extract at 100, 500, and 1000 mg/kg compared to the induced cancer group. The developed tumor was also observed to be smaller when compared to the induced cancer group. The DC 1000 mg/kg group inhibits the expression of Cyclin D1, Ki-67, Bcl-2, and p53 proteins. It was observed that DC 1000 mg/kg induced apoptosis by upregulation of Bax and Casp3 genes and downregulation of Tp53, Bcl-2, Cox-2, Cyclin D1, and EGFR genes when compared to the induced cancer group.

Conclusions

The data indicated that systemic administration of the DC resin methanol extract has anticarcinogenic potency on oral carcinogenesis.

Clinical relevance

Chemoprevention with DC resin methanol extract may significantly reduce morbidity and possibly mortality from OSCC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2E3bBeT

Effect of intermittent teriparatide (PTH 1-34) on the alveolar healing process in orchiectomized rats

Abstract

Objective

To evaluate intermittent teriparatide therapy's influence on the alveolar healing process in rats with induced osteoporosis.

Materials and methods

Fifty-four male rats were divided into three groups: fictitious surgery (SHAM), bilateral orchiectomy (ORQ NT), and bilateral orchiectomy treated with teriparatide (ORQ TERI). Right upper incisor extraction was performed. After 14 and 42 days, the rats were euthanized. Immunolabeling analysis was performed in order to characterize bone turnover through Wnt, alcaline phosphatase, osteocalcin, and TRAP presence in tissue; micro-CT analysis was performed in order to determine the bone volume fraction (BV/TV), trabecular thickness, separation, and number (Tb.Th, Tb.Sp, Tb.N). For the micro-CT data, statistical analysis was performed through one-way ANOVA and Tukey post-test, for parametrical data, with significance level adopted in p < 0.05. Days, Wnt, alkaline phosphatase, and osteocalcin revealed more labeling for ORQ TERI and less for TRAP. For the Tb.N in the ORQ NT group was 0.496 mm, a significant statistical difference was observed between the groups of ORQ NT and ORQ TERI (p < 0.05). For the BV/TV, Tb.Sp, and Tb.Th parameters, no significant statistical difference was observed among the three experimental groups (p > 0.05).

Conclusions

Treatment with intermittent teriparatide reverted impairment in the metabolism of repairing bone tissue in orchiectomized animals.

Clinical relevance

Cases of decreased bone density such as osteoporosis can lead to delayed alveolar repair process. PTH 1-34 has been shown to be a medication that improves this repair, making bone of low quality into one with normal features.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nr7PeM

Yes, You Should Get a Flu Shot in 2018. Here ’s Everything to Know

The 2017-2018 flu season was a bad one. The dominant viral strain, H3N2, was a particularly severe form of influenza, leading to widespread and serious illness across the country. The flu and its complications killed around 80,000 people last year, the CDC estimates, including 180 children. That's the highest flu death toll in four decades. Experts say early indications suggest that this year's flu season will be milder, but the memory of last winter should still serve as motivation to get the flu shot this fall. Here's what you need to know about the 2018 flu shot. When should I get the flu shot? The CDC recommends getting your flu shot by the end of October, before the bulk of the 2018-2019 flu season hits, because it takes about two weeks for the flu shot to take effe...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RvdN1y

Immunotherapy Quiz: 2018 Guidelines on Rhinitis

Where do US guidelines on immunotherapy for rhinitis overlap with new 2018 recommendations from Europe? Answer these 5 questions to find out. (Source: ConsultantLive)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yiYhgu

Yes, You Should Get a Flu Shot in 2018. Here ’s Everything to Know

The 2017-2018 flu season was a bad one. The dominant viral strain, H3N2, was a particularly severe form of influenza, leading to widespread and serious illness across the country. The flu and its complications killed around 80,000 people last year, the CDC estimates, including 180 children. That's the highest flu death toll in four decades. Experts say early indications suggest that this year's flu season will be milder, but the memory of last winter should still serve as motivation to get the flu shot this fall. Here's what you need to know about the 2018 flu shot. When should I get the flu shot? The CDC recommends getting your flu shot by the end of October, before the bulk of the 2018-2019 flu season hits, because it takes about two weeks for the flu shot to take effe...

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Immunotherapy Quiz: 2018 Guidelines on Rhinitis

Where do US guidelines on immunotherapy for rhinitis overlap with new 2018 recommendations from Europe? Answer these 5 questions to find out. (Source: ConsultantLive)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yiYhgu

Technical success and outcomes in pediatric patients undergoing transjugular intrahepatic portosystemic shunt placement: a 20-year experience

Abstract

Background

Transjugular intrahepatic portosystemic shunt (TIPS) placement has been extensively studied in adults. The experience with TIPS placement in pediatric patients, however, is limited.

Objective

The purpose of this study was to report technical success and clinical outcomes in pediatric patients undergoing TIPS placement.

Materials and methods

Twenty-one children — 12 (57%) boys and 9 (43%) girls, mean age 12.1 years (range, 2–17 years) — underwent TIPS placement from January 1997 to January 2017. Etiologies of hepatic dysfunction included biliary atresia (n=5; 24%), cryptogenic cirrhosis (n=4; 19%), portal or hepatic vein thrombosis (n=4, 14%), autosomal-recessive polycystic kidney disease (n=3; 14%), primary sclerosing cholangitis (n=2; 10%) and others (n=3, 14%). Indications for TIPS placement included variceal hemorrhage (n=20; 95%) and refractory ascites (n=1; 5%). Technical success, manometry findings, stent type, hemodynamic success, complications, liver enzymes, and clinical outcomes were recorded.

Results

TIPS placement was technically successful in 20 of 21 (95%) children, with no immediate complications. Mean pre- and post-TIPS portosystemic gradient was 18.5±10.7 mmHg and 7.1±3.9 mmHg, respectively. Twenty-two total stents were successfully placed in 20 children. Stents used included: Viatorr (n=9; 41%), Wallstent (n=7; 32%), Express (n=5; 23%), and iCAST (n=1; 5%). All children had resolution of variceal bleeding or ascites. TIPS revision was required in 9 (45%) children, with a mean of 2.2 revisions. Hepatic encephalopathy developed in 10 children (48%), at a mean of 223.7 days following TIPS placement. During the study, 6 (29%) children underwent liver transplantation.

Conclusion

TIPS placement in pediatric patients has high technical success with excellent resolution of variceal hemorrhage and ascites. TIPS revision was required in nearly half of the cohort, with hepatic encephalopathy common after shunt placement.

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Yes, You Should Get a Flu Shot in 2018. Here ’s Everything to Know

The 2017-2018 flu season was a bad one. The dominant viral strain, H3N2, was a particularly severe form of influenza, leading to widespread and serious illness across the country. The flu and its complications killed around 80,000 people last year, the CDC estimates, including 180 children. That's the highest flu death toll in four decades. Experts say early indications suggest that this year's flu season will be milder, but the memory of last winter should still serve as motivation to get the flu shot this fall. Here's what you need to know about the 2018 flu shot. When should I get the flu shot? The CDC recommends getting your flu shot by the end of October, before the bulk of the 2018-2019 flu season hits, because it takes about two weeks for the flu shot to take effe...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RvdN1y

Technical success and outcomes in pediatric patients undergoing transjugular intrahepatic portosystemic shunt placement: a 20-year experience

Abstract

Background

Transjugular intrahepatic portosystemic shunt (TIPS) placement has been extensively studied in adults. The experience with TIPS placement in pediatric patients, however, is limited.

Objective

The purpose of this study was to report technical success and clinical outcomes in pediatric patients undergoing TIPS placement.

Materials and methods

Twenty-one children — 12 (57%) boys and 9 (43%) girls, mean age 12.1 years (range, 2–17 years) — underwent TIPS placement from January 1997 to January 2017. Etiologies of hepatic dysfunction included biliary atresia (n=5; 24%), cryptogenic cirrhosis (n=4; 19%), portal or hepatic vein thrombosis (n=4, 14%), autosomal-recessive polycystic kidney disease (n=3; 14%), primary sclerosing cholangitis (n=2; 10%) and others (n=3, 14%). Indications for TIPS placement included variceal hemorrhage (n=20; 95%) and refractory ascites (n=1; 5%). Technical success, manometry findings, stent type, hemodynamic success, complications, liver enzymes, and clinical outcomes were recorded.

Results

TIPS placement was technically successful in 20 of 21 (95%) children, with no immediate complications. Mean pre- and post-TIPS portosystemic gradient was 18.5±10.7 mmHg and 7.1±3.9 mmHg, respectively. Twenty-two total stents were successfully placed in 20 children. Stents used included: Viatorr (n=9; 41%), Wallstent (n=7; 32%), Express (n=5; 23%), and iCAST (n=1; 5%). All children had resolution of variceal bleeding or ascites. TIPS revision was required in 9 (45%) children, with a mean of 2.2 revisions. Hepatic encephalopathy developed in 10 children (48%), at a mean of 223.7 days following TIPS placement. During the study, 6 (29%) children underwent liver transplantation.

Conclusion

TIPS placement in pediatric patients has high technical success with excellent resolution of variceal hemorrhage and ascites. TIPS revision was required in nearly half of the cohort, with hepatic encephalopathy common after shunt placement.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RxkJLN

Yes, You Should Get a Flu Shot in 2018. Here ’s Everything to Know

The 2017-2018 flu season was a bad one. The dominant viral strain, H3N2, was a particularly severe form of influenza, leading to widespread and serious illness across the country. The flu and its complications killed around 80,000 people last year, the CDC estimates, including 180 children. That's the highest flu death toll in four decades. Experts say early indications suggest that this year's flu season will be milder, but the memory of last winter should still serve as motivation to get the flu shot this fall. Here's what you need to know about the 2018 flu shot. When should I get the flu shot? The CDC recommends getting your flu shot by the end of October, before the bulk of the 2018-2019 flu season hits, because it takes about two weeks for the flu shot to take effe...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RvdN1y

Immunotherapy Quiz: 2018 Guidelines on Rhinitis

Where do US guidelines on immunotherapy for rhinitis overlap with new 2018 recommendations from Europe? Answer these 5 questions to find out. (Source: ConsultantLive)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yiYhgu

Fc-Dependent Mechanisms of Antibody-Mediated Killing (U01 Clinical Trial Not Allowed)

Funding Opportunity RFA-AI-18-042 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications from institutions and organizations to conduct research focused on elucidating mechanisms of Fc-dependent, antibody-mediated killing of infected or aberrant cells, or antibody-mediated therapeutic ablation of cells implicated in immune pathologies, including autoimmune and allergic diseases. Studies supported by this FOA are expected to define variables that affect efficiencies of antibody-dependent cellular cytotoxicity (ADCC) and/or antibody-dependent cell-mediated phagocytosis (ADCP), both in vitro and in vivo. U01 awardees will be expected to attend annual Program Progress/Steering Committee meetings and present progress to fellow awardees and...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zU80vK

Fc-Dependent Mechanisms of Antibody-Mediated Killing (R21 Clinical Trial Not Allowed)

Funding Opportunity PA-19-020 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites R21 applications for studies that address knowledge gaps in mechanisms of Fc-dependent, antibody-mediated killing of infected cells or aberrant cells, or antibody-mediated therapeutic ablation of cells implicated in immune pathologies, including autoimmune and allergic diseases. More specifically, the purpose of this FOA is to promote innovative and exploratory research to elucidate mechanisms of antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP), and to promote development of tools, technologies, and animal models to facilitate identification and evaluation of cytotoxic killing mechanisms mediated by human ant...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BYW5Ot

Fc-Dependent Mechanisms of Antibody-Mediated Killing (U01 Clinical Trial Not Allowed)

Funding Opportunity RFA-AI-18-042 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites applications from institutions and organizations to conduct research focused on elucidating mechanisms of Fc-dependent, antibody-mediated killing of infected or aberrant cells, or antibody-mediated therapeutic ablation of cells implicated in immune pathologies, including autoimmune and allergic diseases. Studies supported by this FOA are expected to define variables that affect efficiencies of antibody-dependent cellular cytotoxicity (ADCC) and/or antibody-dependent cell-mediated phagocytosis (ADCP), both in vitro and in vivo. U01 awardees will be expected to attend annual Program Progress/Steering Committee meetings and present progress to fellow awardees and...

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Fc-Dependent Mechanisms of Antibody-Mediated Killing (R21 Clinical Trial Not Allowed)

Funding Opportunity PA-19-020 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) invites R21 applications for studies that address knowledge gaps in mechanisms of Fc-dependent, antibody-mediated killing of infected cells or aberrant cells, or antibody-mediated therapeutic ablation of cells implicated in immune pathologies, including autoimmune and allergic diseases. More specifically, the purpose of this FOA is to promote innovative and exploratory research to elucidate mechanisms of antibody-dependent cellular cytotoxicity (ADCC) and antibody-dependent cell-mediated phagocytosis (ADCP), and to promote development of tools, technologies, and animal models to facilitate identification and evaluation of cytotoxic killing mechanisms mediated by human ant...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BYW5Ot

Interactive Musical Created for Children With Autism

Adjusting live performances to fit the needs of audience members with autism or other sensory issues is nothing new. Creating an interactive show especially suited to a neurodiverse audience is less common. Staff and students from Michigan State University's (MSU) theater department created "Farm! A Musical Experience," to fit exactly that niche. According to articles published by ABC News, MSU theater faculty member and outreach coordinator Dionne O'Dell worked with a class of students last year to create "Farm." First, O'Dell visited and worked with theater companies specializing in shows for audiences with special needs. Then, after completing the script, the cast tested the show on students studying special education. Once she felt the show was ready, O'Dell took "Fa...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IHphei

Interactive Musical Created for Children With Autism

Adjusting live performances to fit the needs of audience members with autism or other sensory issues is nothing new. Creating an interactive show especially suited to a neurodiverse audience is less common. Staff and students from Michigan State University's (MSU) theater department created "Farm! A Musical Experience," to fit exactly that niche. According to articles published by ABC News, MSU theater faculty member and outreach coordinator Dionne O'Dell worked with a class of students last year to create "Farm." First, O'Dell visited and worked with theater companies specializing in shows for audiences with special needs. Then, after completing the script, the cast tested the show on students studying special education. Once she felt the show was ready, O'Dell took "Fa...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IHphei

Effect of wild grape on the signaling of histamine H1 receptor gene expression responsible for the pathogenesis of allergic rhinitis.

Authors: Rezwanul I, Hiroyuki M, Aurpita S, Kohei N, Masami Y, Hisashi I, Hiromichi F, Yoshiaki K, Hiroyuki F, Noriaki T Abstract As expression level of allergic disease-sensitive genes are correlated with allergic symptom severity, suppression of these gene expressions could be good therapeutics. We have demonstrated that PKCδ signaling and NFAT signaling, involve in histamine H1 receptor (H1R) and IL-9 gene expressions, respectively, are responsible for the pathogenesis of allergic rhinitis. We explore anti-allergic compounds that suppress these signaling pathways and found that wild grape (WG) contains such compounds. Here, we investigated the effect of WG hot water extract (WGE) on the signaling pathways for PKCδ-mediated H1R and NFAT-mediated IL-9 gene expressions. WGE suppr...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IEwoEc

Manifestation of intraoperative anaphylactic shock along with latex allergy:a pediatric case report.

We report a pediatric case of latex allergy with multiple surgical histories. A 12-year-old girl developed anaphylactic shock during the pyeloplasty for ureteropelvic junction restenosis. Latex gloves or medications used during the surgery were suspected to be the cause of anaphylactic shock. We diagnosed her latex allergy on the basis of the results that serum latex-specific IgE, skin prick tests of extract from NRL gloves and recombinant Hev b 6.02 solution were positive. Basophil activation test of NRL gloves was also positive, supporting the diagnosis of immediate allergic reactions caused by NRL. It was speculated that a history of multiple surgeries in infancy became a trigger of sensitization to latex in this patient. Reoperation after the diagnosis of NRL allergy was carried out in...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CsEQ9B

Biomarkers and new therapeutic targets in renal cell carcinoma.

CONCLUSIONS: The development of targeted therapies has revolutionized the treatment of advanced and metastatic cancers or non-responder patients. Combined therapy between classical chemotherapy and adjuvant immunotherapies has been modifying the cancer patients prognosis and bringing the hope of a cure in many cases. PMID: 30280768 [PubMed - in process] (Source: European Review for Medical and Pharmacological Sciences)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IGFmkn

Effect of wild grape on the signaling of histamine H1 receptor gene expression responsible for the pathogenesis of allergic rhinitis.

Authors: Rezwanul I, Hiroyuki M, Aurpita S, Kohei N, Masami Y, Hisashi I, Hiromichi F, Yoshiaki K, Hiroyuki F, Noriaki T Abstract As expression level of allergic disease-sensitive genes are correlated with allergic symptom severity, suppression of these gene expressions could be good therapeutics. We have demonstrated that PKCδ signaling and NFAT signaling, involve in histamine H1 receptor (H1R) and IL-9 gene expressions, respectively, are responsible for the pathogenesis of allergic rhinitis. We explore anti-allergic compounds that suppress these signaling pathways and found that wild grape (WG) contains such compounds. Here, we investigated the effect of WG hot water extract (WGE) on the signaling pathways for PKCδ-mediated H1R and NFAT-mediated IL-9 gene expressions. WGE suppr...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IEwoEc

Manifestation of intraoperative anaphylactic shock along with latex allergy:a pediatric case report.

We report a pediatric case of latex allergy with multiple surgical histories. A 12-year-old girl developed anaphylactic shock during the pyeloplasty for ureteropelvic junction restenosis. Latex gloves or medications used during the surgery were suspected to be the cause of anaphylactic shock. We diagnosed her latex allergy on the basis of the results that serum latex-specific IgE, skin prick tests of extract from NRL gloves and recombinant Hev b 6.02 solution were positive. Basophil activation test of NRL gloves was also positive, supporting the diagnosis of immediate allergic reactions caused by NRL. It was speculated that a history of multiple surgeries in infancy became a trigger of sensitization to latex in this patient. Reoperation after the diagnosis of NRL allergy was carried out in...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CsEQ9B

Safety and Efficacy Study of Oral Fosfomycin Versus Oral Levofloxacin to Treat Complicated Urinary Syndromes (FOCUS)

Condition:   Urinary Tract Infection Interventions:   Drug: Fosfomycin tromethamine;   Drug: Levofloxacin Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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Effects of FM system fitted into normal hearing ear on speech-in-noise recognition in Japanese school-aged children with unilateral severe-to-profound hearing loss.

CONCLUSION: The results suggested that the FM system is recommended as an audiological management for improvement of speech recognition of children with unilateral hearing loss in noisy classrooms. J. Med. Invest. 65:216-220, August, 2018. PMID: 30282863 [PubMed - in process] (Source: Journal of Medical Investigation)

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Homozygous 2p11.2 deletion supports the implication of ELMOD3 in hearing loss and reveals the potential association of CAPG with ASD/ID etiology.

Authors: Lahbib S, Leblond CS, Hamza M, Regnault B, Lemée L, Mathieu A, Jaouadi H, Mkaouar R, Youssef-Turki IB, Belhadj A, Kraoua I, Bourgeron T, Abdelhak S Abstract Autism spectrum disorder (ASD) is a set of neurodevelopmental conditions characterized by early-onset difficulties in social communication and unusually restricted, repetitive behavior and interests. Parental consanguinity may lead to higher risk of ASD and to more severe clinical presentations in the offspring. Studies of ASD families with high inbreeding enable the identification of inherited variants of this disorder particularly those with an autosomal recessive pattern of inheritance. In our study, using copy number variants (CNV) analysis, we identified a rare homozygous deletion in 2p11.2 region that affects EL...

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Safety and Efficacy Study of Oral Fosfomycin Versus Oral Levofloxacin to Treat Complicated Urinary Syndromes (FOCUS)

Condition:   Urinary Tract Infection Interventions:   Drug: Fosfomycin tromethamine;   Drug: Levofloxacin Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PfXfJx

Effects of FM system fitted into normal hearing ear on speech-in-noise recognition in Japanese school-aged children with unilateral severe-to-profound hearing loss.

CONCLUSION: The results suggested that the FM system is recommended as an audiological management for improvement of speech recognition of children with unilateral hearing loss in noisy classrooms. J. Med. Invest. 65:216-220, August, 2018. PMID: 30282863 [PubMed - in process] (Source: Journal of Medical Investigation)

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Homozygous 2p11.2 deletion supports the implication of ELMOD3 in hearing loss and reveals the potential association of CAPG with ASD/ID etiology.

Authors: Lahbib S, Leblond CS, Hamza M, Regnault B, Lemée L, Mathieu A, Jaouadi H, Mkaouar R, Youssef-Turki IB, Belhadj A, Kraoua I, Bourgeron T, Abdelhak S Abstract Autism spectrum disorder (ASD) is a set of neurodevelopmental conditions characterized by early-onset difficulties in social communication and unusually restricted, repetitive behavior and interests. Parental consanguinity may lead to higher risk of ASD and to more severe clinical presentations in the offspring. Studies of ASD families with high inbreeding enable the identification of inherited variants of this disorder particularly those with an autosomal recessive pattern of inheritance. In our study, using copy number variants (CNV) analysis, we identified a rare homozygous deletion in 2p11.2 region that affects EL...

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Changes in English Past Tense Use by Bilingual School-Age Children With and Without Developmental Language Disorder.

Discussion: Contrary to an earlier report (Jacobson & Schwartz, 2005), the relative greater difficulty with regular and novel verbs was replaced by greater difficulty for irregular past tense, a pattern consistent with monolingual impairment. Age was a contributing factor, particularly for younger children with DLD who produced more stem + ing errors in the novel verb condition. For all children, and particularly for those with DLD, an extended period for irregular past tense learning was evident. The results support a usage-based theory of language acquisition and impairment. PMID: 30286247 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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Service Provision for Children Who Are Hard of Hearing at Preschool and Elementary School Ages.

Conclusions: As preschool-age CHH transition into school, the majority continue to qualify for services. Congruent with national trends, school-age CHH in the Outcomes of Children with Hearing Loss study were most often in general education settings. Without specialized preprofessional or postgraduate training, SLPs and teachers of CDHH did not report comfort with all the skills critical to developing listening and spoken language. This finding supports the need for increased implementation of interprofessional practice among SLPs and teachers of CDHH, as well as audiologists, to best meet the needs unique to this population. PMID: 30286245 [PubMed - as supplied by publisher] (Source: Language, Speech, and Hearing Services in Schools)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Crmea1

Sense of Effort and Fatigue Associated With Talking After Total Laryngectomy.

Conclusions: Effort and fatigue associated with talking are a common report for individuals using alaryngeal speech. The location of effort within the body and the type of fatigue experienced vary to some extent across alaryngeal speaking methods. PMID: 30286222 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zU9wxM

Explaining Reading Comprehension in Children With Developmental Language Disorder: The Importance of Elaborative Inferencing.

Conclusions: These results indicate that interventions targeting the reading comprehension of children with DLD should focus on elaborative inferencing skill. There are also clinical implications as the development of new standardized assessments differentiating between inference types is called for. PMID: 30286246 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NnK0EM

Pilot Study of Audiometric Patterns in Fuchs Corneal Dystrophy.

Conclusion: In the first study to use objectively measured hearing, FCD was associated with poorer low-frequency and better high-frequency audiometric thresholds than population controls. Further studies are needed to characterize this relationship. PMID: 30286242 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2y3Bhmd

Characteristics of Speech Rate in Children With Cerebral Palsy: A Longitudinal Study.

Conclusions: There were no significant age-related differences in speech rate in children with CP regardless of group membership. Sentence length differentially impacted speech rate and its characteristics in both groups of children with CP. This may be due to cognitive-linguistic and/or speech motor control factors. PMID: 30286232 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nr7Dw3

Changes in English Past Tense Use by Bilingual School-Age Children With and Without Developmental Language Disorder.

Discussion: Contrary to an earlier report (Jacobson & Schwartz, 2005), the relative greater difficulty with regular and novel verbs was replaced by greater difficulty for irregular past tense, a pattern consistent with monolingual impairment. Age was a contributing factor, particularly for younger children with DLD who produced more stem + ing errors in the novel verb condition. For all children, and particularly for those with DLD, an extended period for irregular past tense learning was evident. The results support a usage-based theory of language acquisition and impairment. PMID: 30286247 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2y2GmLx

Service Provision for Children Who Are Hard of Hearing at Preschool and Elementary School Ages.

Conclusions: As preschool-age CHH transition into school, the majority continue to qualify for services. Congruent with national trends, school-age CHH in the Outcomes of Children with Hearing Loss study were most often in general education settings. Without specialized preprofessional or postgraduate training, SLPs and teachers of CDHH did not report comfort with all the skills critical to developing listening and spoken language. This finding supports the need for increased implementation of interprofessional practice among SLPs and teachers of CDHH, as well as audiologists, to best meet the needs unique to this population. PMID: 30286245 [PubMed - as supplied by publisher] (Source: Language, Speech, and Hearing Services in Schools)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Crmea1

Sense of Effort and Fatigue Associated With Talking After Total Laryngectomy.

Conclusions: Effort and fatigue associated with talking are a common report for individuals using alaryngeal speech. The location of effort within the body and the type of fatigue experienced vary to some extent across alaryngeal speaking methods. PMID: 30286222 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zU9wxM

Explaining Reading Comprehension in Children With Developmental Language Disorder: The Importance of Elaborative Inferencing.

Conclusions: These results indicate that interventions targeting the reading comprehension of children with DLD should focus on elaborative inferencing skill. There are also clinical implications as the development of new standardized assessments differentiating between inference types is called for. PMID: 30286246 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NnK0EM

Pilot Study of Audiometric Patterns in Fuchs Corneal Dystrophy.

Conclusion: In the first study to use objectively measured hearing, FCD was associated with poorer low-frequency and better high-frequency audiometric thresholds than population controls. Further studies are needed to characterize this relationship. PMID: 30286242 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2y3Bhmd

Characteristics of Speech Rate in Children With Cerebral Palsy: A Longitudinal Study.

Conclusions: There were no significant age-related differences in speech rate in children with CP regardless of group membership. Sentence length differentially impacted speech rate and its characteristics in both groups of children with CP. This may be due to cognitive-linguistic and/or speech motor control factors. PMID: 30286232 [PubMed - as supplied by publisher] (Source: Journal of speech, language, and hearing research : JSLHR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nr7Dw3

Determination of ED50 and time to effectiveness for intrathecal hydromorphone in laboring patients using Dixon’s up-and-down sequential allocation method

Abstract

Background

With the increasing occurrence of drug shortages, understanding the pharmacokinetics of alternative intrathecal opioid administration has gained importance. In particular, additional data are needed to comprehensively evaluate the analgesic properties of intrathecal hydromorphone in the laboring patient. In a phase 2 clinical trial, we set out to determine the median effective dose (ED₅₀) and time to effectiveness for this drug in this population.

Methods

Using Dixon's up-and-down sequential allocation method, twenty women presenting for labor analgesia were prospectively enrolled. A combined spinal-epidural technique was used to deliver the determined dose of intrathecal hydromorphone. Visual analog pain scores were obtained assessing peak pain scores during serial uterine contractions. Effective pain relief was defined as achieving a pain score of less than or equal to 3 out of 10. The dose was deemed to be ineffective if the patient failed to achieve this level of relief after 30 min.

Results

The ED₅₀ of hydromorphone in our population was 10.9 μg (95% confidence interval 5.6–16.2 μg). Amongst patients for whom the dose was effective, the median time to pain relief was 24 min. One patient experienced both nausea and pruritus. No other complications were noted.

Conclusion

Due to the prolonged time to onset, hydromorphone cannot be recommended in favor of substantively better alternatives such as sufentanil and fentanyl.

Trial registration

Clinicaltrials.gov registration number: NCT01598506.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C0Xft7

Sense of Effort and Fatigue Associated With Talking After Total Laryngectomy.

Conclusions: Effort and fatigue associated with talking are a common report for individuals using alaryngeal speech. The location of effort within the body and the type of fatigue experienced vary to some extent across alaryngeal speaking methods. PMID: 30286222 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zU9wxM

Modifying Food Textures: Practices and Beliefs of Staff Involved in Nutrition Care.

Conclusions: Survey respondents conveyed generally positive attitudes and opinions about the use of texture-modified foods, and respondents perceived them to be easy to execute and beneficial to the nutritional well-being of patients. Survey findings clearly highlight the contributions of frontline staff in the service delivery of modified food textures. Consideration must be given to continued reliance on informal, limited instruction about texture-modified foods and possible implications for safe nutrition care. Both professional and frontline staff convey a willingness to customize or alter food textures and the belief that patients should be able to choose the level of texture modification that they want to eat. PMID: 30267081 [PubMed - as supplied by publisher] (Source: American J...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2II4DLi

Determination of ED50 and time to effectiveness for intrathecal hydromorphone in laboring patients using Dixon’s up-and-down sequential allocation method

Abstract

Background

With the increasing occurrence of drug shortages, understanding the pharmacokinetics of alternative intrathecal opioid administration has gained importance. In particular, additional data are needed to comprehensively evaluate the analgesic properties of intrathecal hydromorphone in the laboring patient. In a phase 2 clinical trial, we set out to determine the median effective dose (ED₅₀) and time to effectiveness for this drug in this population.

Methods

Using Dixon's up-and-down sequential allocation method, twenty women presenting for labor analgesia were prospectively enrolled. A combined spinal-epidural technique was used to deliver the determined dose of intrathecal hydromorphone. Visual analog pain scores were obtained assessing peak pain scores during serial uterine contractions. Effective pain relief was defined as achieving a pain score of less than or equal to 3 out of 10. The dose was deemed to be ineffective if the patient failed to achieve this level of relief after 30 min.

Results

The ED₅₀ of hydromorphone in our population was 10.9 μg (95% confidence interval 5.6–16.2 μg). Amongst patients for whom the dose was effective, the median time to pain relief was 24 min. One patient experienced both nausea and pruritus. No other complications were noted.

Conclusion

Due to the prolonged time to onset, hydromorphone cannot be recommended in favor of substantively better alternatives such as sufentanil and fentanyl.

Trial registration

Clinicaltrials.gov registration number: NCT01598506.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C0Xft7

Sense of Effort and Fatigue Associated With Talking After Total Laryngectomy.

Conclusions: Effort and fatigue associated with talking are a common report for individuals using alaryngeal speech. The location of effort within the body and the type of fatigue experienced vary to some extent across alaryngeal speaking methods. PMID: 30286222 [PubMed - as supplied by publisher] (Source: American Journal of Speech-Language Pathology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2zU9wxM

Modifying Food Textures: Practices and Beliefs of Staff Involved in Nutrition Care.

Conclusions: Survey respondents conveyed generally positive attitudes and opinions about the use of texture-modified foods, and respondents perceived them to be easy to execute and beneficial to the nutritional well-being of patients. Survey findings clearly highlight the contributions of frontline staff in the service delivery of modified food textures. Consideration must be given to continued reliance on informal, limited instruction about texture-modified foods and possible implications for safe nutrition care. Both professional and frontline staff convey a willingness to customize or alter food textures and the belief that patients should be able to choose the level of texture modification that they want to eat. PMID: 30267081 [PubMed - as supplied by publisher] (Source: American J...

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HIF-1α, NOTCH1, ADAM12 and HB-EGF are overexpressed in mucoepidermoid carcinoma

Intratumoral hypoxia (IH) occurs during cellular proliferation of malignant tumors. This phenomenon is characterized by a decrease in oxygen levels in the neoplastic microenvironment. Throughout this condition, HIF-1α, NOTCH1, ADAM12, and HB-EGF proteins can be activated, triggering signaling pathways associated with tumor invasiveness through invadopodia formation. This study aimed to evaluate the immunostaining of HIF-1α, NOTCH1, ADAM12, and HBEGF in 19 cases of mucoepidermoid carcinoma (MEC) and 10 samples of salivary glands (control group).

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Comorbid Conditions are a Risk for Osteonecrosis of the Jaw Unrelated to Antiresorptive Therapy

Background: Osteonecrosis of the jaw (ONJ) is commonly associated with antiresorptive therapy. There have been numerous reports of ONJ unrelated to antiresorptive therapy (ONJuat), confounding risk assessment. This study aimed to determine if ONJuat is associated with one or more particular comorbidities.Study Design: Retrospective case-control study for patients with ONJuat and delayed healing (DH). Each case was matched for age, gender and location of the ONJuat or DH lesion to a control who had a history of dentoalveolar surgery with uneventful healing and no history of antiresorptive therapy.

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Comorbid Conditions are a Risk for Osteonecrosis of the Jaw Unrelated to Antiresorptive Therapy

Background: Osteonecrosis of the jaw (ONJ) is commonly associated with antiresorptive therapy. There have been numerous reports of ONJ unrelated to antiresorptive therapy (ONJuat), confounding risk assessment. This study aimed to determine if ONJuat is associated with one or more particular comorbidities.Study Design: Retrospective case-control study for patients with ONJuat and delayed healing (DH). Each case was matched for age, gender and location of the ONJuat or DH lesion to a control who had a history of dentoalveolar surgery with uneventful healing and no history of antiresorptive therapy.

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Metabotropic glutamate receptor subtype 5 is altered in LPS-induced murine neuroinflammation model and in the brains of AD and ALS patients

Abstract

Purpose

The aim of the present study was to determine the expression levels of mGluR5 in different mouse strains after induction of neuroinflammation by lipopolysaccharide (LPS) challenge and in the brains of patients with Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) post mortem to investigate mGluR5 expression in human neurodegenerative diseases.

Methods

C57BL/6 and CD1 mice were injected intraperitoneally with either 10 mg/kg LPS or saline. mGluR5 and TSPO mRNA levels were measured after 1 and 5 days by qPCR, and mGluR5 protein levels were determined by PET imaging with the mGluR5-specific radiotracer [¹⁸F]PSS232. mGluR5 expression was evaluated in the post-mortem brain slices from AD and ALS patients using in vitro autoradiography.

Results

mGluR5 and TSPO mRNA levels were increased in brains of C57BL/6 and CD1 mice 1 day after LPS treatment and remained significantly increased after 5 days in C57BL/6 mice but not in CD1 mice. Brain PET imaging with [¹⁸F]PSS232 confirmed increased mGluR5 levels in the brains of both mouse strains 1 day after LPS treatment. After 5 days, mGluR5 levels in CD1 mice declined to the levels in vehicle-treated mice but remained high in C57BL/6 mice. Autoradiograms revealed a severalfold higher binding of [¹⁸F]PSS232 in post-mortem brain slices from AD and ALS patients compared with the binding in control brains.

Conclusion

LPS-induced neuroinflammation increased mGluR5 levels in mouse brain and is dependent on the mouse strain and time after LPS treatment. mGluR5 levels were also increased in human AD and ALS brains in vitro. PET imaging of mGluR5 levels could potentially be used to diagnose and monitor therapy outcomes in patients with AD and ALS.

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The European Diploma in Radiology (EDiR): investing in the future of the new generations of radiologists

Abstract

This review aims to describe the organisation and the content of the European Diploma in Radiology (EDiR). The EDiR examination is available to radiologists and radiology residents in their last year of training. It certifies that their levels of knowledge and competency are in line with the ESR European Training Curriculum for Radiology (ETC) of the European Society of Radiology (ESR). The EDiR is an additional qualification of excellence, which serves the standardisation and accreditation of radiologists across European borders. It provides an international benchmark for general radiology and is officially and fully endorsed by the European Union of Medical Specialists (UEMS) and the ESR. The EDiR is recognised as an equivalent of the Polish exit training examination, the first part of the Turkish board examination and the image interpretation part of the Finnish national examination. Moreover, in order to practice radiology in The Netherlands, trainees must either pass their national board examination or the EDiR. It has significant value in many other countries. The examination consists of three parts: Multiple Response Questions (MRQs), Short Cases (SCs) and the Clinically Oriented Reasoning Evaluation (CORE). The committees that form the EDiR Scientific Board follow a structured workflow to prepare each examination, ensuring an adequate peer review system for quality assurance.

Key Points

• EDiR helps to standardise radiology training.

• EDiR is an international certification method established across Europe.

• Ideally all training programmes should embrace EDiR as exit examination after completing their training period.

• The EDiR exam consists of multiple response questions, short cases and the Clinically Oriented Reasoning Evaluation.

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FDA grants de novo nod for Bose self-fitted hearing aid

The FDA today said it granted de novo clearance to a self-fitted hearing aid made by Bose Corp. for adults with mild to moderate hearing loss. The Bose Hearing Aid is designed to allow the patient to fit, program and control the hearing aid without help from a healthcare provider, the first such device on the U.S. market, according to the FDA's Center for Devices & Radiological Health. The device uses air conduction by amplifying the signal from microphones into earphones. Patients use a mobile app to control and adjust the device on the fly. "Hearing loss is a significant public health issue, especially as individuals age," Dr. Malvina Eydelman, director of CDRH's ophthalmic & ear, nose & throat devices division, said in prepared remarks. "Today...

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Metabotropic glutamate receptor subtype 5 is altered in LPS-induced murine neuroinflammation model and in the brains of AD and ALS patients

Abstract

Purpose

The aim of the present study was to determine the expression levels of mGluR5 in different mouse strains after induction of neuroinflammation by lipopolysaccharide (LPS) challenge and in the brains of patients with Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS) post mortem to investigate mGluR5 expression in human neurodegenerative diseases.

Methods

C57BL/6 and CD1 mice were injected intraperitoneally with either 10 mg/kg LPS or saline. mGluR5 and TSPO mRNA levels were measured after 1 and 5 days by qPCR, and mGluR5 protein levels were determined by PET imaging with the mGluR5-specific radiotracer [¹⁸F]PSS232. mGluR5 expression was evaluated in the post-mortem brain slices from AD and ALS patients using in vitro autoradiography.

Results

mGluR5 and TSPO mRNA levels were increased in brains of C57BL/6 and CD1 mice 1 day after LPS treatment and remained significantly increased after 5 days in C57BL/6 mice but not in CD1 mice. Brain PET imaging with [¹⁸F]PSS232 confirmed increased mGluR5 levels in the brains of both mouse strains 1 day after LPS treatment. After 5 days, mGluR5 levels in CD1 mice declined to the levels in vehicle-treated mice but remained high in C57BL/6 mice. Autoradiograms revealed a severalfold higher binding of [¹⁸F]PSS232 in post-mortem brain slices from AD and ALS patients compared with the binding in control brains.

Conclusion

LPS-induced neuroinflammation increased mGluR5 levels in mouse brain and is dependent on the mouse strain and time after LPS treatment. mGluR5 levels were also increased in human AD and ALS brains in vitro. PET imaging of mGluR5 levels could potentially be used to diagnose and monitor therapy outcomes in patients with AD and ALS.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pFbso4

The European Diploma in Radiology (EDiR): investing in the future of the new generations of radiologists

Abstract

This review aims to describe the organisation and the content of the European Diploma in Radiology (EDiR). The EDiR examination is available to radiologists and radiology residents in their last year of training. It certifies that their levels of knowledge and competency are in line with the ESR European Training Curriculum for Radiology (ETC) of the European Society of Radiology (ESR). The EDiR is an additional qualification of excellence, which serves the standardisation and accreditation of radiologists across European borders. It provides an international benchmark for general radiology and is officially and fully endorsed by the European Union of Medical Specialists (UEMS) and the ESR. The EDiR is recognised as an equivalent of the Polish exit training examination, the first part of the Turkish board examination and the image interpretation part of the Finnish national examination. Moreover, in order to practice radiology in The Netherlands, trainees must either pass their national board examination or the EDiR. It has significant value in many other countries. The examination consists of three parts: Multiple Response Questions (MRQs), Short Cases (SCs) and the Clinically Oriented Reasoning Evaluation (CORE). The committees that form the EDiR Scientific Board follow a structured workflow to prepare each examination, ensuring an adequate peer review system for quality assurance.

Key Points

• EDiR helps to standardise radiology training.

• EDiR is an international certification method established across Europe.

• Ideally all training programmes should embrace EDiR as exit examination after completing their training period.

• The EDiR exam consists of multiple response questions, short cases and the Clinically Oriented Reasoning Evaluation.

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FDA Allows Sales of First Self-Fitting Hearing Aid

The Bose Hearing Aid is for mild to moderate hearing loss. It's the first of its kind where users can set and fit it themselves. (Source: WebMD Health)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PeeYRt

FDA grants de novo nod for Bose self-fitted hearing aid

The FDA today said it granted de novo clearance to a self-fitted hearing aid made by Bose Corp. for adults with mild to moderate hearing loss. The Bose Hearing Aid is designed to allow the patient to fit, program and control the hearing aid without help from a healthcare provider, the first such device on the U.S. market, according to the FDA's Center for Devices & Radiological Health. The device uses air conduction by amplifying the signal from microphones into earphones. Patients use a mobile app to control and adjust the device on the fly. "Hearing loss is a significant public health issue, especially as individuals age," Dr. Malvina Eydelman, director of CDRH's ophthalmic & ear, nose & throat devices division, said in prepared remarks. "Today...

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Paediatric auditory brainstem implantation: The South Asian experience

ConclusionABI surgery involves frequent anatomical variations surrounding the lateral recess which makes the positioning of the auditory prosthesis difficult. Variants during the surgery can make the placement of ABI electrodes difficult, but promising results were seen all the implantees. (Source: European Annals of Otorhinolaryngology, Head and Neck Diseases)

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Service Provision for Children Who Are Hard of Hearing at Preschool and Elementary School Ages.

Conclusions: As preschool-age CHH transition into school, the majority continue to qualify for services. Congruent with national trends, school-age CHH in the Outcomes of Children with Hearing Loss study were most often in general education settings. Without specialized preprofessional or postgraduate training, SLPs and teachers of CDHH did not report comfort with all the skills critical to developing listening and spoken language. This finding supports the need for increased implementation of interprofessional practice among SLPs and teachers of CDHH, as well as audiologists, to best meet the needs unique to this population. PMID: 30286245 [PubMed - as supplied by publisher] (Source: Language, Speech, and Hearing Services in Schools)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Crmea1

Paediatric auditory brainstem implantation: The South Asian experience

ConclusionABI surgery involves frequent anatomical variations surrounding the lateral recess which makes the positioning of the auditory prosthesis difficult. Variants during the surgery can make the placement of ABI electrodes difficult, but promising results were seen all the implantees. (Source: European Annals of Otorhinolaryngology, Head and Neck Diseases)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IEq67y

Service Provision for Children Who Are Hard of Hearing at Preschool and Elementary School Ages.

Conclusions: As preschool-age CHH transition into school, the majority continue to qualify for services. Congruent with national trends, school-age CHH in the Outcomes of Children with Hearing Loss study were most often in general education settings. Without specialized preprofessional or postgraduate training, SLPs and teachers of CDHH did not report comfort with all the skills critical to developing listening and spoken language. This finding supports the need for increased implementation of interprofessional practice among SLPs and teachers of CDHH, as well as audiologists, to best meet the needs unique to this population. PMID: 30286245 [PubMed - as supplied by publisher] (Source: Language, Speech, and Hearing Services in Schools)

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Multidisciplinary Tracheostomy Care

There have been reports of successful quality-improvement initiatives surrounding tracheostomy care for more than a decade, but widespread adoption of best practices has not been universal. Five key drivers have been found to improve the quality of care for tracheostomy patients: multidisciplinary synchronous ward rounds, standardization of care protocols, appropriate interdisciplinary education and staff allocation, patient and family involvement, and use of data to drive improvement. The Global Tracheostomy Collaborative is a quality-improvement collaborative dedicated to improving the care of tracheostomy patients worldwide through communication, dissemination, and implementation of proven strategies based on these 5 key drivers.

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Publicly Available Databases in Otolaryngology Quality Improvement

The historical context for quality improvement is provided. Important differences are described between the two overarching types of databases: clinical registries and administrative databases. The pros and cons of each are provided as are examples of their utilization in otolaryngology–head and neck surgery.

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Management of Flaccid Facial Paralysis of Less Than Two Years’ Duration

Flaccid facial paralysis results in disfiguring facial changes. The treatment of flaccid facial paralysis is complex and treatment approaches should be determined based on duration and the causes of paralysis, status and accessibility of the affected facial nerve, medical comorbidities, and patient-specific goals. Although primary nerve repair is the preferred treatment strategy when possible, nerve substitution procedures are the mainstay of treatment for patients with flaccid facial paralysis of less than 2 years duration.

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Medical Management of Acute Facial Paralysis

Acute facial paralysis (FP) describes acute onset of partial or complete weakness of the facial muscles innervated by the facial nerve. Acute FP occurs within a few hours to days. The differential diagnosis is broad; however, the most common cause is viral-associated Bell Palsy. A comprehensive history and physical examination are essential in arriving at a diagnosis. Medical treatment for acute FP depends on the specific diagnosis; however, corticosteroids and antiviral medications are the cornerstone of therapy. Lack of recovery after 4 months should prompt further diagnostic workup.

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Delivering Otolaryngologic Care Safely and Successfully

In 2000, when the Institute of Medicine published To Err Is Human,1 the focus of the patient safety movement was on convincing both providers and patients that we had a safety problem. Currently, most people understand that patient safety is a real issue. Unfortunately, there are still an estimated 251,000 deaths2 and over 1,000,000 nonfatal injuries3 from medical errors annually in the United States. The focus now is on how to implement the best practices that we know exist. An additional challenge is creating a culture around safety, with leadership engagement.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OH9QYQ

Rethinking Morbidity and Mortality Conference

This article will discuss the importance of an effective morbidity and mortality (M&M) conference toward supporting a proactive and preventative approach to patient safety and quality improvement (PSQI). Key characteristics will be discussed that enhance this process for being a mechanism for driving positive PSQI culture change that permeates the department. The focus of this article will be on how to approach the structure and process of this conference for maximal benefit.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OH9YHO

Publicly Available Databases in Otolaryngology Quality Improvement

The historical context for quality improvement is provided. Important differences are described between the two overarching types of databases: clinical registries and administrative databases. The pros and cons of each are provided as are examples of their utilization in otolaryngology–head and neck surgery.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Qx9yRJ