The role of cancer stem cells in the modulation of anti-tumor immune responses

Publication date: Available online 24 September 2018Source: Seminars in Cancer BiologyAuthor(s): Cristina Maccalli, Kakil Ibrahim Rasul, Mamoun Elawad, Soldano FerroneAbstractTumor lesions comprise multiple subpopulations of cells including those endowed with "stemness" properties. The latter cells are responsible of tumor initiation, metastasis formation, resistance to conventional therapies and disease recurrence. These relatively rare cells denominated cancer stem cells (CSCs) or cancer initiating cells (CICs) are defined based on self-renewing, multipotency and tumorigenicity. These cells through their immunomodulating features can evade from immunesurveillance, persisting in the form of quiescence and dormancy. They can drive the neoplastic growth and recurrence, even after long l...

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