Nov. 27 (UPI) -- The Centers for Medicare and Medicaid Services, or CMS, on Tuesday unveiled a new online tool that gives consumers the power to compare ...
TUESDAY, Nov. 27, 2018 -- Although the findings are so far only in mice, studies suggest that aspirin -- even the "low-dose" variety -- might help counter multiple ...
The purpose of this study was to assess the use and outcome of rehabilitation after total laryngectomy in Germany.
We enrolled patients who were scheduled for total laryngectomy, approached them again after surgery, after 3 months and 1 year. Patients completed questionnaires and were interviewed.
Of 309 participants, 14% had not received any rehabilitation. Reasons for nonuse were primarily ongoing treatment and poor health. Users of rehabilitation had 4 times the odds of attaining any ability to speak compared to nonusers (odds ratio 3.8, P = .02). The main aim of rehabilitation from the perspective of the users was speech rehabilitation, mentioned by 71% before starting rehabilitation. This was also what most users (27%) found the most helpful part of rehabilitation.
Patients are interested in attending rehabilitation. They especially want to improve their speech capacity, which indeed is better among users of rehabilitation than in those without.
Nov. 27 (UPI) -- The Centers for Medicare and Medicaid Services, or CMS, on Tuesday unveiled a new online tool that gives consumers the power to compare ...
TUESDAY, Nov. 27, 2018 -- Although the findings are so far only in mice, studies suggest that aspirin -- even the "low-dose" variety -- might help counter multiple ...
The purpose of this study was to assess the use and outcome of rehabilitation after total laryngectomy in Germany.
We enrolled patients who were scheduled for total laryngectomy, approached them again after surgery, after 3 months and 1 year. Patients completed questionnaires and were interviewed.
Of 309 participants, 14% had not received any rehabilitation. Reasons for nonuse were primarily ongoing treatment and poor health. Users of rehabilitation had 4 times the odds of attaining any ability to speak compared to nonusers (odds ratio 3.8, P = .02). The main aim of rehabilitation from the perspective of the users was speech rehabilitation, mentioned by 71% before starting rehabilitation. This was also what most users (27%) found the most helpful part of rehabilitation.
Patients are interested in attending rehabilitation. They especially want to improve their speech capacity, which indeed is better among users of rehabilitation than in those without.
In many medical schools, the study of Anatomy is becoming increasingly theoretical owing to the difficulty of having human body parts available, rather than offering the students the possibility of a more realistic and practical approach. We developed a project where we use a 3D printer to produce models of the human skull bones, with high quality and quantity to satisfy the needs for Anatomy classes and to be available for request to study at home.
We selected regular and well-shaped bones of the head upon which we based the 3D models. These bones were scanned using a 64-channel Computed Tomography (high-resolution volumetric acquisition) and the resulting images were then processed with a segmentation software to isolate and reconstruct the structures of interest. The final digital three-dimensional objects were converted into a printable file that the 3D printer could read. We used two filament extrusion type 3D printers, the Prusa i3 and the Zortrax M200.
We have printed successfully several models of the skull bones, such as the temporal, occipital, and sphenoid. All the models have obtained good anatomical detail, thus demonstrating the practicality of this technology. Key aspects of the CT image post-processing are discussed. The production process is cost-effective and technically accessible.
These results confirm the potential of 3D printing to create more complex models (e.g. regional, vascular, nervous system structures) that would allow a similar experience compared with a dissection.
While anatomical variations of the subscapular vessels are frequently encountered during axillary dissection, little is found in the literature. The aim of this cadaveric study was to define arterial and venous anatomical variations and frequencies of the subscapular vascular pedicle and its terminal/afferent vessels in women.
We performed 80 dissections of the axillary region on forty female formalin-embalmed cadavers. Each anatomical arrangement was photographed and recorded on a scheme before analysis.
We propose a new classification of the subscapular pedicle variations. We observed three types of subscapular arterial variation. The type Ia was the most frequent arrangement (71% of our dissections), the type Ib was observed in 11% and the type II in 18% of cases. We observed four types of subscapular venous variation. The type Ia was observed in 63% of cases, the type Ib in 14%, the type II in 14% and the type III in 10% of cases.
This knowledge of the anatomical variation arrangement and frequencies of the subscapular vascular pedicle will assist the surgeon when dissecting the axillary region for malignant or reconstructive procedures.
In many medical schools, the study of Anatomy is becoming increasingly theoretical owing to the difficulty of having human body parts available, rather than offering the students the possibility of a more realistic and practical approach. We developed a project where we use a 3D printer to produce models of the human skull bones, with high quality and quantity to satisfy the needs for Anatomy classes and to be available for request to study at home.
We selected regular and well-shaped bones of the head upon which we based the 3D models. These bones were scanned using a 64-channel Computed Tomography (high-resolution volumetric acquisition) and the resulting images were then processed with a segmentation software to isolate and reconstruct the structures of interest. The final digital three-dimensional objects were converted into a printable file that the 3D printer could read. We used two filament extrusion type 3D printers, the Prusa i3 and the Zortrax M200.
We have printed successfully several models of the skull bones, such as the temporal, occipital, and sphenoid. All the models have obtained good anatomical detail, thus demonstrating the practicality of this technology. Key aspects of the CT image post-processing are discussed. The production process is cost-effective and technically accessible.
These results confirm the potential of 3D printing to create more complex models (e.g. regional, vascular, nervous system structures) that would allow a similar experience compared with a dissection.
While anatomical variations of the subscapular vessels are frequently encountered during axillary dissection, little is found in the literature. The aim of this cadaveric study was to define arterial and venous anatomical variations and frequencies of the subscapular vascular pedicle and its terminal/afferent vessels in women.
We performed 80 dissections of the axillary region on forty female formalin-embalmed cadavers. Each anatomical arrangement was photographed and recorded on a scheme before analysis.
We propose a new classification of the subscapular pedicle variations. We observed three types of subscapular arterial variation. The type Ia was the most frequent arrangement (71% of our dissections), the type Ib was observed in 11% and the type II in 18% of cases. We observed four types of subscapular venous variation. The type Ia was observed in 63% of cases, the type Ib in 14%, the type II in 14% and the type III in 10% of cases.
This knowledge of the anatomical variation arrangement and frequencies of the subscapular vascular pedicle will assist the surgeon when dissecting the axillary region for malignant or reconstructive procedures.
The labor ministry said Wednesday that the thyroid cancer of a male worker, exposed to radiation after the triple meltdown at the Fukushima No. 1 plant, ha.
Thyroid surgeries have steadily fallen in the past five years after experts raised concerns over excessive diagnosis of thyroid cancer in Korea. The number of ...
This report released by Researchvector on the Follicular Thyroid Cancer Drug market is an all-encompassing research on the market trends of Follicular Thyroid ...
Little data are available regarding the accuracy of FNAC performed without ultrasound‐guidance in neck nodes after radiotherapy.
Our retrospective analysis of 100 patients showed a high sensitivity (87%), specificity (83%), positive predictive value (98%) and accuracy (87%) of this method.
Nodal size or lymph node necrosis had no influence on the probability to obtain a diagnostic FNAC.
A positive FNAC result leads to a rapid and cost‐effective therapy decision preventing significant delay for salvage treatment.
A negative FNAC result does not exclude metastatic and/or recurrent disease and warrants further diagnostic work‐up.
This article is protected by copyright. All rights reserved.
Interpace Diagnostics Group (NASDAQ:IDXG) received a $3.00 target price from analysts at HC Wainwright in a report released on Tuesday, November 27th.
This report released by Researchvector on the Follicular Thyroid Cancer Drug market is an all-encompassing research on the market trends of Follicular Thyroid ...
Overweight and obesity accounted for nearly 4 percent of all cancers globally in 2012, and that rate is likely to rise in coming decades, a new study suggests.
Little data are available regarding the accuracy of FNAC performed without ultrasound‐guidance in neck nodes after radiotherapy.
Our retrospective analysis of 100 patients showed a high sensitivity (87%), specificity (83%), positive predictive value (98%) and accuracy (87%) of this method.
Nodal size or lymph node necrosis had no influence on the probability to obtain a diagnostic FNAC.
A positive FNAC result leads to a rapid and cost‐effective therapy decision preventing significant delay for salvage treatment.
A negative FNAC result does not exclude metastatic and/or recurrent disease and warrants further diagnostic work‐up.
This article is protected by copyright. All rights reserved.
The labor ministry said Wednesday that the thyroid cancer of a male worker, exposed to radiation after the triple meltdown at the Fukushima No. 1 plant, ha.
Overweight and obesity accounted for nearly 4 percent of all cancers globally in 2012, and that rate is likely to rise in coming decades, a new study suggests.
Thyroid surgeries have steadily fallen in the past five years after experts raised concerns over excessive diagnosis of thyroid cancer in Korea. The number of ...
Head and Neck Cancer Diagnostics market Report speaks about the Market analysis. The process is analyzed thoroughly with respect three points, viz. Types ...
LIVINGSTON, NJ — Saint Barnabas Medical Center's (SBMC) Department of Radiation Oncology is the first in New Jersey to offer the Halcyon system for ...
Global Head and Neck Cancer Market evaluates the growth of the market, the latest trends in the industry through historical study and estimates future prospects ...
We don't often give our eating habits much thought but the 8% of the population with swallowing disability need to plan carefully to ensure their food is the right ...
We don't often give our eating habits much thought but the 8% of the population with swallowing disability need to plan carefully to ensure their food is the right ...
Head and Neck Cancer Diagnostics market Report speaks about the Market analysis. The process is analyzed thoroughly with respect three points, viz. Types ...
LIVINGSTON, NJ — Saint Barnabas Medical Center's (SBMC) Department of Radiation Oncology is the first in New Jersey to offer the Halcyon system for ...
Global Head and Neck Cancer Market evaluates the growth of the market, the latest trends in the industry through historical study and estimates future prospects ...
Updated Date: Dec 11, 2018 EST (Source: DailyMed Drug Label Updates)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Treatment pathways for isolated distal radius fractures in children are becoming more tailored to specific fracture types and include different management plans for stable buckle fractures versus potentially unstable distal radius fractures.
To propose a measurement rule to aid in differentiating stable buckle fractures from other distal radius fractures in children.
A medical record search identified 203 children with closed distal radius fractures during a 14-month period. A consensus of two senior readers served as a reference standard to distinguish buckle fractures from other distal radius fractures. We measured fracture-to-physis distance on posteroanterior (PA) and lateral radiographs for each of the isolated distal radius fractures. We analyzed diagnostic accuracy, using fracture-to-physis distance as a predictor for buckle fractures, in children ages 3–16 years. We used a receiver operating characteristic (ROC) curve to determine the cut-off values tested.
There were 148 buckle fractures (73%) and 55 isolated potentially unstable distal radius fractures (27%). For children 7–16 years, buckle fracture-to-physis distance was <1 cm in only 1/106 (0.9%) on the PA projection and none on the lateral projection. Diagnostic accuracy for buckle fracture diagnosis was 82% using a cut-off of 14 mm (PA) and 13 mm (lateral). In children 3–6 years old, the buckle fracture-to-physis distance was <1 cm in 1/42 (2.4%) on the PA radiographs and another 1/42 (2.4%) on the lateral radiographs. Diagnostic accuracy was low for younger children for all tested distances.
We propose utilizing a measurement rule to increase diagnostic accuracy for buckle fractures in children ≥7 years old. An isolated distal radius fracture in a child 7 years or older is not likely to be a buckle fracture if the fracture-to-physis distance is <1 cm.
The Global Thyroid Cancer Drugs Market has witnessed continuous growth in the past few years and is projected to grow even further during the forecast period ...
GAINESVILLE, Texas — For the past two weeks KGAF AM 1580 radio in Gainesville has been advertising a really "big" secret to be revealed Wednesday ...
CHICAGO — Patients with ankylosing spondylitis had an increased risk for melanoma, hematological malignancies, kidney and thyroid cancer but a reduced ...
Rwanda is a country of 12 million people with 41% of its population under the age of 14 years. Despite major improvements in health care since the 1994 genocide, pediatric neuroimaging in Rwanda remains challenging. Prenatal and advanced imaging techniques, such as magnetic resonance imaging (MRI), are not widespread. As a result, many children with neurological diseases present unexpectedly as newborns or are in advanced stages of disease at diagnosis. The goal of this essay is to describe some unique features of the practice of pediatric neuroradiology in Rwanda in 2018.
GAINESVILLE, Texas — For the past two weeks KGAF AM 1580 radio in Gainesville has been advertising a really "big" secret to be revealed Wednesday ...
CHICAGO — Patients with ankylosing spondylitis had an increased risk for melanoma, hematological malignancies, kidney and thyroid cancer but a reduced ...
The Global Thyroid Cancer Drugs Market has witnessed continuous growth in the past few years and is projected to grow even further during the forecast period ...
Treatment pathways for isolated distal radius fractures in children are becoming more tailored to specific fracture types and include different management plans for stable buckle fractures versus potentially unstable distal radius fractures.
To propose a measurement rule to aid in differentiating stable buckle fractures from other distal radius fractures in children.
A medical record search identified 203 children with closed distal radius fractures during a 14-month period. A consensus of two senior readers served as a reference standard to distinguish buckle fractures from other distal radius fractures. We measured fracture-to-physis distance on posteroanterior (PA) and lateral radiographs for each of the isolated distal radius fractures. We analyzed diagnostic accuracy, using fracture-to-physis distance as a predictor for buckle fractures, in children ages 3–16 years. We used a receiver operating characteristic (ROC) curve to determine the cut-off values tested.
There were 148 buckle fractures (73%) and 55 isolated potentially unstable distal radius fractures (27%). For children 7–16 years, buckle fracture-to-physis distance was <1 cm in only 1/106 (0.9%) on the PA projection and none on the lateral projection. Diagnostic accuracy for buckle fracture diagnosis was 82% using a cut-off of 14 mm (PA) and 13 mm (lateral). In children 3–6 years old, the buckle fracture-to-physis distance was <1 cm in 1/42 (2.4%) on the PA radiographs and another 1/42 (2.4%) on the lateral radiographs. Diagnostic accuracy was low for younger children for all tested distances.
We propose utilizing a measurement rule to increase diagnostic accuracy for buckle fractures in children ≥7 years old. An isolated distal radius fracture in a child 7 years or older is not likely to be a buckle fracture if the fracture-to-physis distance is <1 cm.
Rwanda is a country of 12 million people with 41% of its population under the age of 14 years. Despite major improvements in health care since the 1994 genocide, pediatric neuroimaging in Rwanda remains challenging. Prenatal and advanced imaging techniques, such as magnetic resonance imaging (MRI), are not widespread. As a result, many children with neurological diseases present unexpectedly as newborns or are in advanced stages of disease at diagnosis. The goal of this essay is to describe some unique features of the practice of pediatric neuroradiology in Rwanda in 2018.
Jiexia Wen, Xiangcai Meng, Bin Xuan, Tao Zhou, Heran Gao, Hui Dong, Yimin Wang (Source: Frontiers in Pharmacology)
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Jiexia Wen, Xiangcai Meng, Bin Xuan, Tao Zhou, Heran Gao, Hui Dong, Yimin Wang (Source: Frontiers in Pharmacology)
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Hypersensitivity pneumonitis (HP) is a TH1 lymphocyte –biased fibrosing alveolitis caused by antigens ranging from avian excreta, fungi, thermophilic bacteria, and protozoa to reactive chemicals found in the workplace. Mimicking a viral syndrome, acute exposures to inciting antigens cause abrupt onset of nonproductive cough, dyspnea, and chills with arthralgias or malaise usually from 4 to 8 hours later so that the temporal relationship between antigen exposure and symptoms might be unsuspected. The histology of HP reveals prominent lymphocyte infiltrates that thicken the alveolar septa with poorly formed granulomas or giant cells. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C7HVKK
Researchers with the Case Western Reserve University's School of Dental Medicine studied 18 HIV-positive people with head and neck cancer and found that ...
LIVINGSTON, NJ — Saint Barnabas Medical Center's (SBMC) Department of Radiation Oncology is the first in New Jersey to offer the Halcyon system for ...
In a recent article, Ba ïz et al1 reported on the presence of Der p 1 mite allergen in two-thirds of breast milk samples from French lactating mothers. Allergen levels in the milk were higher in mothers with a history of asthma or allergies, and children breast-fed by such mothers with high Der p 1 levels in the milk wer e at a significantly higher risk of asthma or allergic rhinitis when compared with children from mothers with low Der p 1 levels in the milk. In addition, a high amount of Der p 1 in the milk was associated with increased total serum IgE. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GbRKv2
Because house dust mites (HDMs) are found in the environment, they are mostly considered as a source of allergens involved in respiratory allergies. The works from Sanchez-Borges et al1 and others have demonstrated that HDMs can contaminate food, which can trigger allergic reactions including severe manifestations such as grade 4 anaphylaxis on its ingestion.2-4 These acute reactions are observed in patients who are already sensitized to HDMs. Our work further highlights that the first step for the development of allergy toward HDMs, that is, allergic sensitization, can be induced by oral exposure to HDMs through breast milk. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rAjVKc
LIVINGSTON, NJ — Saint Barnabas Medical Center's (SBMC) Department of Radiation Oncology is the first in New Jersey to offer the Halcyon system for ...
In a recent article, Ba ïz et al1 reported on the presence of Der p 1 mite allergen in two-thirds of breast milk samples from French lactating mothers. Allergen levels in the milk were higher in mothers with a history of asthma or allergies, and children breast-fed by such mothers with high Der p 1 levels in the milk wer e at a significantly higher risk of asthma or allergic rhinitis when compared with children from mothers with low Der p 1 levels in the milk. In addition, a high amount of Der p 1 in the milk was associated with increased total serum IgE. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GbRKv2
To a large extent, eosinophil recruitment in both homeostasis and allergy is dependent on the eotaxin family of chemokines. CCL11/eotaxin-1 was the first chemokine discovered to have high selectivity for eosinophils through use of a guinea pig model of allergic airway disease.1 After cloning of mouse and human eotaxin orthologues, CCR3 was identified as the eotaxin-1 receptor, which is expressed at high levels on the surfaces of eosinophils.2 Two other eotaxins, CCL24/eotaxin-2 and CCL26/eotaxin-3, were discovered, both showing high selectivity for CCR3. (Source: Journal of Allergy and Clinical Immunology)
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ADULT cancer patients can now be referred by the NHS for high energy proton beam therapy at a Newport centre that is the first to offer the…
Because house dust mites (HDMs) are found in the environment, they are mostly considered as a source of allergens involved in respiratory allergies. The works from Sanchez-Borges et al1 and others have demonstrated that HDMs can contaminate food, which can trigger allergic reactions including severe manifestations such as grade 4 anaphylaxis on its ingestion.2-4 These acute reactions are observed in patients who are already sensitized to HDMs. Our work further highlights that the first step for the development of allergy toward HDMs, that is, allergic sensitization, can be induced by oral exposure to HDMs through breast milk. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rAjVKc
Researchers with the Case Western Reserve University's School of Dental Medicine studied 18 HIV-positive people with head and neck cancer and found that ...
Hypersensitivity pneumonitis (HP) is a TH1 lymphocyte –biased fibrosing alveolitis caused by antigens ranging from avian excreta, fungi, thermophilic bacteria, and protozoa to reactive chemicals found in the workplace. Mimicking a viral syndrome, acute exposures to inciting antigens cause abrupt onset of nonproductive cough, dyspnea, and chills with arthralgias or malaise usually from 4 to 8 hours later so that the temporal relationship between antigen exposure and symptoms might be unsuspected. The histology of HP reveals prominent lymphocyte infiltrates that thicken the alveolar septa with poorly formed granulomas or giant cells. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C7HVKK
VANCOUVER — Huawei's chief financial officer says she has suffered a lifetime of health problems, including thyroid cancer, sleep apnea and high blood ...
ConclusionHSCT could be an alternative and curative therapeutic option for selectedSTAT1 GOF mutant patients with progressive life-threatening disease unresponsive to conventional therapy. Morbidity and mortality-causing complications included secondary graft failure, infections, and bleeding. (Source: Journal of Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rAjT52
The RAGE signaling pathway is involved in intestinal inflammation and represents a promising therapeutic target for Inflammatory Bowel Diseases, Published online: 12 December 2018; doi:10.1038/s41385-018-0119-zThe RAGE signaling pathway is involved in intestinal inflammation and represents a promising therapeutic target for Inflammatory Bowel Diseases (Source: Mucosal Immunology)
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Packaging in five major US grocery stores were tested for PFAS chemicals by environmental watchdogs. Two-thirds of takeout containers used for hot food and ...
Eosinophilic pneumonia (EP) is a rare and severe disease that belongs to the group of pulmonary eosinophilias (PE). There are two clinical presentations: chronic eosinophilic pneumonia (CEP) and acute eosinophilic pneumonia (AEP). In 1989, Allen et al. described the first case of AEP. 1 Many causes of AEP have been described, although the idiopathic form is the most common.3 We herein present a case of AEP probably due to piperacillin/tazobactam (P/T). (Source: Annals of Allergy, Asthma and Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Gegnrc
Women are more at risk than men, with one in eight women developing thyroid problems in her lifetime, especially after pregnancy and menopause. If you notice ...
The incidence of IgE sensitization and associated diseases has been on the rise since the late 19th century reaching epidemic proportions in the current era.1 This increase has occurred over just four generations, a rate that far exceeds the rate at which genetics alone could account for the change. Explaining the cause for this epidemic has proven to be a challenge for epidemiologists, scientists and clinical researchers alike. In 1980, David Strachan proposed the well-known "hygiene hypothesis" which proposed that the increase in hay fever and eczema was a result of the decrease in "opportunity for cross infection in young families" at least partially caused by higher standards of personal cleanliness. (Source: Annals of Allergy, Asthma and Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rwN8pj
In a recent article, Ba ïz et al1 reported on the presence of Der p 1 mite allergen in two-thirds of breast milk samples from French lactating mothers. Allergen levels in the milk were higher in mothers with a history of asthma or allergies, and children breast-fed by such mothers with high Der p 1 levels in the milk wer e at a significantly higher risk of asthma or allergic rhinitis when compared with children from mothers with low Der p 1 levels in the milk. In addition, a high amount of Der p 1 in the milk was associated with increased total serum IgE. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GbRKv2
In the last two decades allergic diseases have seen a rise worldwide with children suffering the highest burden of the condition(1). Food allergies, eczema and asthma are the most common allergic disorders in children(1-2). The increasing burden of allergic conditions is an important public health concern and understanding how to prevent the development of allergic diseases is a vital area of research. (Source: Annals of Allergy, Asthma and Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rx5VRc
Asthma was first described by Hippocrates as a disease of breathlessness, potentially caused by emotional distress1. The 17th century writings of Sir John Floyer describe bronchial constriction and the concepts of attacks and triggers2. In the 20th century, mounting evidence led to the characterization of asthma as an inflammatory condition2. Asthma symptoms were recognized as narrowing of the airways with distinctive sputum and swelling of the bronchial mucous membranes, triggered by a variety of circumstances or exposures that stimulate immune cells2. (Source: Annals of Allergy, Asthma and Immunology)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Because house dust mites (HDMs) are found in the environment, they are mostly considered as a source of allergens involved in respiratory allergies. The works from Sanchez-Borges et al1 and others have demonstrated that HDMs can contaminate food, which can trigger allergic reactions including severe manifestations such as grade 4 anaphylaxis on its ingestion.2-4 These acute reactions are observed in patients who are already sensitized to HDMs. Our work further highlights that the first step for the development of allergy toward HDMs, that is, allergic sensitization, can be induced by oral exposure to HDMs through breast milk. (Source: Journal of Allergy and Clinical Immunology)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
ConclusionSerine protease inAlternaria altered nasal epithelial barrier function. Intracellular ROS induced byAlternaria may influence the barrier function of nasal epithelial cells and enhance the inflammatory process of nasal mucosa. (Source: International Forum of Allergy and Rhinology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rBdvdP
IL-10 signaling prevents gluten-dependent intraepithelial CD4<sup>+</sup> cytotoxic T lymphocyte infiltration and epithelial damage in the small intestine, Published online: 12 December 2018; doi:10.1038/s41385-018-0118-0IL-10 signaling prevents gluten-dependent intraepithelial CD4+ cytotoxic T lymphocyte infiltration and epithelial damage in the small intestine (Source: Mucosal Immunology)
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ConclusionPerforming ESS with IIb+SS provides similar irrigation delivery benefits to ESS with EMLP, without the need for altering natural sinus outflow and creating circumferential scarring. Further studies evaluating its use in patients that are high risk for revision surgery are needed. (Source: International Forum of Allergy and Rhinology)
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Eosinophilic pneumonia (EP) is a rare and severe disease that belongs to the group of pulmonary eosinophilias (PE). There are two clinical presentations: chronic eosinophilic pneumonia (CEP) and acute eosinophilic pneumonia (AEP). In 1989, Allen et al. described the first case of AEP. 1 Many causes of AEP have been described, although the idiopathic form is the most common.3 We herein present a case of AEP probably due to piperacillin/tazobactam (P/T). (Source: Annals of Allergy, Asthma and Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Gegnrc
Asthma was first described by Hippocrates as a disease of breathlessness, potentially caused by emotional distress1. The 17th century writings of Sir John Floyer describe bronchial constriction and the concepts of attacks and triggers2. In the 20th century, mounting evidence led to the characterization of asthma as an inflammatory condition2. Asthma symptoms were recognized as narrowing of the airways with distinctive sputum and swelling of the bronchial mucous membranes, triggered by a variety of circumstances or exposures that stimulate immune cells2. (Source: Annals of Allergy, Asthma and Immunology)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
ConclusionPerforming ESS with IIb+SS provides similar irrigation delivery benefits to ESS with EMLP, without the need for altering natural sinus outflow and creating circumferential scarring. Further studies evaluating its use in patients that are high risk for revision surgery are needed. (Source: International Forum of Allergy and Rhinology)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Women are more at risk than men, with one in eight women developing thyroid problems in her lifetime, especially after pregnancy and menopause. If you notice ...
Packaging in five major US grocery stores were tested for PFAS chemicals by environmental watchdogs. Two-thirds of takeout containers used for hot food and ...
In the last two decades allergic diseases have seen a rise worldwide with children suffering the highest burden of the condition(1). Food allergies, eczema and asthma are the most common allergic disorders in children(1-2). The increasing burden of allergic conditions is an important public health concern and understanding how to prevent the development of allergic diseases is a vital area of research. (Source: Annals of Allergy, Asthma and Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rx5VRc
Because house dust mites (HDMs) are found in the environment, they are mostly considered as a source of allergens involved in respiratory allergies. The works from Sanchez-Borges et al1 and others have demonstrated that HDMs can contaminate food, which can trigger allergic reactions including severe manifestations such as grade 4 anaphylaxis on its ingestion.2-4 These acute reactions are observed in patients who are already sensitized to HDMs. Our work further highlights that the first step for the development of allergy toward HDMs, that is, allergic sensitization, can be induced by oral exposure to HDMs through breast milk. (Source: Journal of Allergy and Clinical Immunology)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
ConclusionHSCT could be an alternative and curative therapeutic option for selectedSTAT1 GOF mutant patients with progressive life-threatening disease unresponsive to conventional therapy. Morbidity and mortality-causing complications included secondary graft failure, infections, and bleeding. (Source: Journal of Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rAjT52
IL-10 signaling prevents gluten-dependent intraepithelial CD4<sup>+</sup> cytotoxic T lymphocyte infiltration and epithelial damage in the small intestine, Published online: 12 December 2018; doi:10.1038/s41385-018-0118-0IL-10 signaling prevents gluten-dependent intraepithelial CD4+ cytotoxic T lymphocyte infiltration and epithelial damage in the small intestine (Source: Mucosal Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GbZ3mM
ConclusionSerine protease inAlternaria altered nasal epithelial barrier function. Intracellular ROS induced byAlternaria may influence the barrier function of nasal epithelial cells and enhance the inflammatory process of nasal mucosa. (Source: International Forum of Allergy and Rhinology)
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The RAGE signaling pathway is involved in intestinal inflammation and represents a promising therapeutic target for Inflammatory Bowel Diseases, Published online: 12 December 2018; doi:10.1038/s41385-018-0119-zThe RAGE signaling pathway is involved in intestinal inflammation and represents a promising therapeutic target for Inflammatory Bowel Diseases (Source: Mucosal Immunology)
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Thomas Powles MBBS, MRCP, MD, discusses the changes to the frontline landscape of bladder cancer and where research should focus moving forward.
Thomas Powles MBBS, MRCP, MD, discusses the changes to the frontline landscape of bladder cancer and where research should focus moving forward.
State Sen. Margaret O'Brien, left, and state Rep. Beth Griffin hand out free bottled water to residents at the Parchment High School, Friday, July 27, 2018.
State Sen. Margaret O'Brien, left, and state Rep. Beth Griffin hand out free bottled water to residents at the Parchment High School, Friday, July 27, 2018.
As the new year approaches—potentially along with a new round of referrals—it's a good time to prepare for new students who have yet to be identified for speech and language issues. Maybe it's a new transfer student or a student receiving multi-tiered systems of support or one on a "watch" list. Handling new referrals involves one particularly sensitive task—planning those conversations with parents about their child. We must strike a careful balance of stating facts, giving our clinical opinion and remaining empathetic to the parent and their perspective. Explaining Language Skill Development to Parents Using a House-Building Analogy My 4 Favorite Tips to Involve Parents in Treatment Help Parents Replace Screen Time With Talking I find the following tips useful in hand...
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As the new year approaches—potentially along with a new round of referrals—it's a good time to prepare for new students who have yet to be identified for speech and language issues. Maybe it's a new transfer student or a student receiving multi-tiered systems of support or one on a "watch" list. Handling new referrals involves one particularly sensitive task—planning those conversations with parents about their child. We must strike a careful balance of stating facts, giving our clinical opinion and remaining empathetic to the parent and their perspective. Explaining Language Skill Development to Parents Using a House-Building Analogy My 4 Favorite Tips to Involve Parents in Treatment Help Parents Replace Screen Time With Talking I find the following tips useful in hand...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
DUBLIN, Dec. 12, 2018 /PRNewswire/ -- The "World Market for Precision Cancer Diagnostic Tests" report has been added to ResearchAndMarkets.com's ...
DUBLIN, Dec. 12, 2018 /PRNewswire/ -- The "World Market for Precision Cancer Diagnostic Tests" report has been added to ResearchAndMarkets.com's ...
Publication date: December 2018Source: Operative Techniques in Otolaryngology-Head and Neck Surgery, Volume 29, Issue 4Author(s): (Source: Operative Techniques in Otolaryngology Head and Neck Surgery)
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Publication date: December 2018Source: Operative Techniques in Otolaryngology-Head and Neck Surgery, Volume 29, Issue 4Author(s): (Source: Operative Techniques in Otolaryngology Head and Neck Surgery)
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The $2.1 million grant will be used to look into the role blood platelets play in the body's natural defense against an infection commonly called "Thrush."
The $2.1 million grant will be used to look into the role blood platelets play in the body's natural defense against an infection commonly called "Thrush."
The respect of diet and lifestyle modifications could be associated with better improvement of laryngopharyngeal symptoms, perceptual dysphonia, and acoustic measurements.
The potential positive impact of alkaline, protein, low‐fat, low‐acid diet could be explained by many physiological effects on esophageal sphincter tonicity, acid and pepsin productions, and gastric emptying time.
Future controlled prospective studies are needed to confirm the potential key role of alkaline, protein, low‐fat, low‐acid diet and lifestyle modifications in the clinical improvement of patients with suspected LPR disease.
This article is protected by copyright. All rights reserved.
There is accumulating evidence for multifaceted roles of cysteinyl leukotrienes (CysLTs) and their receptors in allergic diseases. In asthma, CysLT C4, D4, and E4 are well known to modulate airway inflammation and airway remodeling [1, 2]. CysLTs exert their effects through interacting with receptors which belong to the G-protein-coupled receptor, termed CysLTR1 and CysLTR2 [3] to induce inflammatory responses, such as recruitment of inflammatory cells, cell-cell adhesion, vascular leakage, and platelet activation in asthma [4-7]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
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AbstractMany epidemiological studies have associated bioaerosol exposures with a variety of adverse health effects; however, the role of bioaerosol components in the development and manifestation of hypersensitivity and non-infectious respiratory diseases remains unclear. Despite many studies which have examined allergic responses to bioaerosols, less is known about non-allergenic effects. In order to elucidate the mechanisms by which bioaerosols can exert non-atopic stresses on a cellular level, there is a need for improving existing in vitro approaches. In response, a cohort of toxicology assays were optimized to create a robust analytical suite for studying the effects that biogenic atmospheric pollutants generate on two model human lung cell lines (A549 epithelial line and GDM-1 immatu...
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DUBLIN, Dec. 12, 2018 /PRNewswire/ -- The "World Market for Precision Cancer Diagnostic Tests" report has been added to ResearchAndMarkets.com's ...
The respect of diet and lifestyle modifications could be associated with better improvement of laryngopharyngeal symptoms, perceptual dysphonia, and acoustic measurements.
The potential positive impact of alkaline, protein, low‐fat, low‐acid diet could be explained by many physiological effects on esophageal sphincter tonicity, acid and pepsin productions, and gastric emptying time.
Future controlled prospective studies are needed to confirm the potential key role of alkaline, protein, low‐fat, low‐acid diet and lifestyle modifications in the clinical improvement of patients with suspected LPR disease.
This article is protected by copyright. All rights reserved.
AbstractMany epidemiological studies have associated bioaerosol exposures with a variety of adverse health effects; however, the role of bioaerosol components in the development and manifestation of hypersensitivity and non-infectious respiratory diseases remains unclear. Despite many studies which have examined allergic responses to bioaerosols, less is known about non-allergenic effects. In order to elucidate the mechanisms by which bioaerosols can exert non-atopic stresses on a cellular level, there is a need for improving existing in vitro approaches. In response, a cohort of toxicology assays were optimized to create a robust analytical suite for studying the effects that biogenic atmospheric pollutants generate on two model human lung cell lines (A549 epithelial line and GDM-1 immatu...
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CONCLUSIONS Our study found that adherence to SCIT is low in a real-life setting in southeast Turkey, similar to most previous adherence studies. PMID: 30537763 [PubMed - in process] (Source: Medical Science Monitor)
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There is accumulating evidence for multifaceted roles of cysteinyl leukotrienes (CysLTs) and their receptors in allergic diseases. In asthma, CysLT C4, D4, and E4 are well known to modulate airway inflammation and airway remodeling [1, 2]. CysLTs exert their effects through interacting with receptors which belong to the G-protein-coupled receptor, termed CysLTR1 and CysLTR2 [3] to induce inflammatory responses, such as recruitment of inflammatory cells, cell-cell adhesion, vascular leakage, and platelet activation in asthma [4-7]. (Source: Prostaglandins, Leukotrienes and Essential Fatty Acids)
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DUBLIN, Dec. 12, 2018 /PRNewswire/ -- The "World Market for Precision Cancer Diagnostic Tests" report has been added to ResearchAndMarkets.com's ...
As the new year approaches—potentially along with a new round of referrals—it's a good time to prepare for new students who have yet to be identified for speech and language issues. Maybe it's a new transfer student or a student receiving multi-tiered systems of support or one on a "watch" list. Handling new referrals involves one particularly sensitive task—planning those conversations with parents about their child. We must strike a careful balance of stating facts, giving our clinical opinion and remaining empathetic to the parent and their perspective. Explaining Language Skill Development to Parents Using a House-Building Analogy My 4 Favorite Tips to Involve Parents in Treatment Help Parents Replace Screen Time With Talking I find the following tips useful in hand...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rASQGw
As the new year approaches—potentially along with a new round of referrals—it's a good time to prepare for new students who have yet to be identified for speech and language issues. Maybe it's a new transfer student or a student receiving multi-tiered systems of support or one on a "watch" list. Handling new referrals involves one particularly sensitive task—planning those conversations with parents about their child. We must strike a careful balance of stating facts, giving our clinical opinion and remaining empathetic to the parent and their perspective. Explaining Language Skill Development to Parents Using a House-Building Analogy My 4 Favorite Tips to Involve Parents in Treatment Help Parents Replace Screen Time With Talking I find the following tips useful in hand...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2rASQGw
Conclusion: this study describes and examines the incipient inclusion of SLH professionals in CEREST, providing evidence that indicates regional inequalities and reveals that, despite generally working in health surveillance activities, there remain units where the SLH professionals are only dedicated to specialized care.RESUMO Objetivo: investigar a presen ça do fonoaudiólogo na equipe dos Centros de Referência em Saúde do Trabalhador (Cerest) do Brasil, sua distribuição e características de sua inserção e das ações desenvolvidas. Métodos: estudo epidemiológico descritivo que teve como unidades de observação todos os Cerest do País. D ados primários foram coletados por meio da aplicação de questionário ao coordenador do Cerest ou a um representante designado. Resultado...
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Publication date: Available online 11 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Liza Yue Cruz, Di Wang, Jiwei LiuAbstractSelinium nanoparticles (SeNPs) with minimal toxicity and efficient antioxidant properties were reported earlier for their anti-carcinogenic influence against various types of cancers, thus elevating its potential. In the present study, the anti-carcinogenic effect of selenium nanoparticles against lung cancer was studied. Selenium nanoparticles were biosynthesized and were characterized using UV- Vis absorption spectroscopy. A decrease in the absorption intensity was recorded with the increase in time, which represented the protein consumption during the reduction of SeO32− to Se0. The calculated average crystalline size from ...
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The objective of this study was to characterize the severity of Autism Spectrum Disorder in an adolescent, pre-and post-speech-language therapy, and describe the process of speech-language intervention using Picture Exchange Communication System allied to the principles of behavioral analysis applied to language. The Autism Treatment Evaluation Checklist with the parents was applied. Then, a therapeutic program of 14 sessions of 50 minutes was developed, one per week, and then the questionnaire was reapplied. In the course of the therapeutic process, it was possible to observe an increase in the number of figure exchanges independently, an increase in the number of vocalizations with communicative intention or functional speech, longer time of visual contact and social smile, reduction of ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C7G5cT
Publication date: Available online 11 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Gabriela Adriana Filip, Bianca Moldovan, Ioana Baldea, Diana Olteanu, Ramona Suharoschi, Nicoleta Decea, Cristina Mihaela Cismaru, Emese Gal, Mihai Cenariu, Simona Clichici, Luminita DavidAbstractThe purpose of our study is to investigate the comparative effects of materials based on silver and gold nanoparticles functionalized with polyphenols from Cornus Mas extract (AgNPs-CM and AuNPs-CM) in vivo on experimental inflammation. The nanoparticles were obtained at room temperature under UV irradiation and were characterized by different methods: ultraviolet-visible spectroscopy, transmission electron microscopy, X ray diffraction, Fourier transform infrared spectroscopy...
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Publication date: Available online 12 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Rajesh Pandiyan, Shanmugam Mahalingam, Young-Ho AhnAbstractBacterial and dye pollution are major problems with wastewater treatment. An increasing number of photocatalysts are being used in industry to kill bacterial and reduce pollution. In the present study, highly stable SnO2-doped nanocomposites have been prepared successively by a hydrothermal method. The synthesized nanocomposite was characterized using a range of techniques, such as X-ray diffraction, field emission scanning electron microscopy with energy dispersive X-ray spectroscopy and electron probe micro analysis, ultraviolet–visible spectroscopy, Fourier transform infrared spectroscopy, and high resolut...
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Publication date: Available online 10 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Akihiro Shirai, Yu-ko YasutomoAbstractThe bactericidal activity of ferulic acid (FA) against various microorganisms was remarkably enhanced by ultraviolet-A (UV-A) irradiation (wavelength, 365 nm). However, the bactericidal mechanism in the photo-combination system has not been evaluated. In the present study, this combined treatment was characterized by investigating associated changes in cellular functions of Escherichia coli, including assessments of respiratory activity, lipid peroxidation, membrane permeability, and damage to DNA and the cell surface. FA adsorbed onto and was incorporated into bacterial membranes, and the affinity resulted in decreased respirato...
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Publication date: April 2019Source: Journal of Memory and Language, Volume 105Author(s): Kenneth R. Paap, Regina Anders-Jefferson, Roman Mikulinsky, Shigeaki Masuda, Lauren MasonAbstractOne purpose of this study was to test the hypothesis that prevalent patterns of bilingual language control lead to greater enhancement of the ability to resolve Stimulus-Stimulus conflict compared to Stimulus-Response conflict. To that end 104 bilinguals and 62 monolinguals completed four commonly used nonverbal interference tasks with varied S-S and S-R incompatibilities. No bilingual advantages were observed in any of the tasks. A second purpose was to further investigate whether a general inhibitory-control ability exists by examining inter-task correlations in the current and previous studies. We conclu...
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Publication date: Available online 11 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Liza Yue Cruz, Di Wang, Jiwei LiuAbstractSelinium nanoparticles (SeNPs) with minimal toxicity and efficient antioxidant properties were reported earlier for their anti-carcinogenic influence against various types of cancers, thus elevating its potential. In the present study, the anti-carcinogenic effect of selenium nanoparticles against lung cancer was studied. Selenium nanoparticles were biosynthesized and were characterized using UV- Vis absorption spectroscopy. A decrease in the absorption intensity was recorded with the increase in time, which represented the protein consumption during the reduction of SeO32− to Se0. The calculated average crystalline size from ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2LcPHpp
Conclusion: this study describes and examines the incipient inclusion of SLH professionals in CEREST, providing evidence that indicates regional inequalities and reveals that, despite generally working in health surveillance activities, there remain units where the SLH professionals are only dedicated to specialized care.RESUMO Objetivo: investigar a presen ça do fonoaudiólogo na equipe dos Centros de Referência em Saúde do Trabalhador (Cerest) do Brasil, sua distribuição e características de sua inserção e das ações desenvolvidas. Métodos: estudo epidemiológico descritivo que teve como unidades de observação todos os Cerest do País. D ados primários foram coletados por meio da aplicação de questionário ao coordenador do Cerest ou a um representante designado. Resultado...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
The objective of this study was to characterize the severity of Autism Spectrum Disorder in an adolescent, pre-and post-speech-language therapy, and describe the process of speech-language intervention using Picture Exchange Communication System allied to the principles of behavioral analysis applied to language. The Autism Treatment Evaluation Checklist with the parents was applied. Then, a therapeutic program of 14 sessions of 50 minutes was developed, one per week, and then the questionnaire was reapplied. In the course of the therapeutic process, it was possible to observe an increase in the number of figure exchanges independently, an increase in the number of vocalizations with communicative intention or functional speech, longer time of visual contact and social smile, reduction of ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C7G5cT
Publication date: Available online 11 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Gabriela Adriana Filip, Bianca Moldovan, Ioana Baldea, Diana Olteanu, Ramona Suharoschi, Nicoleta Decea, Cristina Mihaela Cismaru, Emese Gal, Mihai Cenariu, Simona Clichici, Luminita DavidAbstractThe purpose of our study is to investigate the comparative effects of materials based on silver and gold nanoparticles functionalized with polyphenols from Cornus Mas extract (AgNPs-CM and AuNPs-CM) in vivo on experimental inflammation. The nanoparticles were obtained at room temperature under UV irradiation and were characterized by different methods: ultraviolet-visible spectroscopy, transmission electron microscopy, X ray diffraction, Fourier transform infrared spectroscopy...
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
Publication date: January 2019Source: Journal of Phonetics, Volume 72Author(s): Taehong Cho, D.H. Whalen, Gerard DochertyAbstractIn this special collection entitled Marking 50 Years of Research on Voice Onset Time and the Voicing Contrast in the World's Languages, we have compiled eleven studies investigating the voicing contrast in 19 languages. The collection provides extensive data obtained from 270 speakers across those languages, examining VOT and other acoustic, aerodynamic and articulatory measures. The languages studied may be divided into four groups: 'aspirating' languages with a two-way contrast (English, three varieties of German); 'true voicing' languages with a two-way contrast (Russian, Turkish, Brazilian Portuguese, two Iranian languages Pashto and Wakhi); languag...
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Publication date: Available online 12 December 2018Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Rajesh Pandiyan, Shanmugam Mahalingam, Young-Ho AhnAbstractBacterial and dye pollution are major problems with wastewater treatment. An increasing number of photocatalysts are being used in industry to kill bacterial and reduce pollution. In the present study, highly stable SnO2-doped nanocomposites have been prepared successively by a hydrothermal method. The synthesized nanocomposite was characterized using a range of techniques, such as X-ray diffraction, field emission scanning electron microscopy with energy dispersive X-ray spectroscopy and electron probe micro analysis, ultraviolet–visible spectroscopy, Fourier transform infrared spectroscopy, and high resolut...
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Publication date: April 2019Source: Journal of Memory and Language, Volume 105Author(s): Kenneth R. Paap, Regina Anders-Jefferson, Roman Mikulinsky, Shigeaki Masuda, Lauren MasonAbstractOne purpose of this study was to test the hypothesis that prevalent patterns of bilingual language control lead to greater enhancement of the ability to resolve Stimulus-Stimulus conflict compared to Stimulus-Response conflict. To that end 104 bilinguals and 62 monolinguals completed four commonly used nonverbal interference tasks with varied S-S and S-R incompatibilities. No bilingual advantages were observed in any of the tasks. A second purpose was to further investigate whether a general inhibitory-control ability exists by examining inter-task correlations in the current and previous studies. We conclu...
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Previous studies on the impact of wait times for endoscopic sinus surgery (ESS) in medically recalcitrant chronic rhinosinusitis (rCRS) have not examined its influence on the 5 distinct symptoms domains of the 22‐item Sino‐Nasal Outcome Test (SNOT‐22), and have not applied evidence‐based surgical indications. Our primary study objective was to investigate the impact of ESS wait times on postoperative SNOT‐22 global and symptom domain scores in patients with rCRS deemed "appropriate" surgical candidates.
This was a retrospective analysis of adult patients with rCRS undergoing ESS, categorized as "appropriate" surgical candidates. Primary outcome measure was change in SNOT‐22 global/symptom domain score (preoperative – 6‐month postoperative). Correlational analyses were performed between wait time and change in SNOT‐22 global and symptom domain scores. For significant negative correlations, the threshold wait time to generate a worsening in health‐related quality‐of‐life (HRQoL) equivalent to the mean clinically important difference (MCID) was calculated.
A total of 104 patients with a mean ± standard deviation (SD) wait time of 310.8 ± 155.9 days were analyzed. Postoperative SNOT‐22 global and symptom domain scores significantly improved postoperatively. Wait time for ESS was negatively correlated with change in SNOT‐22 global, rhinologic, extranasal rhinologic, and ear/facial domain scores (p < 0.05), and a wait time threshold of 287, 452, 421, and 381 days corresponded to a decrease equivalent to the MCID, respectively.
We identified less improvement in HRQoL after ESS with increasing surgical wait time. Moreover, prolonged wait times may result in less improvement in disease‐specific symptoms, but do not appear to worsen psychological or sleep dysfunction.
Christina El Moussa from 'Flip or Flop' fame got her start studying design in college, along with a business degree that helped in her later house-flipping ...
When you gear up and approach the start line, know that there will be hurdles but don't give up.
Previous studies have demonstrated a high failure rate of endoscopic sinus surgery (ESS) with Draf IIa in patients with diffuse polyposis, asthma, and aspirin‐exacerbated respiratory disease. A high percentage of these patients progress to endoscopic modified Lothrop procedure (EMLP). We describe a modification of the Draf IIb with a superior septectomy (IIb+SS), which may provide similar therapeutic benefit as demonstrated by the distribution of sinus irrigations in the sinus cavity with ESS with IIb+SS vs ESS with EMLP IIb+SS vs ESS with EMLP.
ESS with IIb+SS was performed on 6 cadaver heads. Fluorescein‐dyed irrigations were performed on each head and penetration was recorded using video endoscopy. EMLP was subsequently performed on each head with repeat dye‐irrigation and video endoscopy. The videos were reviewed by 4 blinded fellowship‐trained rhinologists, and irrigant penetration of the maxillary, ethmoid, frontal, sphenoid sinuses, and olfactory cleft was graded 0 to 3 (3 implying complete staining).
The mean scores when comparing IIb+SS to EMLP were as follows: overall 1.99 vs 1.97 (p = 0.816), maxillary sinus 2.67 vs 2.38 (p = 0.128), ethmoid sinus 1.88 vs 1.98 (p = 0.536), sphenoid sinus 2.58 vs 2.50 (p = 0.467), frontal sinus 1.13 vs 1.38 (p = 0.073), and olfactory cleft 1.71 vs 1.63 (p = 0.529). There was no significant difference between subsites. Interrater reliability was good (Cronbach's alpha = 0.781).
Performing ESS with IIb+SS provides similar irrigation delivery benefits to ESS with EMLP, without the need for altering natural sinus outflow and creating circumferential scarring. Further studies evaluating its use in patients that are high risk for revision surgery are needed.
Upper airway barrier dysfunction has been associated with chronic rhinosinusitis and allergic rhinitis. Alternaria is commonly found in nasal secretion and plays a role in the pathogenesis of airway diseases. The aim of this study was to investigate the effects of Alternaria on the junctional complex of nasal epithelial cells.
Air‐liquid interface nasal epithelial cultures from the inferior turbinate of septal surgery patients were stimulated with Alternaria alternate. Production of intracellular reactive oxygen species (ROS) and transepithelial resistance (TER) was measured. The expression of tight junction (TJ) and adherens junction (AJ) molecules was determined using real‐time reverse transcriptase‐polymerase chain reaction, Western blot analysis, and confocal microscopy. Protease activity in Alternaria was determined using protease inhibitors and heat inactivation.
Alternaria enhanced the production of ROS and reduced the TER. Alternaria decreased the messenger RNA and protein expression of TJs (zonula occludens‐1, occludin, and claudin‐1), but did not influence the AJ molecule. When Alternaria was pretreated with serine protease inhibitor and heat inactivation, ROS, TER, and TJ molecule expression returned to their nonstimulated levels.
Serine protease in Alternaria altered nasal epithelial barrier function. Intracellular ROS induced by Alternaria may influence the barrier function of nasal epithelial cells and enhance the inflammatory process of nasal mucosa.
Healthcare disparities related to socioeconomic factors may adversely impact disease states and treatment outcomes. Among patients with chronic rhinosinusitis (CRS), the impact of socioeconomic factors on outcomes following endoscopic sinus surgery (ESS) remains uncertain.
Adult patients with refractory CRS were prospectively enrolled into an observational, multi‐institutional cohort study between March 2011 and June 2015. Socioeconomic factors analyzed included household income, insurance status, years of education completed, race, age, and ethnicity. Income was stratified according to the Thompson and Hickey model. The 22‐item Sino‐Nasal Outcome Test (SNOT‐22) and Brief Smell Identification Test (BSIT) were completed preoperatively and postoperatively.
A total of 392 patients met inclusion criteria. Higher age and male gender were associated with better mean preoperative SNOT‐22 scores (both p < 0.02), whereas Medicare insurance status and male gender were associated with worse preoperative mean BSIT scores (both p < 0.02). Postoperatively, higher household income ($100,001+/year) and lower age were associated with a greater likelihood of improving at least 1 minimal clinically important difference (MCID) on SNOT‐22 scores (OR = 2.40 and 1.03, respectively, both p < 0.05), while no factors were associated with increased odds of achieving a MCID on BSIT scores.
Preoperative olfactory function and postoperative quality of life (QOL) improvement were associated with metrics of socioeconomic status in patients with CRS electing ESS. The odds of experiencing a clinically meaningful QOL improvement were more than twice as likely for patients with the highest household income level compared to other income tiers. Further investigation is warranted to identify barriers to postoperative improvement.
