The "Thyroid Function Test Market - Forecasts From 2018 to 2023" report has been added to ResearchAndMarkets.com's offering. The Thyroid Function Test ...
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Πέμπτη 20 Δεκεμβρίου 2018
The Global Thyroid Function Test Market to 2023: A $2+ Billion Opportunity - EIN News
The Global Thyroid Function Test Market to 2023: A $2+ Billion Opportunity EIN News
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The Global Thyroid Function Test Market to 2023: A $2+ Billion Opportunity - EIN News
The Global Thyroid Function Test Market to 2023: A $2+ Billion Opportunity EIN News
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The "Thyroid Function Test Market - Forecasts From 2018 to 2023" report has been added to ResearchAndMarkets.com's offering. The Thyroid Function Test ...
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Interpace Diagnostics Group (IDXG) Given a $3.00 Price Target by HC Wainwright Analysts - Fairfield Current
Interpace Diagnostics Group (NASDAQ:IDXG) received a $3.00 target price from HC Wainwright in a research report issued on Tuesday, November 27th.
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Thyroid Cancer Treatment Market Analysis and In-depth Research on Market Size, Trends, Emerging Growth Factors and Regional Forecasts to 2025 - DigiTribune
Thyroid Cancer Treatment Market Report covers the manufacturers data, including: shipment, price, revenue, gross profit, interview record, business distribution ...
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Interpace Diagnostics Group (IDXG) Given a $3.00 Price Target by HC Wainwright Analysts - Fairfield Current
Interpace Diagnostics Group (NASDAQ:IDXG) received a $3.00 target price from HC Wainwright in a research report issued on Tuesday, November 27th.
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Thyroid Cancer Treatment Market Analysis and In-depth Research on Market Size, Trends, Emerging Growth Factors and Regional Forecasts to 2025 - DigiTribune
Thyroid Cancer Treatment Market Report covers the manufacturers data, including: shipment, price, revenue, gross profit, interview record, business distribution ...
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Transgene Completes Safety and Tolerability Assessment of TG4001 in Combination with Avelumab in Phase 1b Part of Trial in HPV-Positive Cancer Patients - BioSpace
STRASBOURG, France--(BUSINESS WIRE)-- Regulatory News: Transgene (Paris:TNG), a biotechnology company that designs and develops virus-based ...
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Transgene Completes Safety and Tolerability Assessment of TG4001 in Combination with Avelumab in Phase 1b Part of Trial in HPV-Positive Cancer Patients - BioSpace
STRASBOURG, France--(BUSINESS WIRE)-- Regulatory News: Transgene (Paris:TNG), a biotechnology company that designs and develops virus-based ...
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Thyroid Cancer Drugs Market Projected to be Resilient by 2026 - Coherent Chronicle
Thyroid Cancer Drugs Market Projected to be Resilient by 2026 Coherent Chronicle
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The Global business research report published on "Thyroid Cancer Drugs Market – Growth Drivers, Challenges Ahead, Industry Insights , Supply, Revenue ...
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Thyroid Cancer Drugs Market Projected to be Resilient by 2026 - Coherent Chronicle
Thyroid Cancer Drugs Market Projected to be Resilient by 2026 Coherent Chronicle
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The Global business research report published on "Thyroid Cancer Drugs Market – Growth Drivers, Challenges Ahead, Industry Insights , Supply, Revenue ...
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Rakuten Aspyrian Closes $284 Million Series C Financing for Late-Stage Oncology Pipeline - PRNewswire
Rakuten Aspyrian Closes $284 Million Series C Financing for Late-Stage Oncology Pipeline PRNewswire
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SAN FRANCISCO, Dec. 20, 2018 /PRNewswire/ -- Rakuten Aspyrian, a biotechnology company developing precision-targeted cancer therapies based on its ...
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Rakuten Aspyrian Closes $284 Million Series C Financing for Late-Stage Oncology Pipeline - PRNewswire
Rakuten Aspyrian Closes $284 Million Series C Financing for Late-Stage Oncology Pipeline PRNewswire
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SAN FRANCISCO, Dec. 20, 2018 /PRNewswire/ -- Rakuten Aspyrian, a biotechnology company developing precision-targeted cancer therapies based on its ...
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Prognostic impact of initial treatment in surgically salvaged recurrences of early glottic cancer - MD Linx
Prognostic impact of initial treatment in surgically salvaged recurrences of early glottic cancer MD Linx
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The Laryngoscope — Locatello LG, et al. | December 20, 2018. Advertisement. Researchers analyzed 27 subjects who had transoral laser microsurgery (TLM) ...
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Research Associate in Soft Robotic Implantable Medical Devices job with UNIVERSITY OF BRISTOL | 125823 - Times Higher Education (THE)
Research Associate in Soft Robotic Implantable Medical Devices job with UNIVERSITY OF BRISTOL | 125823 Times Higher Education (THE)
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Division/School School of Computer Science, Electrical and Electronic Engineering and Engineering Maths Contract type Open Ended Working pattern Full time
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Prognostic impact of initial treatment in surgically salvaged recurrences of early glottic cancer - MD Linx
Prognostic impact of initial treatment in surgically salvaged recurrences of early glottic cancer MD Linx
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The Laryngoscope — Locatello LG, et al. | December 20, 2018. Advertisement. Researchers analyzed 27 subjects who had transoral laser microsurgery (TLM) ...
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Research Associate in Soft Robotic Implantable Medical Devices job with UNIVERSITY OF BRISTOL | 125823 - Times Higher Education (THE)
Research Associate in Soft Robotic Implantable Medical Devices job with UNIVERSITY OF BRISTOL | 125823 Times Higher Education (THE)
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Division/School School of Computer Science, Electrical and Electronic Engineering and Engineering Maths Contract type Open Ended Working pattern Full time
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Evaluation of the lingual fracture patterns after bilateral sagittal split osteotomy according to Hunsuck/Epker modified by an additional inferior border osteotomy using a burr or ultrasonic device
This study was conducted to compare fracture patterns and operation times after sagittal split osteotomy (SSO) by Hunsuck/Epker approach, performed using a burr or ultrasonic device, with and without osteotomy modification. A total of 80 SSOs were performed in fresh human cadavers using a burr or ultrasonic device to investigate the influence of surgical instruments as well as an additional bone cut on the inferior border of the mandible in terms of lingual fracture patterns. The times required for osteotomy and sagittal split were measured, and postoperative cone beam computed tomography images of all splits were analyzed. (Source: International Journal of Oral and Maxillofacial Surgery)
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Evaluation of the lingual fracture patterns after bilateral sagittal split osteotomy according to Hunsuck/Epker modified by an additional inferior border osteotomy using a burr or ultrasonic device
This study was conducted to compare fracture patterns and operation times after sagittal split osteotomy (SSO) by Hunsuck/Epker approach, performed using a burr or ultrasonic device, with and without osteotomy modification. A total of 80 SSOs were performed in fresh human cadavers using a burr or ultrasonic device to investigate the influence of surgical instruments as well as an additional bone cut on the inferior border of the mandible in terms of lingual fracture patterns. The times required for osteotomy and sagittal split were measured, and postoperative cone beam computed tomography images of all splits were analyzed. (Source: International Journal of Oral and Maxillofacial Surgery)
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Vermillion (NASDAQ:VRML) vs. Response Genetics (RGDXQ) Critical Survey - PressOracle
Vermillion (NASDAQ:VRML) and Response Genetics (OTCMKTS:RGDXQ) are both small-cap medical companies, but which is the superior investment? We will ...
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Vermillion (NASDAQ:VRML) vs. Response Genetics (RGDXQ) Critical Survey - PressOracle
Vermillion (NASDAQ:VRML) and Response Genetics (OTCMKTS:RGDXQ) are both small-cap medical companies, but which is the superior investment? We will ...
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ALLERGY RELIEF (Loratadine) Tablet [First Aid Direct]
Updated Date: Dec 20, 2018 EST (Source: DailyMed Drug Label Updates)
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ALLERGY RELIEF ANTIHISTAMINE (Diphenhydramine Hcl) Tablet [Cardinal Health (Leader) 49781]
Updated Date: Dec 20, 2018 EST (Source: DailyMed Drug Label Updates)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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ALLERGY RELIEF (Loratadine) Tablet [First Aid Direct]
Updated Date: Dec 20, 2018 EST (Source: DailyMed Drug Label Updates)
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ALLERGY RELIEF ANTIHISTAMINE (Diphenhydramine Hcl) Tablet [Cardinal Health (Leader) 49781]
Updated Date: Dec 20, 2018 EST (Source: DailyMed Drug Label Updates)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
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Atherstone Foods Inc Issues Allergy Alert on Undeclared Soy in “ Greens and Grains Hummus and Quinoa Tabouleh Wrap ”
ATHERSTONE FOODS INC of Richmond, CA is recalling 14.6 ounce (414g) Greens and Grains Hummus and Quinoa Tabouleh Wrap, because it may contain undeclared soy, people who have an allergy or severe sensitivity to soy run the risk of serious or life-threatening allergic reaction if they consume these products. (Source: FDA Food Alergies)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
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Food Allergies Linked to MS Relapses
(MedPage Today) -- MS patients with food allergies also more likely to have lesions (Source: MedPage Today Allergy)
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Food Allergies Linked to MS Relapses
(MedPage Today) -- MS patients with food allergies also more likely to have lesions (Source: MedPage Today Allergy)
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The Latest News in Cancer Research and Treatment - Everyday Health
The Latest News in Cancer Research and Treatment Everyday Health
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December 20, 2018. News breaks in the cancer arena all the time. Sometimes it's big — like word that a breakthrough drug has increased survival for a ...
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Old factory tests positive for PFAS - WILX-TV
Old factory tests positive for PFAS WILX-TV
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The site of an old plating shop in Jackson has tested positive for PFAS.
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Maxim Group Analysts Give Interpace Diagnostics Group (NASDAQ:IDXG) a $4.00 Price Target - Fairfield Current
Interpace Diagnostics Group (NASDAQ:IDXG) has been assigned a $4.00 price objective by research analysts at Maxim Group in a research report issued to ...
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Coil Embolization in Patients with Recurrent Cerebral Aneurysms Who Previously Underwent Surgical Clipping [INTERVENTIONAL]
BACKGROUND AND PURPOSE:
Surgical revision of recurrent cerebral aneurysms is technically difficult. Therefore, coil embolization has been used as an alternative in these cases. The aim of this study was to evaluate the clinical and angiographic outcomes of coil embolization in patients with recurrent cerebral aneurysms after microsurgical clipping.
MATERIALS AND METHODS:Between May 1999 and February 2016, nineteen patients with 19 recurrent aneurysms who previously underwent surgical clipping were treated by coil embolization.
RESULTS:Nine patients presented with subarachnoid hemorrhage (47.4%). The interval between surgical clipping and coil embolization was 143.5 ± 66.1 months (range, 43–276 months). Single- or double-catheter coil embolization was performed in 16 patients. A balloon (n = 1) and stents (n = 2) were used to assist the coil embolization in 3 patients. Immediate radiologic findings after coil embolization showed complete occlusion in 10 patients, a residual neck in 8 patients, and a residual sac in 1 patient. Procedure-related permanent morbidity occurred in 1 patient. The mean clinical follow-up was 58.3 ± 38.8 months. Poor clinical outcomes (modified Rankin Scale score = ≥3) at the end of the clinical follow-up were reported in 5 patients (26.3%). Angiographic follow-up was available for 12 patients (63.2%). Major recurrence was detected in 5 patients (41.7%), and a tendency for aneurysm regrowth rather than coil compaction was noted in all cases.
CONCLUSIONS:In our series, coil embolization for recurrent aneurysms after surgical clipping was feasible but had a high recurrence rate and tended to result in aneurysm regrowth rather than coil compaction.
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Selection of Patients with Stroke for Thrombectomy Must Be Judicious and Should Not Be Offered to Any Patient with Large-Vessel Occlusion with a Femoral Pulse [COMMENTARIES]
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Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study [ADULT BRAIN]
BACKGROUND AND PURPOSE:
Deep gray matter involvement is a consistent feature in multiple sclerosis. The aim of this study was to evaluate the relationship between different deep gray matter alterations and the development of subcortical atrophy, as well as to investigate the possible different substrates of volume loss between phenotypes.
MATERIALS AND METHODS:Seventy-seven patients with MS (52 with relapsing-remitting and 25 with progressive MS) and 41 healthy controls were enrolled in this cross-sectional study. MR imaging investigation included volumetric, DTI, PWI and Quantitative Susceptibility Mapping analyses. Deep gray matter structures were automatically segmented to obtain volumes and mean values for each MR imaging metric in the thalamus, caudate, putamen, and globus pallidus. Between-group differences were probed by ANCOVA analyses, while the contribution of different MR imaging metrics to deep gray matter atrophy was investigated via hierarchic multiple linear regression models.
RESULTS:Patients with MS showed a multifaceted involvement of the thalamus and basal ganglia, with significant atrophy of all deep gray matter structures (P < .001). In the relapsing-remitting MS group, WM lesion burden proved to be the main contributor to volume loss for all deep gray matter structures (P ≤ .006), with a minor role of local microstructural damage, which, in turn, was the main determinant of deep gray matter atrophy in patients with progressive MS (P ≤ .01), coupled with thalamic susceptibility changes (P = .05).
CONCLUSIONS:Our study confirms the diffuse involvement of deep gray matter in MS, demonstrating a different behavior between MS phenotypes, with subcortical GM atrophy mainly determined by global WM lesion burden in patients with relapsing-remitting MS, while local microstructural damage and susceptibility changes mainly accounted for the development of deep gray matter volume loss in patients with progressive MS.
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Deep Learning-Based Detection of Intracranial Aneurysms in 3D TOF-MRA [FUNCTIONAL]
BACKGROUND AND PURPOSE:
The rupture of an intracranial aneurysm is a serious incident, causing subarachnoid hemorrhage associated with high fatality and morbidity rates. Because the demand for radiologic examinations is steadily growing, physician fatigue due to an increased workload is a real concern and may lead to mistaken diagnoses of potentially relevant findings. Our aim was to develop a sufficient system for automated detection of intracranial aneurysms.
MATERIALS AND METHODS:In a retrospective study, we established a system for the detection of intracranial aneurysms from 3D TOF-MRA data. The system is based on an open-source neural network, originally developed for segmentation of anatomic structures in medical images. Eighty-five datasets of patients with a total of 115 intracranial aneurysms were used to train the system and evaluate its performance. Manual annotation of aneurysms based on radiologic reports and critical revision of image data served as the reference standard. Sensitivity, false-positives per case, and positive predictive value were determined for different pipelines with modified pre- and postprocessing.
RESULTS:The highest overall sensitivity of our system for the detection of intracranial aneurysms was 90% with a sensitivity of 96% for aneurysms with a diameter of 3–7 mm and 100% for aneurysms of >7 mm. The best location-dependent performance was in the posterior circulation. Pre- and postprocessing sufficiently reduced the number of false-positives.
CONCLUSIONS:Our system, based on a deep learning convolutional network, can detect intracranial aneurysms with a high sensitivity from 3D TOF-MRA data.
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Radiomics-Based Intracranial Thrombus Features on CT and CTA Predict Recanalization with Intravenous Alteplase in Patients with Acute Ischemic Stroke [FUNCTIONAL]
BACKGROUND AND PURPOSE:
Thrombus characteristics identified on non-contrast CT (NCCT) are potentially associated with recanalization with intravenous (IV) alteplase in patients with acute ischemic stroke (AIS). Our aim was to determine the best radiomics-based features of thrombus on NCCT and CT angiography associated with recanalization with IV alteplase in AIS patients and proximal intracranial thrombi.
MATERIALS AND METHODS:With a nested case-control design, 67 patients with ICA/M1 MCA segment thrombus treated with IV alteplase were included in this analysis. Three hundred twenty-six radiomics features were extracted from each thrombus on both NCCT and CTA images. Linear discriminative analysis was applied to select features most strongly associated with early recanalization with IV alteplase. These features were then used to train a linear support vector machine classifier. Ten times 5-fold cross-validation was used to evaluate the accuracy of the trained classifier and the stability of the selected features.
RESULTS:Receiver operating characteristic curves showed that thrombus radiomics features are predictive of early recanalization with IV alteplase. The combination of radiomics features from NCCT, CTA, and radiomics changes is best associated with early recanalization with IV alteplase (area under the curve = 0.85) and was significantly better than any single feature such as thrombus length (P < .001), volume (P < .001), and permeability as measured by mean attenuation increase (P < .001), maximum attenuation in CTA (P < .001), maximum attenuation increase (P < .001), and assessment of residual flow grade (P < .001).
CONCLUSIONS:Thrombus radiomics features derived from NCCT and CTA are more predictive of recanalization with IV alteplase in patients with acute ischemic stroke with proximal occlusion than previously known thrombus imaging features such as length, volume, and permeability.
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Improved White Matter Cerebrovascular Reactivity after Revascularization in Patients with Steno-Occlusive Disease [FUNCTIONAL]
BACKGROUND AND PURPOSE:
One feature that patients with steno-occlusive cerebrovascular disease have in common is the presence of white matter (WM) lesions on MRI. The purpose of this study was to evaluate the effect of direct surgical revascularization on impaired WM cerebrovascular reactivity in patients with steno-occlusive disease.
MATERIALS AND METHODS:We recruited 35 patients with steno-occlusive disease, Moyamoya disease (n = 24), Moyamoya syndrome (n = 3), atherosclerosis (n = 6), vasculitis (n = 1), and idiopathic stenosis (n = 1), who underwent unilateral brain revascularization using a direct superficial temporal artery–to-MCA bypass (19 women; mean age, 45.8 ± 16.5 years). WM cerebrovascular reactivity was measured preoperatively and postoperatively using blood oxygen level–dependent (BOLD) MR imaging during iso-oxic hypercapnic changes in end-tidal carbon dioxide and was expressed as % BOLD MR signal intensity per millimeter end-tidal partial pressure of CO2.
RESULTS:WM cerebrovascular reactivity significantly improved after direct unilateral superficial temporal artery–to-middle cerebral artery (STA-MCA) bypass in the revascularized hemisphere in the MCA territory (mean ± SD, –0.0005 ± 0.053 to 0.053 ± 0.046 %BOLD/mm Hg; P < .0001) and in the anterior cerebral artery territory (mean, 0.0015 ± 0.059 to 0.021 ± 0.052 %BOLD/mm Hg; P = .005). There was no difference in WM cerebrovascular reactivity in the ipsilateral posterior cerebral artery territory nor in the vascular territories of the nonrevascularized hemisphere (P < .05).
CONCLUSIONS:Cerebral revascularization surgery is an effective treatment for reversing preoperative cerebrovascular reactivity deficits in WM. In addition, direct–STA-MCA bypass may prevent recurrence of preoperative symptoms.
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Clinical Outcome after Thrombectomy in Patients with Stroke with Premorbid Modified Rankin Scale Scores of 3 and 4: A Cohort Study with 136 Patients [INTERVENTIONAL]
BACKGROUND AND PURPOSE:
We aimed to analyze the clinical outcome after mechanical thrombectomy in patients with premorbid mRS 3 and 4 because there are currently no data on this patient group.
MATERIALS AND METHODS:Between January 2009 and November 2017, all patients with premorbid mRS 3 or 4 undergoing mechanical thrombectomy due to anterior circulation stroke were selected. Good outcome was defined as a clinical recovery to the status before stroke onset (ie, equal premorbid mRS and mRS at 90 days). In addition, mortality at discharge and at 90 days was analyzed.
RESULTS:One hundred thirty-six patients were included, of whom 81.6% presented with premorbid mRS 3; and 18.4%, with premorbid mRS 4; 24.0% of patients with premorbid mRS 4 achieved clinical recovery compared with 20.7% of patients with premorbid mRS 3 (P = .788). However, the proportion of hospital mortality and mortality at 90 days was nonsignificant, but markedly higher in patients with premorbid mRS 4. Multivariate analysis identified low NIHSS scores (OR, 0.92; 95% CI, 0.85–0.99; P = .040), high ASPECTS (OR, 1.45; 95% CI, 1.02–2.16; P = .049), and TICI 2b–3 (OR, 7.11; 95% CI, 1.73–49.90; P = .017) as independent predictors of good outcome.
CONCLUSIONS:Good outcome in patients with premorbid mRS 3 and 4 is less frequent compared with premorbid mRS 0–2. Nevertheless, about 20% of the patients return to their premorbid mRS, which may justify endovascular treatment. The most important predictor of good outcome is successful recanalization.
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High-Grade Gliomas in Children with Neurofibromatosis Type 1: Literature Review and Illustrative Cases [PEDIATRICS]
SUMMARY:
High-grade gliomas in patients with neurofibromatosis type 1 are rare and may therefore not be considered in the differential of brain lesions. Here, we describe 5 children with neurofibromatosis type 1; four of them developed various types of high-grade gliomas. The fifth patient had imaging features concerning for a high-grade lesion, but tissue diagnosis showed a low-grade glioma. The cases and literature summary provided here are to raise awareness for the occurrence of high-grade gliomas in children with neurofibromatosis type 1 and the limited ability of imaging features alone to predict a high-grade malignancy.
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Old factory tests positive for PFAS - WILX-TV
Old factory tests positive for PFAS WILX-TV
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The site of an old plating shop in Jackson has tested positive for PFAS.
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Maxim Group Analysts Give Interpace Diagnostics Group (NASDAQ:IDXG) a $4.00 Price Target - Fairfield Current
Interpace Diagnostics Group (NASDAQ:IDXG) has been assigned a $4.00 price objective by research analysts at Maxim Group in a research report issued to ...
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Coil Embolization in Patients with Recurrent Cerebral Aneurysms Who Previously Underwent Surgical Clipping [INTERVENTIONAL]
BACKGROUND AND PURPOSE:
Surgical revision of recurrent cerebral aneurysms is technically difficult. Therefore, coil embolization has been used as an alternative in these cases. The aim of this study was to evaluate the clinical and angiographic outcomes of coil embolization in patients with recurrent cerebral aneurysms after microsurgical clipping.
MATERIALS AND METHODS:Between May 1999 and February 2016, nineteen patients with 19 recurrent aneurysms who previously underwent surgical clipping were treated by coil embolization.
RESULTS:Nine patients presented with subarachnoid hemorrhage (47.4%). The interval between surgical clipping and coil embolization was 143.5 ± 66.1 months (range, 43–276 months). Single- or double-catheter coil embolization was performed in 16 patients. A balloon (n = 1) and stents (n = 2) were used to assist the coil embolization in 3 patients. Immediate radiologic findings after coil embolization showed complete occlusion in 10 patients, a residual neck in 8 patients, and a residual sac in 1 patient. Procedure-related permanent morbidity occurred in 1 patient. The mean clinical follow-up was 58.3 ± 38.8 months. Poor clinical outcomes (modified Rankin Scale score = ≥3) at the end of the clinical follow-up were reported in 5 patients (26.3%). Angiographic follow-up was available for 12 patients (63.2%). Major recurrence was detected in 5 patients (41.7%), and a tendency for aneurysm regrowth rather than coil compaction was noted in all cases.
CONCLUSIONS:In our series, coil embolization for recurrent aneurysms after surgical clipping was feasible but had a high recurrence rate and tended to result in aneurysm regrowth rather than coil compaction.
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Determinants of Deep Gray Matter Atrophy in Multiple Sclerosis: A Multimodal MRI Study [ADULT BRAIN]
BACKGROUND AND PURPOSE:
Deep gray matter involvement is a consistent feature in multiple sclerosis. The aim of this study was to evaluate the relationship between different deep gray matter alterations and the development of subcortical atrophy, as well as to investigate the possible different substrates of volume loss between phenotypes.
MATERIALS AND METHODS:Seventy-seven patients with MS (52 with relapsing-remitting and 25 with progressive MS) and 41 healthy controls were enrolled in this cross-sectional study. MR imaging investigation included volumetric, DTI, PWI and Quantitative Susceptibility Mapping analyses. Deep gray matter structures were automatically segmented to obtain volumes and mean values for each MR imaging metric in the thalamus, caudate, putamen, and globus pallidus. Between-group differences were probed by ANCOVA analyses, while the contribution of different MR imaging metrics to deep gray matter atrophy was investigated via hierarchic multiple linear regression models.
RESULTS:Patients with MS showed a multifaceted involvement of the thalamus and basal ganglia, with significant atrophy of all deep gray matter structures (P < .001). In the relapsing-remitting MS group, WM lesion burden proved to be the main contributor to volume loss for all deep gray matter structures (P ≤ .006), with a minor role of local microstructural damage, which, in turn, was the main determinant of deep gray matter atrophy in patients with progressive MS (P ≤ .01), coupled with thalamic susceptibility changes (P = .05).
CONCLUSIONS:Our study confirms the diffuse involvement of deep gray matter in MS, demonstrating a different behavior between MS phenotypes, with subcortical GM atrophy mainly determined by global WM lesion burden in patients with relapsing-remitting MS, while local microstructural damage and susceptibility changes mainly accounted for the development of deep gray matter volume loss in patients with progressive MS.
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Deep Learning-Based Detection of Intracranial Aneurysms in 3D TOF-MRA [FUNCTIONAL]
BACKGROUND AND PURPOSE:
The rupture of an intracranial aneurysm is a serious incident, causing subarachnoid hemorrhage associated with high fatality and morbidity rates. Because the demand for radiologic examinations is steadily growing, physician fatigue due to an increased workload is a real concern and may lead to mistaken diagnoses of potentially relevant findings. Our aim was to develop a sufficient system for automated detection of intracranial aneurysms.
MATERIALS AND METHODS:In a retrospective study, we established a system for the detection of intracranial aneurysms from 3D TOF-MRA data. The system is based on an open-source neural network, originally developed for segmentation of anatomic structures in medical images. Eighty-five datasets of patients with a total of 115 intracranial aneurysms were used to train the system and evaluate its performance. Manual annotation of aneurysms based on radiologic reports and critical revision of image data served as the reference standard. Sensitivity, false-positives per case, and positive predictive value were determined for different pipelines with modified pre- and postprocessing.
RESULTS:The highest overall sensitivity of our system for the detection of intracranial aneurysms was 90% with a sensitivity of 96% for aneurysms with a diameter of 3–7 mm and 100% for aneurysms of >7 mm. The best location-dependent performance was in the posterior circulation. Pre- and postprocessing sufficiently reduced the number of false-positives.
CONCLUSIONS:Our system, based on a deep learning convolutional network, can detect intracranial aneurysms with a high sensitivity from 3D TOF-MRA data.
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Radiomics-Based Intracranial Thrombus Features on CT and CTA Predict Recanalization with Intravenous Alteplase in Patients with Acute Ischemic Stroke [FUNCTIONAL]
BACKGROUND AND PURPOSE:
Thrombus characteristics identified on non-contrast CT (NCCT) are potentially associated with recanalization with intravenous (IV) alteplase in patients with acute ischemic stroke (AIS). Our aim was to determine the best radiomics-based features of thrombus on NCCT and CT angiography associated with recanalization with IV alteplase in AIS patients and proximal intracranial thrombi.
MATERIALS AND METHODS:With a nested case-control design, 67 patients with ICA/M1 MCA segment thrombus treated with IV alteplase were included in this analysis. Three hundred twenty-six radiomics features were extracted from each thrombus on both NCCT and CTA images. Linear discriminative analysis was applied to select features most strongly associated with early recanalization with IV alteplase. These features were then used to train a linear support vector machine classifier. Ten times 5-fold cross-validation was used to evaluate the accuracy of the trained classifier and the stability of the selected features.
RESULTS:Receiver operating characteristic curves showed that thrombus radiomics features are predictive of early recanalization with IV alteplase. The combination of radiomics features from NCCT, CTA, and radiomics changes is best associated with early recanalization with IV alteplase (area under the curve = 0.85) and was significantly better than any single feature such as thrombus length (P < .001), volume (P < .001), and permeability as measured by mean attenuation increase (P < .001), maximum attenuation in CTA (P < .001), maximum attenuation increase (P < .001), and assessment of residual flow grade (P < .001).
CONCLUSIONS:Thrombus radiomics features derived from NCCT and CTA are more predictive of recanalization with IV alteplase in patients with acute ischemic stroke with proximal occlusion than previously known thrombus imaging features such as length, volume, and permeability.
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Improved White Matter Cerebrovascular Reactivity after Revascularization in Patients with Steno-Occlusive Disease [FUNCTIONAL]
BACKGROUND AND PURPOSE:
One feature that patients with steno-occlusive cerebrovascular disease have in common is the presence of white matter (WM) lesions on MRI. The purpose of this study was to evaluate the effect of direct surgical revascularization on impaired WM cerebrovascular reactivity in patients with steno-occlusive disease.
MATERIALS AND METHODS:We recruited 35 patients with steno-occlusive disease, Moyamoya disease (n = 24), Moyamoya syndrome (n = 3), atherosclerosis (n = 6), vasculitis (n = 1), and idiopathic stenosis (n = 1), who underwent unilateral brain revascularization using a direct superficial temporal artery–to-MCA bypass (19 women; mean age, 45.8 ± 16.5 years). WM cerebrovascular reactivity was measured preoperatively and postoperatively using blood oxygen level–dependent (BOLD) MR imaging during iso-oxic hypercapnic changes in end-tidal carbon dioxide and was expressed as % BOLD MR signal intensity per millimeter end-tidal partial pressure of CO2.
RESULTS:WM cerebrovascular reactivity significantly improved after direct unilateral superficial temporal artery–to-middle cerebral artery (STA-MCA) bypass in the revascularized hemisphere in the MCA territory (mean ± SD, –0.0005 ± 0.053 to 0.053 ± 0.046 %BOLD/mm Hg; P < .0001) and in the anterior cerebral artery territory (mean, 0.0015 ± 0.059 to 0.021 ± 0.052 %BOLD/mm Hg; P = .005). There was no difference in WM cerebrovascular reactivity in the ipsilateral posterior cerebral artery territory nor in the vascular territories of the nonrevascularized hemisphere (P < .05).
CONCLUSIONS:Cerebral revascularization surgery is an effective treatment for reversing preoperative cerebrovascular reactivity deficits in WM. In addition, direct–STA-MCA bypass may prevent recurrence of preoperative symptoms.
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Clinical Outcome after Thrombectomy in Patients with Stroke with Premorbid Modified Rankin Scale Scores of 3 and 4: A Cohort Study with 136 Patients [INTERVENTIONAL]
BACKGROUND AND PURPOSE:
We aimed to analyze the clinical outcome after mechanical thrombectomy in patients with premorbid mRS 3 and 4 because there are currently no data on this patient group.
MATERIALS AND METHODS:Between January 2009 and November 2017, all patients with premorbid mRS 3 or 4 undergoing mechanical thrombectomy due to anterior circulation stroke were selected. Good outcome was defined as a clinical recovery to the status before stroke onset (ie, equal premorbid mRS and mRS at 90 days). In addition, mortality at discharge and at 90 days was analyzed.
RESULTS:One hundred thirty-six patients were included, of whom 81.6% presented with premorbid mRS 3; and 18.4%, with premorbid mRS 4; 24.0% of patients with premorbid mRS 4 achieved clinical recovery compared with 20.7% of patients with premorbid mRS 3 (P = .788). However, the proportion of hospital mortality and mortality at 90 days was nonsignificant, but markedly higher in patients with premorbid mRS 4. Multivariate analysis identified low NIHSS scores (OR, 0.92; 95% CI, 0.85–0.99; P = .040), high ASPECTS (OR, 1.45; 95% CI, 1.02–2.16; P = .049), and TICI 2b–3 (OR, 7.11; 95% CI, 1.73–49.90; P = .017) as independent predictors of good outcome.
CONCLUSIONS:Good outcome in patients with premorbid mRS 3 and 4 is less frequent compared with premorbid mRS 0–2. Nevertheless, about 20% of the patients return to their premorbid mRS, which may justify endovascular treatment. The most important predictor of good outcome is successful recanalization.
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High-Grade Gliomas in Children with Neurofibromatosis Type 1: Literature Review and Illustrative Cases [PEDIATRICS]
SUMMARY:
High-grade gliomas in patients with neurofibromatosis type 1 are rare and may therefore not be considered in the differential of brain lesions. Here, we describe 5 children with neurofibromatosis type 1; four of them developed various types of high-grade gliomas. The fifth patient had imaging features concerning for a high-grade lesion, but tissue diagnosis showed a low-grade glioma. The cases and literature summary provided here are to raise awareness for the occurrence of high-grade gliomas in children with neurofibromatosis type 1 and the limited ability of imaging features alone to predict a high-grade malignancy.
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Knockdown of nucleophosmin 1 suppresses proliferation of triple-negati | CMAR - Dove Medical Press
Knockdown of nucleophosmin 1 suppresses proliferation of triple-negative breast cancer cells through activating CDH1/Skp2/p27kip1 pathway De Zeng,1,* ...
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Tests Find Lake Norman High School Water Has Chemical Connected To Thyroid Cancer - WFAE
Lake Norman High School students in Iredell County are using bottled water this week. Tests of the school's drinking water supply revealed the chemical.
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Knockdown of nucleophosmin 1 suppresses proliferation of triple-negati | CMAR - Dove Medical Press
Knockdown of nucleophosmin 1 suppresses proliferation of triple-negative breast cancer cells through activating CDH1/Skp2/p27kip1 pathway De Zeng,1,* ...
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Food Allergies Linked to MS Relapses
(MedPage Today) -- MS patients with food allergies also more likely to have lesions (Source: MedPage Today Allergy)
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Medical News Today: MS: Disease impact is greater in those with food allergies
People with MS and a reported history of food allergy had more relapses and were likelier to have active lesions on MRI scans than those without allergy. (Source: Health News from Medical News Today)
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Food Allergies Linked to MS Relapses
(MedPage Today) -- MS patients with food allergies also more likely to have lesions (Source: MedPage Today Allergy)
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Medical News Today: MS: Disease impact is greater in those with food allergies
People with MS and a reported history of food allergy had more relapses and were likelier to have active lesions on MRI scans than those without allergy. (Source: Health News from Medical News Today)
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Local nonprofit on mission to protect firefighters with specialty hood - WOKV
Local nonprofit on mission to protect firefighters with specialty hood WOKV
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Cancer is the leading cause of death among firefighters. Jeff Roundtree and Bill Hamilton are trying to do something about that. They started Hoods For Heroes, ...
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Global Head and Neck Cancer Treatment Market: Global Sales, Ex-factory Price, Revenue, Gross Margin Analysis 2025 - DailyHover
Global Head and Neck Cancer Treatment Market: Global Sales, Ex-factory Price, Revenue, Gross Margin Analysis 2025 DailyHover
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Market.Biz Presents Global Head and Neck Cancer Treatment Market 2018 industry research report that covers overall business insights and forecast.
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Global Head and Neck Cancer Treatment Market: Global Sales, Ex-factory Price, Revenue, Gross Margin Analysis 2025 - DailyHover
Global Head and Neck Cancer Treatment Market: Global Sales, Ex-factory Price, Revenue, Gross Margin Analysis 2025 DailyHover
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Market.Biz Presents Global Head and Neck Cancer Treatment Market 2018 industry research report that covers overall business insights and forecast.
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Awaiting allograft antigen: for rejection or tolerance?
(Source: Journal of Allergy and Clinical Immunology)
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Awaiting allograft antigen: for rejection or tolerance?
(Source: Journal of Allergy and Clinical Immunology)
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A tryptophan metabolite of the skin microbiota attenuates inflammation in atopic dermatitis via the aryl hydrocarbon receptor
The microbial-derived Trp metabolite, IAId, was significantly decreased on the skin surface of AD patients and was found to negatively regulate skin inflammation. (Source: Journal of Allergy and Clinical Immunology)
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Cytokine-induced endogenous production of PGD2 is essential for human ILC2 activation
We demonstrate that endogenously produced PGD2 is responsible for cytokine-induced ILC2 activation and that CRTH2 antagonism is a powerful therapeutic approach in allergic inflammation as it prevents not only PGD2-induced, but also indirectly cytokine-induced ILC2 activation. (Source: Journal of Allergy and Clinical Immunology)
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Prevalence of chronic rhinosinusitis in the general population based on sinus radiology and symptomatology
We found a prevalence of 2.9% or 6.1% 'Clinically based CRS', for cut-offs of LM≥4 or LM>0 respectively, in a 'normal' (non-rhinologic imaging of the head) population, based on nasal symptoms and imaging abnormalities. (Source: Journal of Allergy and Clinical Immunology)
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Defective glycosylation leads to defective gp130-dependent STAT3 signaling in PGM3-deficient patients
PGM3 deficient patients have impaired STAT3 signaling downstream of the highly glycosylated protein gp130, thereby constituting the mechanistic basis for the clinical features shared by STAT3-, gp130- and PGM3-deficient patients. (Source: Journal of Allergy and Clinical Immunology)
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Defective glycosylation leads to defective gp130-dependent STAT3 signaling in PGM3-deficient patients
PGM3 deficient patients have impaired STAT3 signaling downstream of the highly glycosylated protein gp130, thereby constituting the mechanistic basis for the clinical features shared by STAT3-, gp130- and PGM3-deficient patients. (Source: Journal of Allergy and Clinical Immunology)
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Fibrostenotic eosinophilic esophagitis may reflect epithelial lysyl oxidase induction by fibroblasts-derived tumor necrosis factor- α
Esophageal fibrosis is a long-term consequence of remodeling in eosinophilic esophagitis, but little is known about the pathophysiology of fibrosis. We now demonstrate that TNF α mediated lysyl oxidase production may be driving fibrostenotic phenotype. (Source: Journal of Allergy and Clinical Immunology)
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Fibrostenotic eosinophilic esophagitis may reflect epithelial lysyl oxidase induction by fibroblasts-derived tumor necrosis factor- α
Esophageal fibrosis is a long-term consequence of remodeling in eosinophilic esophagitis, but little is known about the pathophysiology of fibrosis. We now demonstrate that TNF α mediated lysyl oxidase production may be driving fibrostenotic phenotype. (Source: Journal of Allergy and Clinical Immunology)
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IFN- γ and CD25 drive distinct pathological features during hemophagocytic lymphohistiocytosis
Studying the pathogenesis of hemophagocytic lymphohistiocyosis, we found a striking dichotomy between the hematological and inflammatory components of HLH. Hematological features are strictly dependent of IFN- γ, while inflammation is driven by dysregulated IL-2 signaling. (Source: Journal of Allergy and Clinical Immunology)
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IFN- γ and CD25 drive distinct pathological features during hemophagocytic lymphohistiocytosis
Studying the pathogenesis of hemophagocytic lymphohistiocyosis, we found a striking dichotomy between the hematological and inflammatory components of HLH. Hematological features are strictly dependent of IFN- γ, while inflammation is driven by dysregulated IL-2 signaling. (Source: Journal of Allergy and Clinical Immunology)
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Psoriatic skin molecular and histopathological profiles following treatment with risankizumab versus ustekinumab
This study reports insights into early changes in the histopathology and transcriptomic profiles of skin and blood in patients with psoriasis treated with risankizumab compared with ustekinumab. (Source: Journal of Allergy and Clinical Immunology)
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Large-scale, multi-ethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults
In this large, multi-ethnic GWAS of asthma, we identified novel associations with potential functional relevance for asthma susceptibility in older adults of diverse racial backgrounds. (Source: Journal of Allergy and Clinical Immunology)
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Cytokine-induced endogenous production of PGD2 is essential for human ILC2 activation
We demonstrate that endogenously produced PGD2 is responsible for cytokine-induced ILC2 activation and that CRTH2 antagonism is a powerful therapeutic approach in allergic inflammation as it prevents not only PGD2-induced, but also indirectly cytokine-induced ILC2 activation. (Source: Journal of Allergy and Clinical Immunology)
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Large-scale, multi-ethnic genome-wide association study identifies novel loci contributing to asthma susceptibility in adults
In this large, multi-ethnic GWAS of asthma, we identified novel associations with potential functional relevance for asthma susceptibility in older adults of diverse racial backgrounds. (Source: Journal of Allergy and Clinical Immunology)
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Effects of diet on the childhood gut microbiome and its implications for atopic dermatitis
In this study we found that rural South African children had a high relative abundance of Prevotella copri which was linked to diet and protective for AD. (Source: Journal of Allergy and Clinical Immunology)
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Antibody response to common human viruses is shaped by genetic factors
Using a large twin study we found strong evidence that extent of antibody response to six common human viruses was influenced by genetic factors. In contrast, common environmental factors contributed more to inter-individual variation in serostatus than antibody response. (Source: Journal of Allergy and Clinical Immunology)
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Evaluation of clinical benefit from treatment with mepolizumab for eosinophilic granulomatosis with polyangiitis
This post hoc assessment of a recent clinical trial of mepolizumab in patients with EGPA demonstrates that patients not achieving protocol-defined remission still met important clinical endpoints of remission, glucocorticoid dose reduction and no relapses. (Source: Journal of Allergy and Clinical Immunology)
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Evaluation of clinical benefit from treatment with mepolizumab for eosinophilic granulomatosis with polyangiitis
This post hoc assessment of a recent clinical trial of mepolizumab in patients with EGPA demonstrates that patients not achieving protocol-defined remission still met important clinical endpoints of remission, glucocorticoid dose reduction and no relapses. (Source: Journal of Allergy and Clinical Immunology)
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A tryptophan metabolite of the skin microbiota attenuates inflammation in atopic dermatitis via the aryl hydrocarbon receptor
The microbial-derived Trp metabolite, IAId, was significantly decreased on the skin surface of AD patients and was found to negatively regulate skin inflammation. (Source: Journal of Allergy and Clinical Immunology)
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HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis
In a large observational study, psoriasis patients lacking the susceptibility allele HLA-C*06:02 demonstrate significantly better response to adalimumab than ustekinumab. The effect is stronger than at other HLA alleles and varies with psoriatic arthritis status. (Source: Journal of Allergy and Clinical Immunology)
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Prevalence of chronic rhinosinusitis in the general population based on sinus radiology and symptomatology
We found a prevalence of 2.9% or 6.1% 'Clinically based CRS', for cut-offs of LM≥4 or LM>0 respectively, in a 'normal' (non-rhinologic imaging of the head) population, based on nasal symptoms and imaging abnormalities. (Source: Journal of Allergy and Clinical Immunology)
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3-Methyl-4-nitrophenol triggers nasal allergy by modulating dendritic cell properties
This study aims to elucidate the role of MNP in regulation of dendritic cell (DC) properties and facilitation of allergic rhinitis. (Source: Journal of Allergy and Clinical Immunology)
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HLA-C*06:02 genotype is a predictive biomarker of biologic treatment response in psoriasis
In a large observational study, psoriasis patients lacking the susceptibility allele HLA-C*06:02 demonstrate significantly better response to adalimumab than ustekinumab. The effect is stronger than at other HLA alleles and varies with psoriatic arthritis status. (Source: Journal of Allergy and Clinical Immunology)
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3-Methyl-4-nitrophenol triggers nasal allergy by modulating dendritic cell properties
This study aims to elucidate the role of MNP in regulation of dendritic cell (DC) properties and facilitation of allergic rhinitis. (Source: Journal of Allergy and Clinical Immunology)
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Obesity explains almost 1 in 20 cancer cases globally - Reuters
(Reuters Health) - - Excess body weight is responsible for about 4 percent of all cancer cases worldwide and an even larger proportion of malignancies ...
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DDX58 and Classic Singleton-Merten Syndrome
ConclusionsDDX58 mutations may be associated with the classic features of Singleton-Merten syndrome including dental dysplasia, tendon rupture, and severe cardiac sequela. (Source: Journal of Clinical Immunology)
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Lower airway microbiota associates with inflammatory phenotype in severe preschool wheeze
Capsule Summary: Targeting the lower airway microbiome may provide a novel approach to prevention of preschool wheezing attacks (Source: Journal of Allergy and Clinical Immunology)
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17-beta estradiol protects esophageal epithelium from IL-13-induced barrier dysfunction and remodeling
Eosinophilic esophagitis (EoE) is more common in males than females for reasons that are not yet fully understood. We demonstrate significant dysregulation of the expression of the estrogen receptors and estrogen responsive gene network in EoE. We show that the sex hormone estrogen abrogates IL-13-induced esophageal architectural changes and barrier dysfunction via the downregulation of IL-13-induced Tyk2-STAT6 signaling. These studies suggest that differential estrogen signaling may explain gender-bias in EoE. (Source: Journal of Allergy and Clinical Immunology)
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Lower airway microbiota associates with inflammatory phenotype in severe preschool wheeze
Capsule Summary: Targeting the lower airway microbiome may provide a novel approach to prevention of preschool wheezing attacks (Source: Journal of Allergy and Clinical Immunology)
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Increased protein expression of VEGF-A, VEGF-B, VEGF-C and their receptors in the temporal neocortex of pharmacoresistant temporal lobe epilepsy patients
The vascular endothelial growth factor (VEGF) system has been shown to play a crucial role in several neuropathological processes. Temporal lobe epilepsy (TLE) is the most common focal epilepsy type in adult humans. We assessed the protein expression levels of VEGF-A, VEGF-B, and VEGF-C, their specific receptors VEGFR-2 and -3, their accessory receptors neuropilins 1 and 2, and PI3 and Akt kinases, in temporal neocortex from pharmacoresistant TLE (PR-TLE) patients and control subjects by western blotting. (Source: Journal of Neuroimmunology)
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Crossmark Global Holdings Inc. Purchases New Holdings in Exelixis, Inc. (EXEL) - Fairfield Current
Crossmark Global Holdings Inc. bought a new position in shares of Exelixis, Inc. (NASDAQ:EXEL) in the third quarter, according to the company in its most ...
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AAOMS Helps With ACS Applications
In a new development, AAOMS is offering assistance with review of American College of Surgeons Fellowship applications to dual-degree OMSs that is similar to the assistance offered to single-degree OMSs.
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AAOMS Helps With ACS Applications
In a new development, AAOMS is offering assistance with review of American College of Surgeons Fellowship applications to dual-degree OMSs that is similar to the assistance offered to single-degree OMSs.
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FDA Approves Pembrolizumab for Advanced Merkel Cell Carcinoma - Medscape
FDA Approves Pembrolizumab for Advanced Merkel Cell Carcinoma Medscape
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With this approval, patients with advanced/metastatic MCC will now have another treatment option.
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December Issue Highlights
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JAMA Otolaryngology–Head & Neck Surgery
Mission Statement:JAMA Otolaryngology–Head & Neck Surgery provides timely information for physicians and scientists concerned with diseases of the head and neck. Given the diversity of structure and function based in this anatomic region, JAMA Otolaryngology–Head & Neck Surgery publishes clinical, translational, and population health research from an array of disciplines. We place a high priority on strong study designs that accurately identify etiologies, evaluate diagnostic strategies, and distinguish among treatment options and outcomes. Our objectives are to (1) publish original contributions that will enhance the clinician's understanding of otolaryngologic disorders, benefit the care of our patients, and stimulate research in our field; (2) forecast important advances within otolaryngology—head and neck surgery, particularly as they relate to the prevention, diagnosis, and treatment of disease through clinical and translational research, including that of the human genome and novel imaging techniques; (3) address questions of clinical outcomes and cost-effectiveness that result from clinical intervention, which grow in importance as health care providers are increasingly challenged to provide evidence of enhanced survival and quality of life; (4) provide expert reviews of topics that keep our readers current with true advances and also to provide a valuable educational resource for trainees in the several disciplines that treat patients with diseases of the head and neck; (5) serve as a forum for the concerns of otolaryngologists such as socioeconomic, legal, ethical, and medical issues; (6) provide helpful critiques that enable contributing authors to improve their submissions. We encourage a concise presentation of information and employ an abstract format that efficiently assesses validity and relevance from a clinical perspective. This approach promotes succinct yet complete presentation for our readers and electronic information resources. We believe this approach typifies the commitment of JAMA Otolaryngology–Head & Neck Surgery to providing important information that is easily interpreted by its diverse readership.
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Opioid Prescribing Practice and Needs in Thyroid and Parathyroid Surgery
This cohort study assesses the opioid prescribing practices and opioid needs for patients undergoing thyroid and parathyroid surgery.
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Association of Facility Volume With Positive Margin Rate in Head and Neck Cancer Surgical Treatment
This retrospective cohort study uses data from the National Cancer Database to determine if there is an association between surgical treatment facility volume and positive margin rate in patients with head and neck squamous cell carcinoma.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SeuWwe
Comparison of Objective Outcomes in Dynamic Lower Facial Surgical Reanimation
This case series describes the use of temporalis tendon transfer or gracilis free muscle transfer to adjust the vector of smile and commissure position in patients with facial paralysis.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sjoapn
Misspelled Surname in Byline and Author Contributions
In the article titled "Opioid Prescribing Practice and Needs in Thyroid and Parathyroid Surgery," an author's surname was misspelled in the initial online publication. "Quintinalla-Diek" has been corrected to "Quintanilla-Dieck" in both the article byline and author contributions. This article was corrected online.
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Characterizing the Normative Voice Tremor Frequency in Essential Vocal Tremor
This cross-sectional observational study characterizes the normative voice tremor frequency in patients with essential vocal tremor.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SkITJ2
A Parathyroid Hemangioma of the Retropharynx
This case report describes a man in his 30s who presented with cluster headaches and migraines and was subsequently diagnosed with retropharyngeal parathyroid hemangioma.
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Opioid Prescribing Practice and Needs in Thyroid and Parathyroid Surgery
This cohort study assesses the opioid prescribing practices and opioid needs for patients undergoing thyroid and parathyroid surgery.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S8UURX
Reduction of Opiates for Ambulatory Surgery
According to the US Department of Health and Human Services, 116 people die every day in this country from an opioid-related overdose. That statistic represents more than 42 000 people a year, more than the annual number of deaths due to automobile crashes or homicides. In 2014, 47 055 drug overdose deaths occurred in the United States, and 60.9% of those involved an opioid. The following year, this number grew to 53 000 deaths and the percentage involving at least 1 opioid drug increased to 63.1%. In 1999, only 180 morphine milligram equivalents (MME) per capita were sold in the United States. In 2015, 640 MMEs per capita were sold, representing a 3.6-times increase.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S8UScN
The Role of Otolaryngologists in Eradicating Human Papillomavirus—Reply
In Reply We appreciate the response from Dr Laitman and his colleagues to our Viewpoint. Their survey data demonstrating medical students' limited knowledge of human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma is concerning given that these future doctors will be integral in educating patients in years to come. Their argument to advocate for the inclusion of education of HPV's role in oropharyngeal squamous cell carcinoma is compelling. If our nation's future physicians are unaware of the association, how can we expect the general public to be?
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AaZOXP
Reduction of Opiates for Ambulatory Surgery
According to the US Department of Health and Human Services, 116 people die every day in this country from an opioid-related overdose. That statistic represents more than 42 000 people a year, more than the annual number of deaths due to automobile crashes or homicides. In 2014, 47 055 drug overdose deaths occurred in the United States, and 60.9% of those involved an opioid. The following year, this number grew to 53 000 deaths and the percentage involving at least 1 opioid drug increased to 63.1%. In 1999, only 180 morphine milligram equivalents (MME) per capita were sold in the United States. In 2015, 640 MMEs per capita were sold, representing a 3.6-times increase.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S8UScN
The Role of Otolaryngologists in Eradicating Human Papillomavirus—Reply
In Reply We appreciate the response from Dr Laitman and his colleagues to our Viewpoint. Their survey data demonstrating medical students' limited knowledge of human papillomavirus (HPV) in oropharyngeal squamous cell carcinoma is concerning given that these future doctors will be integral in educating patients in years to come. Their argument to advocate for the inclusion of education of HPV's role in oropharyngeal squamous cell carcinoma is compelling. If our nation's future physicians are unaware of the association, how can we expect the general public to be?
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AaZOXP
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AaZOXP
An Unusual Entity Presenting as Bilateral Cervical Lymphadenopathy
A farmer in his 50s had bilateral periauricular swelling with no fever, weight loss, or loss of appetite. What is your diagnosis?
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2A6R4lm
Association of Facility Volume With Positive Margin Rate in Head and Neck Cancer Surgical Treatment
This retrospective cohort study uses data from the National Cancer Database to determine if there is an association between surgical treatment facility volume and positive margin rate in patients with head and neck squamous cell carcinoma.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SeuWwe
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SeuWwe
Association of Care Processes With Timely, Equitable Postoperative Radiotherapy in HNSCC
This cohort study assesses the care processes associated with timely, equitable postoperative radiotherapy (PORT) among patients with head and neck squamous cell carcinoma.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SesV3t
An Unusual Entity Presenting as Bilateral Cervical Lymphadenopathy
A farmer in his 50s had bilateral periauricular swelling with no fever, weight loss, or loss of appetite. What is your diagnosis?
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Validation of Haptic Properties of Materials for Endoscopic Sinus and Skull Base Surgery Simulation—Reply
In Reply In their analysis of our study, Dr Favier and colleagues suggest improvements in methodology to focus on haptic feedback fidelity through mechanical testing. We appreciate this thoughtful commentary and agree that both subjective and quantifiable measures are needed to optimally evaluate surgical simulators. As seen in their study evaluating mechanical characteristics of 3-dimensionally (3D)-printed material for skull base procedures, certain 3D-printed materials may differ in mechanical forces compared with human cadaver bone. Further, cadaver bone may not realistically represent in vivo sinus lamellae. Accordingly, although objective measurements of mechanical force are ideal, the intended audience of the simulator must also participate in the evaluation to assist in determining realism of the haptic feedback. Although we acknowledge that study participants were mostly resident physicians, surgical trainees are frequently the intended audience for surgical simulation and should be included in the development of such simulators. One method for evaluating the qualifications of study participants would be to choose a set number of live surgical experiences and statistically evaluate whether surgical experience affects participant rating of haptic feedback. Unfortunately, given the small sample size in our study, meaningful conclusions would be difficult to draw with these limited data.
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Standard Clinical Method vs Patient-Centered Tinnitus Likeness Rating
This case series assessed individual test-retest reliability of the 2-alternative forced-choice and tinnitus likeness rating approaches in patients undergoing evaluation for tinnitus.
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Timely Adjuvant Postoperative Radiotherapy
Despite the best efforts of multidisciplinary teams treating head and neck cancer, our report cards for patients with head and neck cancer completing treatment within the optimal package time window are poor, earning at most a D+ but perhaps even an F. Delays result from a multifactorial and chaotic storm of issues, including systematic inefficiencies, social obstacles, and medical or surgical complications. In 2 recent National Cancer Database studies of more than 40 000 and more than 15 000 patients, respectively, only 44.7% initiated postoperative radiotherapy (PORT) within the National Comprehensive Cancer Network (NCCN) guideline-directed window of 6 weeks after surgery, and only 16.7% had a composite treatment package time of no longer than 83 days, which was the minimum threshold before mortality began to rise.
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Notice of Retraction for Schietroma et al
This Notice of Retraction is to retract an article by Schietroma et al.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S8G6CY
Patient Concerns About Nasal Reconstruction and Implications for Shared Decision Making
This study examines the concerns of patients with nonmelanoma skin cancer regarding nasal reconstruction after Mohs surgery to develop an intervention to improve the shared decision-making process of patients and practitioners.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2A6wOjB
Standard Clinical Method vs Patient-Centered Tinnitus Likeness Rating
This case series assessed individual test-retest reliability of the 2-alternative forced-choice and tinnitus likeness rating approaches in patients undergoing evaluation for tinnitus.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2A5FMOc
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2A5FMOc
Notice of Retraction for Schietroma et al
This Notice of Retraction is to retract an article by Schietroma et al.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S8G6CY
Patient Concerns About Nasal Reconstruction and Implications for Shared Decision Making
This study examines the concerns of patients with nonmelanoma skin cancer regarding nasal reconstruction after Mohs surgery to develop an intervention to improve the shared decision-making process of patients and practitioners.
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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2A6wOjB
Comparison of Objective Outcomes in Dynamic Lower Facial Surgical Reanimation
This case series describes the use of temporalis tendon transfer or gracilis free muscle transfer to adjust the vector of smile and commissure position in patients with facial paralysis.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sjoapn
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sjoapn
Demand for Respiratory Care Devices Market 2018 to 2023 | By Monitoring Devices (Pulse Oximeters), Diagnostic Devices (Spirometers), Accessories & Consumables (Disposable Masks), and Application - MRFR - openPR
Global Respiratory Care Devices Market: Therapeutic devices (PAP Devices), monitoring devices (Pulse Oximeters), Diagnostic devices (Spirometers), ...
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Demand for Respiratory Care Devices Market 2018 to 2023 | By Monitoring Devices (Pulse Oximeters), Diagnostic Devices (Spirometers), Accessories & Consumables (Disposable Masks), and Application - MRFR - openPR
Global Respiratory Care Devices Market: Therapeutic devices (PAP Devices), monitoring devices (Pulse Oximeters), Diagnostic devices (Spirometers), ...
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JPMorgan Chase & Co. Reiterates €95.00 Price Target for Merck KGaA (MRK) - Fairfield Current
Merck KGaA (FRA:MRK) has been given a €95.00 ($110.47) price objective by equities research analysts at JPMorgan Chase & Co. in a research note issued to ...
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Contrasting GlobeImmune (GBIM) & DelMar Pharmaceuticals (DMPI) - PressOracle
GlobeImmune (OTCMKTS:GBIM) and DelMar Pharmaceuticals (NASDAQ:DMPI) are both small-cap medical companies, but which is the better business?
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Radioactive iodine doses and recurrence in thyroid cancer | The Lancet Diabetes & Endocrinology - MD Linx
Radioactive iodine doses and recurrence in thyroid cancer | The Lancet Diabetes & Endocrinology MD Linx
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Endocrinology Article: Recurrence after low-dose radioiodine ablation and recombinant human thyroid-stimulating hormone for differentiated thyroid cancer ...
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JPMorgan Chase & Co. Reiterates €95.00 Price Target for Merck KGaA (MRK) - Fairfield Current
Merck KGaA (FRA:MRK) has been given a €95.00 ($110.47) price objective by equities research analysts at JPMorgan Chase & Co. in a research note issued to ...
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Contrasting GlobeImmune (GBIM) & DelMar Pharmaceuticals (DMPI) - PressOracle
GlobeImmune (OTCMKTS:GBIM) and DelMar Pharmaceuticals (NASDAQ:DMPI) are both small-cap medical companies, but which is the better business?
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Radioactive iodine doses and recurrence in thyroid cancer | The Lancet Diabetes & Endocrinology - MD Linx
Radioactive iodine doses and recurrence in thyroid cancer | The Lancet Diabetes & Endocrinology MD Linx
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Endocrinology Article: Recurrence after low-dose radioiodine ablation and recombinant human thyroid-stimulating hormone for differentiated thyroid cancer ...
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Thyroid Function Test Market - Forecasts From 2018 to 2023 - ResearchAndMarkets.com - Business Wire
Thyroid Function Test Market - Forecasts From 2018 to 2023 - ResearchAndMarkets.com Business Wire
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DUBLIN--(BUSINESS WIRE)--The "Thyroid Function Test Market - Forecasts From 2018 to 2023" report has been added to ResearchAndMarkets.com's offering.
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New Yorkers affected by drinking water contamination urge state panel to go further - WRVO Public Media
New Yorkers affected by drinking water contamination urge state panel to go further WRVO Public Media
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The state's Drinking Water Quality Council has issued what it considers to be safe levels for exposure to toxic chemicals, including PFOAs and PFOS that.
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Thyroid Function Test Market - Forecasts From 2018 to 2023 - ResearchAndMarkets.com - Business Wire
Thyroid Function Test Market - Forecasts From 2018 to 2023 - ResearchAndMarkets.com Business Wire
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DUBLIN--(BUSINESS WIRE)--The "Thyroid Function Test Market - Forecasts From 2018 to 2023" report has been added to ResearchAndMarkets.com's offering.
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New Yorkers affected by drinking water contamination urge state panel to go further - WRVO Public Media
New Yorkers affected by drinking water contamination urge state panel to go further WRVO Public Media
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The state's Drinking Water Quality Council has issued what it considers to be safe levels for exposure to toxic chemicals, including PFOAs and PFOS that.
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Dental and craniofacial alterations in long-term survivors of childhood head and neck rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a malignant neoplasia consisting of embryonic cells that differentiate into skeletal muscle.1,2 Approximately 35.0% of the cases affect the head and neck,3,4 and the histopathological embryonal subtype of the tumor more likely develops in this region.1,5 Before the seventies, treatment often had poor outcome and only 25.0% to 30.0% of children went into remission. However, the use of multiple-agent chemotherapy followed by radiation considerably improved survival rates.
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Dental and craniofacial alterations in long-term survivors of childhood head and neck rhabdomyosarcoma
Rhabdomyosarcoma (RMS) is a malignant neoplasia consisting of embryonic cells that differentiate into skeletal muscle.1,2 Approximately 35.0% of the cases affect the head and neck,3,4 and the histopathological embryonal subtype of the tumor more likely develops in this region.1,5 Before the seventies, treatment often had poor outcome and only 25.0% to 30.0% of children went into remission. However, the use of multiple-agent chemotherapy followed by radiation considerably improved survival rates.
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Trouble in Congress for veterans claiming Agent Orange illnesses - Houston Chronicle
Trouble in Congress for veterans claiming Agent Orange illnesses Houston Chronicle
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Veterans prepared for a stinging defeat in Congress's waning hours on Thursday with the Senate set to reject legislation enabling Navy veterans who served on ...
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Trouble in Congress for veterans claiming Agent Orange illnesses - Houston Chronicle
Trouble in Congress for veterans claiming Agent Orange illnesses Houston Chronicle
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Veterans prepared for a stinging defeat in Congress's waning hours on Thursday with the Senate set to reject legislation enabling Navy veterans who served on ...
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GSK-Pfizer deal illustrates risks and rewards of moving up the biopharma value chain - MedCity News
The potential rewards for drugmakers' investments in pharmaceuticals and vaccines are enormous, but so are the risks, an industry consultant said.
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Global Oncology Pipeline Analytics Market, 2018-2024: Current Active Oncology Trial Data Analysis and How They are Affecting the Development Landscape - PRNewswire
Global Oncology Pipeline Analytics Market, 2018-2024: Current Active Oncology Trial Data Analysis and How They are Affecting the Development Landscape PRNewswire
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DUBLIN, Dec. 20, 2018 /PRNewswire/ -- The "Oncology Pipeline Analytics" report has been added to ResearchAndMarkets.com's offering.
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Kirt’s Story: How a Clinical Trial for a Rare Tumor Gave Me a New Lease on Life - On Cancer - Memorial Sloan Kettering
Kirt's Story: How a Clinical Trial for a Rare Tumor Gave Me a New Lease on Life On Cancer - Memorial Sloan Kettering
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Thanks to a clinical trial at MSK, college administrator Kirt Robinson was able to receive targeted therapy for an inoperable desmoid tumor. When Kirt Robinson ...
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GSK-Pfizer deal illustrates risks and rewards of moving up the biopharma value chain - MedCity News
The potential rewards for drugmakers' investments in pharmaceuticals and vaccines are enormous, but so are the risks, an industry consultant said.
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Global Oncology Pipeline Analytics Market, 2018-2024: Current Active Oncology Trial Data Analysis and How They are Affecting the Development Landscape - PRNewswire
Global Oncology Pipeline Analytics Market, 2018-2024: Current Active Oncology Trial Data Analysis and How They are Affecting the Development Landscape PRNewswire
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DUBLIN, Dec. 20, 2018 /PRNewswire/ -- The "Oncology Pipeline Analytics" report has been added to ResearchAndMarkets.com's offering.
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Kirt’s Story: How a Clinical Trial for a Rare Tumor Gave Me a New Lease on Life - On Cancer - Memorial Sloan Kettering
Kirt's Story: How a Clinical Trial for a Rare Tumor Gave Me a New Lease on Life On Cancer - Memorial Sloan Kettering
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Thanks to a clinical trial at MSK, college administrator Kirt Robinson was able to receive targeted therapy for an inoperable desmoid tumor. When Kirt Robinson ...
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Radiation treatment timing in head and neck cancers - On Medicine - BMC Blogs Network
Time is precious, as is the human life. Head and neck cancer (HNC) is a fatal disease and if not managed promptly, can lead to disastrous outcomes.
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Style Q &A: B.C. skin care brand Sealuxe celebrates the power of seaweed - Vancouver Sun
As a young mother, the Crescent Beach-based creative says she needed to make household necessities when money was tight and she was concerned about ...
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FDA Approves Lynparza for 1st-Line Maintenance Therapy in Advanced Ovarian Cancer - R & D Magazine
FDA Approves Lynparza for 1st-Line Maintenance Therapy in Advanced Ovarian Cancer R & D Magazine
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It is the first regulatory approval for a PARP inhibitor in the 1st-line maintenance setting for BRCA-mutated advanced ovarian cancer.
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CIRCULOGENE to Launch Comprehensive, 20-Fusion NTRK Biomarker Testing in Early 2019 - Business Wire
CIRCULOGENE to Launch Comprehensive, 20-Fusion NTRK Biomarker Testing in Early 2019 Business Wire
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CIRCULOGENE announces early 2019 launch of NTRK gene fusion testing to identify patients potentially eligible for new TRK inhibitor targeted therapy.
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Childhood HL Survivors Face High Rates of Second Solid Cancers - MedPage Today
Childhood HL Survivors Face High Rates of Second Solid Cancers MedPage Today
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Quarter century study emphasizes need for individualizing screening in former Hodgkin lymphoma patients.
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CIRCULOGENE to Launch Comprehensive, 20-Fusion NTRK Biomarker Testing in Early 2019 - Business Wire
CIRCULOGENE to Launch Comprehensive, 20-Fusion NTRK Biomarker Testing in Early 2019 Business Wire
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CIRCULOGENE announces early 2019 launch of NTRK gene fusion testing to identify patients potentially eligible for new TRK inhibitor targeted therapy.
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Childhood HL Survivors Face High Rates of Second Solid Cancers - MedPage Today
Childhood HL Survivors Face High Rates of Second Solid Cancers MedPage Today
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Quarter century study emphasizes need for individualizing screening in former Hodgkin lymphoma patients.
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FDA Approves Lynparza for 1st-Line Maintenance Therapy in Advanced Ovarian Cancer - R & D Magazine
FDA Approves Lynparza for 1st-Line Maintenance Therapy in Advanced Ovarian Cancer R & D Magazine
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It is the first regulatory approval for a PARP inhibitor in the 1st-line maintenance setting for BRCA-mutated advanced ovarian cancer.
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Evaluation of the lingual fracture patterns after bilateral sagittal split osteotomy according to Hunsuck/Epker modified by an additional inferior border osteotomy using a burr or ultrasonic device
This study was conducted to compare fracture patterns and operation times after sagittal split osteotomy (SSO) by Hunsuck/Epker approach, performed using a burr or ultrasonic device, with and without osteotomy modification. A total of 80 SSOs were performed in fresh human cadavers using a burr or ultrasonic device to investigate the influence of surgical instruments as well as an additional bone cut on the inferior border of the mandible in terms of lingual fracture patterns. The times required for osteotomy and sagittal split were measured, and postoperative cone beam computed tomography images of all splits were analyzed.
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Evaluation of the lingual fracture patterns after bilateral sagittal split osteotomy according to Hunsuck/Epker modified by an additional inferior border osteotomy using a burr or ultrasonic device
This study was conducted to compare fracture patterns and operation times after sagittal split osteotomy (SSO) by Hunsuck/Epker approach, performed using a burr or ultrasonic device, with and without osteotomy modification. A total of 80 SSOs were performed in fresh human cadavers using a burr or ultrasonic device to investigate the influence of surgical instruments as well as an additional bone cut on the inferior border of the mandible in terms of lingual fracture patterns. The times required for osteotomy and sagittal split were measured, and postoperative cone beam computed tomography images of all splits were analyzed.
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Lower airway microbiota associates with inflammatory phenotype in severe preschool wheeze
Capsule Summary: Targeting the lower airway microbiome may provide a novel approach to prevention of preschool wheezing attacks
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17-beta estradiol protects esophageal epithelium from IL-13-induced barrier dysfunction and remodeling
Eosinophilic esophagitis (EoE) is more common in males than females for reasons that are not yet fully understood. We demonstrate significant dysregulation of the expression of the estrogen receptors and estrogen responsive gene network in EoE. We show that the sex hormone estrogen abrogates IL-13-induced esophageal architectural changes and barrier dysfunction via the downregulation of IL-13-induced Tyk2-STAT6 signaling. These studies suggest that differential estrogen signaling may explain gender-bias in EoE.
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Lower airway microbiota associates with inflammatory phenotype in severe preschool wheeze
Capsule Summary: Targeting the lower airway microbiome may provide a novel approach to prevention of preschool wheezing attacks
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17-beta estradiol protects esophageal epithelium from IL-13-induced barrier dysfunction and remodeling
Eosinophilic esophagitis (EoE) is more common in males than females for reasons that are not yet fully understood. We demonstrate significant dysregulation of the expression of the estrogen receptors and estrogen responsive gene network in EoE. We show that the sex hormone estrogen abrogates IL-13-induced esophageal architectural changes and barrier dysfunction via the downregulation of IL-13-induced Tyk2-STAT6 signaling. These studies suggest that differential estrogen signaling may explain gender-bias in EoE.
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Merck Provides Update on KEYTRUDA® (pembrolizumab) Supplemental Biologics License Application (sBLA) for KEYNOTE-042 Trial - Associated Press
Merck Provides Update on KEYTRUDA® (pembrolizumab) Supplemental Biologics License Application (sBLA) for KEYNOTE-042 Trial Associated Press
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KENILWORTH, N.J.--(BUSINESS WIRE)--Dec 20, 2018--Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the ...
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Merck Provides Update on KEYTRUDA® (pembrolizumab) Supplemental Biologics License Application (sBLA) for KEYNOTE-042 Trial - Associated Press
Merck Provides Update on KEYTRUDA® (pembrolizumab) Supplemental Biologics License Application (sBLA) for KEYNOTE-042 Trial Associated Press
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KENILWORTH, N.J.--(BUSINESS WIRE)--Dec 20, 2018--Merck (NYSE: MRK), known as MSD outside the United States and Canada, today announced that the ...
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Durham Wasps legend Paul Smith dies at home near the city - The Northern Echo
Durham Wasps legend Paul Smith dies at home near the city The Northern Echo
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A KEY figure from one of the North-East's most successful sports teams of recent years has died.
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Durham Wasps legend Paul Smith dies at home near the city - The Northern Echo
Durham Wasps legend Paul Smith dies at home near the city The Northern Echo
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A KEY figure from one of the North-East's most successful sports teams of recent years has died.
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Transgene Completes Safety and Tolerability Assessment of TG4001 in Combination with Avelumab in Phase 1b Part of Trial in HPV-Positive Cancer Patients - Associated Press
Transgene Completes Safety and Tolerability Assessment of TG4001 in Combination with Avelumab in Phase 1b Part of Trial in HPV-Positive Cancer Patients Associated Press
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STRASBOURG, France--(BUSINESS WIRE)--Dec 20, 2018--Regulatory News: Transgene (Paris:TNG), a biotechnology company that designs and develops ...
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Transgene Completes Safety and Tolerability Assessment of TG4001 in Combination with Avelumab in Phase 1b Part of Trial in HPV-Positive Cancer Patients - Associated Press
Transgene Completes Safety and Tolerability Assessment of TG4001 in Combination with Avelumab in Phase 1b Part of Trial in HPV-Positive Cancer Patients Associated Press
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STRASBOURG, France--(BUSINESS WIRE)--Dec 20, 2018--Regulatory News: Transgene (Paris:TNG), a biotechnology company that designs and develops ...
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Brokerages Anticipate Interpace Diagnostics Group Inc (IDXG) Will Post Earnings of -$0.08 Per Share - Modern Readers
Wall Street brokerages expect Interpace Diagnostics Group Inc (NASDAQ:IDXG) to report ($0.08) earnings per share (EPS) for the current quarter, according to ...
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Transgene Completes Safety and Tolerability Assessment of TG4001 in Combination with Avelumab in Phase 1b Part of Trial in HPV-Positive Cancer Patients - Associated Press
Transgene Completes Safety and Tolerability Assessment of TG4001 in Combination with Avelumab in Phase 1b Part of Trial in HPV-Positive Cancer Patients Associated Press
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STRASBOURG, France--(BUSINESS WIRE)--Dec 20, 2018--Regulatory News: Transgene (Paris:TNG), a biotechnology company that designs and develops ...
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Excess body weight responsible for 4% of cancers worldwide, study says - CNN
Excess body fat and obesity were responsible for 3.9% of cancers worldwide in 2012 and an increased risk of at least 13 cancers, including postmenopausal ...
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