Τρίτη 19 Φεβρουαρίου 2019

Evaluating " Signs of Safety " : A Deaf-Accessible Therapy Toolkit for Alcohol Use Disorder and Trauma

Conditions:   Alcohol Use Disorder;   Post Traumatic Stress Disorder Intervention:   Behavioral: Seeking Safety + Signs of Safety toolkit Sponsors:   University of Massachusetts, Worcester;   National Institute on Alcohol Abuse and Alcoholism (NIAAA) Not yet recruiting (Source: ClinicalTrials.gov)

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Evaluating " Signs of Safety " : A Deaf-Accessible Therapy Toolkit for Alcohol Use Disorder and Trauma

Conditions:   Alcohol Use Disorder;   Post Traumatic Stress Disorder Intervention:   Behavioral: Seeking Safety + Signs of Safety toolkit Sponsors:   University of Massachusetts, Worcester;   National Institute on Alcohol Abuse and Alcoholism (NIAAA) Not yet recruiting (Source: ClinicalTrials.gov)

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Synergistic effect of phototherapy and chemotherapy on bladder cancer cells

Publication date: Available online 18 February 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Mehdi Shakibaie, Maryam Vaezjalali, Hashem Rafii-Tabar, Pezhman SasanpourAbstractDrug resistance as an important barrier in cancer treatment, has a close relation with alteration of cancer metabolism. Therefore, in this study the synergistic effect of phototherapy and chemotherapy were investigated on bladder cancer cells viability. The cytotoxicity effect of blue light irradiation was measured by MTT assay. Glucose consumption, lactate and ammonium formation were analyzed in blue LED-irradiated cancer cells culture. Also, the expression of some genes involved in apoptosis and epithelial–mesenchymal transition was assessed using real-time PCR in comparison with contr...

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How do parents of school-aged children respond to their children's extending gestures?

This study explored parental responses to extending gestures in a sample of school-aged children (aged six to eight years) with developmental language disorder, low-language and educational concerns, and typically developing children. Overall there were no group differences in the types of responses parents provided to extending gestures. Parents predominantly responded with positive feedback but also displayed moderate proportions of verbal translations and clarification requests. Within the DLD group, the proportion of parent translations was negatively associated with language ability. Our finding suggests that parent responses serve to enhance communication and engage children in tasks, but there is limited evidence that they support new language learning at this age. PMID: 3077316...

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A phonological assessment test for child Greek.

This article advances a clinical tool for assessing typical and atypical phonological development in children speaking standard Modern Greek or Hellenic (ISO 639.1, el). The proposed tool develops a comprehensive test that is archetypical of the standard idiom and of predominant dialectal variations and seeks to be readily available for logopedics and language researchers of child Greek anywhere. By utilising the constraint-based nonlinear theoretical framework, this Greek battery complements a larger study that utilises equivalent methodology in the evaluation of phonological acquisition of monolingual children with typical and protracted phonological development across several languages. As an example, the efficacy of the tool is tested by administering it to a monolingual Greek-speaking...

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Language activities in a minority-majority language context: book-reading at home is more important for Frisian than for Dutch.

Authors: Bosma E, Blom E Abstract Previous research has shown that in a minority-majority language context, the quantity of language input at home is more important for the development of the minority language than for the development of the majority language. In the current study, we examined whether the same holds true for the frequency of specific language activities at home. In a group of five- and six-year-old Frisian-Dutch bilingual children (n = 120), we investigated to what extent vocabulary and morphology knowledge were predicted by reading activities, watching TV, and story-telling activities in both languages. The results showed that reading in Frisian predicted both Frisian vocabulary and morphology, while reading in Dutch only predicted Dutch vocabulary. This shows tha...

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After the RESTART trial: six guidelines for clinical trials of early stuttering intervention.

CONCLUSION: In addition to guiding future clinical research comparing RESTART-DCM and Lidcombe Program treatment, these recommendations may extend to influence positively other treatment developments for early stuttering. PMID: 30773736 [PubMed - as supplied by publisher] (Source: International Journal of Language and Communication Disorders)

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Auditory Gaydar: Perception of Sexual Orientation Based on Female Voice.

Authors: Sulpizio S, Fasoli F, Antonio R, Eyssel F, Paladino MP, Diehl C Abstract We investigated auditory gaydar (i.e., the ability to recognize sexual orientation) in female speakers, addressing three related issues: whether auditory gaydar is (1) accurate, (2) language-dependent (i.e., occurs only in some languages, but not in others), and (3) ingroup-specific (i.e., occurs only when listeners judge speakers of their own language, but not when they judge foreign language speakers). In three experiments, we asked Italian, Portuguese, and German participants (total N = 466) to listen to voices of Italian, Portuguese, and German women, and to rate their sexual orientation. Our results showed that auditory gaydar was not accurate; listeners were not able to identify speakers' sexual...

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Intra-word consistency and accuracy in Finnish children aged 3-6 years.

This study examined intra-word consistency and accuracy in typically developing Finnish children and their relation to children's vocabulary size and phonological skills. A total of 80 typically developing Finnish children aged 3;0 to 6;11 were asked to name 20 words three separate times during a single assessment session. Responses were classified into four categories: 1) consistently correct productions, 2) consistently incorrect productions, 3) variable productions with hits (variable productions including at least one matched adult target), and 4) variable productions with no hits. The results revealed that 5- and 6-year-old children produced significantly more often consistently correct responses than younger children. However, even for the 3- and 4-year old children the most frequent...

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Exploring the Relationship between Native Language Skills and Foreign Language Learning in Children with Developmental Language Disorders.

Authors: Zoutenbier I, Zwitserlood R Abstract Learning English as a foreign language (FL) is mandatory for children with developmental language disorders (DLD) in elementary education in the Netherlands. Because of their difficulties in acquiring their first language, learning an FL at school can be challenging. To date, almost no literature on children with DLD and FL learning exists. The aim of this study is to investigate the relationship between language proficiency in Dutch of monolingual and multilingual children with DLD and learning English as an FL. A cross-sectional study was conducted in four special education schools for children with DLD. Thirty-five sixth graders (mean age 12;3 years) participated in this study. Twenty-two children were monolingual, and 13 children w...

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Synergistic effect of phototherapy and chemotherapy on bladder cancer cells

Publication date: Available online 18 February 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Mehdi Shakibaie, Maryam Vaezjalali, Hashem Rafii-Tabar, Pezhman SasanpourAbstractDrug resistance as an important barrier in cancer treatment, has a close relation with alteration of cancer metabolism. Therefore, in this study the synergistic effect of phototherapy and chemotherapy were investigated on bladder cancer cells viability. The cytotoxicity effect of blue light irradiation was measured by MTT assay. Glucose consumption, lactate and ammonium formation were analyzed in blue LED-irradiated cancer cells culture. Also, the expression of some genes involved in apoptosis and epithelial–mesenchymal transition was assessed using real-time PCR in comparison with contr...

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Phonotherapeutic Intervention in Patients With Mucosal Leishmaniasis Sequelae

To characterize the voice before and after speech-language intervention, with Humming nasal sound in patients with sequelae Mucosal Leishmaniasis (ML) and Cutaneous Leishmaniasis (CL). (Source: Journal of Voice)

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The Italian Words and Sentences MB-CDI: normative data and concordance between complete and short forms.

This study compares normative data of the Italian Words and Sentences complete form (WS-CF) and short form (WS-SF). The samples included 752 children for the WS-CF and 816 children for the WS-SF designed for children aged 18-36 months. The concordance between WS-SF and WS-CF is analyzed in a subgroup of 65 children. The results revealed strong correlations between WS-CF and WS-SF in both lexical and grammar skills as well as strong relationship between lexical and grammar skills. There was a high percentage agreement (97%) between the two forms for scores below the 10th percentile, suggesting that the two forms may be used interchangeably in order to describe vocabulary and grammatical development. PMID: 30773152 [PubMed - as supplied by publisher] (Source: Journal of Child Language)

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How do parents of school-aged children respond to their children's extending gestures?

This study explored parental responses to extending gestures in a sample of school-aged children (aged six to eight years) with developmental language disorder, low-language and educational concerns, and typically developing children. Overall there were no group differences in the types of responses parents provided to extending gestures. Parents predominantly responded with positive feedback but also displayed moderate proportions of verbal translations and clarification requests. Within the DLD group, the proportion of parent translations was negatively associated with language ability. Our finding suggests that parent responses serve to enhance communication and engage children in tasks, but there is limited evidence that they support new language learning at this age. PMID: 3077316...

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Language activities in a minority-majority language context: book-reading at home is more important for Frisian than for Dutch.

Authors: Bosma E, Blom E Abstract Previous research has shown that in a minority-majority language context, the quantity of language input at home is more important for the development of the minority language than for the development of the majority language. In the current study, we examined whether the same holds true for the frequency of specific language activities at home. In a group of five- and six-year-old Frisian-Dutch bilingual children (n = 120), we investigated to what extent vocabulary and morphology knowledge were predicted by reading activities, watching TV, and story-telling activities in both languages. The results showed that reading in Frisian predicted both Frisian vocabulary and morphology, while reading in Dutch only predicted Dutch vocabulary. This shows tha...

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After the RESTART trial: six guidelines for clinical trials of early stuttering intervention.

CONCLUSION: In addition to guiding future clinical research comparing RESTART-DCM and Lidcombe Program treatment, these recommendations may extend to influence positively other treatment developments for early stuttering. PMID: 30773736 [PubMed - as supplied by publisher] (Source: International Journal of Language and Communication Disorders)

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Intra-word consistency and accuracy in Finnish children aged 3-6 years.

This study examined intra-word consistency and accuracy in typically developing Finnish children and their relation to children's vocabulary size and phonological skills. A total of 80 typically developing Finnish children aged 3;0 to 6;11 were asked to name 20 words three separate times during a single assessment session. Responses were classified into four categories: 1) consistently correct productions, 2) consistently incorrect productions, 3) variable productions with hits (variable productions including at least one matched adult target), and 4) variable productions with no hits. The results revealed that 5- and 6-year-old children produced significantly more often consistently correct responses than younger children. However, even for the 3- and 4-year old children the most frequent...

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Exploring the Relationship between Native Language Skills and Foreign Language Learning in Children with Developmental Language Disorders.

Authors: Zoutenbier I, Zwitserlood R Abstract Learning English as a foreign language (FL) is mandatory for children with developmental language disorders (DLD) in elementary education in the Netherlands. Because of their difficulties in acquiring their first language, learning an FL at school can be challenging. To date, almost no literature on children with DLD and FL learning exists. The aim of this study is to investigate the relationship between language proficiency in Dutch of monolingual and multilingual children with DLD and learning English as an FL. A cross-sectional study was conducted in four special education schools for children with DLD. Thirty-five sixth graders (mean age 12;3 years) participated in this study. Twenty-two children were monolingual, and 13 children w...

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Is there an association between overweight/obesity and dental implant complications? A systematic review and meta-analysis

The aim of this systematic review was to test the following hypotheses: (1) that there is no difference in implant survival rate between individuals with overweight or obesity and those who are within the ideal weight range; (2) that there are no differences between these groups regarding indicators of peri-implant health. Two independent reviewers performed a literature search of the PubMed/MEDLINE, Scopus, and Cochrane Library databases for studies published up to April 1, 2018. A meta-analysis was performed to determine the risk difference for implant failure and mean difference for marginal bone loss, probing depth, and bleeding on probing. (Source: International Journal of Oral and Maxillofacial Surgery)

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Complication rates and clinical outcomes of osseous free flaps: a retrospective comparison of CAD/CAM versus conventional fixation in 128 patients

Studies evaluating plate-related complications in patient-specific versus conventional fixation systems in free flap surgery are lacking. This was a retrospective study of 128 osseous free flaps with a minimum follow-up of 12 months. Wound healing disorders, plate exposure, fixation failure, and subtotal osseous union were recorded and evaluated statistically by univariate and regression analysis. Complication rates were as follows: wound healing disorders 33.6% (computer-aided design and computer-aided manufacturing (CAD/CAM) vs. (Source: International Journal of Oral and Maxillofacial Surgery)

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Is there an association between overweight/obesity and dental implant complications? A systematic review and meta-analysis

The aim of this systematic review was to test the following hypotheses: (1) that there is no difference in implant survival rate between individuals with overweight or obesity and those who are within the ideal weight range; (2) that there are no differences between these groups regarding indicators of peri-implant health. Two independent reviewers performed a literature search of the PubMed/MEDLINE, Scopus, and Cochrane Library databases for studies published up to April 1, 2018. A meta-analysis was performed to determine the risk difference for implant failure and mean difference for marginal bone loss, probing depth, and bleeding on probing. (Source: International Journal of Oral and Maxillofacial Surgery)

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Complication rates and clinical outcomes of osseous free flaps: a retrospective comparison of CAD/CAM versus conventional fixation in 128 patients

Studies evaluating plate-related complications in patient-specific versus conventional fixation systems in free flap surgery are lacking. This was a retrospective study of 128 osseous free flaps with a minimum follow-up of 12 months. Wound healing disorders, plate exposure, fixation failure, and subtotal osseous union were recorded and evaluated statistically by univariate and regression analysis. Complication rates were as follows: wound healing disorders 33.6% (computer-aided design and computer-aided manufacturing (CAD/CAM) vs. (Source: International Journal of Oral and Maxillofacial Surgery)

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Assessment of Oxidative Stress in Patients with Sudden Hearing Loss: A Non-randomized Prospective Clinical Study

AbstractThe etiology of sudden hearing loss (SHL) has not been fully elucidated. Previous studies claimed that different etiological factors may play a role in the pathogenesis of SHL. The aim of the present study is to investigate the presence of oxidative stress (OS) in SHL cases using thiol-disulfide balance. In addition, total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and lipid hydroperoxide levels (LOOH) were investigated. A total of 30 cases (15 female, 15 male, mean age 48.9  ± 8.1 years, age range: 36–68 years) were included in the study. Thiol and disulfide amounts, thiol/disulfide ratios, TOS, TAS, OSI and LOOH scores of the case group and control group were compared. Native thiol (SH) and total thiol (SH + SH) values were sig...

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Assessment of Oxidative Stress in Patients with Sudden Hearing Loss: A Non-randomized Prospective Clinical Study

AbstractThe etiology of sudden hearing loss (SHL) has not been fully elucidated. Previous studies claimed that different etiological factors may play a role in the pathogenesis of SHL. The aim of the present study is to investigate the presence of oxidative stress (OS) in SHL cases using thiol-disulfide balance. In addition, total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and lipid hydroperoxide levels (LOOH) were investigated. A total of 30 cases (15 female, 15 male, mean age 48.9  ± 8.1 years, age range: 36–68 years) were included in the study. Thiol and disulfide amounts, thiol/disulfide ratios, TOS, TAS, OSI and LOOH scores of the case group and control group were compared. Native thiol (SH) and total thiol (SH + SH) values were sig...

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'For God's sake, vaccinate your children': Measles survivor still feels the effects after 69 years

Brenda Shaw spent a month in hospital when she contracted measles as a four-year-old in 1950. The infection burst her eardrum, leaving her deaf in the right ear and causing complications that still trouble her today. (Source: CBC | Health)

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REMEDI HEALTH SOLUTIONS ALLERGY MOLD, DUST AND HAY (Bovista Lycoperdon, Secale Cornutum, Ustilago Maydis, Wyethia Helenioides) Spray [Chc Montana]

Updated Date: Feb 19, 2019 EST (Source: DailyMed Drug Label Updates)

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Nature ’ s Path Foods Recalls A Specific Production Run Of Envirokidz Choco Chimps, Gorilla Munch And Jungle Munch Cereals Due To Undeclared Gluten

Today, Nature ' s Path Foods announced a voluntary recall of a specific production run of EnviroKidz Choco Chimps, Gorilla Munch and Jungle Munch cereals for they may contain undeclared gluten (wheat and barley). People who have a wheat allergy, celiac disease or sensitivity to gluten and wheat should not consume the cereals with the BEST BEFORE DATE listed below due to potential adverse health effects. Nature ' s Path is also removing any affected cereals from customer store shelves and warehouses. (Source: FDA Food Safety)

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'For God's sake, vaccinate your children': Measles survivor still feels the effects after 69 years

Brenda Shaw spent a month in hospital when she contracted measles as a four-year-old in 1950. The infection burst her eardrum, leaving her deaf in the right ear and causing complications that still trouble her today. (Source: CBC | Health)

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REMEDI HEALTH SOLUTIONS ALLERGY MOLD, DUST AND HAY (Bovista Lycoperdon, Secale Cornutum, Ustilago Maydis, Wyethia Helenioides) Spray [Chc Montana]

Updated Date: Feb 19, 2019 EST (Source: DailyMed Drug Label Updates)

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Nature ’ s Path Foods Recalls A Specific Production Run Of Envirokidz Choco Chimps, Gorilla Munch And Jungle Munch Cereals Due To Undeclared Gluten

Today, Nature ' s Path Foods announced a voluntary recall of a specific production run of EnviroKidz Choco Chimps, Gorilla Munch and Jungle Munch cereals for they may contain undeclared gluten (wheat and barley). People who have a wheat allergy, celiac disease or sensitivity to gluten and wheat should not consume the cereals with the BEST BEFORE DATE listed below due to potential adverse health effects. Nature ' s Path is also removing any affected cereals from customer store shelves and warehouses. (Source: FDA Food Safety)

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'For God's sake, vaccinate your children': Measles survivor still feels the effects after 69 years

Brenda Shaw spent a month in hospital when she contracted measles as a four-year-old in 1950. The infection burst her eardrum, leaving her deaf in the right ear and causing complications that still trouble her today. (Source: CBC | Health)

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'For God's sake, vaccinate your children': Measles survivor still feels the effects after 69 years

Brenda Shaw spent a month in hospital when she contracted measles as a four-year-old in 1950. The infection burst her eardrum, leaving her deaf in the right ear and causing complications that still trouble her today. (Source: CBC | Health)

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Concord Fresh Success Recall Mild Salsa Seasoning Mix Due To Undeclared Milk Allergen

Concord Foods, LLC of Brockton, Massachusetts is recalling Concord Fresh Success Mild Salsa Seasoning Mix because it may contain undeclared milk allergen. People who have an allergy or severe sensitivity to milk allergen run the risk of serious or lifethreatening allergic reaction if they consume this product. (Source: Food and Drug Administration)

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Concord Fresh Success Recall Mild Salsa Seasoning Mix Due To Undeclared Milk Allergen

Concord Foods, LLC of Brockton, Massachusetts is recalling Concord Fresh Success Mild Salsa Seasoning Mix because it may contain undeclared milk allergen. People who have an allergy or severe sensitivity to milk allergen run the risk of serious or lifethreatening allergic reaction if they consume this product. (Source: Food and Drug Administration)

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Big Changes in Life Resulted in One SLP Creating ‘Small Steps in Speech’

February 12 is a day anyone who was privileged to know Marc Small will never forget. On that day in 2009, Marc—then my fiancé—lost his life in Afghanistan serving our nation as an Army Special Forces medical sergeant. Instead of planning our wedding, I launched a nonprofit in his memory called Small Steps in Speech. I shared the story of launching the organization in a Leader article, which also explains how Marc thought of the name originally for my future private practice. Jumping forward 10 years…. the legacy of Marc Small has changed the lives of children and their families across the country. Small Steps in Speech assists children with speech and language disorders by funding supplemental treatments not covered by insurance. Our goal is to help children better express themselve...

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Concord Fresh Success Recall Mild Salsa Seasoning Mix Due To Undeclared Milk Allergen

Concord Foods, LLC of Brockton, Massachusetts is recalling Concord Fresh Success Mild Salsa Seasoning Mix because it may contain undeclared milk allergen. People who have an allergy or severe sensitivity to milk allergen run the risk of serious or lifethreatening allergic reaction if they consume this product. (Source: Food and Drug Administration)

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Big Changes in Life Resulted in One SLP Creating ‘Small Steps in Speech’

February 12 is a day anyone who was privileged to know Marc Small will never forget. On that day in 2009, Marc—then my fiancé—lost his life in Afghanistan serving our nation as an Army Special Forces medical sergeant. Instead of planning our wedding, I launched a nonprofit in his memory called Small Steps in Speech. I shared the story of launching the organization in a Leader article, which also explains how Marc thought of the name originally for my future private practice. Jumping forward 10 years…. the legacy of Marc Small has changed the lives of children and their families across the country. Small Steps in Speech assists children with speech and language disorders by funding supplemental treatments not covered by insurance. Our goal is to help children better express themselve...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2V5DIhh

Concord Fresh Success Recall Mild Salsa Seasoning Mix Due To Undeclared Milk Allergen

Concord Foods, LLC of Brockton, Massachusetts is recalling Concord Fresh Success Mild Salsa Seasoning Mix because it may contain undeclared milk allergen. People who have an allergy or severe sensitivity to milk allergen run the risk of serious or lifethreatening allergic reaction if they consume this product. (Source: Food and Drug Administration)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Gy5qjF

Big Changes in Life Resulted in One SLP Creating ‘Small Steps in Speech’

February 12 is a day anyone who was privileged to know Marc Small will never forget. On that day in 2009, Marc—then my fiancé—lost his life in Afghanistan serving our nation as an Army Special Forces medical sergeant. Instead of planning our wedding, I launched a nonprofit in his memory called Small Steps in Speech. I shared the story of launching the organization in a Leader article, which also explains how Marc thought of the name originally for my future private practice. Jumping forward 10 years…. the legacy of Marc Small has changed the lives of children and their families across the country. Small Steps in Speech assists children with speech and language disorders by funding supplemental treatments not covered by insurance. Our goal is to help children better express themselve...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2V5DIhh

Big Changes in Life Resulted in One SLP Creating ‘Small Steps in Speech’

February 12 is a day anyone who was privileged to know Marc Small will never forget. On that day in 2009, Marc—then my fiancé—lost his life in Afghanistan serving our nation as an Army Special Forces medical sergeant. Instead of planning our wedding, I launched a nonprofit in his memory called Small Steps in Speech. I shared the story of launching the organization in a Leader article, which also explains how Marc thought of the name originally for my future private practice. Jumping forward 10 years…. the legacy of Marc Small has changed the lives of children and their families across the country. Small Steps in Speech assists children with speech and language disorders by funding supplemental treatments not covered by insurance. Our goal is to help children better express themselve...

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Evaluation of basophil activation caused by transgenic rice seeds expressing whole T cell epitopes of the major Japanese cedar pollen allergens

Abstract

Background

Japanese cedar (JC) pollinosis is a serious type I allergic disease in Japan. Although subcutaneous immunotherapy and sublingual immunotherapy have been applied to treat JC pollinosis, high doses of allergens may cause IgE-mediated allergic reactions. The transgenic rice seeds that contain genetically modified Cry j 1 and Cry j 2, the two major allergens of JC pollen, have been developed as candidates for oral immunotherapy. Although the antigens in the transgenic rice seeds (Tg-rice seeds) were engineered such that they decrease binding ability with IgE and they are of insufficient length to cross-link IgE on the surface of mast cells or basophils, the safety of Tg-rice seeds for patients with JC pollinosis was unclear.

Methods

To verify the safety of Tg-rice seeds in terms of allergies, we investigated the percentage of activated basophils induced by Tg-rice seed extract in the basophil activation test. Blood samples from 29 patients with JC pollinosis were collected. Tg-rice seed extract, non-transgenic wild-type rice seed extract, and Cry j 1 and Cry j 2 were mixed with the blood with reagents. The percentage of activated basophils was assessed by CD203c expression, a basophil activation marker.

Results

The percentage of activated basophils after the stimulation with Tg-rice seed extract was 4.5 ± 1.6% (mean ± SD) compared with 62.9 ± 20.2% after Cry j 1- and Cry j 2-stimulation (difference 58.4%, P < 0.001, 95% confidence interval 51.0–65.9%).

Conclusions

The results will contribute to the safety of Tg-rice seeds in terms of allergies.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TXwnQT

Evaluation of basophil activation caused by transgenic rice seeds expressing whole T cell epitopes of the major Japanese cedar pollen allergens

Abstract

Background

Japanese cedar (JC) pollinosis is a serious type I allergic disease in Japan. Although subcutaneous immunotherapy and sublingual immunotherapy have been applied to treat JC pollinosis, high doses of allergens may cause IgE-mediated allergic reactions. The transgenic rice seeds that contain genetically modified Cry j 1 and Cry j 2, the two major allergens of JC pollen, have been developed as candidates for oral immunotherapy. Although the antigens in the transgenic rice seeds (Tg-rice seeds) were engineered such that they decrease binding ability with IgE and they are of insufficient length to cross-link IgE on the surface of mast cells or basophils, the safety of Tg-rice seeds for patients with JC pollinosis was unclear.

Methods

To verify the safety of Tg-rice seeds in terms of allergies, we investigated the percentage of activated basophils induced by Tg-rice seed extract in the basophil activation test. Blood samples from 29 patients with JC pollinosis were collected. Tg-rice seed extract, non-transgenic wild-type rice seed extract, and Cry j 1 and Cry j 2 were mixed with the blood with reagents. The percentage of activated basophils was assessed by CD203c expression, a basophil activation marker.

Results

The percentage of activated basophils after the stimulation with Tg-rice seed extract was 4.5 ± 1.6% (mean ± SD) compared with 62.9 ± 20.2% after Cry j 1- and Cry j 2-stimulation (difference 58.4%, P < 0.001, 95% confidence interval 51.0–65.9%).

Conclusions

The results will contribute to the safety of Tg-rice seeds in terms of allergies.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2TXwnQT

Letters to the Editor

We thank Drs Sembronio, Tel, and Robiony for their interest and constructive comments regarding our recently published article.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DXPpiW

Tinnitus in the side with better hearing

ConclusionTinnitus was associated with deterioration of hearing even when it occurred in the better-hearing side. Among the possible etiologies, fluctuating hearing loss in the tinnitus side was the most common audiologic finding. Assessment of hearing level at each frequency was more effective in detecting high-frequency hearing loss rather than the use of the mean hearing level. In addition, somatosensory tinnitus should not be ignored. (Source: American Journal of Otolaryngology)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GX0uE2

Successful treatment of a child with definite Meniere's disease with the migraine regimen

We report a 5-year-old girl with a 6-month history of left-sided hearing loss followed by daily episodes of vertigo, headache, and vomiting who met the criteria for definite MD. The patient became symptom-free and gained near normal hearing levels after starting on a 6-week migraine diet/lifestyle regimen with riboflavin and magnesium. We believe that the symptoms of MD may be primarily due to a vestibular migraine phenomenon. Pediatric MD patients may benefit from migraine lifestyle/dietary changes with control of both cochlear and vestibular symptoms. (Source: American Journal of Otolaryngology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2tsRYon

Corrigendum to "The SIRT2 inhibitor AK-7 decreases cochlear cell apoptosis and attenuates noise-induced hearing loss" [Biochem. Biophys. Res. Commun. 509 (3) (2019) 641-646].

Corrigendum to "The SIRT2 inhibitor AK-7 decreases cochlear cell apoptosis and attenuates noise-induced hearing loss" [Biochem. Biophys. Res. Commun. 509 (3) (2019) 641-646]. Biochem Biophys Res Commun. 2019 Feb 14;: Authors: Liu Y, Ao L, Li Y, Zhao Y, Wen Y, Ding H PMID: 30773260 [PubMed - as supplied by publisher] (Source: Biochemical and Biophysical Research communications)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GX0pQK

Tinnitus in the side with better hearing

ConclusionTinnitus was associated with deterioration of hearing even when it occurred in the better-hearing side. Among the possible etiologies, fluctuating hearing loss in the tinnitus side was the most common audiologic finding. Assessment of hearing level at each frequency was more effective in detecting high-frequency hearing loss rather than the use of the mean hearing level. In addition, somatosensory tinnitus should not be ignored. (Source: American Journal of Otolaryngology)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GX0uE2

Successful treatment of a child with definite Meniere's disease with the migraine regimen

We report a 5-year-old girl with a 6-month history of left-sided hearing loss followed by daily episodes of vertigo, headache, and vomiting who met the criteria for definite MD. The patient became symptom-free and gained near normal hearing levels after starting on a 6-week migraine diet/lifestyle regimen with riboflavin and magnesium. We believe that the symptoms of MD may be primarily due to a vestibular migraine phenomenon. Pediatric MD patients may benefit from migraine lifestyle/dietary changes with control of both cochlear and vestibular symptoms. (Source: American Journal of Otolaryngology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2tsRYon

Corrigendum to "The SIRT2 inhibitor AK-7 decreases cochlear cell apoptosis and attenuates noise-induced hearing loss" [Biochem. Biophys. Res. Commun. 509 (3) (2019) 641-646].

Corrigendum to "The SIRT2 inhibitor AK-7 decreases cochlear cell apoptosis and attenuates noise-induced hearing loss" [Biochem. Biophys. Res. Commun. 509 (3) (2019) 641-646]. Biochem Biophys Res Commun. 2019 Feb 14;: Authors: Liu Y, Ao L, Li Y, Zhao Y, Wen Y, Ding H PMID: 30773260 [PubMed - as supplied by publisher] (Source: Biochemical and Biophysical Research communications)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2GX0pQK

Letters to the Editor

We thank Drs Sembronio, Tel, and Robiony for their interest and constructive comments regarding our recently published article.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DXPpiW

Letters to the Editor

We thank Drs Sembronio, Tel, and Robiony for their interest and constructive comments regarding our recently published article.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DXPpiW

Big Changes in Life Resulted in One SLP Creating ‘Small Steps in Speech’

February 12 is a day anyone who was privileged to know Marc Small will never forget. On that day in 2009, Marc—then my fiancé—lost his life in Afghanistan serving our nation as an Army Special Forces medical sergeant. Instead of planning our wedding, I launched a nonprofit in his memory called Small Steps in Speech. I shared the story of launching the organization in a Leader article, which also explains how Marc thought of the name originally for my future private practice. Jumping forward 10 years…. the legacy of Marc Small has changed the lives of children and their families across the country. Small Steps in Speech assists children with speech and language disorders by funding supplemental treatments not covered by insurance. Our goal is to help children better express themselve...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GP1x94

Big Changes in Life Resulted in One SLP Creating ‘Small Steps in Speech’

February 12 is a day anyone who was privileged to know Marc Small will never forget. On that day in 2009, Marc—then my fiancé—lost his life in Afghanistan serving our nation as an Army Special Forces medical sergeant. Instead of planning our wedding, I launched a nonprofit in his memory called Small Steps in Speech. I shared the story of launching the organization in a Leader article, which also explains how Marc thought of the name originally for my future private practice. Jumping forward 10 years…. the legacy of Marc Small has changed the lives of children and their families across the country. Small Steps in Speech assists children with speech and language disorders by funding supplemental treatments not covered by insurance. Our goal is to help children better express themselve...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GP1x94

Using Young People ’s Blood to Prevent Aging Has No Proven Clinical Benefits, FDA Warns

(Bloomberg) — Taking a young person's plasma and infusing it into an older person to ward off aging — a therapy that's fascinated some of the biggest names in Silicon Valley — has no proven clinical benefit, the Food and Drug Administration said. The agency issued a safety alert on Tuesday about the infusion of plasma from young donors for the prevention of conditions such as aging or memory loss, or for the treatment of such conditions as dementia, Parkinson's disease, multiple sclerosis, Alzheimer's disease, heart disease or post‐traumatic stress disorder. "There is no proven clinical benefit of infusion of plasma from young donors to cure, mitigate, treat or prevent these conditions, and there are risks associated with the use of any...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tam7Yp

Food allergies and multiple sclerosis: study reveals a new link

(Brigham and Women's Hospital) Investigating the correlation between allergy and inflammatory disease activity, a team of investigators from Brigham and Women's Hospital has found new evidence connecting food allergies and relapses of multiple sclerosis. (Source: EurekAlert! - Medicine and Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sgca6U

Using Young People ’s Blood to Prevent Aging Has No Proven Clinical Benefits, FDA Warns

(Bloomberg) — Taking a young person's plasma and infusing it into an older person to ward off aging — a therapy that's fascinated some of the biggest names in Silicon Valley — has no proven clinical benefit, the Food and Drug Administration said. The agency issued a safety alert on Tuesday about the infusion of plasma from young donors for the prevention of conditions such as aging or memory loss, or for the treatment of such conditions as dementia, Parkinson's disease, multiple sclerosis, Alzheimer's disease, heart disease or post‐traumatic stress disorder. "There is no proven clinical benefit of infusion of plasma from young donors to cure, mitigate, treat or prevent these conditions, and there are risks associated with the use of any...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tam7Yp

Food allergies and multiple sclerosis: study reveals a new link

(Brigham and Women's Hospital) Investigating the correlation between allergy and inflammatory disease activity, a team of investigators from Brigham and Women's Hospital has found new evidence connecting food allergies and relapses of multiple sclerosis. (Source: EurekAlert! - Medicine and Health)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Sgca6U

Using Young People ’s Blood to Prevent Aging Has No Proven Clinical Benefits, FDA Warns

(Bloomberg) — Taking a young person's plasma and infusing it into an older person to ward off aging — a therapy that's fascinated some of the biggest names in Silicon Valley — has no proven clinical benefit, the Food and Drug Administration said. The agency issued a safety alert on Tuesday about the infusion of plasma from young donors for the prevention of conditions such as aging or memory loss, or for the treatment of such conditions as dementia, Parkinson's disease, multiple sclerosis, Alzheimer's disease, heart disease or post‐traumatic stress disorder. "There is no proven clinical benefit of infusion of plasma from young donors to cure, mitigate, treat or prevent these conditions, and there are risks associated with the use of any...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tam7Yp

Using Young People ’s Blood to Prevent Aging Has No Proven Clinical Benefits, FDA Warns

(Bloomberg) — Taking a young person's plasma and infusing it into an older person to ward off aging — a therapy that's fascinated some of the biggest names in Silicon Valley — has no proven clinical benefit, the Food and Drug Administration said. The agency issued a safety alert on Tuesday about the infusion of plasma from young donors for the prevention of conditions such as aging or memory loss, or for the treatment of such conditions as dementia, Parkinson's disease, multiple sclerosis, Alzheimer's disease, heart disease or post‐traumatic stress disorder. "There is no proven clinical benefit of infusion of plasma from young donors to cure, mitigate, treat or prevent these conditions, and there are risks associated with the use of any...

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Tam7Yp

Effects of Different Head Positioning Methods on Facial Soft Tissue Analysis Using Stereophotogrammetry

The purpose of this study was to compare sagittal tilt of the head in different head positioning techniques by an inclinometer and facial stereophotogrammetry measurements among different head positioning records.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2NfRGKX

Relationship between surgical difficulty of third molar extraction under local anesthesia and the postoperative evolution of clinical and blood parameters.

To determine whether the Pederson scale is a good predictor of the surgical difficulty of third molar extraction and establish whether such surgical difficulty is directly related to the postoperative course as assessed from clinical (pain, inflammation and trismus) and blood parameters (C-reactive protein, IL-6 and fibrinogen).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Ne2YiC

Root elongation after autotransplantation in 58 transplanted premolars: the radiographic width of the apex as a predictor

Autotransplantation of premolars with incomplete root development is a reliable treatment option for tooth replacement. Nevertheless, little is known about development of roots after transplantation of teeth. The aim of this study was to evaluate the preoperative root development stage and radiographic width of the apex as predictors for root elongation after autotransplantation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GEhVu7

Intraoperative Depth of Invasion is Accurate in Early Stage Oral Cavity Squamous Cell Carcinoma

Depth of invasion (DOI) is one predictor of nodal metastasis in oral cavity squamous cell carcinoma (OCSCC) and can facilitate the decision to complete an elective neck dissection (END) in early stage disease with a clinically negative neck. The purpose of this study was to investigate the accuracy of DOI on intraoperative frozen specimen for T1N0 oral OCSCC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gyuw1Q

Intraoperative Depth of Invasion is Accurate in Early Stage Oral Cavity Squamous Cell Carcinoma

Depth of invasion (DOI) is one predictor of nodal metastasis in oral cavity squamous cell carcinoma (OCSCC) and can facilitate the decision to complete an elective neck dissection (END) in early stage disease with a clinically negative neck. The purpose of this study was to investigate the accuracy of DOI on intraoperative frozen specimen for T1N0 oral OCSCC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gyuw1Q

Effects of Different Head Positioning Methods on Facial Soft Tissue Analysis Using Stereophotogrammetry

The purpose of this study was to compare sagittal tilt of the head in different head positioning techniques by an inclinometer and facial stereophotogrammetry measurements among different head positioning records.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2NfRGKX

Relationship between surgical difficulty of third molar extraction under local anesthesia and the postoperative evolution of clinical and blood parameters.

To determine whether the Pederson scale is a good predictor of the surgical difficulty of third molar extraction and establish whether such surgical difficulty is directly related to the postoperative course as assessed from clinical (pain, inflammation and trismus) and blood parameters (C-reactive protein, IL-6 and fibrinogen).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Ne2YiC

Root elongation after autotransplantation in 58 transplanted premolars: the radiographic width of the apex as a predictor

Autotransplantation of premolars with incomplete root development is a reliable treatment option for tooth replacement. Nevertheless, little is known about development of roots after transplantation of teeth. The aim of this study was to evaluate the preoperative root development stage and radiographic width of the apex as predictors for root elongation after autotransplantation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GEhVu7

Reconstruction of the oral commissure with the Zisser flap

The aim of this study was to investigate the role of the Zisser flap in the reconstruction of defects of the oral commissure. The investigators describe their personal experience with this method and present some interesting aspects from the relevant literature.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2NgQZky

Complication rates and clinical outcomes of osseous free flaps: a retrospective comparison of CAD/CAM versus conventional fixation in 128 patients

Studies evaluating plate-related complications in patient-specific versus conventional fixation systems in free flap surgery are lacking. This was a retrospective study of 128 osseous free flaps with a minimum follow-up of 12 months. Wound healing disorders, plate exposure, fixation failure, and subtotal osseous union were recorded and evaluated statistically by univariate and regression analysis. Complication rates were as follows: wound healing disorders 33.6% (computer-aided design and computer-aided manufacturing (CAD/CAM) vs.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Nea0nv

Is there an association between overweight/obesity and dental implant complications? A systematic review and meta-analysis

The aim of this systematic review was to test the following hypotheses: (1) that there is no difference in implant survival rate between individuals with overweight or obesity and those who are within the ideal weight range; (2) that there are no differences between these groups regarding indicators of peri-implant health. Two independent reviewers performed a literature search of the PubMed/MEDLINE, Scopus, and Cochrane Library databases for studies published up to April 1, 2018. A meta-analysis was performed to determine the risk difference for implant failure and mean difference for marginal bone loss, probing depth, and bleeding on probing.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GxNdmj

Reconstruction of the oral commissure with the Zisser flap

The aim of this study was to investigate the role of the Zisser flap in the reconstruction of defects of the oral commissure. The investigators describe their personal experience with this method and present some interesting aspects from the relevant literature.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2NgQZky

Root elongation after autotransplantation in 58 transplanted premolars: the radiographic width of the apex as a predictor

Autotransplantation of premolars with incomplete root development is a reliable treatment option for tooth replacement. Nevertheless, little is known about development of roots after transplantation of teeth. The aim of this study was to evaluate the preoperative root development stage and radiographic width of the apex as predictors for root elongation after autotransplantation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GEhVu7

Effects of Different Head Positioning Methods on Facial Soft Tissue Analysis Using Stereophotogrammetry

The purpose of this study was to compare sagittal tilt of the head in different head positioning techniques by an inclinometer and facial stereophotogrammetry measurements among different head positioning records.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2NfRGKX

Intraoperative Depth of Invasion is Accurate in Early Stage Oral Cavity Squamous Cell Carcinoma

Depth of invasion (DOI) is one predictor of nodal metastasis in oral cavity squamous cell carcinoma (OCSCC) and can facilitate the decision to complete an elective neck dissection (END) in early stage disease with a clinically negative neck. The purpose of this study was to investigate the accuracy of DOI on intraoperative frozen specimen for T1N0 oral OCSCC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gyuw1Q

Relationship between surgical difficulty of third molar extraction under local anesthesia and the postoperative evolution of clinical and blood parameters.

To determine whether the Pederson scale is a good predictor of the surgical difficulty of third molar extraction and establish whether such surgical difficulty is directly related to the postoperative course as assessed from clinical (pain, inflammation and trismus) and blood parameters (C-reactive protein, IL-6 and fibrinogen).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Ne2YiC

Complication rates and clinical outcomes of osseous free flaps: a retrospective comparison of CAD/CAM versus conventional fixation in 128 patients

Studies evaluating plate-related complications in patient-specific versus conventional fixation systems in free flap surgery are lacking. This was a retrospective study of 128 osseous free flaps with a minimum follow-up of 12 months. Wound healing disorders, plate exposure, fixation failure, and subtotal osseous union were recorded and evaluated statistically by univariate and regression analysis. Complication rates were as follows: wound healing disorders 33.6% (computer-aided design and computer-aided manufacturing (CAD/CAM) vs.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Nea0nv

Is there an association between overweight/obesity and dental implant complications? A systematic review and meta-analysis

The aim of this systematic review was to test the following hypotheses: (1) that there is no difference in implant survival rate between individuals with overweight or obesity and those who are within the ideal weight range; (2) that there are no differences between these groups regarding indicators of peri-implant health. Two independent reviewers performed a literature search of the PubMed/MEDLINE, Scopus, and Cochrane Library databases for studies published up to April 1, 2018. A meta-analysis was performed to determine the risk difference for implant failure and mean difference for marginal bone loss, probing depth, and bleeding on probing.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GxNdmj

Reconstruction of the oral commissure with the Zisser flap

The aim of this study was to investigate the role of the Zisser flap in the reconstruction of defects of the oral commissure. The investigators describe their personal experience with this method and present some interesting aspects from the relevant literature.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2NgQZky

Root elongation after autotransplantation in 58 transplanted premolars: the radiographic width of the apex as a predictor

Autotransplantation of premolars with incomplete root development is a reliable treatment option for tooth replacement. Nevertheless, little is known about development of roots after transplantation of teeth. The aim of this study was to evaluate the preoperative root development stage and radiographic width of the apex as predictors for root elongation after autotransplantation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GEhVu7

Effects of Different Head Positioning Methods on Facial Soft Tissue Analysis Using Stereophotogrammetry

The purpose of this study was to compare sagittal tilt of the head in different head positioning techniques by an inclinometer and facial stereophotogrammetry measurements among different head positioning records.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2NfRGKX

Intraoperative Depth of Invasion is Accurate in Early Stage Oral Cavity Squamous Cell Carcinoma

Depth of invasion (DOI) is one predictor of nodal metastasis in oral cavity squamous cell carcinoma (OCSCC) and can facilitate the decision to complete an elective neck dissection (END) in early stage disease with a clinically negative neck. The purpose of this study was to investigate the accuracy of DOI on intraoperative frozen specimen for T1N0 oral OCSCC.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Gyuw1Q

Relationship between surgical difficulty of third molar extraction under local anesthesia and the postoperative evolution of clinical and blood parameters.

To determine whether the Pederson scale is a good predictor of the surgical difficulty of third molar extraction and establish whether such surgical difficulty is directly related to the postoperative course as assessed from clinical (pain, inflammation and trismus) and blood parameters (C-reactive protein, IL-6 and fibrinogen).

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Ne2YiC

Deaf woman claims she will become a MILLIONAIRE by teaching sign language from her home

Katie Redstar, 34, is set to teach sign language to huge corporate companies. The entrepreneur from Leeds has also signed a book deal. (Source: the Mail online | Health)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SNI6oE

Deaf woman claims she will become a MILLIONAIRE by teaching sign language from her home

Katie Redstar, 34, is set to teach sign language to huge corporate companies. The entrepreneur from Leeds has also signed a book deal. (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SNI6oE

Letter comments on JPRAS paper: Absorbable sutures for skin closure after carpal tunnel decompression: A Cochrane review summary

I write regarding 'Absorbable sutures for skin closure after carpal tunnel decompression: A Cochrane review summary1'. In my opinion, the learned authors make a common mistake, in that they make conclusions which their data are unable to support.1

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2V28hnS

Letter comments on JPRAS paper: Absorbable sutures for skin closure after carpal tunnel decompression: A Cochrane review summary

I write regarding 'Absorbable sutures for skin closure after carpal tunnel decompression: A Cochrane review summary1'. In my opinion, the learned authors make a common mistake, in that they make conclusions which their data are unable to support.1

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2V28hnS

You CAN become dependent on Zyrtec and have itchy withdrawals from the allergy drug

Zyrtech is not addictive, but the bodies histamine receptors can become accustomed to always having it present - and itchy anxious withdrawals are 'absolute hell' - but the label doesn't warn you. (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SdlqbZ

Teva aims for 25% of U.S. EpiPen market by 2020

Teva (NYSE:TEVA) expects its generic EpiPen auto-injector to claim 25% of the U.S. market by the end of this year, according to a report from Seeking Alpha. For years, Mylan's (NSDQ:MYL) brand-name emergency allergy device has dominated the markets. But the company faced widespread criticism in 2016 when reports revealed that Mylan hiked the price of the EpiPen by nearly 500% since 2007. In response, Mylan launched its own EpiPen generic for roughly $300. Get the full story at our sister site, Drug Delivery Business News. The post Teva aims for 25% of U.S. EpiPen market by 2020 appeared first on MassDevice. (Source: Mass Device)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T2xQI7

Preventing 'cell wall remodeling' may hold key to defeating intransigent super bugs

(Case Western Reserve University) With a $3.34 million grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, Edward W. Yu, Ph.D., professor of pharmacology at Case Western Reserve University School of Medicine, is conducting research that could help physicians better understand how bacteria such as B. multivorans resist antibiotics, potentially leading to improved treatments. (Source: EurekAlert! - Infectious and Emerging Diseases)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgmBrr

You CAN become dependent on Zyrtec and have itchy withdrawals from the allergy drug

Zyrtech is not addictive, but the bodies histamine receptors can become accustomed to always having it present - and itchy anxious withdrawals are 'absolute hell' - but the label doesn't warn you. (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SdlqbZ

Teva aims for 25% of U.S. EpiPen market by 2020

Teva (NYSE:TEVA) expects its generic EpiPen auto-injector to claim 25% of the U.S. market by the end of this year, according to a report from Seeking Alpha. For years, Mylan's (NSDQ:MYL) brand-name emergency allergy device has dominated the markets. But the company faced widespread criticism in 2016 when reports revealed that Mylan hiked the price of the EpiPen by nearly 500% since 2007. In response, Mylan launched its own EpiPen generic for roughly $300. Get the full story at our sister site, Drug Delivery Business News. The post Teva aims for 25% of U.S. EpiPen market by 2020 appeared first on MassDevice. (Source: Mass Device)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T2xQI7

Preventing 'cell wall remodeling' may hold key to defeating intransigent super bugs

(Case Western Reserve University) With a $3.34 million grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, Edward W. Yu, Ph.D., professor of pharmacology at Case Western Reserve University School of Medicine, is conducting research that could help physicians better understand how bacteria such as B. multivorans resist antibiotics, potentially leading to improved treatments. (Source: EurekAlert! - Infectious and Emerging Diseases)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgmBrr

Trauma on a Recently Augmented Breast as a Trigger for Mondor’s Disease

Abstract

Mondor's disease is the eponym used to describe a self-limited phlebitis or thrombophlebitis of the superficial veins localized mainly on the thoracoabdominal area of the human body. Its clinical manifestation includes painful superficial cords causing skin retraction. This medical condition could be idiopathic, iatrogenic or a manifestation of underlying pathology such as breast cancer and seems to be more common than has been previously thought. The vast majority of the clinical studies and case reports to date focus on Mondor's disease as a disorder which is more or less directly related to a previous surgical intervention. In this case report, the author discusses the possible role of breast surgery as a predisposing factor only and the trauma on the operated breast as a trigger for onset and earlier manifestation of Mondor's disease. A special emphasis is put on the importance of trauma prevention in breast augmentation surgery, especially when maneuvers like postoperative massages are considered.

Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.



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Camouflage of the Nasal Dorsum in Thin-Skinned Patients with Diced Cartilage Combined with a New Cross-Linked Hyaluronan (NCH) Gel and Blood: A New Method

Abstract

Introduction

Nasal dorsum irregularities after rhinoplasty are still one of the most common complaints among both surgeons and patients. In this study, we used a new cross-linked hyaluronan (NCH) gel and blood mixture as the stabilisation scaffold. Diced cartilage combined with the NCH gel and blood mixture was used for nasal dorsum camouflage.

Patients and Methods

Fifty-two thin-skinned patients (29 females and 23 males) underwent primary rhinoplasty including nasal dorsum enhancement with diced cartilage combined with the NCH gel and blood mixture. The cartilage tissue was diced into small pieces; then, 1 cc NCH gel and blood were added into diced cartilage. The mixture was delivered onto the nasal dorsum via dorsal retractor.

Results

After 1 year of follow-up, there were no irregularities in the nasal dorsum area observed, nor any displacement or absorbance of the camouflage material. No complications occurred.

Conclusion

The use of diced cartilage combined with the NCH gel and blood is an effective, simple and safe method for nasal dorsum camouflage in thin-skinned patients in rhinoplasty. The NCH gel within the mixed graft also reduces adhesions at the osteotomy lines.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.



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The Joint Tip Graft: A Joint Support for Rim, Facet and Infratip Lobule in Rhinoplasty

Abstract

Background

The authors of this study have developed a novel graft called the 'The Joint Tip Graft' which adds support to the lateral crus, camouflages the tip grafts, supports the facet and adds volume to the nasal tip as a single graft. The aim of this study was to define and introduce the tripod graft.

Methods

Thirty patients who underwent primary rhinoplasty at a tertiary academic center were included. Patients were randomly assigned into two groups according to the grafts used: group 1: Joint tip graft was additionally used, and group 2: Joint tip graft was not used. All patients were photographed by a photographer who is familiar with medical photography. Preoperative and postoperative sixth month photographs were taken for analysis. The brightest point of the infratip lobule and the darkest point of the facets were selected and analyzed with computer software. The luminance ratio of facet to infratip lobule was calculated to overcome light and head position differences.

Results

Mean infratip luminance scores were 112.20 ± 5.72 and 109.73 ± 7.13 in groups 1 and 2, respectively (p > 0.05). Mean facet luminance scores were 101.33 ± 4.91 and 89.27 ± 5.11 in groups 1 and 2, respectively (p < 0.05). Facet/infratip luminance ratios were calculated for each group. Mean facet/infratip luminance ratios were 0.90 ± 0.01 and 0.82 ± 0.16 for groups 1 and 2, respectively (p < 0.05).

Conclusions

The joint tip graft is a novel graft that is easy to harvest and apply. It spans both of the alar cartilages, supports the facet area and creates a smooth gradual light shadow transition. Additionally, it acts as a camouflage over the tip grafts.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GO74Nk

Trauma on a Recently Augmented Breast as a Trigger for Mondor’s Disease

Abstract

Mondor's disease is the eponym used to describe a self-limited phlebitis or thrombophlebitis of the superficial veins localized mainly on the thoracoabdominal area of the human body. Its clinical manifestation includes painful superficial cords causing skin retraction. This medical condition could be idiopathic, iatrogenic or a manifestation of underlying pathology such as breast cancer and seems to be more common than has been previously thought. The vast majority of the clinical studies and case reports to date focus on Mondor's disease as a disorder which is more or less directly related to a previous surgical intervention. In this case report, the author discusses the possible role of breast surgery as a predisposing factor only and the trauma on the operated breast as a trigger for onset and earlier manifestation of Mondor's disease. A special emphasis is put on the importance of trauma prevention in breast augmentation surgery, especially when maneuvers like postoperative massages are considered.

Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tr1jx6

Camouflage of the Nasal Dorsum in Thin-Skinned Patients with Diced Cartilage Combined with a New Cross-Linked Hyaluronan (NCH) Gel and Blood: A New Method

Abstract

Introduction

Nasal dorsum irregularities after rhinoplasty are still one of the most common complaints among both surgeons and patients. In this study, we used a new cross-linked hyaluronan (NCH) gel and blood mixture as the stabilisation scaffold. Diced cartilage combined with the NCH gel and blood mixture was used for nasal dorsum camouflage.

Patients and Methods

Fifty-two thin-skinned patients (29 females and 23 males) underwent primary rhinoplasty including nasal dorsum enhancement with diced cartilage combined with the NCH gel and blood mixture. The cartilage tissue was diced into small pieces; then, 1 cc NCH gel and blood were added into diced cartilage. The mixture was delivered onto the nasal dorsum via dorsal retractor.

Results

After 1 year of follow-up, there were no irregularities in the nasal dorsum area observed, nor any displacement or absorbance of the camouflage material. No complications occurred.

Conclusion

The use of diced cartilage combined with the NCH gel and blood is an effective, simple and safe method for nasal dorsum camouflage in thin-skinned patients in rhinoplasty. The NCH gel within the mixed graft also reduces adhesions at the osteotomy lines.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ts4jt5

The Joint Tip Graft: A Joint Support for Rim, Facet and Infratip Lobule in Rhinoplasty

Abstract

Background

The authors of this study have developed a novel graft called the 'The Joint Tip Graft' which adds support to the lateral crus, camouflages the tip grafts, supports the facet and adds volume to the nasal tip as a single graft. The aim of this study was to define and introduce the tripod graft.

Methods

Thirty patients who underwent primary rhinoplasty at a tertiary academic center were included. Patients were randomly assigned into two groups according to the grafts used: group 1: Joint tip graft was additionally used, and group 2: Joint tip graft was not used. All patients were photographed by a photographer who is familiar with medical photography. Preoperative and postoperative sixth month photographs were taken for analysis. The brightest point of the infratip lobule and the darkest point of the facets were selected and analyzed with computer software. The luminance ratio of facet to infratip lobule was calculated to overcome light and head position differences.

Results

Mean infratip luminance scores were 112.20 ± 5.72 and 109.73 ± 7.13 in groups 1 and 2, respectively (p > 0.05). Mean facet luminance scores were 101.33 ± 4.91 and 89.27 ± 5.11 in groups 1 and 2, respectively (p < 0.05). Facet/infratip luminance ratios were calculated for each group. Mean facet/infratip luminance ratios were 0.90 ± 0.01 and 0.82 ± 0.16 for groups 1 and 2, respectively (p < 0.05).

Conclusions

The joint tip graft is a novel graft that is easy to harvest and apply. It spans both of the alar cartilages, supports the facet area and creates a smooth gradual light shadow transition. Additionally, it acts as a camouflage over the tip grafts.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.



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You CAN become dependent on Zyrtec and have itchy withdrawals from the allergy drug

Zyrtech is not addictive, but the bodies histamine receptors can become accustomed to always having it present - and itchy anxious withdrawals are 'absolute hell' - but the label doesn't warn you. (Source: the Mail online | Health)

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Teva aims for 25% of U.S. EpiPen market by 2020

Teva (NYSE:TEVA) expects its generic EpiPen auto-injector to claim 25% of the U.S. market by the end of this year, according to a report from Seeking Alpha. For years, Mylan's (NSDQ:MYL) brand-name emergency allergy device has dominated the markets. But the company faced widespread criticism in 2016 when reports revealed that Mylan hiked the price of the EpiPen by nearly 500% since 2007. In response, Mylan launched its own EpiPen generic for roughly $300. Get the full story at our sister site, Drug Delivery Business News. The post Teva aims for 25% of U.S. EpiPen market by 2020 appeared first on MassDevice. (Source: Mass Device)

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Preventing 'cell wall remodeling' may hold key to defeating intransigent super bugs

(Case Western Reserve University) With a $3.34 million grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, Edward W. Yu, Ph.D., professor of pharmacology at Case Western Reserve University School of Medicine, is conducting research that could help physicians better understand how bacteria such as B. multivorans resist antibiotics, potentially leading to improved treatments. (Source: EurekAlert! - Infectious and Emerging Diseases)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgmBrr

You CAN become dependent on Zyrtec and have itchy withdrawals from the allergy drug

Zyrtech is not addictive, but the bodies histamine receptors can become accustomed to always having it present - and itchy anxious withdrawals are 'absolute hell' - but the label doesn't warn you. (Source: the Mail online | Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SdlqbZ

Teva aims for 25% of U.S. EpiPen market by 2020

Teva (NYSE:TEVA) expects its generic EpiPen auto-injector to claim 25% of the U.S. market by the end of this year, according to a report from Seeking Alpha. For years, Mylan's (NSDQ:MYL) brand-name emergency allergy device has dominated the markets. But the company faced widespread criticism in 2016 when reports revealed that Mylan hiked the price of the EpiPen by nearly 500% since 2007. In response, Mylan launched its own EpiPen generic for roughly $300. Get the full story at our sister site, Drug Delivery Business News. The post Teva aims for 25% of U.S. EpiPen market by 2020 appeared first on MassDevice. (Source: Mass Device)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T2xQI7

Preventing 'cell wall remodeling' may hold key to defeating intransigent super bugs

(Case Western Reserve University) With a $3.34 million grant from the National Institute of Allergy and Infectious Diseases of the National Institutes of Health, Edward W. Yu, Ph.D., professor of pharmacology at Case Western Reserve University School of Medicine, is conducting research that could help physicians better understand how bacteria such as B. multivorans resist antibiotics, potentially leading to improved treatments. (Source: EurekAlert! - Infectious and Emerging Diseases)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgmBrr

Trauma on a Recently Augmented Breast as a Trigger for Mondor’s Disease

Abstract

Mondor's disease is the eponym used to describe a self-limited phlebitis or thrombophlebitis of the superficial veins localized mainly on the thoracoabdominal area of the human body. Its clinical manifestation includes painful superficial cords causing skin retraction. This medical condition could be idiopathic, iatrogenic or a manifestation of underlying pathology such as breast cancer and seems to be more common than has been previously thought. The vast majority of the clinical studies and case reports to date focus on Mondor's disease as a disorder which is more or less directly related to a previous surgical intervention. In this case report, the author discusses the possible role of breast surgery as a predisposing factor only and the trauma on the operated breast as a trigger for onset and earlier manifestation of Mondor's disease. A special emphasis is put on the importance of trauma prevention in breast augmentation surgery, especially when maneuvers like postoperative massages are considered.

Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tr1jx6

Camouflage of the Nasal Dorsum in Thin-Skinned Patients with Diced Cartilage Combined with a New Cross-Linked Hyaluronan (NCH) Gel and Blood: A New Method

Abstract

Introduction

Nasal dorsum irregularities after rhinoplasty are still one of the most common complaints among both surgeons and patients. In this study, we used a new cross-linked hyaluronan (NCH) gel and blood mixture as the stabilisation scaffold. Diced cartilage combined with the NCH gel and blood mixture was used for nasal dorsum camouflage.

Patients and Methods

Fifty-two thin-skinned patients (29 females and 23 males) underwent primary rhinoplasty including nasal dorsum enhancement with diced cartilage combined with the NCH gel and blood mixture. The cartilage tissue was diced into small pieces; then, 1 cc NCH gel and blood were added into diced cartilage. The mixture was delivered onto the nasal dorsum via dorsal retractor.

Results

After 1 year of follow-up, there were no irregularities in the nasal dorsum area observed, nor any displacement or absorbance of the camouflage material. No complications occurred.

Conclusion

The use of diced cartilage combined with the NCH gel and blood is an effective, simple and safe method for nasal dorsum camouflage in thin-skinned patients in rhinoplasty. The NCH gel within the mixed graft also reduces adhesions at the osteotomy lines.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ts4jt5

The Joint Tip Graft: A Joint Support for Rim, Facet and Infratip Lobule in Rhinoplasty

Abstract

Background

The authors of this study have developed a novel graft called the 'The Joint Tip Graft' which adds support to the lateral crus, camouflages the tip grafts, supports the facet and adds volume to the nasal tip as a single graft. The aim of this study was to define and introduce the tripod graft.

Methods

Thirty patients who underwent primary rhinoplasty at a tertiary academic center were included. Patients were randomly assigned into two groups according to the grafts used: group 1: Joint tip graft was additionally used, and group 2: Joint tip graft was not used. All patients were photographed by a photographer who is familiar with medical photography. Preoperative and postoperative sixth month photographs were taken for analysis. The brightest point of the infratip lobule and the darkest point of the facets were selected and analyzed with computer software. The luminance ratio of facet to infratip lobule was calculated to overcome light and head position differences.

Results

Mean infratip luminance scores were 112.20 ± 5.72 and 109.73 ± 7.13 in groups 1 and 2, respectively (p > 0.05). Mean facet luminance scores were 101.33 ± 4.91 and 89.27 ± 5.11 in groups 1 and 2, respectively (p < 0.05). Facet/infratip luminance ratios were calculated for each group. Mean facet/infratip luminance ratios were 0.90 ± 0.01 and 0.82 ± 0.16 for groups 1 and 2, respectively (p < 0.05).

Conclusions

The joint tip graft is a novel graft that is easy to harvest and apply. It spans both of the alar cartilages, supports the facet area and creates a smooth gradual light shadow transition. Additionally, it acts as a camouflage over the tip grafts.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GO74Nk

Trauma on a Recently Augmented Breast as a Trigger for Mondor’s Disease

Abstract

Mondor's disease is the eponym used to describe a self-limited phlebitis or thrombophlebitis of the superficial veins localized mainly on the thoracoabdominal area of the human body. Its clinical manifestation includes painful superficial cords causing skin retraction. This medical condition could be idiopathic, iatrogenic or a manifestation of underlying pathology such as breast cancer and seems to be more common than has been previously thought. The vast majority of the clinical studies and case reports to date focus on Mondor's disease as a disorder which is more or less directly related to a previous surgical intervention. In this case report, the author discusses the possible role of breast surgery as a predisposing factor only and the trauma on the operated breast as a trigger for onset and earlier manifestation of Mondor's disease. A special emphasis is put on the importance of trauma prevention in breast augmentation surgery, especially when maneuvers like postoperative massages are considered.

Level of Evidence V This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tr1jx6

Camouflage of the Nasal Dorsum in Thin-Skinned Patients with Diced Cartilage Combined with a New Cross-Linked Hyaluronan (NCH) Gel and Blood: A New Method

Abstract

Introduction

Nasal dorsum irregularities after rhinoplasty are still one of the most common complaints among both surgeons and patients. In this study, we used a new cross-linked hyaluronan (NCH) gel and blood mixture as the stabilisation scaffold. Diced cartilage combined with the NCH gel and blood mixture was used for nasal dorsum camouflage.

Patients and Methods

Fifty-two thin-skinned patients (29 females and 23 males) underwent primary rhinoplasty including nasal dorsum enhancement with diced cartilage combined with the NCH gel and blood mixture. The cartilage tissue was diced into small pieces; then, 1 cc NCH gel and blood were added into diced cartilage. The mixture was delivered onto the nasal dorsum via dorsal retractor.

Results

After 1 year of follow-up, there were no irregularities in the nasal dorsum area observed, nor any displacement or absorbance of the camouflage material. No complications occurred.

Conclusion

The use of diced cartilage combined with the NCH gel and blood is an effective, simple and safe method for nasal dorsum camouflage in thin-skinned patients in rhinoplasty. The NCH gel within the mixed graft also reduces adhesions at the osteotomy lines.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.



from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ts4jt5

The Joint Tip Graft: A Joint Support for Rim, Facet and Infratip Lobule in Rhinoplasty

Abstract

Background

The authors of this study have developed a novel graft called the 'The Joint Tip Graft' which adds support to the lateral crus, camouflages the tip grafts, supports the facet and adds volume to the nasal tip as a single graft. The aim of this study was to define and introduce the tripod graft.

Methods

Thirty patients who underwent primary rhinoplasty at a tertiary academic center were included. Patients were randomly assigned into two groups according to the grafts used: group 1: Joint tip graft was additionally used, and group 2: Joint tip graft was not used. All patients were photographed by a photographer who is familiar with medical photography. Preoperative and postoperative sixth month photographs were taken for analysis. The brightest point of the infratip lobule and the darkest point of the facets were selected and analyzed with computer software. The luminance ratio of facet to infratip lobule was calculated to overcome light and head position differences.

Results

Mean infratip luminance scores were 112.20 ± 5.72 and 109.73 ± 7.13 in groups 1 and 2, respectively (p > 0.05). Mean facet luminance scores were 101.33 ± 4.91 and 89.27 ± 5.11 in groups 1 and 2, respectively (p < 0.05). Facet/infratip luminance ratios were calculated for each group. Mean facet/infratip luminance ratios were 0.90 ± 0.01 and 0.82 ± 0.16 for groups 1 and 2, respectively (p < 0.05).

Conclusions

The joint tip graft is a novel graft that is easy to harvest and apply. It spans both of the alar cartilages, supports the facet area and creates a smooth gradual light shadow transition. Additionally, it acts as a camouflage over the tip grafts.

Level of Evidence IV

This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.



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Amalgamation of Central Lymph Node Dissection in Papillary Thyroid Carcinoma: Study from South Indian Population

AbstractThe aim of this study was to evaluate the correlation between central lymph node (CLN) metastasis and Clinicopathological characteristics of papillary thyroid cancer (PTC). In addition, we investigated the incidence and risk factors for ipsilateral and contra lateral CLN metastasis in unilateral PTC and the appropriate surgical extent for CLN dissection. A prospective study of 143 patients with unilateral PTC who underwent total thyroidectomy and prophylactic bilateral CLN dissection was conducted. Of 143 patients, 58 had CLN metastases. The rate of CLN metastasis was considerably higher in cases of maximal tumor size>  1 cm (P <  0.0001; OR 5.81). Ipsilateral CLN metastasis was detected in 41% of cases of unilateral PTC, and contra lateral CLN metastases was found in ...

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Deaf woman claims she will become a MILLIONAIRE by teaching sign language from her home

Katie Redstar, 34, is set to teach sign language to huge corporate companies. The entrepreneur from Leeds has also signed a book deal. (Source: the Mail online | Health)

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Amalgamation of Central Lymph Node Dissection in Papillary Thyroid Carcinoma: Study from South Indian Population

AbstractThe aim of this study was to evaluate the correlation between central lymph node (CLN) metastasis and Clinicopathological characteristics of papillary thyroid cancer (PTC). In addition, we investigated the incidence and risk factors for ipsilateral and contra lateral CLN metastasis in unilateral PTC and the appropriate surgical extent for CLN dissection. A prospective study of 143 patients with unilateral PTC who underwent total thyroidectomy and prophylactic bilateral CLN dissection was conducted. Of 143 patients, 58 had CLN metastases. The rate of CLN metastasis was considerably higher in cases of maximal tumor size>  1 cm (P <  0.0001; OR 5.81). Ipsilateral CLN metastasis was detected in 41% of cases of unilateral PTC, and contra lateral CLN metastases was found in ...

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Deaf woman claims she will become a MILLIONAIRE by teaching sign language from her home

Katie Redstar, 34, is set to teach sign language to huge corporate companies. The entrepreneur from Leeds has also signed a book deal. (Source: the Mail online | Health)

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Assessment of Oxidative Stress in Patients with Sudden Hearing Loss: A Non-randomized Prospective Clinical Study

Abstract

The etiology of sudden hearing loss (SHL) has not been fully elucidated. Previous studies claimed that different etiological factors may play a role in the pathogenesis of SHL. The aim of the present study is to investigate the presence of oxidative stress (OS) in SHL cases using thiol-disulfide balance. In addition, total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and lipid hydroperoxide levels (LOOH) were investigated. A total of 30 cases (15 female, 15 male, mean age 48.9 ± 8.1 years, age range: 36–68 years) were included in the study. Thiol and disulfide amounts, thiol/disulfide ratios, TOS, TAS, OSI and LOOH scores of the case group and control group were compared. Native thiol (SH) and total thiol (SH + SH) values were significantly lower in the SHL group than in the control group (p = 0.028 and p = 0.044, respectively). The LOOH value, TOS value and OSI value were significantly higher in the SHL group than in the control group (all p values < 0.05). The TAS value was significantly lower in the SHL group than in the control group (p = 0.0001). The present study has presented that the thiol-disulfide balance was impaired in SHL cases. OS may play a role in the development of SHL.



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Assessment of Oxidative Stress in Patients with Sudden Hearing Loss: A Non-randomized Prospective Clinical Study

Abstract

The etiology of sudden hearing loss (SHL) has not been fully elucidated. Previous studies claimed that different etiological factors may play a role in the pathogenesis of SHL. The aim of the present study is to investigate the presence of oxidative stress (OS) in SHL cases using thiol-disulfide balance. In addition, total oxidant status (TOS), total antioxidant status (TAS), oxidative stress index (OSI) and lipid hydroperoxide levels (LOOH) were investigated. A total of 30 cases (15 female, 15 male, mean age 48.9 ± 8.1 years, age range: 36–68 years) were included in the study. Thiol and disulfide amounts, thiol/disulfide ratios, TOS, TAS, OSI and LOOH scores of the case group and control group were compared. Native thiol (SH) and total thiol (SH + SH) values were significantly lower in the SHL group than in the control group (p = 0.028 and p = 0.044, respectively). The LOOH value, TOS value and OSI value were significantly higher in the SHL group than in the control group (all p values < 0.05). The TAS value was significantly lower in the SHL group than in the control group (p = 0.0001). The present study has presented that the thiol-disulfide balance was impaired in SHL cases. OS may play a role in the development of SHL.



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Experimental Human Infection With Neisseria Gonorrhoeae

Condition:   Gonococcal Infection Interventions:   Drug: Cefixime;   Drug: Ceftriaxone;   Drug: Ciprofloxacin;   Biological: Neisseria gonorrhoeae strain FA1090 A26;   Biological: Neisseria gonorrhoeae strain FA7537 Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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Impact of MEditerranean Diet, Inflammation and Microbiome After an Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome Interventions:   Other: Microbiota analysis;   Other: Immunological analysis;   Other: Proteome analysis;   Other: Metabolome analysis;   Other: Clinical evaluation;   Other: Diet evaluation;   Other: MedDiet Sponsors:   Consorcio Centro de Investigación Biomédica en Red, M.P.;   Hospital General Universitario Gregorio Marañon;   Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana;   University of Navarra;   Institut National de la Santé Et de la Recher che Médicale, France;   Tel Aviv University;   Göteborg University Not yet recruiting (Source: ClinicalTrials.gov)

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Effect of Migalastat on Cardiac Involvement in Fabry Disease

Conditions:   Fabry Disease;   Heart Diseases Intervention:   Diagnostic Test: Cardiological evaluation Sponsors:   Ospedale San Donato;   Amicus Therapeutics;   Institute of Biomedicine and Molecular Immunology - CNR Recruiting (Source: ClinicalTrials.gov)

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Study in Cat-Allergic Patients With Asthma to Evaluate the Efficacy of a Single Dose of REGN1908-1909 to Reduce Bronchoconstriction Upon Cat Allergen Challenge

Conditions:   Cat Allergy;   Mild Asthma Interventions:   Drug: REGN1908-1909;   Drug: Placebo Sponsor:   Regeneron Pharmaceuticals Not yet recruiting (Source: ClinicalTrials.gov)

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Combining TLR9 Agonist With bNAbs for Reservoir Reduction and Immunological Control of HIV

Condition:   HIV-1-infection Interventions:   Drug: Saline;   Drug: Lefitolimod;   Drug: 3BNC117 and 10-1074 Sponsors:   University of Aarhus;   Aalborg Universitetshospital;   Odense University Hospital;   Rigshospitalet, Denmark;   Hvidovre University Hospital;   The Peter Doherty Institute for Infection and Immunity;   University of Utah Not yet recruiting (Source: ClinicalTrials.gov)

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Combination Therapy With VRC-HIVMAB060-00-AB (VRC01) and 10-1074 in HIV-Infected Individuals Undergoing Sequential Treatment Interruptions

Condition:   HIV Interventions:   Biological: VRC-HIVMAB060-00-AB (VRC01);   Biological: 10-1074;   Biological: Normal Saline Placebo Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2tuAbgD

The Influence of ANS-6637 on Midazolam Pharmacokinetics in Healthy Volunteers

Condition:   Opioid Addiction Interventions:   Drug: MDZ;   Drug: ANS-6637 Sponsors:   National Institutes of Health Clinical Center (CC);   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GS3hOT

Experimental Human Infection With Neisseria Gonorrhoeae

Condition:   Gonococcal Infection Interventions:   Drug: Cefixime;   Drug: Ceftriaxone;   Drug: Ciprofloxacin;   Biological: Neisseria gonorrhoeae strain FA1090 A26;   Biological: Neisseria gonorrhoeae strain FA7537 Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GPmelr

Impact of MEditerranean Diet, Inflammation and Microbiome After an Acute Coronary Syndrome

Condition:   Acute Coronary Syndrome Interventions:   Other: Microbiota analysis;   Other: Immunological analysis;   Other: Proteome analysis;   Other: Metabolome analysis;   Other: Clinical evaluation;   Other: Diet evaluation;   Other: MedDiet Sponsors:   Consorcio Centro de Investigación Biomédica en Red, M.P.;   Hospital General Universitario Gregorio Marañon;   Fundación para el Fomento de la Investigación Sanitaria y Biomédica de la Comunitat Valenciana;   University of Navarra;   Institut National de la Santé Et de la Recher che Médicale, France;   Tel Aviv University;   Göteborg University Not yet recruiting (Source: ClinicalTrials.gov)

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