We thank the authors of the letter entitled "Five decades of orofacial cleft management and research in Brazil"1 for their comments on our article regarding short-term surgical missions for the management of orofacial clefts (OFCs) in South America2. It was certainly not our intention to minimize the efforts of the Brazilian cleft team; w e are truly glad for the advancements they have made since 1967. We agree that there is a need to increase national efforts in South America and international collaborative support to provide specialized care for patients with OFCs. (Source: International Journal of Oral and Maxillofacial Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A60sWC
Πέμπτη 11 Οκτωβρίου 2018
Response to comments on “Orofacial cleft management by short-term surgical missions in South America: literature review”
Titanium mesh associated with rhBMP-2 in alveolar ridge reconstruction
A systematic review of the literature was performed regarding the use of titanium mesh in association with recombinant human bone morphogenetic protein (rhBMP) for alveolar ridge reconstruction. The PubMed, Scopus, and Cochrane databases were searched for articles in English published up until June 2017. The inclusion criteria encompassed studies in humans − randomized clinical trials, prospective and retrospective studies, and case series. The screening and selection process was performed by three independent reviewers, with verification by a senior researcher in the case of disagreement. (Source: International Journal of Oral and Maxillofacial Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QNr4S5
Response to comments on “Orofacial cleft management by short-term surgical missions in South America: literature review”
We thank the authors of the letter entitled "Five decades of orofacial cleft management and research in Brazil"1 for their comments on our article regarding short-term surgical missions for the management of orofacial clefts (OFCs) in South America2. It was certainly not our intention to minimize the efforts of the Brazilian cleft team; w e are truly glad for the advancements they have made since 1967. We agree that there is a need to increase national efforts in South America and international collaborative support to provide specialized care for patients with OFCs. (Source: International Journal of Oral and Maxillofacial Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A60sWC
Titanium mesh associated with rhBMP-2 in alveolar ridge reconstruction
A systematic review of the literature was performed regarding the use of titanium mesh in association with recombinant human bone morphogenetic protein (rhBMP) for alveolar ridge reconstruction. The PubMed, Scopus, and Cochrane databases were searched for articles in English published up until June 2017. The inclusion criteria encompassed studies in humans − randomized clinical trials, prospective and retrospective studies, and case series. The screening and selection process was performed by three independent reviewers, with verification by a senior researcher in the case of disagreement. (Source: International Journal of Oral and Maxillofacial Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QNr4S5
Dacryocystorhinostomy: Indications and Surgical Technique
The following article reviews the clinical presentation, evaluation, and surgical treatment of patients with nasolacrimal duct obstruction, with an emphasis placed on the surgical techniques of external and internal/endoscopic dacryocystorhinostomy. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A7ax5R
Management of Orbital Fractures
Fractures of the orbit are a very common injury, and are often treated by multiple facial subspecialties. Many fractures can be asymptomatic and do not require surgical therapy, but for those fractures where intervention is indicated, neglect, delay or inappropriate technique can have permanent consequences on visual function and facial deformity. In this article, the indications and techniques of repair for specific fractures will be discussed, as well as possible risks and complications. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QI44np
Techniques of Enucleation and Evisceration
This article will discuss the indications for removal of the eye, as well as describe the alternative techniques of enucleation and evisceration, including their relative advantages. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A5FZBe
Multimodal Approaches in the Management of Malignancies Involving the Orbit
Malignancies involving the orbit comprise heterogeneous pathologies with a variety of ophthalmic and otolaryngic presentations resulting from compression and destruction of native orbital contents. Surgical ablation with negative margins with adjuvant treatment remains a cornerstone for optimal oncologic control and successful operative outcomes. Historically, attempts at tumor extirpation were first performed by neurosurgeons via open craniotomies to access orbital contents. While these approaches remain a mainstay within the superolateral compartment, endoscopic techniques pioneered by otolaryngologists have emerged as a standard in managing inferomedial orbital tumors. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QI1HRt
Imaging of salivary gland pathology
The major salivary glands can be affected by a variety of acute or chronic, systemic, and neoplastic conditions. Several modalities can be used for salivary gland imaging, each with its own advantages and limitations. The article reviews the optimal imaging modality for different clinical scenarios, the typical imaging appearance of commonly encountered pathologies, and seeks to provide a framework for generating an appropriate differential diagnosis. Additionally, with regard to neoplastic conditions, the goals of the review are to highlight features suggestive of benign or low-grade lesions verses high grade malignancy, while recognizing the limitations of imaging in making specific histologic diagnoses. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A7qVTQ
Surgical Excision of the Submandibular Gland
A variety of pathology commonly affects the salivary glands including both benign and malignant tumors as well as infectious and inflammatory disease. Although newer techniques including sialo-endoscopy are emerging for the treatment of inflammatory and obstructive disorders, excision of the submandibular gland remains the treatment of choice for tumors of the submandibular gland and remains an important option for the treatment of refractory inflammatory disease. Relevant surgical anatomy, perioperative management, surgical technique, and possible complications are discussed. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QMCq8Q
Deep Lobe Parotidectomy
This article describes the relevant anatomy and steps required to perform a DLP with and without facial nerve sacrifice. In addition, the history of the procedure, patient work up, indications, and possible complications are discussed. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A5WOfo
Identification and dissection of the facial nerve during parotidectomy
Facial nerve injury during parotidectomy remains one of the most significant complications associated this operation. Preventing facial nerve injury begins with a detailed understanding of the extratemporal course of the facial nerve beginning with identification of the main trunk at the stylomastoid foramen. Reliable anatomic landmarks are present which facilitate identification and preservation of the main trunk of the facial nerve and facilitate antegrade dissection and preservation of the facial nerve distally. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QJbPcQ
Dacryocystorhinostomy: Indications and Surgical Technique
The following article reviews the clinical presentation, evaluation, and surgical treatment of patients with nasolacrimal duct obstruction, with an emphasis placed on the surgical techniques of external and internal/endoscopic dacryocystorhinostomy. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A7ax5R
Management of Orbital Fractures
Fractures of the orbit are a very common injury, and are often treated by multiple facial subspecialties. Many fractures can be asymptomatic and do not require surgical therapy, but for those fractures where intervention is indicated, neglect, delay or inappropriate technique can have permanent consequences on visual function and facial deformity. In this article, the indications and techniques of repair for specific fractures will be discussed, as well as possible risks and complications. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QI44np
Techniques of Enucleation and Evisceration
This article will discuss the indications for removal of the eye, as well as describe the alternative techniques of enucleation and evisceration, including their relative advantages. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A5FZBe
Multimodal Approaches in the Management of Malignancies Involving the Orbit
Malignancies involving the orbit comprise heterogeneous pathologies with a variety of ophthalmic and otolaryngic presentations resulting from compression and destruction of native orbital contents. Surgical ablation with negative margins with adjuvant treatment remains a cornerstone for optimal oncologic control and successful operative outcomes. Historically, attempts at tumor extirpation were first performed by neurosurgeons via open craniotomies to access orbital contents. While these approaches remain a mainstay within the superolateral compartment, endoscopic techniques pioneered by otolaryngologists have emerged as a standard in managing inferomedial orbital tumors. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QI1HRt
Imaging of salivary gland pathology
The major salivary glands can be affected by a variety of acute or chronic, systemic, and neoplastic conditions. Several modalities can be used for salivary gland imaging, each with its own advantages and limitations. The article reviews the optimal imaging modality for different clinical scenarios, the typical imaging appearance of commonly encountered pathologies, and seeks to provide a framework for generating an appropriate differential diagnosis. Additionally, with regard to neoplastic conditions, the goals of the review are to highlight features suggestive of benign or low-grade lesions verses high grade malignancy, while recognizing the limitations of imaging in making specific histologic diagnoses. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A7qVTQ
Surgical Excision of the Submandibular Gland
A variety of pathology commonly affects the salivary glands including both benign and malignant tumors as well as infectious and inflammatory disease. Although newer techniques including sialo-endoscopy are emerging for the treatment of inflammatory and obstructive disorders, excision of the submandibular gland remains the treatment of choice for tumors of the submandibular gland and remains an important option for the treatment of refractory inflammatory disease. Relevant surgical anatomy, perioperative management, surgical technique, and possible complications are discussed. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QMCq8Q
Deep Lobe Parotidectomy
This article describes the relevant anatomy and steps required to perform a DLP with and without facial nerve sacrifice. In addition, the history of the procedure, patient work up, indications, and possible complications are discussed. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A5WOfo
Introduction
It is truly an honor to be invited to be the guest editor of an issue of Operative Techniques in Otolaryngology Head and Neck Surgery. What's more, the issue focusses on one of my favorite subjects: salivary gland pathology and surgery. When considering parotid tumors alone, the incidence is approximately 4/100,000 in the United States. The current census of the United States is 324 million and approximately 25% of whom are children1. If one assumes that 243 million Americans over the age 18 are at risk for developing these tumors, then approximately 10,000 parotid tumors will occur and potentially present each year. (Source: Operative Techniques in Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A7qJnA
IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive anti-viral immunity
IL-33 is implicated in asthma exacerbation but its role is unclear. We demonstrate that IL-33 drives influenza-induced asthma exacerbation suppressing anti-viral innate and adaptive responses in immune and epithelial cells. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RJ0A5p
Donor white blood cell survival and cytokine profiles following red blood cell transfusion in Australian major trauma patients
ConclusionIn this cohort, TAM was found to occur in one patient of the 11 who received a blood transfusion. Elevated IL-6 and IL-10 cytokines were detected in those patients who were transfused. However, the incidence of TAM could not be correlated with the elevated cytokine profiles for this cohort. (Source: Molecular Immunology)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RLNBA3
microRNA-199a may be involved in the pathogenesis of lupus nephritis via modulating the activation of NF-κB by targeting Klotho
Publication date: November 2018Source: Molecular Immunology, Volume 103Author(s): Hong Ye, Bofeng Su, Haizhen Ni, Linlin Li, Xuduan Chen, Xiaohan You, Huidi ZhangAbstractKlotho is considered to have renal protective effect by prohibiting the activation of the nuclear factor (NF)-κB pathway, while the role of microRNA-199a (miR-199a)/Klotho in lupus nephritis (LN) is still unknown. A single dose of pristane (0.5 ml) was intraperitoneally injected into 8 weeks-old female mice to establish the LN model. MiR-199a mimic or miR-199a inhibitor, Klotho plasmid or Klotho siRNA, and miR-199a inhibitor plus si-Klotho were transfected into lipopolysaccharides (LPS) stimulated human embryonic kidney 293 T (HEK293 T) cells. Western Blot was adopted to measure p-P65 expression. Tumor necrosis fact...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EdgEtd
Differential diagnosis of late ‐type reactions to injected local anaesthetics: Inflammation at the injection site is the only indicator of allergic hypersensitivity
Contact Dermatitis, EarlyView. (Source: Contact Dermatitis)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RLNjJt
Improvement in diagnostic delays over time in patients with hereditary angioedema: findings from the Icatibant Outcome Survey
The objective of this analysis was to evaluate the change over time in age at first symptoms, age at diagnosis, and delay in diagnosis using data from the Icatibant Outcome Survey (IOS). Patients with a diagnosis of C1-INH-HAE who were born before the year 1990 and who were diagnosed before they reached 25 years of age were included in the analysis. Both age at diagnosis and delay in diagnosis of C1-INH-HAE appear to decline with later decade of birth, despite wide variation across the countries assessed, suggesting that improved disease awareness causes increased rates of earlier diagnosis over tim e. Our findings demonstrate that some patients are still experiencing long delays to diagnosis, indicating an ongoing need for improved disease awareness. (Source: Clinical and Translational ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Edglyz
IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive anti-viral immunity
IL-33 is implicated in asthma exacerbation but its role is unclear. We demonstrate that IL-33 drives influenza-induced asthma exacerbation suppressing anti-viral innate and adaptive responses in immune and epithelial cells. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RJ0A5p
Donor white blood cell survival and cytokine profiles following red blood cell transfusion in Australian major trauma patients
ConclusionIn this cohort, TAM was found to occur in one patient of the 11 who received a blood transfusion. Elevated IL-6 and IL-10 cytokines were detected in those patients who were transfused. However, the incidence of TAM could not be correlated with the elevated cytokine profiles for this cohort. (Source: Molecular Immunology)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RLNBA3
microRNA-199a may be involved in the pathogenesis of lupus nephritis via modulating the activation of NF-κB by targeting Klotho
Publication date: November 2018Source: Molecular Immunology, Volume 103Author(s): Hong Ye, Bofeng Su, Haizhen Ni, Linlin Li, Xuduan Chen, Xiaohan You, Huidi ZhangAbstractKlotho is considered to have renal protective effect by prohibiting the activation of the nuclear factor (NF)-κB pathway, while the role of microRNA-199a (miR-199a)/Klotho in lupus nephritis (LN) is still unknown. A single dose of pristane (0.5 ml) was intraperitoneally injected into 8 weeks-old female mice to establish the LN model. MiR-199a mimic or miR-199a inhibitor, Klotho plasmid or Klotho siRNA, and miR-199a inhibitor plus si-Klotho were transfected into lipopolysaccharides (LPS) stimulated human embryonic kidney 293 T (HEK293 T) cells. Western Blot was adopted to measure p-P65 expression. Tumor necrosis fact...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EdgEtd
Differential diagnosis of late ‐type reactions to injected local anaesthetics: Inflammation at the injection site is the only indicator of allergic hypersensitivity
Contact Dermatitis, EarlyView. (Source: Contact Dermatitis)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RLNjJt
Improvement in diagnostic delays over time in patients with hereditary angioedema: findings from the Icatibant Outcome Survey
The objective of this analysis was to evaluate the change over time in age at first symptoms, age at diagnosis, and delay in diagnosis using data from the Icatibant Outcome Survey (IOS). Patients with a diagnosis of C1-INH-HAE who were born before the year 1990 and who were diagnosed before they reached 25 years of age were included in the analysis. Both age at diagnosis and delay in diagnosis of C1-INH-HAE appear to decline with later decade of birth, despite wide variation across the countries assessed, suggesting that improved disease awareness causes increased rates of earlier diagnosis over tim e. Our findings demonstrate that some patients are still experiencing long delays to diagnosis, indicating an ongoing need for improved disease awareness. (Source: Clinical and Translational ...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Edglyz
IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive anti-viral immunity
IL-33 is implicated in asthma exacerbation but its role is unclear. We demonstrate that IL-33 drives influenza-induced asthma exacerbation suppressing anti-viral innate and adaptive responses in immune and epithelial cells. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RJ0A5p
Duration of Antibiotic Therapy and Major Surgical Site Infection in Cochlear Implantation
This cohort study describes the rates of major surgical site infection for patients undergoing cochlear implantation who receive prolonged antibiotic treatment compared with those who receive a single perioperative dose of antibiotic prophylaxis. (Source: JAMA Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C9iIQC
Duration of Antibiotic Therapy and Major Surgical Site Infection in Cochlear Implantation
This cohort study describes the rates of major surgical site infection for patients undergoing cochlear implantation who receive prolonged antibiotic treatment compared with those who receive a single perioperative dose of antibiotic prophylaxis. (Source: JAMA Otolaryngology - Head and Neck Surgery)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C9iIQC
Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy
We report the evaluation of >300 patient samples across 22 tumor types from four KEYNOTE clinical trials. Tumor mutational burden (TMB) and a T cell–inflamed gene expression profile (GEP) exhibited joint predictive utility in identifying responders and nonresponders to the PD-1 antibody pembrolizumab. TMB and GEP were independently predictive of response and demonstrated low correlation, suggesting that they capture distinct features of neoantigenicity and T cell activation. Analysis of The Cancer Genome Atlas database showed TMB and GEP to have a low correlation, and analysis by joint stratification revealed biomarker-defined patterns of targetable-resistance biology. These biomarkers may have utility in clinical trial design by guiding rational selection of anti–PD-1 monot...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pP2ftv
Mining immunotherapy clinical trials
(Source: ScienceNOW)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ISmuz1
Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy
We report the evaluation of >300 patient samples across 22 tumor types from four KEYNOTE clinical trials. Tumor mutational burden (TMB) and a T cell–inflamed gene expression profile (GEP) exhibited joint predictive utility in identifying responders and nonresponders to the PD-1 antibody pembrolizumab. TMB and GEP were independently predictive of response and demonstrated low correlation, suggesting that they capture distinct features of neoantigenicity and T cell activation. Analysis of The Cancer Genome Atlas database showed TMB and GEP to have a low correlation, and analysis by joint stratification revealed biomarker-defined patterns of targetable-resistance biology. These biomarkers may have utility in clinical trial design by guiding rational selection of anti–PD-1 monot...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pP2ftv
Mining immunotherapy clinical trials
(Source: ScienceNOW)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ISmuz1
Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy
We report the evaluation of >300 patient samples across 22 tumor types from four KEYNOTE clinical trials. Tumor mutational burden (TMB) and a T cell–inflamed gene expression profile (GEP) exhibited joint predictive utility in identifying responders and nonresponders to the PD-1 antibody pembrolizumab. TMB and GEP were independently predictive of response and demonstrated low correlation, suggesting that they capture distinct features of neoantigenicity and T cell activation. Analysis of The Cancer Genome Atlas database showed TMB and GEP to have a low correlation, and analysis by joint stratification revealed biomarker-defined patterns of targetable-resistance biology. These biomarkers may have utility in clinical trial design by guiding rational selection of anti–PD-1 monot...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pP2ftv
Mining immunotherapy clinical trials
(Source: ScienceNOW)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ISmuz1
Pan-tumor genomic biomarkers for PD-1 checkpoint blockade-based immunotherapy
We report the evaluation of >300 patient samples across 22 tumor types from four KEYNOTE clinical trials. Tumor mutational burden (TMB) and a T cell–inflamed gene expression profile (GEP) exhibited joint predictive utility in identifying responders and nonresponders to the PD-1 antibody pembrolizumab. TMB and GEP were independently predictive of response and demonstrated low correlation, suggesting that they capture distinct features of neoantigenicity and T cell activation. Analysis of The Cancer Genome Atlas database showed TMB and GEP to have a low correlation, and analysis by joint stratification revealed biomarker-defined patterns of targetable-resistance biology. These biomarkers may have utility in clinical trial design by guiding rational selection of anti–PD-1 monot...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pP2ftv
Mining immunotherapy clinical trials
(Source: ScienceNOW)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ISmuz1
Conceptualization, operationalization, and content validity of the EQOL-questionnaire measuring quality of life and participation for persons with disabilities
Measurement of quality of life demands thoroughly developed and validated instruments. The development steps from theory to concepts and from empirical data to items are sparsely described in the literature of...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pQRsyU
Hip complaints differ across age and sex: a population-based reference data for the Hip disability and Osteoarthritis Outcome Score (HOOS)
The Hip disability and Osteoarthritis Outcome Score (HOOS) is a self-administered hip-specific questionnaire intended to evaluate symptoms and functional limitations, and it is commonly used to evaluate interv...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IQN9Mt
Study on the cost attributable to central venous catheter-related bloodstream infection and its influencing factors in a tertiary hospital in China
Central venous catheters (CVC) have been widely used for patients with severe conditions. However, they increase the risk of catheter-related bloodstream infection (CRBSI), which is associated with high econom...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pQRbvS
Conceptualization, operationalization, and content validity of the EQOL-questionnaire measuring quality of life and participation for persons with disabilities
Measurement of quality of life demands thoroughly developed and validated instruments. The development steps from theory to concepts and from empirical data to items are sparsely described in the literature of...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pQRsyU
Hip complaints differ across age and sex: a population-based reference data for the Hip disability and Osteoarthritis Outcome Score (HOOS)
The Hip disability and Osteoarthritis Outcome Score (HOOS) is a self-administered hip-specific questionnaire intended to evaluate symptoms and functional limitations, and it is commonly used to evaluate interv...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IQN9Mt
Study on the cost attributable to central venous catheter-related bloodstream infection and its influencing factors in a tertiary hospital in China
Central venous catheters (CVC) have been widely used for patients with severe conditions. However, they increase the risk of catheter-related bloodstream infection (CRBSI), which is associated with high econom...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pQRbvS
Balloon-Guide Catheters Are Needed for Effective Flow Reversal during Mechanical Thrombectomy [INTERVENTIONAL]
BACKGROUND AND PURPOSE:
Blood flow management in the carotid artery during mechanical thrombectomy is crucial for safety and effectiveness. There is an ongoing discussion about whether balloon-guide catheters or large-bore sheaths are needed for effective flow management. We compared general flow characteristics of proximal aspiration through a large-bore sheath and a balloon-guide catheter in a porcine in vivo model.
MATERIALS AND METHODS:We investigated blood flow in a porcine common carotid artery with and without aspiration (VacLok syringe and Penumbra pump, Pump MAX) through an 8F-long sheath and an 8F balloon-guide catheter. Blood hemodynamics were assessed via continuous duplex sonography.
RESULTS:Average vessel diameter and baseline blood flow were 4.4 ± 0.2 mm and 244 ± 20 mL/min, respectively. For the 8F sheath, pump aspiration resulted in a significant flow reduction (225 ± 25 mL/min, P < .001), but with a persisting antegrade stream. Manual aspiration resulted in collapse of the vessel in 2 of 7 measurements and oscillatory flow with antegrade systolic and retrograde diastolic components in the remaining 5 measurements. Net flow was antegrade (52 ± 44 mL/min) in 3 and retrograde (–95 ± 52 mL/min) in the remaining 2 measurements. For balloon-guide catheters, balloon inflation always resulted in flow arrest. Additional pump or manual aspiration resulted in significant flow reversal of –1100 ± 230 and –468 ± 46 mL/min, respectively (both, P < .001).
CONCLUSIONS:Only balloon-guide catheters allow reliable blood flow arrest and flow reversal in combination with aspiration via syringes or high-flow pump systems. Aspiration through an 8F sheath results in either collapse of the vessel or oscillatory flow, which can result in a net antegrade or retrograde stream.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OOIujR
Cerebral Blood Flow and Marrow Diffusion Alterations in Children with Sickle Cell Anemia after Bone Marrow Transplantation and Transfusion [PEDIATRICS]
BACKGROUND AND PURPOSE:
Hematopoietic marrow hyperplasia and hyperperfusion are compensatory mechanisms in sickle cell anemia. We have observed marrow diffusion and arterial spin-labeling perfusion changes in sickle cell anemia following bone marrow transplantation. We aimed to compare arterial spin-labeling perfusion and marrow diffusion/ADC values in patients with sickle cell anemia before and after bone marrow transplantation or transfusion.
MATERIALS AND METHODS:We reviewed brain MRIs from patients with sickle cell anemia obtained during 6 consecutive years at a children's hospital. Quantitative marrow diffusion values were procured from the occipital and sphenoid bones. Pseudocontinuous arterial spin-labeling perfusion values (milliliters/100 g of tissue/min) of MCA, anterior cerebral artery, and posterior cerebral artery territories were determined. Territorial CBF, whole-brain average CBF, and marrow ADC values were compared for changes before and after either bone marrow transplantation or transfusion. Bone marrow transplantation and transfusion groups were compared. Two-tailed paired and unpaired Student t tests were used; P < .05 was considered significant.
RESULTS:Fifty-three examinations from 17 patients with bone marrow transplantation and 29 examinations from 9 patients with transfusion were included. ADC values significantly increased in the sphenoid and occipital marrow following bone marrow transplantation in contrast to patients with transfusion (P > .83). Whole-brain mean CBF significantly decreased following bone marrow transplantation (77.39 ± 13.78 to 60.39 ± 13.62 ml/100 g tissue/min; P < .001), without significant change thereafter. CBF did not significantly change following the first (81.11 ± 12.23 to 80.25 ± 8.27 ml/100 g tissue/min; P = .47) or subsequent transfusions. There was no significant difference in mean CBF between groups before intervention (P = .22).
CONCLUSIONS:Improved CBF and marrow diffusion eventuate following bone marrow transplantation in children with sickle cell anemia in contrast to transfusion therapy.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nzg6xq
The Woven EndoBridge Finally Coming Home across the Atlantic: What to Expect? [EDITORIALS]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NCwMnE
MR Venous Flow in Sigmoid Sinus Diverticulum [HEAD & NECK]
BACKGROUND AND PURPOSE:
Case reports demonstrate that coiling of a sigmoid sinus diverticulum can treat pulsatile tinnitus. We hypothesized that MR imaging 4D flow and computational fluid dynamics would reveal distinct blood flow patterns in the venous outflow tract in these patients.
MATERIALS AND METHODS:Patients with pulsatile tinnitus of suspected venous etiology underwent MR imaging at 3T, using venous phase contrast-enhanced MR angiography, 4D flow, and 2D phase contrast. The contrast-enhanced MRA contours were evaluated to determine the presence and extent of a sigmoid sinus diverticulum. Computational fluid dynamics analysis was performed using the 4D flow inlet flow and the luminal contours from contrast-enhanced MRA as boundary conditions. In addition, computational fluid dynamics was performed for the expected post treatment conditions by smoothing the venous geometry to exclude the sigmoid sinus diverticulum from the anatomic boundary conditions. Streamlines were generated from the 4D flow and computational fluid dynamics velocity maps, and flow patterns were examined for the presence of rotational components.
RESULTS:Twenty-five patients with pulsatile tinnitus of suspected venous etiology and 10 control subjects were enrolled. Five (20%) of the symptomatic subjects had sigmoid sinus diverticula, all associated with an upstream stenosis. In each of these patients, but none of the controls, a stenosis-related flow jet was directed toward the opening of the sigmoid sinus diverticulum with rotational flow patterns in the sigmoid sinus diverticulum and parent sigmoid sinus on both 4D flow and computational fluid dynamics.
CONCLUSIONS:Consistent patterns of blood flow can be visualized in a sigmoid sinus diverticulum and the parent sinus using 4D flow and computational fluid dynamics. Strong components of rotational blood flow were seen in subjects with sigmoid sinus diverticula that were absent in controls.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ORB13l
Balloon-Guide Catheters Are Needed for Effective Flow Reversal during Mechanical Thrombectomy [INTERVENTIONAL]
BACKGROUND AND PURPOSE:
Blood flow management in the carotid artery during mechanical thrombectomy is crucial for safety and effectiveness. There is an ongoing discussion about whether balloon-guide catheters or large-bore sheaths are needed for effective flow management. We compared general flow characteristics of proximal aspiration through a large-bore sheath and a balloon-guide catheter in a porcine in vivo model.
MATERIALS AND METHODS:We investigated blood flow in a porcine common carotid artery with and without aspiration (VacLok syringe and Penumbra pump, Pump MAX) through an 8F-long sheath and an 8F balloon-guide catheter. Blood hemodynamics were assessed via continuous duplex sonography.
RESULTS:Average vessel diameter and baseline blood flow were 4.4 ± 0.2 mm and 244 ± 20 mL/min, respectively. For the 8F sheath, pump aspiration resulted in a significant flow reduction (225 ± 25 mL/min, P < .001), but with a persisting antegrade stream. Manual aspiration resulted in collapse of the vessel in 2 of 7 measurements and oscillatory flow with antegrade systolic and retrograde diastolic components in the remaining 5 measurements. Net flow was antegrade (52 ± 44 mL/min) in 3 and retrograde (–95 ± 52 mL/min) in the remaining 2 measurements. For balloon-guide catheters, balloon inflation always resulted in flow arrest. Additional pump or manual aspiration resulted in significant flow reversal of –1100 ± 230 and –468 ± 46 mL/min, respectively (both, P < .001).
CONCLUSIONS:Only balloon-guide catheters allow reliable blood flow arrest and flow reversal in combination with aspiration via syringes or high-flow pump systems. Aspiration through an 8F sheath results in either collapse of the vessel or oscillatory flow, which can result in a net antegrade or retrograde stream.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OOIujR
Cerebral Blood Flow and Marrow Diffusion Alterations in Children with Sickle Cell Anemia after Bone Marrow Transplantation and Transfusion [PEDIATRICS]
BACKGROUND AND PURPOSE:
Hematopoietic marrow hyperplasia and hyperperfusion are compensatory mechanisms in sickle cell anemia. We have observed marrow diffusion and arterial spin-labeling perfusion changes in sickle cell anemia following bone marrow transplantation. We aimed to compare arterial spin-labeling perfusion and marrow diffusion/ADC values in patients with sickle cell anemia before and after bone marrow transplantation or transfusion.
MATERIALS AND METHODS:We reviewed brain MRIs from patients with sickle cell anemia obtained during 6 consecutive years at a children's hospital. Quantitative marrow diffusion values were procured from the occipital and sphenoid bones. Pseudocontinuous arterial spin-labeling perfusion values (milliliters/100 g of tissue/min) of MCA, anterior cerebral artery, and posterior cerebral artery territories were determined. Territorial CBF, whole-brain average CBF, and marrow ADC values were compared for changes before and after either bone marrow transplantation or transfusion. Bone marrow transplantation and transfusion groups were compared. Two-tailed paired and unpaired Student t tests were used; P < .05 was considered significant.
RESULTS:Fifty-three examinations from 17 patients with bone marrow transplantation and 29 examinations from 9 patients with transfusion were included. ADC values significantly increased in the sphenoid and occipital marrow following bone marrow transplantation in contrast to patients with transfusion (P > .83). Whole-brain mean CBF significantly decreased following bone marrow transplantation (77.39 ± 13.78 to 60.39 ± 13.62 ml/100 g tissue/min; P < .001), without significant change thereafter. CBF did not significantly change following the first (81.11 ± 12.23 to 80.25 ± 8.27 ml/100 g tissue/min; P = .47) or subsequent transfusions. There was no significant difference in mean CBF between groups before intervention (P = .22).
CONCLUSIONS:Improved CBF and marrow diffusion eventuate following bone marrow transplantation in children with sickle cell anemia in contrast to transfusion therapy.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nzg6xq
Optimization of Acquisition and Analysis Methods for Clinical Dynamic Susceptibility Contrast MRI Using a Population-Based Digital Reference Object [RESEARCH PERSPECTIVES]
BACKGROUND AND PURPOSE:
The accuracy of DSC-MR imaging CBV maps in glioblastoma depends on acquisition and analysis protocols. Multisite protocol heterogeneity has challenged standardization initiatives due to the difficulties of in vivo validation. This study sought to compare the accuracy of routinely used protocols using a digital reference object.
MATERIALS AND METHODS:The digital reference object consisted of approximately 10,000 simulated voxels recapitulating typical signal heterogeneity encountered in vivo. The influence of acquisition and postprocessing methods on CBV reliability was evaluated across 6912 parameter combinations, including contrast agent dosing schemes, pulse sequence parameters, field strengths, and postprocessing methods. Accuracy and precision were assessed using the concordance correlation coefficient and coefficient of variation.
RESULTS:Across all parameter space, the optimal protocol included full-dose contrast agent preload and bolus, intermediate (60°) flip angle, 30-ms TE, and postprocessing with a leakage-correction algorithm (concordance correlation coefficient = 0.97, coefficient of variation = 6.6%). Protocols with no preload or fractional dose preload and bolus using these acquisition parameters were generally less robust. However, a protocol with no preload, full-dose bolus, and low (30°) flip angle performed very well (concordance correlation coefficient = 0.93, coefficient of variation = 8.7% at 1.5T and concordance correlation coefficient = 0.92, coefficient of variation = 8.2% at 3T).
CONCLUSIONS:Schemes with full-dose preload and bolus maximize CBV accuracy and reduce variability, which could enable smaller sample sizes and more reliable detection of CBV changes in clinical trials. When a lower total contrast agent dose is desired, use of a low flip angle, no preload, and full-dose bolus protocol may provide an attractive alternative.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OTbHtQ
The Woven EndoBridge Finally Coming Home across the Atlantic: What to Expect? [EDITORIALS]
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NCwMnE
MR Venous Flow in Sigmoid Sinus Diverticulum [HEAD & NECK]
BACKGROUND AND PURPOSE:
Case reports demonstrate that coiling of a sigmoid sinus diverticulum can treat pulsatile tinnitus. We hypothesized that MR imaging 4D flow and computational fluid dynamics would reveal distinct blood flow patterns in the venous outflow tract in these patients.
MATERIALS AND METHODS:Patients with pulsatile tinnitus of suspected venous etiology underwent MR imaging at 3T, using venous phase contrast-enhanced MR angiography, 4D flow, and 2D phase contrast. The contrast-enhanced MRA contours were evaluated to determine the presence and extent of a sigmoid sinus diverticulum. Computational fluid dynamics analysis was performed using the 4D flow inlet flow and the luminal contours from contrast-enhanced MRA as boundary conditions. In addition, computational fluid dynamics was performed for the expected post treatment conditions by smoothing the venous geometry to exclude the sigmoid sinus diverticulum from the anatomic boundary conditions. Streamlines were generated from the 4D flow and computational fluid dynamics velocity maps, and flow patterns were examined for the presence of rotational components.
RESULTS:Twenty-five patients with pulsatile tinnitus of suspected venous etiology and 10 control subjects were enrolled. Five (20%) of the symptomatic subjects had sigmoid sinus diverticula, all associated with an upstream stenosis. In each of these patients, but none of the controls, a stenosis-related flow jet was directed toward the opening of the sigmoid sinus diverticulum with rotational flow patterns in the sigmoid sinus diverticulum and parent sigmoid sinus on both 4D flow and computational fluid dynamics.
CONCLUSIONS:Consistent patterns of blood flow can be visualized in a sigmoid sinus diverticulum and the parent sinus using 4D flow and computational fluid dynamics. Strong components of rotational blood flow were seen in subjects with sigmoid sinus diverticula that were absent in controls.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2ORB13l
What's the “buzz” about propolis? Propolis‐induced systemic contact dermatitis
Contact Dermatitis, EarlyView.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RKoayL
Differential diagnosis of late‐type reactions to injected local anaesthetics: Inflammation at the injection site is the only indicator of allergic hypersensitivity
Contact Dermatitis, EarlyView.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EbqLyO
What's the “buzz” about propolis? Propolis‐induced systemic contact dermatitis
Contact Dermatitis, EarlyView.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RKoayL
Differential diagnosis of late‐type reactions to injected local anaesthetics: Inflammation at the injection site is the only indicator of allergic hypersensitivity
Contact Dermatitis, EarlyView.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EbqLyO
Beta-propiolactone inactivated bivalent bluetongue virus vaccine containing Montanide ISA-71VG adjuvant induces long-term immune response in sheep against serotypes 4 and 16 even after 3 years of controlled vaccine storage
In this study, we developed and evaluated the beta-propiolactone inactivated bivalent bluetongue virus (BTV) serotypes 4 and 16 vaccine delivered with Montanide™ ISA-71VG adjuvant. The safety, stability and immunological profile of the fresh and after three years of long-term storage of the vaccine formulation was analyzed. We observed after long-term storage that the vaccine emulsion was stable as indicated by unchanged pH and viscosity. The stored vaccine formulation induced virus neutralizing antibodies (VNA) in sheep against both the bluetongue virus serotypes at 7 to 10 day post-vaccination (dpv). VNA titers reached the peak by 60 dpv and detectable during the entire study period. Antibodies against bluetongue virus structural protein VP7 were detected by ELISA in all BTV vaccinated...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CaNecB
Functional characterization of a matrix metalloproteinase 2 gene in Litopenaeus vannamei
Publication date: Available online 11 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): Yu-Ying Lian, Hong-Hui He, Chao-Zheng Zhang, Xin-cang Li, Yi-Hong ChenAbstractMatrix metalloproteinases (MMPs) contribute to both normal and pathological tissue remodeling. They act as regulatory molecules by working in enzyme cascades as well as processing matrix proteins, cytokines, growth factors and adhesion molecules to generate fragments with biological effects. So MMPs could play distrinct roles in the process of pathogen infection. In present study, we cloned a MMP-2 (LvMMP-2) gene from Litopenaeus vannamei. LvMMP-2, highly expressed in epidermis, located to endoplasmic reticulum in S2 cells. Results of real-time RT-PCR assay showed that LvMMP-2 was induced in shrimp hemocytes upon unfol...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CFkgCQ
Oxidative stress, apoptosis activation and symbiosis disruption in giant clam Tridacna crocea under high temperature
Publication date: Available online 11 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): Zhi Zhou, Zhaoqiu Liu, Lingui Wang, Jian Luo, Hailang LiAbstractGiant clams are one of the most important animals in coral reef ecosystem, and its growth and reproduction are being threatened by acute heat stress due to global warming. In the present study, the symbiont density, the crucial enzymes to physiological activities and the transcriptome were investigated in the outer mantle of giant clam Tridacna crocea after the acute exposure of high temperature. The density of symbiotic zooxanthellae decreased significantly during 12–24 h, with the minimum level (7.75 × 105 cell cm−2, p < 0.05) at 12 h after heat stress. The activities of superoxide dismutase in the heat stre...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CaRgll
Separate and combined effects of neurotoxic and lytic compounds of Alexandrium strains on Mytilus edulis feeding activity and hemocyte function
Publication date: Available online 11 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): Virginia Angélica Bianchi, Hendrick Langeloh, Urban Tillmann, Bernd Krock, Annegret Müller, Ulf Bickmeyer, Doris AbeleAbstractMultiple toxic and bioactive compounds produced by Alexandrium spp. cause adverse effects on bivalves, but these effects are frequently difficult to attribute to a single compound class. To disentangle the effect of neurotoxic vs lytic secondary metabolites, we exposed blue mussels to either a paralytic shellfish toxin (PST) producing Alexandrium spp. strain, or to an exclusively lytic compound (LC) producing strain, or a strain containing both compound classes, to evaluate the time dependent effects after 3 and 7 days of feeding. Tested parameters comprised signs of pa...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CEJSQ6
Editorial Board
Publication date: December 2018Source: Fish & Shellfish Immunology, Volume 83Author(s): (Source: Fish and Shellfish Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CayaM8
Functional characterization of a matrix metalloproteinase 2 gene in Litopenaeus vannamei
Publication date: Available online 11 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): Yu-Ying Lian, Hong-Hui He, Chao-Zheng Zhang, Xin-cang Li, Yi-Hong ChenAbstractMatrix metalloproteinases (MMPs) contribute to both normal and pathological tissue remodeling. They act as regulatory molecules by working in enzyme cascades as well as processing matrix proteins, cytokines, growth factors and adhesion molecules to generate fragments with biological effects. So MMPs could play distrinct roles in the process of pathogen infection. In present study, we cloned a MMP-2 (LvMMP-2) gene from Litopenaeus vannamei. LvMMP-2, highly expressed in epidermis, located to endoplasmic reticulum in S2 cells. Results of real-time RT-PCR assay showed that LvMMP-2 was induced in shrimp hemocytes upon unfol...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CFkgCQ
Separate and combined effects of neurotoxic and lytic compounds of Alexandrium strains on Mytilus edulis feeding activity and hemocyte function
Publication date: Available online 11 October 2018Source: Fish & Shellfish ImmunologyAuthor(s): Virginia Angélica Bianchi, Hendrick Langeloh, Urban Tillmann, Bernd Krock, Annegret Müller, Ulf Bickmeyer, Doris AbeleAbstractMultiple toxic and bioactive compounds produced by Alexandrium spp. cause adverse effects on bivalves, but these effects are frequently difficult to attribute to a single compound class. To disentangle the effect of neurotoxic vs lytic secondary metabolites, we exposed blue mussels to either a paralytic shellfish toxin (PST) producing Alexandrium spp. strain, or to an exclusively lytic compound (LC) producing strain, or a strain containing both compound classes, to evaluate the time dependent effects after 3 and 7 days of feeding. Tested parameters comprised signs of pa...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CEJSQ6
Editorial Board
Publication date: December 2018Source: Fish & Shellfish Immunology, Volume 83Author(s): (Source: Fish and Shellfish Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CayaM8
Transnasal Esophagoscopy—Our Experience
Int Arch Otorhinolaryngol
DOI: 10.1055/s-0038-1661359
Introduction Transnasal esophagoscopy (TNE) is a widely used tool both in the diagnosis and treatment of patients presenting complaints within the head and the neck. This is because this investigative adjunct examination provides the advantage of visualizing above the level of the cricopharyngeus muscle when compared to the more widely used esophagogastroduodenoscopy (EGD). Objectives We have assessed if the implementation of TNE within a district general hospital (DGH) was feasible, and investigated if the resources of our patients could be better directed away from other investigations such as barium swallow and EGD in favor of this novel technique. The TNE technique has been largely applied in central teaching hospitals within the United Kingdom, but there are still no published reports of a DGH investigating its applicability in this smaller-sized clinical environment. Method We have analyzed our theater database to find all the patients who had undergone TNE, and recorded their reason for presenting, the preceding investigations, and the procedural findings. Results In most cases, the TNE was conducted without technical issues, and we were able to identify positive findings in 43% of the patients who underwent Esophagogastroduodenoscopy (EGD). We were able to treat patients successfully during the investigation when a cricopharyngeal stricture or narrowing was found. A normal EGD did not preclude further investigations with TNE. All but one of our patients were treated as day-case procedures. Conclusion Transnasal esophagoscopy can be successfully delivered within a DGH. A previous EGD does not mean that the TNE will not reveal positive findings due to its superior visualization of the pharynx and the upper esophagus.
[...]
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil
Article in Thieme eJournals:
Table of contents | Abstract | open access Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OhuVKd
Hearing Rehabilitation through Bone-Conducted Sound Stimulation: Preliminary Results
Int Arch Otorhinolaryngol
DOI: 10.1055/s-0038-1670694
Introduction The bone-anchored hearing aid (BAHA) is a bone conduction system that transmits the sound directly to the inner ear by surpassing the skin impedance and the subcutaneous tissue. It is indicated for patients with mixed, conductive and unilateral sensorineural hearing loss who did not benefit from conventional hearing aids (HAs). Although the benefits from BAHA are well demonstrated internationally, this field still lacks studies in Brazil. Objective To assess the auditory rehabilitation process in BAHA users through audiological, speech perception and tinnitus aspects. Methods Individuals with hearing loss were assessed before and after the implantation. The participants were subjected to pure tone audiometry in free field, functional gain audiometry, speech perception tests, tinnitus handicap inventory (THI) in open format, and to the visual analog scale (VAS). Results It was found that the participants benefited from the use of BAHA. The difference in the performance of the participants before and after the BAHA surgery was significant in terms of hearing acuity. There was no statistically significant difference in the speech perception tests. The tinnitus assessment showed that 80% of the participants scored slight tinnitus severity in THI after using a BAHA. Eighty percent of the participants classified their tinnitus as absent to mild in the VAS after the surgery. Conclusion Based on the results of the current study, we can conclude that the participants improved both the auditory perception and the tinnitus handicap.
[...]
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil
Article in Thieme eJournals:
Table of contents | Abstract | open access Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yxuoZY
Transnasal Esophagoscopy—Our Experience
Int Arch Otorhinolaryngol
DOI: 10.1055/s-0038-1661359
Introduction Transnasal esophagoscopy (TNE) is a widely used tool both in the diagnosis and treatment of patients presenting complaints within the head and the neck. This is because this investigative adjunct examination provides the advantage of visualizing above the level of the cricopharyngeus muscle when compared to the more widely used esophagogastroduodenoscopy (EGD). Objectives We have assessed if the implementation of TNE within a district general hospital (DGH) was feasible, and investigated if the resources of our patients could be better directed away from other investigations such as barium swallow and EGD in favor of this novel technique. The TNE technique has been largely applied in central teaching hospitals within the United Kingdom, but there are still no published reports of a DGH investigating its applicability in this smaller-sized clinical environment. Method We have analyzed our theater database to find all the patients who had undergone TNE, and recorded their reason for presenting, the preceding investigations, and the procedural findings. Results In most cases, the TNE was conducted without technical issues, and we were able to identify positive findings in 43% of the patients who underwent Esophagogastroduodenoscopy (EGD). We were able to treat patients successfully during the investigation when a cricopharyngeal stricture or narrowing was found. A normal EGD did not preclude further investigations with TNE. All but one of our patients were treated as day-case procedures. Conclusion Transnasal esophagoscopy can be successfully delivered within a DGH. A previous EGD does not mean that the TNE will not reveal positive findings due to its superior visualization of the pharynx and the upper esophagus.
[...]
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil
Article in Thieme eJournals:
Table of contents | Abstract | open access Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OhuVKd
Hearing Rehabilitation through Bone-Conducted Sound Stimulation: Preliminary Results
Int Arch Otorhinolaryngol
DOI: 10.1055/s-0038-1670694
Introduction The bone-anchored hearing aid (BAHA) is a bone conduction system that transmits the sound directly to the inner ear by surpassing the skin impedance and the subcutaneous tissue. It is indicated for patients with mixed, conductive and unilateral sensorineural hearing loss who did not benefit from conventional hearing aids (HAs). Although the benefits from BAHA are well demonstrated internationally, this field still lacks studies in Brazil. Objective To assess the auditory rehabilitation process in BAHA users through audiological, speech perception and tinnitus aspects. Methods Individuals with hearing loss were assessed before and after the implantation. The participants were subjected to pure tone audiometry in free field, functional gain audiometry, speech perception tests, tinnitus handicap inventory (THI) in open format, and to the visual analog scale (VAS). Results It was found that the participants benefited from the use of BAHA. The difference in the performance of the participants before and after the BAHA surgery was significant in terms of hearing acuity. There was no statistically significant difference in the speech perception tests. The tinnitus assessment showed that 80% of the participants scored slight tinnitus severity in THI after using a BAHA. Eighty percent of the participants classified their tinnitus as absent to mild in the VAS after the surgery. Conclusion Based on the results of the current study, we can conclude that the participants improved both the auditory perception and the tinnitus handicap.
[...]
Thieme Revinter Publicações Ltda Rio de Janeiro, Brazil
Article in Thieme eJournals:
Table of contents | Abstract | open access Full text
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yxuoZY
Improvement in diagnostic delays over time in patients with hereditary angioedema: findings from the Icatibant Outcome Survey
Abstract
The objective of this analysis was to evaluate the change over time in age at first symptoms, age at diagnosis, and delay in diagnosis using data from the Icatibant Outcome Survey (IOS). Patients with a diagnosis of C1-INH-HAE who were born before the year 1990 and who were diagnosed before they reached 25 years of age were included in the analysis. Both age at diagnosis and delay in diagnosis of C1-INH-HAE appear to decline with later decade of birth, despite wide variation across the countries assessed, suggesting that improved disease awareness causes increased rates of earlier diagnosis over time. Our findings demonstrate that some patients are still experiencing long delays to diagnosis, indicating an ongoing need for improved disease awareness.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yeNFzT
Improvement in diagnostic delays over time in patients with hereditary angioedema: findings from the Icatibant Outcome Survey
Abstract
The objective of this analysis was to evaluate the change over time in age at first symptoms, age at diagnosis, and delay in diagnosis using data from the Icatibant Outcome Survey (IOS). Patients with a diagnosis of C1-INH-HAE who were born before the year 1990 and who were diagnosed before they reached 25 years of age were included in the analysis. Both age at diagnosis and delay in diagnosis of C1-INH-HAE appear to decline with later decade of birth, despite wide variation across the countries assessed, suggesting that improved disease awareness causes increased rates of earlier diagnosis over time. Our findings demonstrate that some patients are still experiencing long delays to diagnosis, indicating an ongoing need for improved disease awareness.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yeNFzT
Widex A/S - WIDEX BABY440 - Class 2 Recall
Widex BABY hearing aid (referred to as BABY440), powered by zinc-air batteries size 10 Intended use: BABY440 is intended for, but not limited to, babies (0 to 3 years of age) to be used as air conduction amplification devices in everyday listening environments. (Source: Medical Device Recalls)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Cai3y4
Widex A/S - WIDEX BABY440 - Class 2 Recall
Widex BABY hearing aid (referred to as BABY440), powered by zinc-air batteries size 10 Intended use: BABY440 is intended for, but not limited to, babies (0 to 3 years of age) to be used as air conduction amplification devices in everyday listening environments. (Source: Medical Device Recalls)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Cai3y4
Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells
The activating mutation BRAFV600E is a frequent genetic event in papillary thyroid carcinomas (PTC). Mutation BRAFV600E is associated with the loss of a sodium/iodine symporter (NIS), and subsequent radioiodide-r...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A5gJuZ
Synergistic inhibition of MEK/ERK and BRAF V600E with PD98059 and PLX4032 induces sodium/iodide symporter (NIS) expression and radioiodine uptake in BRAF mutated papillary thyroid cancer cells
The activating mutation BRAFV600E is a frequent genetic event in papillary thyroid carcinomas (PTC). Mutation BRAFV600E is associated with the loss of a sodium/iodine symporter (NIS), and subsequent radioiodide-r...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2A5gJuZ
Effect of Shenmai injection on cognitive function after cardiopulmonary bypass in cardiac surgical patients: a randomized controlled trial
Abstract
Background
Postoperative cognitive dysfunction (POCD) is a common complication after cardiac surgery that influences the clinical outcomes and quality of life of patients. This study aimed to evaluate the effects of Shenmai injection (SMI) on POCD of patients who underwent cardiac valve replacement under cardiopulmonary bypass (CPB).
Methods
This prospective, randomized, controlled trial was conducted from September 2014 to January 2017. Eighty-eight patients receiving cardiac valve replacement under CPB were randomized into the control (C) or the SMI (S) group. SMI (0.6 mL/kg) was administered intravenously from the time of anesthesia induction to the beginning of CPB. Cognitive function was assessed at 3 days before surgery and 3 days, 7 days, and 1 month after surgery using the Beijing version of the Montreal Cognitive Assessment (MoCA-BJ) score. The serum levels of neuroglobin (Ngb), hypoxia-inducible factor-1α (HIF-1α), and neuron-specific enolase (NSE) were measured at 30 min after induction (T0), immediately after the endonasal temperature rewarmed to 36 °C (T1), and 1 h (T2), 6 h (T3), 24 h (T4), 48 h (T5), and 72 h (T6) after CPB.
Results
Compared with the baseline values at T0, the serum Ngb levels in group C were significantly decreased at T1–2 and then increased at T3–6, while the levels in group S were decreased at T1–2 and increased at T4–6, compared to group C (p < 0.05). The serum HIF-1α levels at T1–4 and the serum NSE levels at T1–6 were significantly increased in both groups (p < 0.05). The serum levels of Ngb at T3, HIF-1α at T1–3, and NSE at T3–4,6 were lower in group S, compared to group C (p < 0.01). The MoCA-BJ scores were decreased at 3 and 7 days after surgery in both groups, and the MoCA-BJ scores in group S were higher than those in group C at 3 and 7 days after surgery (p < 0.01).
Conclusion
Cognitive function is impaired postoperatively in patients who have undergone cardiac valve replacement under CPB. In addition, treatment with the traditional Chinese medicine SMI decreases the serum levels of Ngb, HIF-1α, and NSE as well as attenuates cognitive dysfunction.
Trial registration
This trial was registered with Clinicaltrials.gov as ChiCTR-TRC-14004373 on March 11, 2014.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IRXkAL
Effect of Shenmai injection on cognitive function after cardiopulmonary bypass in cardiac surgical patients: a randomized controlled trial
Abstract
Background
Postoperative cognitive dysfunction (POCD) is a common complication after cardiac surgery that influences the clinical outcomes and quality of life of patients. This study aimed to evaluate the effects of Shenmai injection (SMI) on POCD of patients who underwent cardiac valve replacement under cardiopulmonary bypass (CPB).
Methods
This prospective, randomized, controlled trial was conducted from September 2014 to January 2017. Eighty-eight patients receiving cardiac valve replacement under CPB were randomized into the control (C) or the SMI (S) group. SMI (0.6 mL/kg) was administered intravenously from the time of anesthesia induction to the beginning of CPB. Cognitive function was assessed at 3 days before surgery and 3 days, 7 days, and 1 month after surgery using the Beijing version of the Montreal Cognitive Assessment (MoCA-BJ) score. The serum levels of neuroglobin (Ngb), hypoxia-inducible factor-1α (HIF-1α), and neuron-specific enolase (NSE) were measured at 30 min after induction (T0), immediately after the endonasal temperature rewarmed to 36 °C (T1), and 1 h (T2), 6 h (T3), 24 h (T4), 48 h (T5), and 72 h (T6) after CPB.
Results
Compared with the baseline values at T0, the serum Ngb levels in group C were significantly decreased at T1–2 and then increased at T3–6, while the levels in group S were decreased at T1–2 and increased at T4–6, compared to group C (p < 0.05). The serum HIF-1α levels at T1–4 and the serum NSE levels at T1–6 were significantly increased in both groups (p < 0.05). The serum levels of Ngb at T3, HIF-1α at T1–3, and NSE at T3–4,6 were lower in group S, compared to group C (p < 0.01). The MoCA-BJ scores were decreased at 3 and 7 days after surgery in both groups, and the MoCA-BJ scores in group S were higher than those in group C at 3 and 7 days after surgery (p < 0.01).
Conclusion
Cognitive function is impaired postoperatively in patients who have undergone cardiac valve replacement under CPB. In addition, treatment with the traditional Chinese medicine SMI decreases the serum levels of Ngb, HIF-1α, and NSE as well as attenuates cognitive dysfunction.
Trial registration
This trial was registered with Clinicaltrials.gov as ChiCTR-TRC-14004373 on March 11, 2014.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IRXkAL
CT, conventional, and functional MRI features of skull lymphoma: a series of eight cases in a single institution
Abstract
Objective
With the hypothesis that the combination of CT, conventional, and functional MRI can indicate a possible diagnosis of skull lymphoma, this study aimed to systematically explore CT, conventional, and functional MRI features of this rare entity.
Materials and methods
This retrospective study included eight patients with pathologically confirmed skull lymphomas. CT and conventional MRI findings, including the location, size, attenuation/signal intensity, cystic/necrosis, hemorrhage, calcification, enhancement, skull change, brain parenchyma edema and adjacent structure invasion, were reviewed. We also reviewed multi-parametric functional MR imaging features obtained from diffusion-weighted imaging (DWI, n = 4), susceptibility-weighted imaging (SWI, n = 3) and dynamic susceptibility-weighted contrast-enhanced perfusion-weighted imaging (DSC-PWI, n = 1).
Results
The eight patients in this series consisted of five males and three females, with a mean age of 51.1 years. All skull lymphomas showed the tumors extending to extra- and intra-cranial spaces with permeative destruction of the intervening skull. Intratumoral cystic/necrosis was seen in one case. Hemorrhage or calcification was absent. Dural mater infiltration was detected in all cases. Two clivus lymphomas encased internal carotid artery without narrowing the lumen. Three cases invaded brain parenchyma with moderate edema. The tumors demonstrated high signal on DWI with low ADC values comparing to muscles. SWI images showed little intratumoral hemorrhage and vessel. Low relative cerebral blood volume (rCBV) value was detected.
Conclusions
Skull lymphomas commonly presented as a homogenous solid tumor extending either intra- or extra-cranially with permeative bone destruction. Restricted diffusion, little intratumoral susceptibility signal, and lower perfusion may indicate a specific diagnosis. Multi-parametric functional MRI may be a promising tool for the diagnosis of skull lymphomas.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IS3Nvl
The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal - Pilot
Condition: Penicillin Allergy Intervention: Other: Penicillin Allergic Risk Stratification Best Practice Alert Sponsors: Vanderbilt University Medical Center; Vanderbilt Institute for Clinical and Translational Research (Learning Healthcare System) Not yet recruiting (Source: ClinicalTrials.gov)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RJmLIM
The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal
Condition: Penicillin Allergy Intervention: Other: Penicillin Allergic Risk Stratification Best Practice Alert Sponsors: Vanderbilt University Medical Center; Vanderbilt Institute for Clinical and Translational Research (Learning Healthcare System) Not yet recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EikjWP
Durability and Impact of the Seasonal Influenza Vaccine on H5 Induced B Cell Response
Condition: Influenza A Subtype H5N1 Infection Intervention: Biological: Seasonal Influenza Vaccine Sponsors: Emory University; National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RJmmGg
Yoga Training in Allergic Rhinitis Patients
Condition: Allergic Rhinitis Intervention: Other: Yoga training Sponsor: Chulalongkorn University Completed (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ega9WR
CT, conventional, and functional MRI features of skull lymphoma: a series of eight cases in a single institution
Abstract
Objective
With the hypothesis that the combination of CT, conventional, and functional MRI can indicate a possible diagnosis of skull lymphoma, this study aimed to systematically explore CT, conventional, and functional MRI features of this rare entity.
Materials and methods
This retrospective study included eight patients with pathologically confirmed skull lymphomas. CT and conventional MRI findings, including the location, size, attenuation/signal intensity, cystic/necrosis, hemorrhage, calcification, enhancement, skull change, brain parenchyma edema and adjacent structure invasion, were reviewed. We also reviewed multi-parametric functional MR imaging features obtained from diffusion-weighted imaging (DWI, n = 4), susceptibility-weighted imaging (SWI, n = 3) and dynamic susceptibility-weighted contrast-enhanced perfusion-weighted imaging (DSC-PWI, n = 1).
Results
The eight patients in this series consisted of five males and three females, with a mean age of 51.1 years. All skull lymphomas showed the tumors extending to extra- and intra-cranial spaces with permeative destruction of the intervening skull. Intratumoral cystic/necrosis was seen in one case. Hemorrhage or calcification was absent. Dural mater infiltration was detected in all cases. Two clivus lymphomas encased internal carotid artery without narrowing the lumen. Three cases invaded brain parenchyma with moderate edema. The tumors demonstrated high signal on DWI with low ADC values comparing to muscles. SWI images showed little intratumoral hemorrhage and vessel. Low relative cerebral blood volume (rCBV) value was detected.
Conclusions
Skull lymphomas commonly presented as a homogenous solid tumor extending either intra- or extra-cranially with permeative bone destruction. Restricted diffusion, little intratumoral susceptibility signal, and lower perfusion may indicate a specific diagnosis. Multi-parametric functional MRI may be a promising tool for the diagnosis of skull lymphomas.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IS3Nvl
The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal - Pilot
Condition: Penicillin Allergy Intervention: Other: Penicillin Allergic Risk Stratification Best Practice Alert Sponsors: Vanderbilt University Medical Center; Vanderbilt Institute for Clinical and Translational Research (Learning Healthcare System) Not yet recruiting (Source: ClinicalTrials.gov)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RJmLIM
The Effect of Providing Stratification of Low Risk Penicillin Allergies on Penicillin Allergy Label Removal
Condition: Penicillin Allergy Intervention: Other: Penicillin Allergic Risk Stratification Best Practice Alert Sponsors: Vanderbilt University Medical Center; Vanderbilt Institute for Clinical and Translational Research (Learning Healthcare System) Not yet recruiting (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2EikjWP
Yoga Training in Allergic Rhinitis Patients
Condition: Allergic Rhinitis Intervention: Other: Yoga training Sponsor: Chulalongkorn University Completed (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ega9WR
Food Allergy Diagnostic Test Response to Previous Oral Challenge Response
Condition: Food Hypersensitivity Intervention: Other: Conjunctival Allergen Challenge Sponsor: ORA, Inc. Completed (Source: ClinicalTrials.gov)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2RH0n2x
Early Immunologic Response of Irreversible Electroporation versus Cryoablation in a Rodent Model of Pancreatic Cancer
ConclusionsIn a mouse model of pancreatic cancer, IRE evokes a more robust infiltration of macrophages and T cells than cryoablation within 24 hours. (Source: Journal of Vascular and Interventional Radiology)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IS3mRJ
Instrument for evaluating child hearing health services: construction and validity
Conclusion The matrix of indicators was considered valid for evaluating child hearing health services. (Source: Revista da Escola de Enfermagem da USP)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pP8b5N
Time will tell: Temporal landmarks influence metaphorical associations between space and time
Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IQtmNw
The multimodal marking of aspect: The case of five periphrastic auxiliary constructions in North American English
Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pO2Zz1
Does early object exploration support gesture and language development in extremely preterm infants and full-term infants?
CONCLUSIONS: Cascading effects of specific object exploration skills on gestures and language comprehension and production in preterm infants and FT infants are discussed. Clinical implications for early assessment of and interventions involving object exploration skills, which may affect language development, are considered for the preterm population. PMID: 30300842 [PubMed - as supplied by publisher] (Source: Journal of Communication Disorders)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IOME5K
Early Immunologic Response of Irreversible Electroporation versus Cryoablation in a Rodent Model of Pancreatic Cancer
ConclusionsIn a mouse model of pancreatic cancer, IRE evokes a more robust infiltration of macrophages and T cells than cryoablation within 24 hours. (Source: Journal of Vascular and Interventional Radiology)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IS3mRJ
Time will tell: Temporal landmarks influence metaphorical associations between space and time
Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IQtmNw
The multimodal marking of aspect: The case of five periphrastic auxiliary constructions in North American English
Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pO2Zz1
Does early object exploration support gesture and language development in extremely preterm infants and full-term infants?
CONCLUSIONS: Cascading effects of specific object exploration skills on gestures and language comprehension and production in preterm infants and FT infants are discussed. Clinical implications for early assessment of and interventions involving object exploration skills, which may affect language development, are considered for the preterm population. PMID: 30300842 [PubMed - as supplied by publisher] (Source: Journal of Communication Disorders)
MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2IOME5K
Management of Orbital Fractures
Fractures of the orbit are a very common injury, and are often treated by multiple facial subspecialties. Many fractures can be asymptomatic and do not require surgical therapy, but for those fractures where intervention is indicated, neglect, delay or inappropriate technique can have permanent consequences on visual function and facial deformity. In this article, the indications and techniques of repair for specific fractures will be discussed, as well as possible risks and complications.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yeHYlI
Techniques of Enucleation and Evisceration
There are many conditions that may require removal of the eye. The most common and obvious reasons involve severe irreversible trauma or potentially life-threatening malignancy. There are, however, other reasons for the therapeutic removal of the eye, including recalcitrant pain and cosmetic deformity. This article will discuss the indications for removal of the eye, as well as describe the alternative techniques of enucleation and evisceration, including their relative advantages.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Pv7cCP
Dacryocystorhinostomy: Indications and Surgical Technique
The following article reviews the clinical presentation, evaluation, and surgical treatment of patients with nasolacrimal duct obstruction, with an emphasis placed on the surgical techniques of external and internal/endoscopic dacryocystorhinostomy.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yac61q
Management of Orbital Fractures
Fractures of the orbit are a very common injury, and are often treated by multiple facial subspecialties. Many fractures can be asymptomatic and do not require surgical therapy, but for those fractures where intervention is indicated, neglect, delay or inappropriate technique can have permanent consequences on visual function and facial deformity. In this article, the indications and techniques of repair for specific fractures will be discussed, as well as possible risks and complications.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yeHYlI
Techniques of Enucleation and Evisceration
There are many conditions that may require removal of the eye. The most common and obvious reasons involve severe irreversible trauma or potentially life-threatening malignancy. There are, however, other reasons for the therapeutic removal of the eye, including recalcitrant pain and cosmetic deformity. This article will discuss the indications for removal of the eye, as well as describe the alternative techniques of enucleation and evisceration, including their relative advantages.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Pv7cCP
Dacryocystorhinostomy: Indications and Surgical Technique
The following article reviews the clinical presentation, evaluation, and surgical treatment of patients with nasolacrimal duct obstruction, with an emphasis placed on the surgical techniques of external and internal/endoscopic dacryocystorhinostomy.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2yac61q
Multimodal Approaches in the Management of Malignancies Involving the Orbit
Malignancies involving the orbit comprise heterogeneous pathologies with a variety of ophthalmic and otolaryngic presentations resulting from compression and destruction of native orbital contents. Surgical ablation with negative margins with adjuvant treatment remains a cornerstone for optimal oncologic control and successful operative outcomes. Historically, attempts at tumor extirpation were first performed by neurosurgeons via open craniotomies to access orbital contents. While these approaches remain a mainstay within the superolateral compartment, endoscopic techniques pioneered by otolaryngologists have emerged as a standard in managing inferomedial orbital tumors.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PqAToB
Scientists develop novel vaccine for lassa fever and rabies
(NIH/National Institute of Allergy and Infectious Diseases) A novel vaccine designed to protect people from both Lassa fever and rabies showed promise in preclinical testing, according to new research published in Nature Communications. The investigational vaccine, called LASSARAB, was developed and tested by scientists at Thomas Jefferson University in Philadelphia; the University of Minho in Braga, Portugal; the University of California, San Diego; and the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. (Source: EurekAlert! - Infectious and Emerging Diseases)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PuNTK3
Scientists develop novel vaccine for lassa fever and rabies
(NIH/National Institute of Allergy and Infectious Diseases) A novel vaccine designed to protect people from both Lassa fever and rabies showed promise in preclinical testing, according to new research published in Nature Communications. The investigational vaccine, called LASSARAB, was developed and tested by scientists at Thomas Jefferson University in Philadelphia; the University of Minho in Braga, Portugal; the University of California, San Diego; and the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. (Source: EurekAlert! - Infectious and Emerging Diseases)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PuNTK3
Effects of Silicone Implants on the Mammary Gland: Ultrasonographic and 3D Study
Abstract
Background
Breast implants may be responsible for secondary deformities produced by parenchymal atrophy. However, few studies in the literature have reported changes in breast tissue after augmentation surgery. In this study, the breast thickness of patients undergoing breast augmentation was monitored by ultrasound, and correlations with surface, volume and projection measurements were examined.
Methods
We studied the parenchymal thickness at the lower pole of the breast with ultrasound in 36 women (72 breasts). In another group of 33 patients (66 breasts), we studied the thickness at the upper and lower poles along the meridian of each breast by ultrasound and measured the anthropometric metrics, volume and projection of the breast with a 3D camera.
Results
Midline measurements close to the areola showed reduced thickness at the lower pole, with 31.8% at the midpoint of the lower pole and 42% at the infra-areolar level (p < 0.0001). At the upper pole, there was a decrease of 14.6% (p < 0.001), but the thickness was increased by 6% and 38% at more cranial levels. No correlations with volume were found. Anatomical implants produced more atrophy at the lower pole, and round implants at the upper pole. More atrophy was found with subfascial than submuscular augmentation. Compared with the expected values, the final volume was very similar, but the projection was 29% less. Surface measurements changed significantly up to 4 months postoperatively and remained stable thereafter.
Conclusions
Implants affect significatively the thickness of the glandular tissue. All changes occur very soon postoperatively but stabilize after 4 months.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CGUFJC
Removal of Polyurethane Implants
Abstract
Polyurethane (PU) implants are associated with great difficulties in extraction if secondary surgery is needed. The published data are contradictory, often misleading, making the decision for the secondary surgery complicated, the time period and the procedure itself not optimal, thus negatively influencing the final result.
Materials and Methods
Typical videos of PU implant removal in different periods after primary surgeries with polyurethane implants were selected for the study. The videos show the strength and extent of the tissue ingrowth and the manipulations needed for implant extraction in different periods from the initial procedure. Classifications of the types of adhesion and adhesion patterns are introduced.
Conclusions
The data provided in this article facilitate the decision-making process if secondary surgery is indicated. Secondary surgery should be performed in the first 30 days after the initial surgery or in the period after 6 months. The optimal layer for removal of the PU implant depends on the time after the primary surgery. The polyurethane implant should be exchanged after 1 month if the properties of the polyurethane foam are expected to be used.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C82wyO
Effects of Silicone Implants on the Mammary Gland: Ultrasonographic and 3D Study
Abstract
Background
Breast implants may be responsible for secondary deformities produced by parenchymal atrophy. However, few studies in the literature have reported changes in breast tissue after augmentation surgery. In this study, the breast thickness of patients undergoing breast augmentation was monitored by ultrasound, and correlations with surface, volume and projection measurements were examined.
Methods
We studied the parenchymal thickness at the lower pole of the breast with ultrasound in 36 women (72 breasts). In another group of 33 patients (66 breasts), we studied the thickness at the upper and lower poles along the meridian of each breast by ultrasound and measured the anthropometric metrics, volume and projection of the breast with a 3D camera.
Results
Midline measurements close to the areola showed reduced thickness at the lower pole, with 31.8% at the midpoint of the lower pole and 42% at the infra-areolar level (p < 0.0001). At the upper pole, there was a decrease of 14.6% (p < 0.001), but the thickness was increased by 6% and 38% at more cranial levels. No correlations with volume were found. Anatomical implants produced more atrophy at the lower pole, and round implants at the upper pole. More atrophy was found with subfascial than submuscular augmentation. Compared with the expected values, the final volume was very similar, but the projection was 29% less. Surface measurements changed significantly up to 4 months postoperatively and remained stable thereafter.
Conclusions
Implants affect significatively the thickness of the glandular tissue. All changes occur very soon postoperatively but stabilize after 4 months.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CGUFJC
Removal of Polyurethane Implants
Abstract
Polyurethane (PU) implants are associated with great difficulties in extraction if secondary surgery is needed. The published data are contradictory, often misleading, making the decision for the secondary surgery complicated, the time period and the procedure itself not optimal, thus negatively influencing the final result.
Materials and Methods
Typical videos of PU implant removal in different periods after primary surgeries with polyurethane implants were selected for the study. The videos show the strength and extent of the tissue ingrowth and the manipulations needed for implant extraction in different periods from the initial procedure. Classifications of the types of adhesion and adhesion patterns are introduced.
Conclusions
The data provided in this article facilitate the decision-making process if secondary surgery is indicated. Secondary surgery should be performed in the first 30 days after the initial surgery or in the period after 6 months. The optimal layer for removal of the PU implant depends on the time after the primary surgery. The polyurethane implant should be exchanged after 1 month if the properties of the polyurethane foam are expected to be used.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C82wyO
Scientists develop novel vaccine for lassa fever and rabies
(NIH/National Institute of Allergy and Infectious Diseases) A novel vaccine designed to protect people from both Lassa fever and rabies showed promise in preclinical testing, according to new research published in Nature Communications. The investigational vaccine, called LASSARAB, was developed and tested by scientists at Thomas Jefferson University in Philadelphia; the University of Minho in Braga, Portugal; the University of California, San Diego; and the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. (Source: EurekAlert! - Infectious and Emerging Diseases)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PuNTK3
Scientists develop novel vaccine for lassa fever and rabies
(NIH/National Institute of Allergy and Infectious Diseases) A novel vaccine designed to protect people from both Lassa fever and rabies showed promise in preclinical testing, according to new research published in Nature Communications. The investigational vaccine, called LASSARAB, was developed and tested by scientists at Thomas Jefferson University in Philadelphia; the University of Minho in Braga, Portugal; the University of California, San Diego; and the National Institute of Allergy and Infectious Diseases (NIAID), part of the National Institutes of Health. (Source: EurekAlert! - Infectious and Emerging Diseases)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PuNTK3
Titanium mesh associated with rhBMP-2 in alveolar ridge reconstruction
A systematic review of the literature was performed regarding the use of titanium mesh in association with recombinant human bone morphogenetic protein (rhBMP) for alveolar ridge reconstruction. The PubMed, Scopus, and Cochrane databases were searched for articles in English published up until June 2017. The inclusion criteria encompassed studies in humans − randomized clinical trials, prospective and retrospective studies, and case series. The screening and selection process was performed by three independent reviewers, with verification by a senior researcher in the case of disagreement.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CDKOEn
Response to comments on “Orofacial cleft management by short-term surgical missions in South America: literature review”
We thank the authors of the letter entitled "Five decades of orofacial cleft management and research in Brazil"1 for their comments on our article regarding short-term surgical missions for the management of orofacial clefts (OFCs) in South America2. It was certainly not our intention to minimize the efforts of the Brazilian cleft team; we are truly glad for the advancements they have made since 1967. We agree that there is a need to increase national efforts in South America and international collaborative support to provide specialized care for patients with OFCs.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C87YSi
Titanium mesh associated with rhBMP-2 in alveolar ridge reconstruction
A systematic review of the literature was performed regarding the use of titanium mesh in association with recombinant human bone morphogenetic protein (rhBMP) for alveolar ridge reconstruction. The PubMed, Scopus, and Cochrane databases were searched for articles in English published up until June 2017. The inclusion criteria encompassed studies in humans − randomized clinical trials, prospective and retrospective studies, and case series. The screening and selection process was performed by three independent reviewers, with verification by a senior researcher in the case of disagreement.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CDKOEn
Response to comments on “Orofacial cleft management by short-term surgical missions in South America: literature review”
We thank the authors of the letter entitled "Five decades of orofacial cleft management and research in Brazil"1 for their comments on our article regarding short-term surgical missions for the management of orofacial clefts (OFCs) in South America2. It was certainly not our intention to minimize the efforts of the Brazilian cleft team; we are truly glad for the advancements they have made since 1967. We agree that there is a need to increase national efforts in South America and international collaborative support to provide specialized care for patients with OFCs.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C87YSi
IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive anti-viral immunity
IL-33 is implicated in asthma exacerbation but its role is unclear. We demonstrate that IL-33 drives influenza-induced asthma exacerbation suppressing anti-viral innate and adaptive responses in immune and epithelial cells.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OPzsTL
IL-33 drives influenza-induced asthma exacerbations by halting innate and adaptive anti-viral immunity
IL-33 is implicated in asthma exacerbation but its role is unclear. We demonstrate that IL-33 drives influenza-induced asthma exacerbation suppressing anti-viral innate and adaptive responses in immune and epithelial cells.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OPzsTL
Effects of Silicone Implants on the Mammary Gland: Ultrasonographic and 3D Study
Abstract
Background
Breast implants may be responsible for secondary deformities produced by parenchymal atrophy. However, few studies in the literature have reported changes in breast tissue after augmentation surgery. In this study, the breast thickness of patients undergoing breast augmentation was monitored by ultrasound, and correlations with surface, volume and projection measurements were examined.
Methods
We studied the parenchymal thickness at the lower pole of the breast with ultrasound in 36 women (72 breasts). In another group of 33 patients (66 breasts), we studied the thickness at the upper and lower poles along the meridian of each breast by ultrasound and measured the anthropometric metrics, volume and projection of the breast with a 3D camera.
Results
Midline measurements close to the areola showed reduced thickness at the lower pole, with 31.8% at the midpoint of the lower pole and 42% at the infra-areolar level (p < 0.0001). At the upper pole, there was a decrease of 14.6% (p < 0.001), but the thickness was increased by 6% and 38% at more cranial levels. No correlations with volume were found. Anatomical implants produced more atrophy at the lower pole, and round implants at the upper pole. More atrophy was found with subfascial than submuscular augmentation. Compared with the expected values, the final volume was very similar, but the projection was 29% less. Surface measurements changed significantly up to 4 months postoperatively and remained stable thereafter.
Conclusions
Implants affect significatively the thickness of the glandular tissue. All changes occur very soon postoperatively but stabilize after 4 months.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these Evidence-Based Medicine ratings, please refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2CGUFJC
Removal of Polyurethane Implants
Abstract
Polyurethane (PU) implants are associated with great difficulties in extraction if secondary surgery is needed. The published data are contradictory, often misleading, making the decision for the secondary surgery complicated, the time period and the procedure itself not optimal, thus negatively influencing the final result.
Materials and Methods
Typical videos of PU implant removal in different periods after primary surgeries with polyurethane implants were selected for the study. The videos show the strength and extent of the tissue ingrowth and the manipulations needed for implant extraction in different periods from the initial procedure. Classifications of the types of adhesion and adhesion patterns are introduced.
Conclusions
The data provided in this article facilitate the decision-making process if secondary surgery is indicated. Secondary surgery should be performed in the first 30 days after the initial surgery or in the period after 6 months. The optimal layer for removal of the PU implant depends on the time after the primary surgery. The polyurethane implant should be exchanged after 1 month if the properties of the polyurethane foam are expected to be used.
Level of Evidence IV
This journal requires that authors assign a level of evidence to each article. For a full description of these evidence-based medicine ratings, refer to the Table of Contents or the online Instructions to Authors www.springer.com/00266.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2C82wyO
Εγγραφή σε:
Αναρτήσεις (Atom)