Development of high‐resolution 3D MR fingerprinting for detection and characterization of epileptic lesions

Background

Conventional MRI can be limited in detecting subtle epileptic lesions or identifying active/epileptic lesions among widespread, multifocal lesions.

Purpose

We developed a high‐resolution 3D MR fingerprinting (MRF) protocol to simultaneously provide quantitative T₁, T₂, proton density, and tissue fraction maps for detection and characterization of epileptic lesions.

Study type

Prospective.

Population

National Institute of Standards and Technology (NIST) / International Society for Magnetic Resonance in Medicine (ISMRM) phantom, five healthy volunteers and 15 patients with medically intractable epilepsy undergoing presurgical evaluation with noninvasive or invasive electroclinical data.

Field Strength/Sequence

3D MRF scans and routine clinical epilepsy MR protocols were acquired at 3 T.

Assessment

The accuracy of the T₁ and T₂ values were first evaluated using the NIST/ISMRM phantom. The repeatability was then estimated with both phantom and volunteers based on the coefficient of variance (CV). For epilepsy patients, all the maps were qualitatively reviewed for lesion detection by three independent reviewers (S.E.J., M.L., I.N.) blinded to clinical data. Region of interest (ROI) analysis was performed on T₁ and T₂ maps to quantify the multiparametric signal differences between lesion and normal tissues. Findings from qualitative review and quantitative ROI analysis were compared with patients' electroclinical data to assess concordance.

Statistical Tests

Phantom results were compared using R‐squared, and patient results were compared using linear regression models.

Results

The phantom study showed high accuracy with the standard values, with an R² of 0.99. The volunteer study showed high repeatability, with an average CV of 4.3% for T₁ and T₂ in various tissue regions. For the 15 patients, MRF showed additional findings in four patients, with the remaining 11 patients showing findings consistent with conventional MRI. The additional MRF findings were highly concordant with patients' electroclinical presentation.

Data Conclusion

The 3D MRF protocol showed potential to identify otherwise inconspicuous epileptogenic lesions from the patients with negative conventional MRI diagnosis, as well as to correlate with different levels of epileptogenicity when widespread lesions were present.

Level of Evidence: 3.

Technical Efficacy Stage: 3.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2PYInOV

Development of high‐resolution 3D MR fingerprinting for detection and characterization of epileptic lesions

Background

Conventional MRI can be limited in detecting subtle epileptic lesions or identifying active/epileptic lesions among widespread, multifocal lesions.

Purpose

We developed a high‐resolution 3D MR fingerprinting (MRF) protocol to simultaneously provide quantitative T₁, T₂, proton density, and tissue fraction maps for detection and characterization of epileptic lesions.

Study type

Prospective.

Population

National Institute of Standards and Technology (NIST) / International Society for Magnetic Resonance in Medicine (ISMRM) phantom, five healthy volunteers and 15 patients with medically intractable epilepsy undergoing presurgical evaluation with noninvasive or invasive electroclinical data.

Field Strength/Sequence

3D MRF scans and routine clinical epilepsy MR protocols were acquired at 3 T.

Assessment

The accuracy of the T₁ and T₂ values were first evaluated using the NIST/ISMRM phantom. The repeatability was then estimated with both phantom and volunteers based on the coefficient of variance (CV). For epilepsy patients, all the maps were qualitatively reviewed for lesion detection by three independent reviewers (S.E.J., M.L., I.N.) blinded to clinical data. Region of interest (ROI) analysis was performed on T₁ and T₂ maps to quantify the multiparametric signal differences between lesion and normal tissues. Findings from qualitative review and quantitative ROI analysis were compared with patients' electroclinical data to assess concordance.

Statistical Tests

Phantom results were compared using R‐squared, and patient results were compared using linear regression models.

Results

The phantom study showed high accuracy with the standard values, with an R² of 0.99. The volunteer study showed high repeatability, with an average CV of 4.3% for T₁ and T₂ in various tissue regions. For the 15 patients, MRF showed additional findings in four patients, with the remaining 11 patients showing findings consistent with conventional MRI. The additional MRF findings were highly concordant with patients' electroclinical presentation.

Data Conclusion

The 3D MRF protocol showed potential to identify otherwise inconspicuous epileptogenic lesions from the patients with negative conventional MRI diagnosis, as well as to correlate with different levels of epileptogenicity when widespread lesions were present.

Level of Evidence: 3.

Technical Efficacy Stage: 3.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2PYInOV

Squamous cell carcinoma of the tongue in a patient with dyskeratosis congenita: a rare entity

We report a patient with dyskeratosis congenita who presented with squamous cell carcinoma of the oral tongue. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T2OuDO

Short- and long-term mortality and causes of death after reconstruction of cancers of the head and neck with free flaps

The use of free flaps to reconstruct cancers of the head and neck is accompanied by appreciable postoperative morbidity and high long-term mortality, but the causes of death and the impact of postoperative complications on survival have not been well studied. We have therefore analysed retrospectively the causes of death and survival of 146 such patients operated on between 2008 and 2016 of whom a total of 62 (43%) had died by the end of 2016. The cause of death was the primary disease in 45 of the 62. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Cy3W5L

---

There are increasing numbers of clinicians, predominantly plastic surgeons, who are offering surgical treatment to patients with migraine. This concept reached the public media arena over a decade ago, when the London Evening Standard published a review of the topic in 2008. The US news network CNN produced a documentary on it in 2016, but the technique is still regarded as controversial, and an option of last resort by its opponents. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T5MHht

Abstract withdrawn 12 June 2018

(Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CwKgPK

Re-operative factors in Zygomatico-orbital trauma

Introduction: The principle of facial fracture treatment is that satisfactory initial management will reduce the risk of long term morbidity. A need to return to theatre (RTT) after surgical treatment may suggest failure of initial management. Research on indications for RTT is scarce and no predictive factors have been identified to date. Early appreciation of such factors may improve initial management of fractures. We reviewed 5 years of trauma to identify cases requiring RTT, and attempt to establish predictive factors. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T9NjTo

Treatment of lip dysplasia with imiquimod 5%: Results from a single OMFS unit

Introduction: Lip dysplasia is a pre-malignant pathological condition and as such requires treatment to prevent malignant transformation. Management of moderate to severe dysplasia with surgical resection; such as vermilionectomy (lip shave) or CO2 laser ablation has been described. Non-surgical treatment of all grades of dysplasia can be achieved using topical agents such as imiquimod. Having described the first use of imiquimod to treat lip dysplasia, we present the first50 patients through our department. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Cv1cpt

Do inpatient records reflect a ‘seven day NHS?’

Introduction: To comply with NHS standards, suitable consultants must clinically assess all emergency hospital admissions within 14hours. Furthermore, consultant led handovers and ward rounds should occur daily with outcomes clearly documented. Patients should be actively involved in shared decision-making and be provided clear information to make informed choices. At Queen Victoria Hospital, like many UK trusts, paper inpatient records are utilised to document clinical information. This creates significant variability in standardisation of documentation. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T9f8ef

A comparison of patient outcomes following orthognathic surgery with and without the use of hilotherapy

Patients undergoing orthognathic surgery commonly complain of bruising and swelling postoperatively, frequently leading to a delay to return to work. We propose the use of a cooling face mask called "hilotherapy" postoperatively to aid the patients return to work and reduce the burden of care to the NHS. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CvYqQN

The Use of Patient Specific Implants and Genioplasty to refine the results of Orthognathic Surgery in Severe Facial Asymmetry

Introduction: The use of patient-specific implants (PSI) in OMFS are becoming increasingly popular in aesthetic and functional reconstruction. There are few reports of the use of PSI in transposition genioplasty procedures to correct marked mandibular asymmetry. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T5MGKr

Emergency management of the neck breather A closed loop, multi-centre audit

Aims: A multi centre completed audit cycle to ascertain improvements in knowledge of emergency tracheostomy and laryngectomy management following implementation of a teaching programme. Results were compared with The Global Tracheostomy Safety Project emergency management algorithm with a standard of 100% compliance. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CwKczu

Frequency of Level IIb Neck Dissections for OSCC

This study was undertaken to ascertain the frequency of undertaking Level IIb dissection and the rate of Nodal metastasis to this level. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Ta98Cg

Advertising and marketing breaches by non-surgical aesthetic trainers

The practice of non-surgical aesthetics is a booming industry, and discussion is being had about how this area of practice requires regulation in order to protect patients from undue harm. Whilst GMC guidance is available and often adhered to by clinicians advertising clinical services, there is guidance available from the Advertising Standards Authority (ASA) regarding medical services provision and the methods used to promote such practice. Having reviewed these ASA guidelines, we wanted to establish how many providers were in fact in breach of the ASA and GMC guidance. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CwuUe0

Operating time and postoperative length of stay in modern orthognathic surgery- A retrospective review of 562 osteotomies by a single UK surgeon

Introduction: Literature review reveals that shorter duration of operation has better patient outcomes. We aimed to present the operating time and postoperative length of stay for patients undergoing orthognathic surgery under a single UK surgeon from 2009-2017. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TaVtLf

‘The mind is not a vessel to be filled, but a fire to be kindled’: The influence of positive role models on the development and retention of female maxillofacial surgeons-in-training in the UK and the impact of lifestyle factors

Introduction: Positive role models have been seen to double the expression of interest in surgical careers in junior doctors (Ravindra, 2011). Perceived and actual barriers to maxillofacial training such as financial pressures and extended training (Minks 2015) exist, with additional gender-specific difficulties including the lack of female role models and sexual harassment (Rostami, 2010). Whilst the specialty has seen an increase in the number of female consultants/specialists (14%), the recent problem of retention of junior doctors in general, combined with ongoing low uptake of surgical training in women in particular, may negatively influence the future gender ratio. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CwuTGY

Squamous cell carcinoma of the tongue in a patient with dyskeratosis congenita: a rare entity

We report a patient with dyskeratosis congenita who presented with squamous cell carcinoma of the oral tongue. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T2OuDO

Short- and long-term mortality and causes of death after reconstruction of cancers of the head and neck with free flaps

The use of free flaps to reconstruct cancers of the head and neck is accompanied by appreciable postoperative morbidity and high long-term mortality, but the causes of death and the impact of postoperative complications on survival have not been well studied. We have therefore analysed retrospectively the causes of death and survival of 146 such patients operated on between 2008 and 2016 of whom a total of 62 (43%) had died by the end of 2016. The cause of death was the primary disease in 45 of the 62. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Cy3W5L

---

There are increasing numbers of clinicians, predominantly plastic surgeons, who are offering surgical treatment to patients with migraine. This concept reached the public media arena over a decade ago, when the London Evening Standard published a review of the topic in 2008. The US news network CNN produced a documentary on it in 2016, but the technique is still regarded as controversial, and an option of last resort by its opponents. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T5MHht

Abstract withdrawn 12 June 2018

(Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CwKgPK

Re-operative factors in Zygomatico-orbital trauma

Introduction: The principle of facial fracture treatment is that satisfactory initial management will reduce the risk of long term morbidity. A need to return to theatre (RTT) after surgical treatment may suggest failure of initial management. Research on indications for RTT is scarce and no predictive factors have been identified to date. Early appreciation of such factors may improve initial management of fractures. We reviewed 5 years of trauma to identify cases requiring RTT, and attempt to establish predictive factors. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T9NjTo

Treatment of lip dysplasia with imiquimod 5%: Results from a single OMFS unit

Introduction: Lip dysplasia is a pre-malignant pathological condition and as such requires treatment to prevent malignant transformation. Management of moderate to severe dysplasia with surgical resection; such as vermilionectomy (lip shave) or CO2 laser ablation has been described. Non-surgical treatment of all grades of dysplasia can be achieved using topical agents such as imiquimod. Having described the first use of imiquimod to treat lip dysplasia, we present the first50 patients through our department. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Cv1cpt

Do inpatient records reflect a ‘seven day NHS?’

Introduction: To comply with NHS standards, suitable consultants must clinically assess all emergency hospital admissions within 14hours. Furthermore, consultant led handovers and ward rounds should occur daily with outcomes clearly documented. Patients should be actively involved in shared decision-making and be provided clear information to make informed choices. At Queen Victoria Hospital, like many UK trusts, paper inpatient records are utilised to document clinical information. This creates significant variability in standardisation of documentation. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T9f8ef

A comparison of patient outcomes following orthognathic surgery with and without the use of hilotherapy

Patients undergoing orthognathic surgery commonly complain of bruising and swelling postoperatively, frequently leading to a delay to return to work. We propose the use of a cooling face mask called "hilotherapy" postoperatively to aid the patients return to work and reduce the burden of care to the NHS. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CvYqQN

The Use of Patient Specific Implants and Genioplasty to refine the results of Orthognathic Surgery in Severe Facial Asymmetry

Introduction: The use of patient-specific implants (PSI) in OMFS are becoming increasingly popular in aesthetic and functional reconstruction. There are few reports of the use of PSI in transposition genioplasty procedures to correct marked mandibular asymmetry. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T5MGKr

Emergency management of the neck breather A closed loop, multi-centre audit

Aims: A multi centre completed audit cycle to ascertain improvements in knowledge of emergency tracheostomy and laryngectomy management following implementation of a teaching programme. Results were compared with The Global Tracheostomy Safety Project emergency management algorithm with a standard of 100% compliance. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CwKczu

Frequency of Level IIb Neck Dissections for OSCC

This study was undertaken to ascertain the frequency of undertaking Level IIb dissection and the rate of Nodal metastasis to this level. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Ta98Cg

Advertising and marketing breaches by non-surgical aesthetic trainers

The practice of non-surgical aesthetics is a booming industry, and discussion is being had about how this area of practice requires regulation in order to protect patients from undue harm. Whilst GMC guidance is available and often adhered to by clinicians advertising clinical services, there is guidance available from the Advertising Standards Authority (ASA) regarding medical services provision and the methods used to promote such practice. Having reviewed these ASA guidelines, we wanted to establish how many providers were in fact in breach of the ASA and GMC guidance. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CwuUe0

Operating time and postoperative length of stay in modern orthognathic surgery- A retrospective review of 562 osteotomies by a single UK surgeon

Introduction: Literature review reveals that shorter duration of operation has better patient outcomes. We aimed to present the operating time and postoperative length of stay for patients undergoing orthognathic surgery under a single UK surgeon from 2009-2017. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TaVtLf

‘The mind is not a vessel to be filled, but a fire to be kindled’: The influence of positive role models on the development and retention of female maxillofacial surgeons-in-training in the UK and the impact of lifestyle factors

Introduction: Positive role models have been seen to double the expression of interest in surgical careers in junior doctors (Ravindra, 2011). Perceived and actual barriers to maxillofacial training such as financial pressures and extended training (Minks 2015) exist, with additional gender-specific difficulties including the lack of female role models and sexual harassment (Rostami, 2010). Whilst the specialty has seen an increase in the number of female consultants/specialists (14%), the recent problem of retention of junior doctors in general, combined with ongoing low uptake of surgical training in women in particular, may negatively influence the future gender ratio. (Source: The British Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CwuTGY

Move Over, Air Filter. Scientists Have a Greener Idea

Title: Move Over, Air Filter. Scientists Have a Greener IdeaCategory: Health NewsCreated: 12/20/2018 12:00:00 AMLast Editorial Review: 12/21/2018 12:00:00 AM (Source: MedicineNet Allergies General)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ELNgsG

Move Over, Air Filter. Scientists Have a Greener Idea

Title: Move Over, Air Filter. Scientists Have a Greener IdeaCategory: Health NewsCreated: 12/20/2018 12:00:00 AMLast Editorial Review: 12/21/2018 12:00:00 AM (Source: MedicineNet Allergies General)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ELNgsG

Move Over, Air Filter. Scientists Have a Greener Idea

Title: Move Over, Air Filter. Scientists Have a Greener IdeaCategory: Health NewsCreated: 12/20/2018 12:00:00 AMLast Editorial Review: 12/21/2018 12:00:00 AM (Source: MedicineNet Allergies General)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ELNgsG

Move Over, Air Filter. Scientists Have a Greener Idea

Title: Move Over, Air Filter. Scientists Have a Greener IdeaCategory: Health NewsCreated: 12/20/2018 12:00:00 AMLast Editorial Review: 12/21/2018 12:00:00 AM (Source: MedicineNet Allergies General)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ELNgsG

Carotid body tumor with hidden internal carotid artery aneurysm

Abstract

Background

The most common head and neck paraganglioma is the carotid body paraganglioma. Treatment of carotid body tumors is primarily surgical, and uncontrolled growth leads to cranial nerve deficits and more morbid resection.

Methods

A 60‐year‐old man was referred for evaluation of carotid body tumor, and workup revealed an internal carotid artery (ICA) aneurysm within the known mass.

Results

Interventional Radiology performed angiogram and stenting across aneurysm with interval dramatic reduction in size of mass, and surgery was avoided altogether.

Conclusions

Surgical resection is indicated for carotid body paragangliomas when the patient can tolerate the surgery and when the tumor was not very advanced. This patient had a small tumor that initially appeared easily resectable. Failure to detect the ICA aneurysm before resection may have resulted in devastating vascular injury and possible stroke or death. Identification of underlying vascular pathology is essential for safe treatment and should be prioritized, especially considering this case.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rResPa

Carotid body tumor with hidden internal carotid artery aneurysm

Abstract

Background

The most common head and neck paraganglioma is the carotid body paraganglioma. Treatment of carotid body tumors is primarily surgical, and uncontrolled growth leads to cranial nerve deficits and more morbid resection.

Methods

A 60‐year‐old man was referred for evaluation of carotid body tumor, and workup revealed an internal carotid artery (ICA) aneurysm within the known mass.

Results

Interventional Radiology performed angiogram and stenting across aneurysm with interval dramatic reduction in size of mass, and surgery was avoided altogether.

Conclusions

Surgical resection is indicated for carotid body paragangliomas when the patient can tolerate the surgery and when the tumor was not very advanced. This patient had a small tumor that initially appeared easily resectable. Failure to detect the ICA aneurysm before resection may have resulted in devastating vascular injury and possible stroke or death. Identification of underlying vascular pathology is essential for safe treatment and should be prioritized, especially considering this case.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rResPa

Simulation‐Guided Tracheotomy in a Patient With Fibrodysplasia Ossificans Progressiva

Fibrodysplasia ossificans progressiva (FOP) is a rare disorder that causes heterotopic bone formation leading to chest wall and spinal deformities. This case describes an 11‐year‐old female with FOP who presented in respiratory failure necessitating two emergent fiberoptic nasotracheal intubations. The patient had severe trismus, rotary flexion of the neck, and distortion of the airway. A three‐dimensional printed model based off of a computed tomography reconstruction was created for an in situ simulation before the true procedure. The surgery and trach change were both uneventful. We propose that with careful preoperative planning, tracheotomy can be an appropriate option for FOP patients. Laryngoscope, 2018

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ShPqo5

Simulation‐Guided Tracheotomy in a Patient With Fibrodysplasia Ossificans Progressiva

Fibrodysplasia ossificans progressiva (FOP) is a rare disorder that causes heterotopic bone formation leading to chest wall and spinal deformities. This case describes an 11‐year‐old female with FOP who presented in respiratory failure necessitating two emergent fiberoptic nasotracheal intubations. The patient had severe trismus, rotary flexion of the neck, and distortion of the airway. A three‐dimensional printed model based off of a computed tomography reconstruction was created for an in situ simulation before the true procedure. The surgery and trach change were both uneventful. We propose that with careful preoperative planning, tracheotomy can be an appropriate option for FOP patients. Laryngoscope, 2018

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ShPqo5

VEGF -2549 -2567 del18 polymorphism and irreversible bronchoconstriction in asthmatics.

CONCLUSIONS: Our results showed that the presence of del18 genotype at -2549 -2567 position in the promoter of VEGF gene, along with disease duration and other factors like cigarette smoking, associate with the risk of irreversible bronchoconstriction in asthmatics. PMID: 30574871 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ShQqbR

Relationship between air pollution, meteorological factors and grass pollen counts, with seasonal allergic rhinitis in Madrid (1996 and 2009).

CONCLUSIONS: The effect of the temperature and pollution (mainly O3, even at lower atmospheric concentrations than the established guidelines about its effects on health), could contributed to the observed higher seasonal allergic rhinitis symptom score in 2009. PMID: 30574872 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AflEcr

VEGF -2549 -2567 del18 polymorphism and irreversible bronchoconstriction in asthmatics.

CONCLUSIONS: Our results showed that the presence of del18 genotype at -2549 -2567 position in the promoter of VEGF gene, along with disease duration and other factors like cigarette smoking, associate with the risk of irreversible bronchoconstriction in asthmatics. PMID: 30574871 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ShQqbR

Relationship between air pollution, meteorological factors and grass pollen counts, with seasonal allergic rhinitis in Madrid (1996 and 2009).

CONCLUSIONS: The effect of the temperature and pollution (mainly O3, even at lower atmospheric concentrations than the established guidelines about its effects on health), could contributed to the observed higher seasonal allergic rhinitis symptom score in 2009. PMID: 30574872 [PubMed - as supplied by publisher] (Source: Journal of Investigational Allergology and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AflEcr

"Med Oral Patol Oral Cir Bucal"[jour]; +17 new citations

17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:

"Med Oral Patol Oral Cir Bucal"[jour]

These pubmed results were generated on 2018/12/23

PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CwT200

"Med Oral Patol Oral Cir Bucal"[jour]; +17 new citations

17 new pubmed citations were retrieved for your search. Click on the search hyperlink below to display the complete search results:

"Med Oral Patol Oral Cir Bucal"[jour]

These pubmed results were generated on 2018/12/23

PubMed comprises more than millions of citations for biomedical literature from MEDLINE, life science journals, and online books. Citations may include links to full-text content from PubMed Central and publisher web sites.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CwT200

Inflammation and allergic disease: An irrefutable combination

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgEJSx

A cross-sectional study of the prevalence of food allergies among children younger than ages 14 years in a Beijing urban region

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Ad4egu

Clinical updates in aspirin-exacerbated respiratory disease

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SjuOM0

New and evolving therapies for hereditary angioedema

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AeCect

Update on peanut allergy: Prevention and immunotherapy

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgEJC1

Clinical burden of asynchrony in patients with asthma when using metered-dose inhalers for control

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AfedSz

Effect of inhaled corticosteroids on serum periostin levels in adult patients with mild-moderate asthma

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgEGGl

Systemic reaction rates with omalizumab, subcutaneous immunotherapy, and combination therapy in children with allergic asthma

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AgWb2i

Anaphylaxis risk factors for hospitalization and intensive care: A comparison between adults and children in an upstate New York emergency department

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgEEyd

A cross-sectional, population-based survey of U.S. adults with symptoms of chronic rhinosinusitis

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AdK0mR

Direct oral amoxicillin challenge without preliminary skin testing in adult patients with allergy and at low risk with reported penicillin allergy

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Pearls and pitfalls of food challenges in infants

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For the Patient

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Abstracts presented at the New England Society of Allergy, October 20‐21, 2018, Plymouth MA

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AeC9FH

Inflammation and allergic disease: An irrefutable combination

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgEJSx

A cross-sectional study of the prevalence of food allergies among children younger than ages 14 years in a Beijing urban region

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Ad4egu

Clinical updates in aspirin-exacerbated respiratory disease

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SjuOM0

New and evolving therapies for hereditary angioedema

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AeCect

Update on peanut allergy: Prevention and immunotherapy

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgEJC1

Clinical burden of asynchrony in patients with asthma when using metered-dose inhalers for control

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AfedSz

Effect of inhaled corticosteroids on serum periostin levels in adult patients with mild-moderate asthma

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgEGGl

Systemic reaction rates with omalizumab, subcutaneous immunotherapy, and combination therapy in children with allergic asthma

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AgWb2i

Anaphylaxis risk factors for hospitalization and intensive care: A comparison between adults and children in an upstate New York emergency department

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SgEEyd

A cross-sectional, population-based survey of U.S. adults with symptoms of chronic rhinosinusitis

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AdK0mR

Direct oral amoxicillin challenge without preliminary skin testing in adult patients with allergy and at low risk with reported penicillin allergy

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SkxJ7s

Pearls and pitfalls of food challenges in infants

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AgW5Yu

For the Patient

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SiR1tJ

Abstracts presented at the New England Society of Allergy, October 20‐21, 2018, Plymouth MA

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2AeC9FH

Rise and be surprised: Aspectual profilingand mirativity in Odia light verb constructions

Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BAI33W

Rise and be surprised: Aspectual profilingand mirativity in Odia light verb constructions

Journal Name: Cognitive Linguistics Issue: Ahead of print (Source: Cognitive Linguistics)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BAI33W

The Consortium for Food Allergy Research (CoFAR) The First Generation

The Consortium for Food Allergy Research (CoFAR) was established by the The National Institute of Allergy and Infectious Diseases (NIAID) in 2005 as a collaborative research program bringing together centers focused on the study of food allergy. The Consortium was charged with developing studies to better understand the pathogenesis and natural history of food allergy, as well as potential approaches to the treatment of food allergy. In its first iteration, an observational study of infants with milk and egg allergy was established and studies of oral immunotherapy for egg allergy and sublingual immunotherapy for peanut allergy were initiated, as was a Phase 1 study of a recombinant peanut protein vaccine.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2V9MBHg

The Consortium for Food Allergy Research (CoFAR) The First Generation

The Consortium for Food Allergy Research (CoFAR) was established by the The National Institute of Allergy and Infectious Diseases (NIAID) in 2005 as a collaborative research program bringing together centers focused on the study of food allergy. The Consortium was charged with developing studies to better understand the pathogenesis and natural history of food allergy, as well as potential approaches to the treatment of food allergy. In its first iteration, an observational study of infants with milk and egg allergy was established and studies of oral immunotherapy for egg allergy and sublingual immunotherapy for peanut allergy were initiated, as was a Phase 1 study of a recombinant peanut protein vaccine.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2V9MBHg

Multivector functioning muscle transfer using superficial subslips of the serratus anterior muscle for longstanding facial paralysis

Various donor muscles have been identified for restoring facial function due to longstanding facial paralysis. Donor muscles, such as the gracilis and latissimus dorsi, are frequently used and often produce one or two reliable vectors of force. There are drawbacks to using these muscles including the instability of separating multivector functioning muscle units and limited amount of muscle contraction. Serratus anterior muscle transfer has the advantages of multiple independently functioning motor units that can be created with a single neurovascular pedicle.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SjmN9S

Multivector functioning muscle transfer using superficial subslips of the serratus anterior muscle for longstanding facial paralysis

Various donor muscles have been identified for restoring facial function due to longstanding facial paralysis. Donor muscles, such as the gracilis and latissimus dorsi, are frequently used and often produce one or two reliable vectors of force. There are drawbacks to using these muscles including the instability of separating multivector functioning muscle units and limited amount of muscle contraction. Serratus anterior muscle transfer has the advantages of multiple independently functioning motor units that can be created with a single neurovascular pedicle.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SjmN9S

Squamous cell carcinoma of the tongue in a patient with dyskeratosis congenita: a rare entity

Dyskeratosis congenita is a rare genetic disorder that results from progressive failure of the bone marrow. It presents with a classic triad of reticular pigmentations of the skin, dystrophic nails, and oral leukoplakia; patients rarely develop cancers. We report a patient with dyskeratosis congenita who presented with squamous cell carcinoma of the oral tongue.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EFDrwC

Are large movements a risk factor for subsequent plate removal in bilateral sagittal split osteotomy?

Background: Metal plate removal is a common complication of mandibular osteotomy with up to 27.5% of patients requiring removal of some or all of their hardware. However, little is known about the risk factors for removal. We hypothesised that large advances and setbacks may result in stretching of overlying soft tissues which could increase risk of dehiscence and infection, and hence plate removal.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ELvjLJ

Squamous cell carcinoma of the tongue in a patient with dyskeratosis congenita: a rare entity

Dyskeratosis congenita is a rare genetic disorder that results from progressive failure of the bone marrow. It presents with a classic triad of reticular pigmentations of the skin, dystrophic nails, and oral leukoplakia; patients rarely develop cancers. We report a patient with dyskeratosis congenita who presented with squamous cell carcinoma of the oral tongue.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EFDrwC

Are large movements a risk factor for subsequent plate removal in bilateral sagittal split osteotomy?

Background: Metal plate removal is a common complication of mandibular osteotomy with up to 27.5% of patients requiring removal of some or all of their hardware. However, little is known about the risk factors for removal. We hypothesised that large advances and setbacks may result in stretching of overlying soft tissues which could increase risk of dehiscence and infection, and hence plate removal.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ELvjLJ

UK Scientist Speaks Out About the Dangers of Aluminum Adjuvants in Vaccinations

Expert scientist is concerned about the use of aluminum adjuvants in childhood vaccinations. VacTruth.com (Source: vactruth.com)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ELYOgD

Food Allergies and Holiday Meal Planning

When planning your holiday meals this season, you may have to keep in mind friends or family members with a food allergy or intolerance. Allergic reactions might include itching, abdominal cramps, drop in blood pressure or trouble breathing. Learn how to avoid cross-contamination when cooking and how to manage food allergies on the food allergy health topic page from MedlinePlus, the National Library of Medicine's trusted consumer health information resource. (Source: BHIC)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EG7RPb

UK Scientist Speaks Out About the Dangers of Aluminum Adjuvants in Vaccinations

Expert scientist is concerned about the use of aluminum adjuvants in childhood vaccinations. VacTruth.com (Source: vactruth.com)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ELYOgD

Food Allergies and Holiday Meal Planning

When planning your holiday meals this season, you may have to keep in mind friends or family members with a food allergy or intolerance. Allergic reactions might include itching, abdominal cramps, drop in blood pressure or trouble breathing. Learn how to avoid cross-contamination when cooking and how to manage food allergies on the food allergy health topic page from MedlinePlus, the National Library of Medicine's trusted consumer health information resource. (Source: BHIC)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EG7RPb

Prevalence and Incidence of Lassa Virus Infection in Southern Mali

Condition:   Lassa Virus Infection Intervention:   Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rSMin0

Dose, Safety, Tolerability, and Immunogenicity of an HIV-1 Vaccine, VRC-HIVRGP096-00-VP, With Alum in Healthy Adults < TAB >

Condition:   Human Immunodeficiency Virus (HIV) Intervention:   Biological: VRC-HIVRGP096-00-VP Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2LuQzWA

Identification of Allergic Asthmatics Reactive to Felis Catus (Cat Hair) Allergen Inhalation

Condition:   Asthma Atopic Intervention:   Biological: Felis Catus Sponsors:   University of North Carolina, Chapel Hill;   National Heart, Lung, and Blood Institute (NHLBI) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rTJwOp

Therapeutic Drug Monitoring of Tocilizumab in Rheumatoid Arthritis

Conditions:   Rheumatoid Arthritis;   Tocilizumab Intervention:   Drug: Tocilizumab Sponsors:   Tel-Aviv Sourasky Medical Center;   Amsterdam Rheumatology and Immunology Center Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2LuQtyc

Safety and Efficacy of Low-dose IL-2 in Allergy to Birch Pollen

Conditions:   Allergic Rhinoconjunctivitis to Birch Pollen;   With an Apple Oral Allergic Syndrome (OAS) to Apple;   With a Positive Skin Prick Test to Birch Pollen Intervention:   Drug: ILT-101 ld-(IL2) Sponsors:   Assistance Publique - Hôpitaux de Paris;   Iltoo Pharma Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rPwOQC

Impact of Pollution on Allergic Rhinitis and Sleep Quality: the POLLAR Study

Conditions:   Sleep Apnea;   Allergic Rhinitis;   Allergic Asthma;   Pollution; Exposure;   Pollution Related Respiratory Disorder Intervention:   Other: Pollution exposure Sponsors:   University Hospital, Grenoble;   Assistance Publique - Hôpitaux de Paris Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Lz2qTF

Cetirizine Chewable Bioequivalence and Food Effect Study

Condition:   Allergy Interventions:   Drug: Cetirizine 10mg;   Drug: Cetirizine 10 mg Sponsor:   Johnson& Johnson Consumer Inc., McNeil Consumer Healthcare Division Recruiting (Source: ClinicalTrials.gov)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rU4Kf6

DOT Diary Mobile App for Pre-Exposure Prophylaxis Adherence in Young Men

Conditions:   Adherence, Medication;   Risk Behavior;   Pre-Exposure Prophylaxis;   HIV Prevention Interventions:   Drug: Emtricitabine / Tenofovir Disoproxil Oral Tablet;   Other: DOT Diary mobile app Sponsors:   Public Health Foundation Enterprises, Inc.;   National Institute of Mental Health (NIMH);   San Francisco Department of Public Health;   Emory University;   AiCure;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2LvkRbP

Pilot Study of Short Term Aspirin on the Biologic and Immunologic Changes of the Fallopian Tube

Conditions:   Fallopian Tube Cancer;   Fallopian Tube Infection Intervention:   Drug: Aspirin 81 mg Sponsor:   University of Oklahoma Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2s0zIlT

Prevalence and Incidence of Lassa Virus Infection in Southern Mali

Condition:   Lassa Virus Infection Intervention:   Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rSMin0

Dose, Safety, Tolerability, and Immunogenicity of an HIV-1 Vaccine, VRC-HIVRGP096-00-VP, With Alum in Healthy Adults < TAB >

Condition:   Human Immunodeficiency Virus (HIV) Intervention:   Biological: VRC-HIVRGP096-00-VP Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2LuQzWA

Identification of Allergic Asthmatics Reactive to Felis Catus (Cat Hair) Allergen Inhalation

Condition:   Asthma Atopic Intervention:   Biological: Felis Catus Sponsors:   University of North Carolina, Chapel Hill;   National Heart, Lung, and Blood Institute (NHLBI) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rTJwOp

Therapeutic Drug Monitoring of Tocilizumab in Rheumatoid Arthritis

Conditions:   Rheumatoid Arthritis;   Tocilizumab Intervention:   Drug: Tocilizumab Sponsors:   Tel-Aviv Sourasky Medical Center;   Amsterdam Rheumatology and Immunology Center Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2LuQtyc

Safety and Efficacy of Low-dose IL-2 in Allergy to Birch Pollen

Conditions:   Allergic Rhinoconjunctivitis to Birch Pollen;   With an Apple Oral Allergic Syndrome (OAS) to Apple;   With a Positive Skin Prick Test to Birch Pollen Intervention:   Drug: ILT-101 ld-(IL2) Sponsors:   Assistance Publique - Hôpitaux de Paris;   Iltoo Pharma Not yet recruiting (Source: ClinicalTrials.gov)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rPwOQC

Impact of Pollution on Allergic Rhinitis and Sleep Quality: the POLLAR Study

Conditions:   Sleep Apnea;   Allergic Rhinitis;   Allergic Asthma;   Pollution; Exposure;   Pollution Related Respiratory Disorder Intervention:   Other: Pollution exposure Sponsors:   University Hospital, Grenoble;   Assistance Publique - Hôpitaux de Paris Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Lz2qTF

Cetirizine Chewable Bioequivalence and Food Effect Study

Condition:   Allergy Interventions:   Drug: Cetirizine 10mg;   Drug: Cetirizine 10 mg Sponsor:   Johnson& Johnson Consumer Inc., McNeil Consumer Healthcare Division Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rU4Kf6

DOT Diary Mobile App for Pre-Exposure Prophylaxis Adherence in Young Men

Conditions:   Adherence, Medication;   Risk Behavior;   Pre-Exposure Prophylaxis;   HIV Prevention Interventions:   Drug: Emtricitabine / Tenofovir Disoproxil Oral Tablet;   Other: DOT Diary mobile app Sponsors:   Public Health Foundation Enterprises, Inc.;   National Institute of Mental Health (NIMH);   San Francisco Department of Public Health;   Emory University;   AiCure;   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2LvkRbP

Pilot Study of Short Term Aspirin on the Biologic and Immunologic Changes of the Fallopian Tube

Conditions:   Fallopian Tube Cancer;   Fallopian Tube Infection Intervention:   Drug: Aspirin 81 mg Sponsor:   University of Oklahoma Not yet recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2s0zIlT

International symposium defines the future role of oral physicians

Abstract

On 7 October 2017, an international forward‐looking symposium for approximately 800 dental personnel entitled "Dentistry in the future ‐ through information from different countries" was held in Sakata, Japan. The contents of the 12^th annual symposium were full of significant indications and suggestions on future healthcare which we think are worth reporting.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ScC7VT

International symposium defines the future role of oral physicians

Abstract

On 7 October 2017, an international forward‐looking symposium for approximately 800 dental personnel entitled "Dentistry in the future ‐ through information from different countries" was held in Sakata, Japan. The contents of the 12^th annual symposium were full of significant indications and suggestions on future healthcare which we think are worth reporting.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ScC7VT

Alteration of FDG uptake by performing novel object recognition task in a rat model of Traumatic Brain Injury

Publication date: March 2019

Source: NeuroImage, Volume 188

Author(s): Shalini Jaiswal, Nicole Hockenbury, Hongna Pan, Andrew Knutsen, Bernard J. Dardzinski, Kimberly R. Byrnes

Abstract

Traumatic Brain Injury (TBI) affects approximately 2.5 million people in the United States, of which 80% are considered to be mild (mTBI). Previous studies have shown that cerebral glucose uptake and metabolism are altered after brain trauma and functional metabolic deficits observed following mTBI are associated with changes in cognitive performance. Imaging of glucose uptake using [¹⁸F] Fluorodeoxyglucose (FDG) based Positron Emission Tomography (PET) with anesthesia during the uptake period demonstrated limited variability in results, but may have depressed uptake. Anesthesia has been found to interfere with blood glucose levels, and hence, FDG uptake. Conversely, forced cognitive testing during uptake may increase glucose demand in targeted regions, such as hippocampus, allowing for better differentiation of outcomes. Therefore, the objective of this study was to investigate the influence of a directed cognitive function task during the FDG uptake period on uptake measurements both in naïve rats and at 2 days after mild lateral fluid percussion (mLFP) TBI. Adult male Sprague Dawley rats underwent FDG uptake with either cognitive testing with the Novel Object Recognition (NOR) test or No Novel Object (NNO), followed by PET scans at baseline (prior to injury) and at 2days post mLFP. At baseline, FDG uptake in the right hippocampus was elevated in rats completing the NOR in comparison to the NNO (control group). Further, the NNO group rats demonstrated a greater fold change in the FDG uptake between baseline and post injury scans than the NOR group. Overall, these data suggest that cognitive activity during FDG uptake affects the regional uptake pattern in the brain, increasing uptake at baseline and suppressing the effects of injury.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EK1Im7

Alteration of FDG uptake by performing novel object recognition task in a rat model of Traumatic Brain Injury

Publication date: March 2019

Source: NeuroImage, Volume 188

Author(s): Shalini Jaiswal, Nicole Hockenbury, Hongna Pan, Andrew Knutsen, Bernard J. Dardzinski, Kimberly R. Byrnes

Abstract

Traumatic Brain Injury (TBI) affects approximately 2.5 million people in the United States, of which 80% are considered to be mild (mTBI). Previous studies have shown that cerebral glucose uptake and metabolism are altered after brain trauma and functional metabolic deficits observed following mTBI are associated with changes in cognitive performance. Imaging of glucose uptake using [¹⁸F] Fluorodeoxyglucose (FDG) based Positron Emission Tomography (PET) with anesthesia during the uptake period demonstrated limited variability in results, but may have depressed uptake. Anesthesia has been found to interfere with blood glucose levels, and hence, FDG uptake. Conversely, forced cognitive testing during uptake may increase glucose demand in targeted regions, such as hippocampus, allowing for better differentiation of outcomes. Therefore, the objective of this study was to investigate the influence of a directed cognitive function task during the FDG uptake period on uptake measurements both in naïve rats and at 2 days after mild lateral fluid percussion (mLFP) TBI. Adult male Sprague Dawley rats underwent FDG uptake with either cognitive testing with the Novel Object Recognition (NOR) test or No Novel Object (NNO), followed by PET scans at baseline (prior to injury) and at 2days post mLFP. At baseline, FDG uptake in the right hippocampus was elevated in rats completing the NOR in comparison to the NNO (control group). Further, the NNO group rats demonstrated a greater fold change in the FDG uptake between baseline and post injury scans than the NOR group. Overall, these data suggest that cognitive activity during FDG uptake affects the regional uptake pattern in the brain, increasing uptake at baseline and suppressing the effects of injury.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2EK1Im7

In the Loop: Doctor heeds the call for one Ed Sheeran fan

Kate Fossum and her mom had traveled far to hear Ed Sheeran in concert, only to realize they forgot the supplies for Kate's cochlear implants. A late-night call to Mayo turned their luck around.? Kate Fossum had been anticipating the concert for months. She, her mom and some friends had just driven nine hours from [...] (Source: News from Mayo Clinic)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rR4VYv

The road to hearing for baby Aida

For many parents, the first months of having a new baby are full of cuddles, kisses, some sleepless nights and joy. That's exactly what life was like for the Little family after baby Aida was born. But when she was one month old, her parents realized their happy, beautiful daughter was deaf. Experts at Mayo [...] (Source: News from Mayo Clinic)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Lw1kb9

In the Loop: Doctor heeds the call for one Ed Sheeran fan

Kate Fossum and her mom had traveled far to hear Ed Sheeran in concert, only to realize they forgot the supplies for Kate's cochlear implants. A late-night call to Mayo turned their luck around.? Kate Fossum had been anticipating the concert for months. She, her mom and some friends had just driven nine hours from [...] (Source: News from Mayo Clinic)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rR4VYv

The road to hearing for baby Aida

For many parents, the first months of having a new baby are full of cuddles, kisses, some sleepless nights and joy. That's exactly what life was like for the Little family after baby Aida was born. But when she was one month old, her parents realized their happy, beautiful daughter was deaf. Experts at Mayo [...] (Source: News from Mayo Clinic)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Lw1kb9

In the Loop: Doctor heeds the call for one Ed Sheeran fan

Kate Fossum and her mom had traveled far to hear Ed Sheeran in concert, only to realize they forgot the supplies for Kate's cochlear implants. A late-night call to Mayo turned their luck around.? Kate Fossum had been anticipating the concert for months. She, her mom and some friends had just driven nine hours from [...] (Source: News from Mayo Clinic)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rR4VYv

The road to hearing for baby Aida

For many parents, the first months of having a new baby are full of cuddles, kisses, some sleepless nights and joy. That's exactly what life was like for the Little family after baby Aida was born. But when she was one month old, her parents realized their happy, beautiful daughter was deaf. Experts at Mayo [...] (Source: News from Mayo Clinic)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Lw1kb9

In the Loop: Doctor heeds the call for one Ed Sheeran fan

Kate Fossum and her mom had traveled far to hear Ed Sheeran in concert, only to realize they forgot the supplies for Kate's cochlear implants. A late-night call to Mayo turned their luck around.? Kate Fossum had been anticipating the concert for months. She, her mom and some friends had just driven nine hours from [...] (Source: News from Mayo Clinic)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2rR4VYv

The road to hearing for baby Aida

For many parents, the first months of having a new baby are full of cuddles, kisses, some sleepless nights and joy. That's exactly what life was like for the Little family after baby Aida was born. But when she was one month old, her parents realized their happy, beautiful daughter was deaf. Experts at Mayo [...] (Source: News from Mayo Clinic)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Lw1kb9

Differential impact of age on survival in head and neck cancer according to classic Cox regression and decision tree analysis

Abstract

Objectives

To assess the impact of age on the survival of patients with head and neck squamous cell carcinoma (HNSCC) using different statistical methods.

Design

A retrospective population based study.

Setting

Surveillance, Epidemiology, and End Results database.

Subjects and methods

A total of 28639 patients with newly diagnosed HNSCC were enrolled between January 1, 2007, and December 31, 2013. The effect of age on 5‐year disease‐specific survival was calculated using a Kaplan‐Meier method and compared using log‐rank tests. A Cox proportional hazards model was used for a multivariate analysis. A classification and regression tree (CART) analysis that partitioned patients with significantly different Kaplan‐Meier curves was introduced to identify the important cancer‐related parameters influencing survival.

Results

Uni‐ and multivariate analyses indicated that patients who were older than 60 years had poorer 5‐year disease‐specific survival regardless of tumor subsite and TNM stage. However, the CART analysis determined that age played only a minor role in survival after comparing with other prognosticators. The relative importance of age using the Gini index was as follows: 3.21% for oral cancer, 8.32% for oropharyngeal cancer, 2.56% for hypopharyngeal cancer, and 16.51% for laryngeal cancer.

Conclusions

Different to traditional statistical methods, the CART analysis which was used to identify homogeneous populations, revealed that the impact of age varied for different patient groups according to the presence or absence of other prognosticators. This important information could help to guide our clinical decisions and future researches.

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Differential impact of age on survival in head and neck cancer according to classic Cox regression and decision tree analysis

Abstract

Objectives

To assess the impact of age on the survival of patients with head and neck squamous cell carcinoma (HNSCC) using different statistical methods.

Design

A retrospective population based study.

Setting

Surveillance, Epidemiology, and End Results database.

Subjects and methods

A total of 28639 patients with newly diagnosed HNSCC were enrolled between January 1, 2007, and December 31, 2013. The effect of age on 5‐year disease‐specific survival was calculated using a Kaplan‐Meier method and compared using log‐rank tests. A Cox proportional hazards model was used for a multivariate analysis. A classification and regression tree (CART) analysis that partitioned patients with significantly different Kaplan‐Meier curves was introduced to identify the important cancer‐related parameters influencing survival.

Results

Uni‐ and multivariate analyses indicated that patients who were older than 60 years had poorer 5‐year disease‐specific survival regardless of tumor subsite and TNM stage. However, the CART analysis determined that age played only a minor role in survival after comparing with other prognosticators. The relative importance of age using the Gini index was as follows: 3.21% for oral cancer, 8.32% for oropharyngeal cancer, 2.56% for hypopharyngeal cancer, and 16.51% for laryngeal cancer.

Conclusions

Different to traditional statistical methods, the CART analysis which was used to identify homogeneous populations, revealed that the impact of age varied for different patient groups according to the presence or absence of other prognosticators. This important information could help to guide our clinical decisions and future researches.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2PZFbTg

A randomized controlled trial on the efficiency of free‐handed, pilot‐drill guided and fully‐guided implant surgery in partially edentulous patients

Abstract

Objectives

To compare the effectiveness of free‐handed (FH), pilot‐drill guided (PG) and fully‐guided (FG) implant surgery by means of the Apical Global Deviation (AGD) in relation to the additional financial cost and time spent.

Materials and methods

Thirty‐three partially edentulous patients in need of ≥2 implants in the posterior maxilla were randomly allocated to one of the following treatment groups: FH, PG, FG. Eleven patients (mean age 57; 8 females; altogether 26 implants) were treated by FH surgery, 11 (mean age 53; 7 females; altogether 24 implants) by PG surgery and 10 (mean age 60; 6 females; altogether 21 implants) by FG surgery. The accuracy in implant positioning was assessed by comparing the actual implant position to its planned position with the AGD as the main measure of effectiveness. Cost analysis included data on time investment (pre‐ and per‐operative) and operational cost. The efficiency of PG and FG surgery was assessed by means of the incremental cost‐effectiveness ratio (ICER), defined as the extra investment that is needed per unit reduction in AGD when compared to FH surgery.

Results

FG surgery was most effective (mean AGD: 0.97mm) and FH surgery was least effective (mean AGD: 2.11mm) in terms of surgical accuracy. As a result, 5/26 implants had to be restored with a cement‐retained restoration following FH surgery, although screw‐retention was planned for all implants in every group. The total time investment did not differ significantly between the 3 groups (p=0.811). A significant additional cost per implant was found for PG and FG as compared to FH surgery pointing to 8.29% (€176.54) and 10.45% (€222.52), respectively (p<0.001). The ICER revealed an additional cost of €5.48 and €4.12 per percent reduction in AGD for PG and FG surgery, respectively.

Conclusion

The extra operational cost for guided implant surgery is acceptable and clinically justified since cementation can be avoided. FG surgery is the most efficient surgical approach, even though the absolute operational cost is higher when compared to PG and FH surgery.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2PYh8V0

A randomized controlled trial on the efficiency of free‐handed, pilot‐drill guided and fully‐guided implant surgery in partially edentulous patients

Abstract

Objectives

To compare the effectiveness of free‐handed (FH), pilot‐drill guided (PG) and fully‐guided (FG) implant surgery by means of the Apical Global Deviation (AGD) in relation to the additional financial cost and time spent.

Materials and methods

Thirty‐three partially edentulous patients in need of ≥2 implants in the posterior maxilla were randomly allocated to one of the following treatment groups: FH, PG, FG. Eleven patients (mean age 57; 8 females; altogether 26 implants) were treated by FH surgery, 11 (mean age 53; 7 females; altogether 24 implants) by PG surgery and 10 (mean age 60; 6 females; altogether 21 implants) by FG surgery. The accuracy in implant positioning was assessed by comparing the actual implant position to its planned position with the AGD as the main measure of effectiveness. Cost analysis included data on time investment (pre‐ and per‐operative) and operational cost. The efficiency of PG and FG surgery was assessed by means of the incremental cost‐effectiveness ratio (ICER), defined as the extra investment that is needed per unit reduction in AGD when compared to FH surgery.

Results

FG surgery was most effective (mean AGD: 0.97mm) and FH surgery was least effective (mean AGD: 2.11mm) in terms of surgical accuracy. As a result, 5/26 implants had to be restored with a cement‐retained restoration following FH surgery, although screw‐retention was planned for all implants in every group. The total time investment did not differ significantly between the 3 groups (p=0.811). A significant additional cost per implant was found for PG and FG as compared to FH surgery pointing to 8.29% (€176.54) and 10.45% (€222.52), respectively (p<0.001). The ICER revealed an additional cost of €5.48 and €4.12 per percent reduction in AGD for PG and FG surgery, respectively.

Conclusion

The extra operational cost for guided implant surgery is acceptable and clinically justified since cementation can be avoided. FG surgery is the most efficient surgical approach, even though the absolute operational cost is higher when compared to PG and FH surgery.

This article is protected by copyright. All rights reserved.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2PYh8V0