The Role of Palliative Care in Oral Cavity Carcinoma

Abstract

Purpose of Review

The purpose of this study is to review the current and future role of palliative care in relation to oral cavity carcinoma (OCC).

Recent Findings

Palliative care for patients with OCC has traditionally been reserved for patients with advanced disease, recurrent disease, or poor performance status who are unable to undergo surgical or adjuvant treatments. Patients with early- or mid-stage disease were not typically offered palliative services. However, patients at all stages face quality of life issues including disruption of speech, eating, pain, mood, self-image, social interactions, work, and daily activities. This can directly affect performance status and has been shown to increase length of hospitalizations and decrease overall survival. Recent evidence suggests that involving palliative care earlier may decrease rates of depression, decrease cost, improve communication, and increase overall survival outcomes. Furthermore, new applications and innovations in radiation therapy, immunotherapy, and chemotherapy have broadened the palliative therapies available to patients with incurable disease.

Summary

Given the impact that OCC has on quality of life during all stages of disease, a paradigm shift is occurring to involve palliative care at earlier stages. Recent evidence has shown that upstream palliative care increases quality of life and ultimately overall survival.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NOmLVt

Bildgebende Diagnostik bei medikamenteninduzierten Kiefernekrosen

Zusammenfassung

Medikamenteninduzierte Osteonekrosen der Kiefer stellen ein relativ neues, multifaktoriell ausgelöstes Krankheitsbild dar. Erkrankungen mit erhöhter Knochenresorption werden heute breit mit Antiresorptiva therapiert. Aufgrund des aktiven Knochenstoffwechsels, insbesondere im Unterkiefer, kann es bei gestörter Barrierefunktion in der Mundhöhle sowie kompliziert durch systemische Begleiterkrankungen in Abhängigkeit von Dauer, Intensität und Applikation der antiresorptiven Therapie zu Osteonekrosen kommen. Wegen des besonderen Einflusses dieser Veränderungen auf die Lebensqualität und wegen des komplexen Therapiemanagements kommt der Früherkennung bzw. der Ausdehnungsbestimmung durch die Bildgebung eine besondere Bedeutung zu. Die Orthopantomographie der Kiefer stellt eine gute Basisuntersuchung, vor allem auch für die Detektion dentogener Ursachen als mögliche Differenzialdiagnose, dar. Die dreidimensionalen bildgebenden Verfahren wie die Computertomographie (CT) und insbesondere die Magnetresonanztomographie (MRT) können aber ossäre Veränderungen wesentlich sensitiver detektieren und die in höheren Erkrankungsstadien manifesten komplexen Pathologien erfassen.

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Immediate implant placement following 1-year treatment with oral versus intravenous bisphosphonates: a histomorphometric canine study on peri-implant bone

Abstract

Objectives

Bisphosphonates (BPs) are anti-resorptive medications with inhibitory effects on osteoclasts which decrease bone turnover. The present study aimed to assess the early effects of BPs on peri-implant bone.

Materials and methods

Twelve female mongrel dogs were assigned to one control and two experimental groups as follows: 12 months of oral alendronate (ALN, 3.5 mg/kg/week) or intravenous (IV) pamidronate (PAM, 1 mg/kg/week) for experimental groups. Following 8 weeks after implant insertion, the specimens were sacrificed, histological evaluation was performed, and C-terminal telopeptide of collagen I (CTx) analysis was performed on serums.

Results

PAM demonstrated the greatest marginal bone level (MBL), 2.64 ± 0.48, followed by ALN and control, 2.5 ± 0.4 and 0.66 ± 0.5 respectively. The least bone-implant contact was observed in PAM group (%39 ± 0.03) while it was significantly greater in the control group (p < 0.05). PAM and ALN demonstrated < 10 CTx levels versus > 300 in controls.

Conclusion

It is assumed that long-term oral or IV BP therapy decreases marginal bone resorption and osseointegration. These changes were more accentuated in IV BP administration. CTx does not seem to be a precise predictor for bisphosphonate-related osteonecrosis of the jaw.

Clinical relevance

BPs impair peri-implant bone remodeling and this phenomena may be effective for reducing resorption at esthetic zone implants; however, decrease in osseointegration may be a concern for implant treatment in patients receiving BPs.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ci5jak

The Role of Palliative Care in Oral Cavity Carcinoma

Abstract

Purpose of Review

The purpose of this study is to review the current and future role of palliative care in relation to oral cavity carcinoma (OCC).

Recent Findings

Palliative care for patients with OCC has traditionally been reserved for patients with advanced disease, recurrent disease, or poor performance status who are unable to undergo surgical or adjuvant treatments. Patients with early- or mid-stage disease were not typically offered palliative services. However, patients at all stages face quality of life issues including disruption of speech, eating, pain, mood, self-image, social interactions, work, and daily activities. This can directly affect performance status and has been shown to increase length of hospitalizations and decrease overall survival. Recent evidence suggests that involving palliative care earlier may decrease rates of depression, decrease cost, improve communication, and increase overall survival outcomes. Furthermore, new applications and innovations in radiation therapy, immunotherapy, and chemotherapy have broadened the palliative therapies available to patients with incurable disease.

Summary

Given the impact that OCC has on quality of life during all stages of disease, a paradigm shift is occurring to involve palliative care at earlier stages. Recent evidence has shown that upstream palliative care increases quality of life and ultimately overall survival.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NOmLVt

Bildgebende Diagnostik bei medikamenteninduzierten Kiefernekrosen

Zusammenfassung

Medikamenteninduzierte Osteonekrosen der Kiefer stellen ein relativ neues, multifaktoriell ausgelöstes Krankheitsbild dar. Erkrankungen mit erhöhter Knochenresorption werden heute breit mit Antiresorptiva therapiert. Aufgrund des aktiven Knochenstoffwechsels, insbesondere im Unterkiefer, kann es bei gestörter Barrierefunktion in der Mundhöhle sowie kompliziert durch systemische Begleiterkrankungen in Abhängigkeit von Dauer, Intensität und Applikation der antiresorptiven Therapie zu Osteonekrosen kommen. Wegen des besonderen Einflusses dieser Veränderungen auf die Lebensqualität und wegen des komplexen Therapiemanagements kommt der Früherkennung bzw. der Ausdehnungsbestimmung durch die Bildgebung eine besondere Bedeutung zu. Die Orthopantomographie der Kiefer stellt eine gute Basisuntersuchung, vor allem auch für die Detektion dentogener Ursachen als mögliche Differenzialdiagnose, dar. Die dreidimensionalen bildgebenden Verfahren wie die Computertomographie (CT) und insbesondere die Magnetresonanztomographie (MRT) können aber ossäre Veränderungen wesentlich sensitiver detektieren und die in höheren Erkrankungsstadien manifesten komplexen Pathologien erfassen.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nfwas2

Immediate implant placement following 1-year treatment with oral versus intravenous bisphosphonates: a histomorphometric canine study on peri-implant bone

Abstract

Objectives

Bisphosphonates (BPs) are anti-resorptive medications with inhibitory effects on osteoclasts which decrease bone turnover. The present study aimed to assess the early effects of BPs on peri-implant bone.

Materials and methods

Twelve female mongrel dogs were assigned to one control and two experimental groups as follows: 12 months of oral alendronate (ALN, 3.5 mg/kg/week) or intravenous (IV) pamidronate (PAM, 1 mg/kg/week) for experimental groups. Following 8 weeks after implant insertion, the specimens were sacrificed, histological evaluation was performed, and C-terminal telopeptide of collagen I (CTx) analysis was performed on serums.

Results

PAM demonstrated the greatest marginal bone level (MBL), 2.64 ± 0.48, followed by ALN and control, 2.5 ± 0.4 and 0.66 ± 0.5 respectively. The least bone-implant contact was observed in PAM group (%39 ± 0.03) while it was significantly greater in the control group (p < 0.05). PAM and ALN demonstrated < 10 CTx levels versus > 300 in controls.

Conclusion

It is assumed that long-term oral or IV BP therapy decreases marginal bone resorption and osseointegration. These changes were more accentuated in IV BP administration. CTx does not seem to be a precise predictor for bisphosphonate-related osteonecrosis of the jaw.

Clinical relevance

BPs impair peri-implant bone remodeling and this phenomena may be effective for reducing resorption at esthetic zone implants; however, decrease in osseointegration may be a concern for implant treatment in patients receiving BPs.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ci5jak

Editorial Board/Reviewing Committee

(Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2oIaF58

Management of seborrhoeic keratosis and actinic keratosis with an erbium:YAG laser —experience with 547 patients

This article presents the authors ' experience of lesion- and field-directed erbium:YAG laser treatment of 547 patients (Fotona Dualis XS Laser). In this series of patients, those who had resurfacing as field therapy showed no recurrence during the 12-month review period. (Source: International Journal of Oral and Maxillofacial Surgery)

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The Role of Palliative Care in Oral Cavity Carcinoma

Abstract

Purpose of Review

The purpose of this study is to review the current and future role of palliative care in relation to oral cavity carcinoma (OCC).

Recent Findings

Palliative care for patients with OCC has traditionally been reserved for patients with advanced disease, recurrent disease, or poor performance status who are unable to undergo surgical or adjuvant treatments. Patients with early- or mid-stage disease were not typically offered palliative services. However, patients at all stages face quality of life issues including disruption of speech, eating, pain, mood, self-image, social interactions, work, and daily activities. This can directly affect performance status and has been shown to increase length of hospitalizations and decrease overall survival. Recent evidence suggests that involving palliative care earlier may decrease rates of depression, decrease cost, improve communication, and increase overall survival outcomes. Furthermore, new applications and innovations in radiation therapy, immunotherapy, and chemotherapy have broadened the palliative therapies available to patients with incurable disease.

Summary

Given the impact that OCC has on quality of life during all stages of disease, a paradigm shift is occurring to involve palliative care at earlier stages. Recent evidence has shown that upstream palliative care increases quality of life and ultimately overall survival.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NOmLVt

Editorial Board/Reviewing Committee

(Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2oIaF58

The Role of Palliative Care in Oral Cavity Carcinoma

Abstract

Purpose of Review

The purpose of this study is to review the current and future role of palliative care in relation to oral cavity carcinoma (OCC).

Recent Findings

Palliative care for patients with OCC has traditionally been reserved for patients with advanced disease, recurrent disease, or poor performance status who are unable to undergo surgical or adjuvant treatments. Patients with early- or mid-stage disease were not typically offered palliative services. However, patients at all stages face quality of life issues including disruption of speech, eating, pain, mood, self-image, social interactions, work, and daily activities. This can directly affect performance status and has been shown to increase length of hospitalizations and decrease overall survival. Recent evidence suggests that involving palliative care earlier may decrease rates of depression, decrease cost, improve communication, and increase overall survival outcomes. Furthermore, new applications and innovations in radiation therapy, immunotherapy, and chemotherapy have broadened the palliative therapies available to patients with incurable disease.

Summary

Given the impact that OCC has on quality of life during all stages of disease, a paradigm shift is occurring to involve palliative care at earlier stages. Recent evidence has shown that upstream palliative care increases quality of life and ultimately overall survival.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NOmLVt

Incidence and cost of perioperative red blood cell transfusion for elective spine fusion in a high-volume center for spine surgery

Abstract

Background

Spine fusion is a surgical procedure characterized by a significant perioperative bleeding, which often requires red blood cell (RBC) transfusion.

Methods

The incidence and the cost of RBC transfusion were evaluated in all patients undergoing elective surgery for spine fusion in our Institution, a high-volume center for spine surgery, over a period of 3 years. The analysis specifically addressed the RBC transfusion need in all the different spine fusion procedures (atlanto-axial, cervical, dorsal, lumbar, revisions) with the different surgical approaches (anterior, posterior).

Results

During the 3 years of observation, a total of 1.882 elective spine fusions were performed. More than half of the procedures (n = 964) were posterior lumbar fusions. Overall, 5% of the patients (n = 103) required RBC transfusion. The cervical fusions were the procedures with the lowest percentage of RBC need (0–5%), while the dorsal and the lumbar ones, with the anterior approach, represented the procedures with the highest rate of transfusion (29% and 25% respectively). More than 60 % of the RBC units were employed in the instance of posterior lumbar fusion, while a variable 1–10% of the units was used in each of the other procedures. The overall transfusion cost was of 46.000 euros, with a distribution of costs that paralleled the amount of units transfused for each procedure.

Conclusions

Several surgical and patient factors may contribute to the perioperative blood loss. An accurate patient blood management, may efficiently decrease transfusion requirements and ultimately healthcare costs.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6Ra2O

Comparison of upper airway patency in patients with mild obstructive sleep apnea during dexmedetomidine or propofol sedation: a prospective, randomized, controlled trial

Abstract

Background

In addition to propofol, dexmedetomidine is a suitable alternative for intraoperative sedation in procedures requiring regional anesthesia. To date, however, little is known about the influences of each drug on upper airway patency. Accordingly, the authors investigated differences between dexmedetomidine and propofol sedation in the occurrence of upper airway obstruction and requirements for airway intervention in patients with mild obstructive sleep apnea.

Methods

Patients with an apnea/hypopnea index of 5–14/h according to Watch-PAT 200 analysis were enrolled in this study. Spinal anesthesia was routinely performed for surgery. Intraoperative sedation was initiated using either dexmedetomidine or propofol infusion at a level of modified observer's assessment of alertness/sedation scale 3. The primary outcome was the proportion of patients exhibiting signs of upper airway obstruction. A sign of upper airway obstruction was defined as no detection of end-tidal carbon dioxide for at least 10 s despite respiratory efforts.

Results

A total of 50 patients were included in the final analysis (dexmedetomidine [n = 26]; propofol [n = 24]). During the intraoperative sedation period, there was a significantly lower proportion of patients exhibiting signs of upper airway obstruction in the dexmedetomidine group than in the propofol group (11.5% vs. 41.7%, P = 0.035). An artificial airway was inserted in 1 patients (3.8%) and 5 patient (20.8%) in the dexmedetomidine and propofol groups, respectively (P = 0.093).

Conclusion

Dexmedetomidine sedation was associated with a lower incidence of upper airway obstruction than propofol sedation in patients with mild obstructive sleep apnea.

Trial registration number

Clinical trials.gov (NCT02993718): Retrospectively registered.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2LXzZxf

Ultrasound-guided phrenic nerve block for intraoperative persistent hiccups: a case report

Abstract

Background

Continuous hiccups during surgery not only affect the surgical procedure, they can also cause adverse effects for the patient. Apart from active investigation of the cause of the hiccups, their timely termination is also necessary.

Case presentation

We reported a case of a 70-year-old woman with continuous intraoperative hiccups that appeared during vaginal hysterectomy under low continuous epidural anesthesia. After the ineffectiveness CO₂ repeated inhalation and intravenous administration of chlorpromazine and methoxychlorpromide, we performed unilateral phrenic nerve block under ultrasound guidance. Hiccups were terminated without any related complications.

Conclusions

During intraoperative continuous hiccups, ultrasound guided phrenic nerve block may be a suitable treatment option when physical methods and drug therapy are not effective. However, given the absence of a vital risk related to hiccups, this block should imply the complete absence of any respiratory contraindication and a prolonged postoperative respiratory monitoring.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q2bjal

Incidence and cost of perioperative red blood cell transfusion for elective spine fusion in a high-volume center for spine surgery

Abstract

Background

Spine fusion is a surgical procedure characterized by a significant perioperative bleeding, which often requires red blood cell (RBC) transfusion.

Methods

The incidence and the cost of RBC transfusion were evaluated in all patients undergoing elective surgery for spine fusion in our Institution, a high-volume center for spine surgery, over a period of 3 years. The analysis specifically addressed the RBC transfusion need in all the different spine fusion procedures (atlanto-axial, cervical, dorsal, lumbar, revisions) with the different surgical approaches (anterior, posterior).

Results

During the 3 years of observation, a total of 1.882 elective spine fusions were performed. More than half of the procedures (n = 964) were posterior lumbar fusions. Overall, 5% of the patients (n = 103) required RBC transfusion. The cervical fusions were the procedures with the lowest percentage of RBC need (0–5%), while the dorsal and the lumbar ones, with the anterior approach, represented the procedures with the highest rate of transfusion (29% and 25% respectively). More than 60 % of the RBC units were employed in the instance of posterior lumbar fusion, while a variable 1–10% of the units was used in each of the other procedures. The overall transfusion cost was of 46.000 euros, with a distribution of costs that paralleled the amount of units transfused for each procedure.

Conclusions

Several surgical and patient factors may contribute to the perioperative blood loss. An accurate patient blood management, may efficiently decrease transfusion requirements and ultimately healthcare costs.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Q6Ra2O

Comparison of upper airway patency in patients with mild obstructive sleep apnea during dexmedetomidine or propofol sedation: a prospective, randomized, controlled trial

Abstract

Background

In addition to propofol, dexmedetomidine is a suitable alternative for intraoperative sedation in procedures requiring regional anesthesia. To date, however, little is known about the influences of each drug on upper airway patency. Accordingly, the authors investigated differences between dexmedetomidine and propofol sedation in the occurrence of upper airway obstruction and requirements for airway intervention in patients with mild obstructive sleep apnea.

Methods

Patients with an apnea/hypopnea index of 5–14/h according to Watch-PAT 200 analysis were enrolled in this study. Spinal anesthesia was routinely performed for surgery. Intraoperative sedation was initiated using either dexmedetomidine or propofol infusion at a level of modified observer's assessment of alertness/sedation scale 3. The primary outcome was the proportion of patients exhibiting signs of upper airway obstruction. A sign of upper airway obstruction was defined as no detection of end-tidal carbon dioxide for at least 10 s despite respiratory efforts.

Results

A total of 50 patients were included in the final analysis (dexmedetomidine [n = 26]; propofol [n = 24]). During the intraoperative sedation period, there was a significantly lower proportion of patients exhibiting signs of upper airway obstruction in the dexmedetomidine group than in the propofol group (11.5% vs. 41.7%, P = 0.035). An artificial airway was inserted in 1 patients (3.8%) and 5 patient (20.8%) in the dexmedetomidine and propofol groups, respectively (P = 0.093).

Conclusion

Dexmedetomidine sedation was associated with a lower incidence of upper airway obstruction than propofol sedation in patients with mild obstructive sleep apnea.

Trial registration number

Clinical trials.gov (NCT02993718): Retrospectively registered.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2LXzZxf

CCRC moots centre for cancer drug research

CCRC moots centre for cancer drug research  Times of IndiaFull coverage

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Genomic Era Reaches Pediatric Oncology

Genomic Era Reaches Pediatric Oncology  OncLiveFull coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MP9Shp

John Schlarman's Attitude Even More Amazing Than His Physical Toughness To Troy Coach Neal Brown

John Schlarman's Attitude Even More Amazing Than His Physical Toughness To Troy Coach Neal Brown  LEX18 Lexington KY NewsFull coverage

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Discovery suggests which thyroid cancer patients may need more aggressive treatment

Discovery suggests which thyroid cancer patients may need more aggressive treatment  Folio - University of AlbertaThyroid cancer patients may need more aggressive treatment: Alberta researchers  Globalnews.caFull coverage

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Pembrolizumab Gets Priority Review for Merkel Cell Carcinoma

Pembrolizumab Gets Priority Review for Merkel Cell Carcinoma  AJMC.com Managed Markets NetworkFull coverage

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MD Anderson Head and Neck Surgeon Takes to the Water

MD Anderson Head and Neck Surgeon Takes to the Water  Texas Medical Center NewsFull coverage

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Five microRNAs predict course, recurrence of HPV-negative head and neck cancer

Five microRNAs predict course, recurrence of HPV-negative head and neck cancer  News-Medical.netFull coverage

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Stop steep rise in cancer prevalence

Stop steep rise in cancer prevalence  Daily NationFull coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PCDJXj

The Dangers That Come with the Asian Flush

The Dangers That Come with the Asian Flush  DCODE by Discovery (blog)Full coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MMvfjw

Safest level of alcohol consumption is none, worldwide study shows

Safest level of alcohol consumption is none, worldwide study shows  Washington PostStudy Has Sobering News for Moderate Drinkers  NewserNo safe level of alcohol, scientific study concludes  UW Medicine Newsroom (press release) (blog)Full coverage

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إقرار لائحة تعرفة جديدة بالأجور الطبية / تفاصيل

إقرار لائحة تعرفة جديدة بالأجور الطبية / تفاصيل  sawaleif.comFull coverage

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CCRC moots centre for cancer drug research

CCRC moots centre for cancer drug research  Times of IndiaFull coverage

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Buddy Check 4 - Thyroid Cancer

Buddy Check 4 - Thyroid Cancer  WTVY, DothanFull coverage

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Genomic Era Reaches Pediatric Oncology

Genomic Era Reaches Pediatric Oncology  OncLiveFull coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MP9Shp

John Schlarman's Attitude Even More Amazing Than His Physical Toughness To Troy Coach Neal Brown

John Schlarman's Attitude Even More Amazing Than His Physical Toughness To Troy Coach Neal Brown  LEX18 Lexington KY NewsFull coverage

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Discovery suggests which thyroid cancer patients may need more aggressive treatment

Discovery suggests which thyroid cancer patients may need more aggressive treatment  Folio - University of AlbertaThyroid cancer patients may need more aggressive treatment: Alberta researchers  Globalnews.caFull coverage

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Pembrolizumab Gets Priority Review for Merkel Cell Carcinoma

Pembrolizumab Gets Priority Review for Merkel Cell Carcinoma  AJMC.com Managed Markets NetworkFull coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Ct7Y1k

MD Anderson Head and Neck Surgeon Takes to the Water

MD Anderson Head and Neck Surgeon Takes to the Water  Texas Medical Center NewsFull coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MPAWNi

Five microRNAs predict course, recurrence of HPV-negative head and neck cancer

Five microRNAs predict course, recurrence of HPV-negative head and neck cancer  News-Medical.netFull coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PAlBx3

Stop steep rise in cancer prevalence

Stop steep rise in cancer prevalence  Daily NationFull coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PCDJXj

The Dangers That Come with the Asian Flush

The Dangers That Come with the Asian Flush  DCODE by Discovery (blog)Full coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MMvfjw

Safest level of alcohol consumption is none, worldwide study shows

Safest level of alcohol consumption is none, worldwide study shows  Washington PostStudy Has Sobering News for Moderate Drinkers  NewserNo safe level of alcohol, scientific study concludes  UW Medicine Newsroom (press release) (blog)Full coverage

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2BIe3GN

إقرار لائحة تعرفة جديدة بالأجور الطبية / تفاصيل

إقرار لائحة تعرفة جديدة بالأجور الطبية / تفاصيل  sawaleif.comFull coverage

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#Medicine-Sfakianaki

now

Resident memory T cells, critical components in tumor immunology

Abstract CD8+ T lymphocytes are the major anti-tumor effector cells. Most cancer immunotherapeutic approaches seek to amplify cytotoxic T lymphocytes (CTL) specific to malignant cells. A recently identified subpopulation of memory CD8+ T cells, named tissue-resident memory T (TRM) cells,...

Latest Results for Journal for I...

 

1m

Review article: the relationship between obesity, bariatric surgery, and inflammatory bowel disease

Alimentary Pharmacology &Therapeutics, EarlyView.

Alimentary Pharmacology &amp; Therapeutics

 

2m

From Biological Determination to Entangled Causation

Abstract Biologists and philosophers often use the language of determination in order to describe the nature of developmental phenomena. Accounts in terms of determination have often been reductionist. One common idea is that DNA is supposed to play a special explanatory role in developmental...

Acta Biotheoretica

 

3m

New Quantization Approach for the Anomaly: The Increase in Time Float following Consumption

Anomalous scenarios in projects with generalized precedence relations (GPRs) have been arousing widely interest. A recent relevant discovery of anomaly under GPRs is that an activity's time float increases following its consumption. The scenario is contrary to a common idea for plan management, and it...

Hindawi Publishing Corporation

3m

The Comparison of the Body Composition of Children at the Early School Age from Urban and Rural Area in Southwestern Poland

The aim of the study was to compare the segmental body composition with the use of fat–fat-free (FFF) index in children at early school age, depending on sex and place of residence, with particular emphasis on urban and rural areas. The study consisted of 329 children aged 7.78 (SD = 0.88; mean age in...

Hindawi Publishing Corporation

 

3m

Reversible Data Hiding with Pixel Prediction and Additive Homomorphism for Encrypted Image

Data hiding in encrypted image is a recent popular topic of data security. In this paper, we propose a reversible data hiding algorithm with pixel prediction and additive homomorphism for encrypted image. Specifically, the proposed algorithm applies pixel prediction to the input image for generating...

Hindawi Publishing Corporation

 

3m

Cinobufacini Injection Improves the Efficacy of Chemotherapy on Advanced Stage Gastric Cancer: A Systemic Review and Meta-Analysis

Gastric cancer has a high morbidity and mortality. Chemotherapy regimens are routine advanced stage gastric cancer (AGC) treatment protocols, but most of these drugs have side-effects such as myelosuppression and gastrointestinal disorders. Cinobufacini, an extractive from TCM, could suppress cell proliferation...

Hindawi Publishing Corporation

 

3m

A New Semisupervised-Entropy Framework of Hyperspectral Image Classification Based on Random Forest

The purposes of the algorithm presented in this paper are to select features with the highest average separability by using the random forest method to distinguish categories that are easy to distinguish and to select the most divisible features from the most difficult categories using the weighted entropy...

Hindawi Publishing Corporation

3m

Feature Extraction Strategy with Improved Permutation Entropy and Its Application in Fault Diagnosis of Bearings

Feature extraction is one of the most difficult aspects of mechanical fault diagnosis, and it is directly related to the accuracy of bearing fault diagnosis. In this study, improved permutation entropy (IPE) is defined as the feature for bearing fault diagnosis. In this method, ensemble empirical mode...

Hindawi Publishing Corporation

 

3m

Damage Evaluation for Rock Burst Proneness of Deep Hard Rock under Triaxial Cyclic Loading

High stress and strong excavation disturbance are the main causes of dynamic disasters, rock burst in deep hard rocks, and are more frequent and violent than those in shallow, which seriously restricts the deep mining. Given rock burst encountered in deep mining of Lingnan metal mines, the optimized...

Hindawi Publishing Corporation

 

3m

A Peer-to-Peer Architecture for Distributed Data Monetization in Fog Computing Scenarios

Modern IoT deployments do require considerable investments that might only be justified if the data being gathered could be monetized, which leads to the need for a digital data marketplace. In many cases, the provider of the IoT data needs to process it locally for data curation, aggregation, stream...

Hindawi Publishing Corporation

 

22m

Corrections

Publication date: Available online 3 September 2018Source: The Lancet Infectious DiseasesAuthor(s):

ScienceDirect Publication: The Lancet Infectious Diseases

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GSE113597 Minipuberty and Sexual Dimorphism in the Infant Human Thymus

Series Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.

New GEO Series

 

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The governance structure for data access in the DIRECT consortium: an innovative medicines initiative (IMI) project

Abstract Biomedical research projects involving multiple partners from public and private sectors require coherent internal governance mechanisms to engender good working relationships. The DIRECT project is an example of such a venture, funded by the Innovative Medicines Initiative...

Latest Results for Life Sciences...

 

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Drugs of abuse from a different toxicological perspective: an updated review of cocaine genotoxicity

Abstract Cocaine is one of the most widely consumed psychoactive substances and has been recognized as a major public health concern for many years. While several aspects of the toxicology of cocaine have been thoroughly described in the literature, namely its effects on different...

Latest Results for Archives of Toxicology

 

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In vitro assessment of hepatotoxicity by metabolomics: a review

Abstract Omics technologies, and in particular metabolomics, have received an increasing attention during the assessment of hepatotoxicity in vitro. However, at present, a consensus on good metabolomics practices has yet to be reached. Therefore, in this review, a range of experimental...

Latest Results for Archives of Toxicology

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Mechanistic evidence that benzo[a]pyrene promotes an inflammatory microenvironment that drives the metastatic potential of human mammary cells

Abstract Benzo[a]pyrene (B(a)P) is a major cancer-causing contaminant present in food such as cooked meats and cereals, and is ubiquitous in the environment in smoke derived from the combustion of organic material. Exposure to B(a)P is epidemiologically linked with the incidence...

Latest Results for Archives of Toxicology

 

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Replica to the Opinion Letter regarding the article "Sensitization of colorectal cancer cells to irinotecan by the Survivin inhibitor LLP3 depends on XAF1 proficiency in the context of mutated p53" ( Arch Toxicol https://doi.org/10.1007/s00204-018-240-x)

Latest Results for Archives of Toxicology

 

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Evaluation of FSH, LH, testosterone levels and semen parameters in male boron workers under extreme exposure conditions

Abstract Boric acid and sodium borates are currently classified in the EU-CLP regulation as "toxic to reproduction" under "Category 1B", with hazard statement of H360FD. However, so far field studies on male reproduction in China and in Turkey could not confirm such boron-associated...

Latest Results for Archives of Toxicology

 

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2,4-Dimethylaniline generates phosphorylated histone H2AX in human urothelial and hepatic cells through reactive oxygen species produced by cytochrome P450 2E1

Abstract The Japanese Ministry of Health, Labour, and Welfare recently reported an outbreak of bladder cancer among workers who handled aromatic amines in Japan. 2,4-dimethylaniline (2,4-DMA) is one of the chemicals that workers are considered to have the most opportunities to be...

Latest Results for Archives of Toxicology

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Effect of acute exposure to toluene on cortical excitability, neuroplasticity, and motor learning in healthy humans

Abstract Toluene is a well-known neurotoxic organic solvent and a major component of many industrial and commercial products such as adhesives, paint thinners and gasoline. Many workers are regularly exposed to toluene in their working environment and occupational exposure limits...

Latest Results for Archives of Toxicology

 

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Characterization of hepatocyte-based in vitro systems for reliable toxicity testing

Abstract A plethora of human hepatocyte-based in vitro systems for toxicity testing has been developed over the past few years. These systems are either directly derived from liver tissue or have been generated through stem cell technology. A wide variety of parameters is currently...

Latest Results for Archives of Toxicology

 

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Correction to: Glucuronidation of deoxynivalenol (DON) by different animal species: identification of iso-DON glucuronides and iso-deepoxy-DON glucuronides as novel DON metabolites in pigs, rats, mice, and cows

The original article can be found online.

Latest Results for Archives of Toxicology

 

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Possible neurotoxicity of the anesthetic propofol: evidence for the inhibition of complex II of the respiratory chain in area CA3 of rat hippocampal slices

Abstract Propofol is the most frequently used intravenous anesthetic for induction and maintenance of anesthesia. Propofol acts first and formost as a GABAA-agonist, but effects on other neuronal receptors and voltage-gated ion channels have been described. Besides its direct effect...

Latest Results for Archives of Toxicology

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PCB 95 promotes dendritic growth in primary rat hippocampal neurons via mTOR-dependent mechanisms

Abstract Polychlorinated biphenyls (PCBs), and in particular non-dioxin-like (NDL) congeners, continue to pose a significant risk to the developing nervous system. PCB 95, a prevalent NDL congener in the human chemosphere, promotes dendritic growth in rodent primary neurons by activating...

Latest Results for Archives of Toxicology

 

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Chemical-induced contact allergy: from mechanistic understanding to risk prevention

Abstract Chemical allergens are small molecules able to form a sensitizing complex once they bound to proteins. One of the most frequent manifestations of chemical allergy is contact hypersensitivity, which can have serious impact on quality of life. Allergic contact dermatitis is...

Latest Results for Archives of Toxicology

 

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Advancing the predictivity of skin sensitization by applying a novel HMOX1 reporter system

Abstract Reporter cell lines are a particularly useful tool to screen for the skin sensitization potential of chemicals. Current cell models based on Keap1-Nrf2 mimic induction by conducting antioxidant response element-luciferase plasmids. However, plasmid-based reporters may ignore...

Latest Results for Archives of Toxicology

 

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3D human liver tissue from pluripotent stem cells displays stable phenotype in vitro and supports compromised liver function in vivo

Abstract Liver disease is an escalating global health issue. While liver transplantation is an effective mode of therapy, patient mortality has increased due to the shortage of donor organs. Developing renewable sources of human liver tissue is therefore attractive. Pluripotent stem...

Latest Results for Archives of Toxicology

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A novel multi-parametric high content screening assay in ciPTEC-OAT1 to predict drug-induced nephrotoxicity during drug discovery

Abstract Drug-induced nephrotoxicity is a major concern in the clinic and hampers the use of available treatments as well as the development of innovative medicines. It is typically discovered late during drug development, which reflects a lack of in vitro nephrotoxicity assays available...

Latest Results for Archives of Toxicology

 

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Production of chlorzoxazone glucuronides via cytochrome P4502E1 dependent and independent pathways in human hepatocytes

Abstract CYP2E1 activity is measured in vitro and in vivo via hydroxylation of the Chlorzoxazone (CHZ) producing the 6-hydroxychlorzoxazone (OH-CHZ) further metabolized as a glucuronide excreted in urine. Thus, the quantification of the OH-CHZ following enzymatic hydrolysis of CHZ-derived...

Latest Results for Archives of Toxicology

 

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In vivo positive mutagenicity of 1,4-dioxane and quantitative analysis of its mutagenicity and carcinogenicity in rats

Abstract 1,4-Dioxane is a widely used synthetic industrial chemical and its contamination of drinking water and food is a potential health concern. It induces liver tumors when administered in the drinking water to rats and mice. However, the mode of action (MOA) of the hepatocarcinogenicity...

Latest Results for Archives of Toxicology

 

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Revue de presse scientifique

Publication date: Available online 3 September 2018Source: Archives des Maladies Professionnelles et de l'EnvironnementAuthor(s):

Maladies Professionnelles et de l'Environnement

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Up-regulated lipocalin-2 in pediatric thyroid cancer correlated with poor clinical characteristics

Abstract Background The incidence of thyroid cancer is fast increasing in both adults and children. The pediatric thyroid cancer had often already progressed to a more advanced stage of the disease at diagnosis. Early detection of pediatric...

Latest Results for European Arch...

 

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Highly efficient fluoride extraction from simulant leachate of spent potlining via La-loaded chelating resin. An equilibrium study

ScienceDirect Publication: Journal of Hazardous Materials

 

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Bacterial community and climate change implication affected the diversity and abundance of antibiotic resistance genes in wetlands on the Qinghai-Tibetan Plateau

ScienceDirect Publication: Journal of Hazardous Materials

 

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Corrigendum to 'Current state and challenges in developing oral vaccines' [Adv. Drug Deliv. Rev. 114 (2017) 116-131]

Publication date: Available online 3 September 2018Source: Advanced Drug Delivery ReviewsAuthor(s): Julia E. Vela Ramirez, Lindsey A. Sharpe, Nicholas A. Peppas

ScienceDirect Publication Advanced Drug Delivery Reviews

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Correction to: Inter-provincial inequality of public health services in China: the perspective of local officials' behavior

Unfortunately, after publication of this article [1], it was noticed that a value in Table 2 is incorrect.

Latest Results for International Journal for Equity in Health

 

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A facile synthesis of polydopamine/TiO₂ composite films for cell sheet harvest application

Colloid & interphases B

 

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Évaluez-vous !

Publication date: September 2018Source: Actualités Pharmaceutiques, Volume 57, Issue 578, SupplementAuthor(s): Nicolas Clere, Sébastien FaureCette formation doit se faire progressivement. Chacun doit trouver le moyen qui lui correspond. Proposez cette formation aux membres de l'équipe officinale et à...

ScienceDirect Publication Actualités Pharmaceutiques

 

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Les thérapies ciblées <em>per os</em>

Publication date: September 2018Source: Actualités Pharmaceutiques, Volume 57, Issue 578, SupplementAuthor(s): Nelly Étienne-SelloumRésuméLe manque de sélectivité des chimiothérapies cytotoxiques, donc leur toxicité relativement importante, ainsi que l'amélioration des connaissances sur les mécanismes...

ScienceDirect Publication Actualités Pharmaceutiques