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Abstract CD8+ T lymphocytes are the major anti-tumor effector cells. Most cancer immunotherapeutic approaches seek to amplify cytotoxic T lymphocytes (CTL) specific to malignant cells. A recently identified subpopulation of memory CD8+ T cells, named tissue-resident memory T (TRM) cells,...
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Alimentary Pharmacology &Therapeutics, EarlyView.
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Abstract Biologists and philosophers often use the language of determination in order to describe the nature of developmental phenomena. Accounts in terms of determination have often been reductionist. One common idea is that DNA is supposed to play a special explanatory role in developmental...
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Anomalous scenarios in projects with generalized precedence relations (GPRs) have been arousing widely interest. A recent relevant discovery of anomaly under GPRs is that an activity's time float increases following its consumption. The scenario is contrary to a common idea for plan management, and it...
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The aim of the study was to compare the segmental body composition with the use of fat–fat-free (FFF) index in children at early school age, depending on sex and place of residence, with particular emphasis on urban and rural areas. The study consisted of 329 children aged 7.78 (SD = 0.88; mean age in...
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Data hiding in encrypted image is a recent popular topic of data security. In this paper, we propose a reversible data hiding algorithm with pixel prediction and additive homomorphism for encrypted image. Specifically, the proposed algorithm applies pixel prediction to the input image for generating...
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Gastric cancer has a high morbidity and mortality. Chemotherapy regimens are routine advanced stage gastric cancer (AGC) treatment protocols, but most of these drugs have side-effects such as myelosuppression and gastrointestinal disorders. Cinobufacini, an extractive from TCM, could suppress cell proliferation...
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The purposes of the algorithm presented in this paper are to select features with the highest average separability by using the random forest method to distinguish categories that are easy to distinguish and to select the most divisible features from the most difficult categories using the weighted entropy...
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Feature extraction is one of the most difficult aspects of mechanical fault diagnosis, and it is directly related to the accuracy of bearing fault diagnosis. In this study, improved permutation entropy (IPE) is defined as the feature for bearing fault diagnosis. In this method, ensemble empirical mode...
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High stress and strong excavation disturbance are the main causes of dynamic disasters, rock burst in deep hard rocks, and are more frequent and violent than those in shallow, which seriously restricts the deep mining. Given rock burst encountered in deep mining of Lingnan metal mines, the optimized...
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Modern IoT deployments do require considerable investments that might only be justified if the data being gathered could be monetized, which leads to the need for a digital data marketplace. In many cases, the provider of the IoT data needs to process it locally for data curation, aggregation, stream...
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Publication date: Available online 3 September 2018Source: The Lancet Infectious DiseasesAuthor(s):
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Series Type : Expression profiling by array ; Non-coding RNA profiling by arrayOrganism : Homo sapiensThis SuperSeries is composed of the SubSeries listed below.
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Abstract Biomedical research projects involving multiple partners from public and private sectors require coherent internal governance mechanisms to engender good working relationships. The DIRECT project is an example of such a venture, funded by the Innovative Medicines Initiative...
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Drugs of abuse from a different toxicological perspective: an updated review of cocaine genotoxicity
Abstract Cocaine is one of the most widely consumed psychoactive substances and has been recognized as a major public health concern for many years. While several aspects of the toxicology of cocaine have been thoroughly described in the literature, namely its effects on different...
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Abstract Omics technologies, and in particular metabolomics, have received an increasing attention during the assessment of hepatotoxicity in vitro. However, at present, a consensus on good metabolomics practices has yet to be reached. Therefore, in this review, a range of experimental...
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Abstract Benzo[a]pyrene (B(a)P) is a major cancer-causing contaminant present in food such as cooked meats and cereals, and is ubiquitous in the environment in smoke derived from the combustion of organic material. Exposure to B(a)P is epidemiologically linked with the incidence...
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Abstract Boric acid and sodium borates are currently classified in the EU-CLP regulation as "toxic to reproduction" under "Category 1B", with hazard statement of H360FD. However, so far field studies on male reproduction in China and in Turkey could not confirm such boron-associated...
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Abstract The Japanese Ministry of Health, Labour, and Welfare recently reported an outbreak of bladder cancer among workers who handled aromatic amines in Japan. 2,4-dimethylaniline (2,4-DMA) is one of the chemicals that workers are considered to have the most opportunities to be...
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Abstract Toluene is a well-known neurotoxic organic solvent and a major component of many industrial and commercial products such as adhesives, paint thinners and gasoline. Many workers are regularly exposed to toluene in their working environment and occupational exposure limits...
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Abstract A plethora of human hepatocyte-based in vitro systems for toxicity testing has been developed over the past few years. These systems are either directly derived from liver tissue or have been generated through stem cell technology. A wide variety of parameters is currently...
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The original article can be found online.
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Abstract Propofol is the most frequently used intravenous anesthetic for induction and maintenance of anesthesia. Propofol acts first and formost as a GABAA-agonist, but effects on other neuronal receptors and voltage-gated ion channels have been described. Besides its direct effect...
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Abstract Polychlorinated biphenyls (PCBs), and in particular non-dioxin-like (NDL) congeners, continue to pose a significant risk to the developing nervous system. PCB 95, a prevalent NDL congener in the human chemosphere, promotes dendritic growth in rodent primary neurons by activating...
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Abstract Chemical allergens are small molecules able to form a sensitizing complex once they bound to proteins. One of the most frequent manifestations of chemical allergy is contact hypersensitivity, which can have serious impact on quality of life. Allergic contact dermatitis is...
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Abstract Reporter cell lines are a particularly useful tool to screen for the skin sensitization potential of chemicals. Current cell models based on Keap1-Nrf2 mimic induction by conducting antioxidant response element-luciferase plasmids. However, plasmid-based reporters may ignore...
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Abstract Liver disease is an escalating global health issue. While liver transplantation is an effective mode of therapy, patient mortality has increased due to the shortage of donor organs. Developing renewable sources of human liver tissue is therefore attractive. Pluripotent stem...
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Abstract Drug-induced nephrotoxicity is a major concern in the clinic and hampers the use of available treatments as well as the development of innovative medicines. It is typically discovered late during drug development, which reflects a lack of in vitro nephrotoxicity assays available...
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Abstract CYP2E1 activity is measured in vitro and in vivo via hydroxylation of the Chlorzoxazone (CHZ) producing the 6-hydroxychlorzoxazone (OH-CHZ) further metabolized as a glucuronide excreted in urine. Thus, the quantification of the OH-CHZ following enzymatic hydrolysis of CHZ-derived...
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Abstract 1,4-Dioxane is a widely used synthetic industrial chemical and its contamination of drinking water and food is a potential health concern. It induces liver tumors when administered in the drinking water to rats and mice. However, the mode of action (MOA) of the hepatocarcinogenicity...
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Publication date: Available online 3 September 2018Source: Archives des Maladies Professionnelles et de l'EnvironnementAuthor(s):
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Abstract Background The incidence of thyroid cancer is fast increasing in both adults and children. The pediatric thyroid cancer had often already progressed to a more advanced stage of the disease at diagnosis. Early detection of pediatric...
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Publication date: Available online 3 September 2018Source: Advanced Drug Delivery ReviewsAuthor(s): Julia E. Vela Ramirez, Lindsey A. Sharpe, Nicholas A. Peppas
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Unfortunately, after publication of this article [1], it was noticed that a value in Table 2 is incorrect.
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Publication date: September 2018Source: Actualités Pharmaceutiques, Volume 57, Issue 578, SupplementAuthor(s): Nicolas Clere, Sébastien FaureCette formation doit se faire progressivement. Chacun doit trouver le moyen qui lui correspond. Proposez cette formation aux membres de l'équipe officinale et à...
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Publication date: September 2018Source: Actualités Pharmaceutiques, Volume 57, Issue 578, SupplementAuthor(s): Nelly Étienne-SelloumRésuméLe manque de sélectivité des chimiothérapies cytotoxiques, donc leur toxicité relativement importante, ainsi que l'amélioration des connaissances sur les mécanismes...
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