B cells, CMV, and stem cell transplant

(Source: ScienceNOW)

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Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation

Cytomegalovirus infection is a frequent and life-threatening complication that significantly limits positive transplantation outcomes. We developed preclinical mouse models of cytomegalovirus reactivation after transplantation and found that humoral immunity is essential for preventing viral recrudescence. Preexisting antiviral antibodies decreased after transplant in the presence of graft-versus-host disease and were not replaced, owing to poor reconstitution of donor B cells and elimination of recipient plasma cells. Viral reactivation was prevented by the transfer of immune serum, without a need to identify and target specific antigenic determinants. Notably, serotherapy afforded complete protection, provided that the serum was matched to the infecting viral strain. Thus, we define the ...

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B cells, CMV, and stem cell transplant

(Source: ScienceNOW)

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European Society of Neuroradiology (ESNR)

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Serotherapy treats a transplant hurdle

(Source: ScienceNOW)

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2018/2019

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Strain-specific antibody therapy prevents cytomegalovirus reactivation after transplantation

Cytomegalovirus infection is a frequent and life-threatening complication that significantly limits positive transplantation outcomes. We developed preclinical mouse models of cytomegalovirus reactivation after transplantation and found that humoral immunity is essential for preventing viral recrudescence. Preexisting antiviral antibodies decreased after transplant in the presence of graft-versus-host disease and were not replaced, owing to poor reconstitution of donor B cells and elimination of recipient plasma cells. Viral reactivation was prevented by the transfer of immune serum, without a need to identify and target specific antigenic determinants. Notably, serotherapy afforded complete protection, provided that the serum was matched to the infecting viral strain. Thus, we define the ...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FHWJSl

European Society of Neuroradiology (ESNR)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MjqSJ5

2018/2019

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Multiple Proposals for Continuous Arabic Sign Language Recognition

AbstractThe deaf community relies on sign language as the primary means of communication. For the millions of people around the world who suffer from hearing loss, interaction with hearing people is quite difficult. The main objective of sign language recognition (SLR) is the development of automatic SLR systems to facilitate communication with the deaf community. Arabic SLR (ArSLR) specifically did not receive much attention until recent years. This work presents a comprehensive comparison between two different recognition techniques for continuous ArSLR, namely a Modified k-Nearest Neighbor which is suitable for sequential data and Hidden Markov Models (HMMs) techniques based on two different toolkits. Additionally, in this work, two new ArSL datasets composed of 40 Arabic sentences ...

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Nonsurgical Management of Single-Sided Deafness: Contralateral Routing of Signal

J Neurol Surg B DOI: 10.1055/s-0039-1677687In recent years, an increasing research effort has been directed toward remediation of single-sided deafness. Contralateral routing of signal (CROS) is the longest standing rehabilitation solution for individuals with single-sided deafness. The primary goal of CROS technology is to transfer the signal received at the deaf ear to the better hearing ear, thereby reducing the impact of the acoustic head-shadow. This allows for individuals with single-sided deafness to regain access to sounds located at the deaf ear. The hearing deficits associated with single-sided deafness are often debilitating. While surgical management of single-sided deafness is on the rise, CROS hearing aids offer a nonsurgical option to compensate for some of the deficits that...

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Optimising Medical Management in CRS

Abstract

Purpose of Review

We assess the literature on different medical treatment options and their effectiveness in chronic rhinosinusitis (CRS).

Recent Findings

Although there is significant overlap in the management of CRS, not all therapies are equally effective within CRS phenotypes.

Summary

CRS is one of the most common chronic health problems affecting a large proportion of adult population and generating significant economic implications. Despite an unclear pathophysiology of this complex disorder, it is widely recognised that surgery alone does not resolve the chronic inflammation and that ongoing medical treatment remains the key to the successful management of patients with CRS.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2W3ip11

Multiple Proposals for Continuous Arabic Sign Language Recognition

AbstractThe deaf community relies on sign language as the primary means of communication. For the millions of people around the world who suffer from hearing loss, interaction with hearing people is quite difficult. The main objective of sign language recognition (SLR) is the development of automatic SLR systems to facilitate communication with the deaf community. Arabic SLR (ArSLR) specifically did not receive much attention until recent years. This work presents a comprehensive comparison between two different recognition techniques for continuous ArSLR, namely a Modified k-Nearest Neighbor which is suitable for sequential data and Hidden Markov Models (HMMs) techniques based on two different toolkits. Additionally, in this work, two new ArSL datasets composed of 40 Arabic sentences ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FLv0QG

Nonsurgical Management of Single-Sided Deafness: Contralateral Routing of Signal

J Neurol Surg B DOI: 10.1055/s-0039-1677687In recent years, an increasing research effort has been directed toward remediation of single-sided deafness. Contralateral routing of signal (CROS) is the longest standing rehabilitation solution for individuals with single-sided deafness. The primary goal of CROS technology is to transfer the signal received at the deaf ear to the better hearing ear, thereby reducing the impact of the acoustic head-shadow. This allows for individuals with single-sided deafness to regain access to sounds located at the deaf ear. The hearing deficits associated with single-sided deafness are often debilitating. While surgical management of single-sided deafness is on the rise, CROS hearing aids offer a nonsurgical option to compensate for some of the deficits that...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2FAvWs6

Optimising Medical Management in CRS

Abstract

Purpose of Review

We assess the literature on different medical treatment options and their effectiveness in chronic rhinosinusitis (CRS).

Recent Findings

Although there is significant overlap in the management of CRS, not all therapies are equally effective within CRS phenotypes.

Summary

CRS is one of the most common chronic health problems affecting a large proportion of adult population and generating significant economic implications. Despite an unclear pathophysiology of this complex disorder, it is widely recognised that surgery alone does not resolve the chronic inflammation and that ongoing medical treatment remains the key to the successful management of patients with CRS.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2W3ip11

Optimising Medical Management in CRS

Abstract

Purpose of Review

We assess the literature on different medical treatment options and their effectiveness in chronic rhinosinusitis (CRS).

Recent Findings

Although there is significant overlap in the management of CRS, not all therapies are equally effective within CRS phenotypes.

Summary

CRS is one of the most common chronic health problems affecting a large proportion of adult population and generating significant economic implications. Despite an unclear pathophysiology of this complex disorder, it is widely recognised that surgery alone does not resolve the chronic inflammation and that ongoing medical treatment remains the key to the successful management of patients with CRS.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2W3ip11

Optimising Medical Management in CRS

Abstract

Purpose of Review

We assess the literature on different medical treatment options and their effectiveness in chronic rhinosinusitis (CRS).

Recent Findings

Although there is significant overlap in the management of CRS, not all therapies are equally effective within CRS phenotypes.

Summary

CRS is one of the most common chronic health problems affecting a large proportion of adult population and generating significant economic implications. Despite an unclear pathophysiology of this complex disorder, it is widely recognised that surgery alone does not resolve the chronic inflammation and that ongoing medical treatment remains the key to the successful management of patients with CRS.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2W3ip11

Quality auditing in breast reconstruction using funnel plots and indicators: a semi-anonymous and practical method for your practice

Abstract

Background

In recent years, there is an increasing focus on the delivery of high-quality care in a cost-efficient fashion. A key strategy in improving practice is gaining insight in outcome differences. We present a simple and quick method of quality auditing in a local practice, aiming to start a discussion between surgeons and reduce complication rates by improving protocols.

Methods

Patients who underwent breast reconstruction with implants were evaluated on explantation rate within 60 days of insertion. Patients were traced using administrative data. Results were compared during yearly audits between 2014 and 2017. Each year, a meeting was held in which the data of all surgeons were compared using funnel plots in a semi-anonymous manner.

Results

At baseline, 6.1% (15/244) of all implants and 9.9% (9/91) of all tissue expanders had to be explanted, mainly due to infection (60.0% and 77.8%, resp.). Discussion at the audit led to the implementation of an anti-infection protocol. In the following years, explantation rates decreased to 3.8% (8/208) and 7.8% (8/102) in 2015 (infection 55.6% and 63%), and 3.4% (6/176) and 3.1% (2/64) in 2017 (infection 50% and 100%) and in 2016.

Conclusion

Audit feedback and the subsequent discussion about the causes of inter-surgeon differences led to a change in practice protocols for breast implant surgery and a reduction of breast implant explantation in our center.

Level of Evidence: Level III, risk / prognostic study

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Quality auditing in breast reconstruction using funnel plots and indicators: a semi-anonymous and practical method for your practice

Abstract

Background

In recent years, there is an increasing focus on the delivery of high-quality care in a cost-efficient fashion. A key strategy in improving practice is gaining insight in outcome differences. We present a simple and quick method of quality auditing in a local practice, aiming to start a discussion between surgeons and reduce complication rates by improving protocols.

Methods

Patients who underwent breast reconstruction with implants were evaluated on explantation rate within 60 days of insertion. Patients were traced using administrative data. Results were compared during yearly audits between 2014 and 2017. Each year, a meeting was held in which the data of all surgeons were compared using funnel plots in a semi-anonymous manner.

Results

At baseline, 6.1% (15/244) of all implants and 9.9% (9/91) of all tissue expanders had to be explanted, mainly due to infection (60.0% and 77.8%, resp.). Discussion at the audit led to the implementation of an anti-infection protocol. In the following years, explantation rates decreased to 3.8% (8/208) and 7.8% (8/102) in 2015 (infection 55.6% and 63%), and 3.4% (6/176) and 3.1% (2/64) in 2017 (infection 50% and 100%) and in 2016.

Conclusion

Audit feedback and the subsequent discussion about the causes of inter-surgeon differences led to a change in practice protocols for breast implant surgery and a reduction of breast implant explantation in our center.

Level of Evidence: Level III, risk / prognostic study

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2W2wxYj

Association of type 2 cytokines in severe rhinovirus bronchiolitis during infancy with risk of developing asthma: A multicenter prospective study

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TX6XSJ

Association of type 2 cytokines in severe rhinovirus bronchiolitis during infancy with risk of developing asthma: A multicenter prospective study

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TX6XSJ

Quality auditing in breast reconstruction using funnel plots and indicators: a semi-anonymous and practical method for your practice

Abstract

Background

In recent years, there is an increasing focus on the delivery of high-quality care in a cost-efficient fashion. A key strategy in improving practice is gaining insight in outcome differences. We present a simple and quick method of quality auditing in a local practice, aiming to start a discussion between surgeons and reduce complication rates by improving protocols.

Methods

Patients who underwent breast reconstruction with implants were evaluated on explantation rate within 60 days of insertion. Patients were traced using administrative data. Results were compared during yearly audits between 2014 and 2017. Each year, a meeting was held in which the data of all surgeons were compared using funnel plots in a semi-anonymous manner.

Results

At baseline, 6.1% (15/244) of all implants and 9.9% (9/91) of all tissue expanders had to be explanted, mainly due to infection (60.0% and 77.8%, resp.). Discussion at the audit led to the implementation of an anti-infection protocol. In the following years, explantation rates decreased to 3.8% (8/208) and 7.8% (8/102) in 2015 (infection 55.6% and 63%), and 3.4% (6/176) and 3.1% (2/64) in 2017 (infection 50% and 100%) and in 2016.

Conclusion

Audit feedback and the subsequent discussion about the causes of inter-surgeon differences led to a change in practice protocols for breast implant surgery and a reduction of breast implant explantation in our center.

Level of Evidence: Level III, risk / prognostic study

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2W2wxYj

Quality auditing in breast reconstruction using funnel plots and indicators: a semi-anonymous and practical method for your practice

Abstract

Background

In recent years, there is an increasing focus on the delivery of high-quality care in a cost-efficient fashion. A key strategy in improving practice is gaining insight in outcome differences. We present a simple and quick method of quality auditing in a local practice, aiming to start a discussion between surgeons and reduce complication rates by improving protocols.

Methods

Patients who underwent breast reconstruction with implants were evaluated on explantation rate within 60 days of insertion. Patients were traced using administrative data. Results were compared during yearly audits between 2014 and 2017. Each year, a meeting was held in which the data of all surgeons were compared using funnel plots in a semi-anonymous manner.

Results

At baseline, 6.1% (15/244) of all implants and 9.9% (9/91) of all tissue expanders had to be explanted, mainly due to infection (60.0% and 77.8%, resp.). Discussion at the audit led to the implementation of an anti-infection protocol. In the following years, explantation rates decreased to 3.8% (8/208) and 7.8% (8/102) in 2015 (infection 55.6% and 63%), and 3.4% (6/176) and 3.1% (2/64) in 2017 (infection 50% and 100%) and in 2016.

Conclusion

Audit feedback and the subsequent discussion about the causes of inter-surgeon differences led to a change in practice protocols for breast implant surgery and a reduction of breast implant explantation in our center.

Level of Evidence: Level III, risk / prognostic study

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2W2wxYj

Utility of Dynamic Susceptibility Contrast Perfusion-Weighted MR Imaging and 11C-Methionine PET/CT for Differentiation of Tumor Recurrence from Radiation Injury in Patients with High-Grade Gliomas [FUNCTIONAL]

BACKGROUND AND PURPOSE:

Both ¹¹C-methionine PET/CT and DSC-PWI could be used to differentiate radiation injury from recurrent brain tumors. Our aim was to assess the performance of MET PET/CT and DSC-PWI for differentiation of recurrence and radiation injury in patients with high-grade gliomas and to quantitatively analyze the diagnostic values of PET and PWI parameters.

MATERIALS AND METHODS:

Forty-two patients with high-grade gliomas were enrolled in this study. The final diagnosis was determined by histopathologic analysis or clinical follow-up. PWI and PET parameters were recorded and compared between patients with recurrence and those with radiation injury using Student t tests. Receiver operating characteristic and logistic regression analyses were used to determine the diagnostic performance of each parameter.

RESULTS:

The final diagnosis was recurrence in 33 patients and radiation injury in 9. PET/CT showed a patient-based sensitivity and specificity of 0.909 and 0.556, respectively, while PWI showed values of 0.667 and 0.778, respectively. The maximum standardized uptake value, mean standardized uptake value, tumor-to-background maximum standardized uptake value, and mean relative CBV were significantly higher for patients with recurrence than for patients with radiation injury. All these parameters showed a high discriminative power in receiver operating characteristic analysis. The optimal cutoff values for the tumor-to-background maximum standardized uptake value and mean relative CBV were 1.85 and 1.83, respectively, and corresponding sensitivities and specificities for the diagnosis of recurrence were 0.97 and 0.667 and 0.788 and 0.88, respectively. Areas under the curve for the tumor-to-background maximum standardized uptake value and mean relative CBV were 0.847 ± 0.077 and 0.845 ± 0.078, respectively. Combined assessment of the tumor-to-background maximum standardized uptake value and mean relative CBV showed the largest area under the curve (0.953 ± 0.031), with corresponding sensitivity and specificity of 0.848 and 1.0, respectively.

CONCLUSIONS:

Both ¹¹C-methionine PET/CT and PWI are equally accurate in the differentiation of recurrence from radiation injury in patients with high-grade gliomas, and a combination of the 2 modalities could result in increased diagnostic accuracy.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T37bb2

Transient Ischemic Attack and Carotid Web [EXTRACRANIAL VASCULAR]

BACKGROUND AND PURPOSE:

Carotid web was recognized as a cause of ischemic stroke. We sought to determine the clinical and imaging profiles of patients with a carotid web as well as its association with TIA.

MATERIALS AND METHODS:

A retrospective review of carotid CT angiography studies and brain MR imaging in patients with TIA during the past 3 years (n = 135) was performed to determine the presence of carotid webs by 2 experienced neuroradiologists according to previously published criteria. Demographics and clinical and imaging characteristics are shown by descriptive statistics for patients with an identified carotid web. The agreement in the detection of carotid webs between 2 neuroradiologists was examined using statistics.

RESULTS:

There were 12 (8.9%) carotid webs at the symptomatic bifurcation and 1 carotid web (0.7%) at the asymptomatic bifurcation, and no hyperintensity was seen on DWI of these 12 patients. Eight of these 12 (75%) patients with a carotid web were women. None of the 12 patients with a carotid web had major risk factors or other causes of TIA. Fair-to-good interobserver agreement ( = 0.87) was seen for diagnosing a carotid web with CT angiography. The rate (10/12, 83.3%) of short-term recurrent episodes of TIA in patients with TIA with a carotid web was significantly higher than that of patients without a carotid web (15/123, 12.2%) (P < .001).

CONCLUSIONS:

The incidence of carotid web in patients with TIA was 8.9%. There is an association between carotid web and patients with TIA without other identified risks. Carotid web may be an underestimated risk factor for TIA.

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Percutaneous CT-Guided Skull Biopsy: Feasibility, Safety, and Diagnostic Yield [INTERVENTIONAL]

BACKGROUND AND PURPOSE:

Although percutaneous musculoskeletal biopsies are routinely performed in the axial and appendicular skeleton, there are no published data on the systematic evaluation of the feasibility, safety, and diagnostic accuracy of percutaneous skull biopsy. In certain clinical encounters such as patients with primary skull tumors or patients with known cancer and isolated skull lesions suspected of calvarial metastasis or synchronous primary tumor, percutaneous skull biopsy may be considered a viable option. The purpose of this study was to evaluate the feasibility, safety profile, and diagnostic yield of percutaneous CT-guided skull biopsy.

MATERIALS AND METHODS:

Percutaneous CT-guided skull biopsy was performed in 14 patients. Patient demographics, cancer history, indication for initial imaging, imaging technique of diagnosis, skull tumor anatomic location, and final histologic diagnosis were documented. Preprocedural imaging of each skull lesion was reviewed to determine tumor size and characteristics. Procedural notes were reviewed to determine the total conscious sedation time or anesthesia time, type of biopsy needle, and the number and length of obtained core specimens. Procedure-related complications were also documented according to the Society of Interventional Radiology classification.

RESULTS:

All CT-guided percutaneous skull biopsy procedures were performed as preoperatively planned and were technically successful. Procedures were performed with the patient under conscious sedation in 93% (13/14) of cases. Definitive histologic diagnosis was achieved in 86% (12/14) of cases. There were no acute or delayed procedure-related complications.

CONCLUSIONS:

The results of this retrospective initial study suggest that percutaneous CT-guided skull biopsy is feasible with an excellent safety profile, affords a high diagnostic yield for histologic characterization, and may obviate more invasive open skull biopsies.

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Sexual Dimorphism and Hemispheric Asymmetry of Hippocampal Volumetric Integrity in Normal Aging and Alzheimer Disease [ADULT BRAIN]

BACKGROUND AND PURPOSE:

Asymmetric atrophy of the hippocampus is an important clinical finding in normal aging and Alzheimer disease. In this study, we investigate the associations between the magnitude and asymmetry of hippocampal volumetric integrity and age, sex, and dementia severity.

MATERIALS AND METHODS:

We have recently developed a rapid fully automatic algorithm to measure the hippocampal parenchymal fraction, an index of hippocampal volumetric integrity on structural MR imaging of the brain. We applied this algorithm to measure the hippocampal parenchymal fraction bilaterally on 775 MR imaging volumes scanned from 198 volunteers in a publicly available data base. All subjects were right-handed and older than 60 years of age. Subjects were categorized as cognitively healthy (n = 98), with mild cognitive impairment (n = 70), or with mild/moderate Alzheimer disease (n = 30). We used linear mixed-effects models to analyze the hippocampal parenchymal fraction and its asymmetry with respect to age, sex, dementia severity, and intracranial volume.

RESULTS:

After controlling for age, sex, and intracranial volume, we found that the magnitude of the hippocampal parenchymal fraction decreased and its asymmetry increased significantly with dementia severity. Also, hippocampal parenchymal fraction asymmetry was significantly higher in men after controlling for all other variables, but there was no sex effect on hippocampal parenchymal fraction magnitude. The magnitude of the hippocampal parenchymal fraction decreased and its asymmetry increased significantly with age in subjects who were cognitively healthy, but associations with age were different in nature in the mild cognitive impairment and Alzheimer disease groups.

CONCLUSIONS:

Hippocampal atrophy progresses asymmetrically with age in cognitively healthy subjects. Hippocampal parenchymal fraction asymmetry is significantly higher in men than women and in mild cognitive impairment/Alzheimer disease relative to cognitively healthy individuals.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SZbNyP

Brain DSC MR Perfusion in Children: A Clinical Feasibility Study Using Different Technical Standards of Contrast Administration [FUNCTIONAL]

BACKGROUND AND PURPOSE:

Dynamic susceptibility contrast MR perfusion imaging has limited results in children due to difficulties in reproducing technical standards derived from adults. This prospective, multicenter study aimed to determine DSC feasibility and quality in children using custom administration of a standard dose of gadolinium.

MATERIALS AND METHODS:

Eighty-three consecutive children with brain tumors underwent DSC perfusion with a standard dose of gadobutrol administered by an automated power injector. The location and size of intravenous catheters and gadobutrol volume and flow rates were reported, and local and/or systemic adverse effects were recorded. DSC was qualitatively evaluated by CBV maps and signal intensity–time curves and quantitatively by the percentage of signal drop and full width at half-maximum, and the data were compared with the standards reported for adults. Quantitative data were grouped by flow rate, and differences among groups were assessed by analysis of covariance and tested for statistical significance with a t test.

RESULTS:

No local or systemic adverse events were recorded independent of catheter location (63 arm, 14 hand, 6 foot), size (24–18 ga), and flow rates (1–5 mL/s). High-quality CBV maps and signal intensity–time curves were achieved in all patients, and quantitative evaluations were equal or superior to those reported for adults. No significant differences (P ≥ .05) were identified among the higher-flow-rate groups in the quantitative data.

CONCLUSIONS:

A custom administration of a standard dose of gadobutrol allows safe and high-quality DSC MR perfusion imaging in children.

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A Review of Magnetic Particle Imaging and Perspectives on Neuroimaging [REVIEW ARTICLE]

SUMMARY:

Magnetic particle imaging is an emerging tomographic technique with the potential for simultaneous high-resolution, high-sensitivity, and real-time imaging. Magnetic particle imaging is based on the unique behavior of superparamagnetic iron oxide nanoparticles modeled by the Langevin theory, with the ability to track and quantify nanoparticle concentrations without tissue background noise. It is a promising new imaging technique for multiple applications, including vascular and perfusion imaging, oncology imaging, cell tracking, inflammation imaging, and trauma imaging. In particular, many neuroimaging applications may be enabled and enhanced with magnetic particle imaging. In this review, we will provide an overview of magnetic particle imaging principles and implementation, current applications, promising neuroimaging applications, and practical considerations.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SZbG6n

Renal Contrast on CT Myelography: Diagnostic Value in Patients with Spontaneous Intracranial Hypotension [SPINE]

BACKGROUND AND PURPOSE:

The significance of renal contrast on CT myelography is uncertain. This project examined different patient populations undergoing CT myelography for the presence of renal contrast to determine whether this finding is of diagnostic value in spontaneous intracranial hypotension.

MATERIALS AND METHODS:

Four groups of patients were analyzed for renal contrast on CT myelography. The control group underwent CT myelography for reasons other than spontaneous intracranial hypotension (n = 47). Patients in study group 1 had spontaneous intracranial hypotension but CT myelography negative for dural CSF leak and CSF venous fistula (n = 83). Patients in study group 2 had spontaneous intracranial hypotension and CT myelography positive for dural CSF leak (n = 44). Patients in study group 3 had spontaneous intracranial hypotension and CT myelography suggestive of CSF venous fistula due to a hyperdense paraspinal vein (n = 17, eleven surgically confirmed).

RESULTS:

Renal contrast was present on the initial CT myelography in 0/47 patients in the control group, 10/83 patients in group one, 1/44 patients in group 2, and 7/17 patients in group 3. Renal contrast on initial CT myelography in patients with suspected or surgically confirmed CSF venous fistula was significantly more likely than in patients with a dural CSF leak (P = .0003).

CONCLUSIONS:

Renal contrast on initial CT myelography was seen only in patients with spontaneous intracranial hypotension. This was more common in confirmed/suspected CSF venous fistulas compared with dural leaks. Early renal contrast in patients with spontaneous intracranial hypotension should prompt scrutiny for a hyperdense paraspinal vein, and, if none is found, potentially advanced diagnostic studies.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2APdhoo

MR Imaging Scoring System for White Matter Injury after Deep Medullary Vein Thrombosis and Infarction in Neonates [PEDIATRICS]

BACKGROUND AND PURPOSE:

Advanced imaging techniques have allowed earlier and more accurate detection of cerebral deep medullary vein thrombosis and infarction. Our objective was to develop an MR imaging scoring system to evaluate the severity of white matter injury in neonates with deep medullary vein thrombosis and infarction.

MATERIALS AND METHODS:

This was a retrospective study of infants born ≥32 weeks' gestation (2000–2016) diagnosed with deep medullary vein thrombosis and infarction on neuroimaging in the first 30 days of life. A 102-point deep medullary vein white matter injury global severity score was developed. MR images were scored by 2 pediatric radiologists. Subject clinical data and regional and global severity scores were recorded.

RESULTS:

Fifty-one patients (mean gestational age, 37.3 ± 2.2 weeks; mean birth weight, 3182 ± 720 g) were included with a mean age at diagnosis via MR imaging of postnatal day 10.1 ± 6.1. Global severity scores ranged from 1 to 53, with a median score of 11 (interquartile range, 5–25). Lesions were more common in the frontal and parietal regions and less common in the occipital and temporal regions. Fifty-five percent of the group had neonatal seizures. No difference in perinatal risk factors (gestational age, birthweight, 5-minute Apgar score, chorioamnionitis, delivery room resuscitation, ventilator, or inotrope requirement) was observed among severity score quartiles.

CONCLUSIONS:

An MR imaging scoring system provides a comprehensive and objective classification of WM injury after deep medullary vein thrombosis and infarction in late preterm and term neonates. The global severity score is independent of gestational age and other antenatal risk factors, consistent with presentation in previously healthy-appearing neonates.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SZbOTp

Utility of Dynamic Susceptibility Contrast Perfusion-Weighted MR Imaging and 11C-Methionine PET/CT for Differentiation of Tumor Recurrence from Radiation Injury in Patients with High-Grade Gliomas [FUNCTIONAL]

BACKGROUND AND PURPOSE:

Both ¹¹C-methionine PET/CT and DSC-PWI could be used to differentiate radiation injury from recurrent brain tumors. Our aim was to assess the performance of MET PET/CT and DSC-PWI for differentiation of recurrence and radiation injury in patients with high-grade gliomas and to quantitatively analyze the diagnostic values of PET and PWI parameters.

MATERIALS AND METHODS:

Forty-two patients with high-grade gliomas were enrolled in this study. The final diagnosis was determined by histopathologic analysis or clinical follow-up. PWI and PET parameters were recorded and compared between patients with recurrence and those with radiation injury using Student t tests. Receiver operating characteristic and logistic regression analyses were used to determine the diagnostic performance of each parameter.

RESULTS:

The final diagnosis was recurrence in 33 patients and radiation injury in 9. PET/CT showed a patient-based sensitivity and specificity of 0.909 and 0.556, respectively, while PWI showed values of 0.667 and 0.778, respectively. The maximum standardized uptake value, mean standardized uptake value, tumor-to-background maximum standardized uptake value, and mean relative CBV were significantly higher for patients with recurrence than for patients with radiation injury. All these parameters showed a high discriminative power in receiver operating characteristic analysis. The optimal cutoff values for the tumor-to-background maximum standardized uptake value and mean relative CBV were 1.85 and 1.83, respectively, and corresponding sensitivities and specificities for the diagnosis of recurrence were 0.97 and 0.667 and 0.788 and 0.88, respectively. Areas under the curve for the tumor-to-background maximum standardized uptake value and mean relative CBV were 0.847 ± 0.077 and 0.845 ± 0.078, respectively. Combined assessment of the tumor-to-background maximum standardized uptake value and mean relative CBV showed the largest area under the curve (0.953 ± 0.031), with corresponding sensitivity and specificity of 0.848 and 1.0, respectively.

CONCLUSIONS:

Both ¹¹C-methionine PET/CT and PWI are equally accurate in the differentiation of recurrence from radiation injury in patients with high-grade gliomas, and a combination of the 2 modalities could result in increased diagnostic accuracy.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2T37bb2

Transient Ischemic Attack and Carotid Web [EXTRACRANIAL VASCULAR]

BACKGROUND AND PURPOSE:

Carotid web was recognized as a cause of ischemic stroke. We sought to determine the clinical and imaging profiles of patients with a carotid web as well as its association with TIA.

MATERIALS AND METHODS:

A retrospective review of carotid CT angiography studies and brain MR imaging in patients with TIA during the past 3 years (n = 135) was performed to determine the presence of carotid webs by 2 experienced neuroradiologists according to previously published criteria. Demographics and clinical and imaging characteristics are shown by descriptive statistics for patients with an identified carotid web. The agreement in the detection of carotid webs between 2 neuroradiologists was examined using statistics.

RESULTS:

There were 12 (8.9%) carotid webs at the symptomatic bifurcation and 1 carotid web (0.7%) at the asymptomatic bifurcation, and no hyperintensity was seen on DWI of these 12 patients. Eight of these 12 (75%) patients with a carotid web were women. None of the 12 patients with a carotid web had major risk factors or other causes of TIA. Fair-to-good interobserver agreement ( = 0.87) was seen for diagnosing a carotid web with CT angiography. The rate (10/12, 83.3%) of short-term recurrent episodes of TIA in patients with TIA with a carotid web was significantly higher than that of patients without a carotid web (15/123, 12.2%) (P < .001).

CONCLUSIONS:

The incidence of carotid web in patients with TIA was 8.9%. There is an association between carotid web and patients with TIA without other identified risks. Carotid web may be an underestimated risk factor for TIA.

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Standardized MR Perfusion Scoring System for Evaluation of Sequential Perfusion Changes and Surgical Outcome of Moyamoya Disease [FUNCTIONAL]

BACKGROUND AND PURPOSE:

Simple-but-precise evaluation of cerebral perfusion is crucial for the treatment of Moyamoya disease. We aimed to develop a standardized scoring system for MR perfusion suitable for Moyamoya disease evaluation and investigate the postoperative serial changes and outcome predictors.

MATERIALS AND METHODS:

From January 2013 to December 2016, patients diagnosed with Moyamoya disease and receiving indirect revascularization were recruited prospectively. Clinical data and serial imaging studies were analyzed. The TTP maps were standardized using cerebellar reference values. We developed a scoring system of standardized TTP maps: 14 points for each hemisphere with higher points indicating better perfusion.

RESULTS:

In total, 24 children (4–17 years of age, 41 hemispheres) and 20 adults (18–51 years of age, 34 hemispheres) were included. The mean preoperative TTP scores were higher in children (7.34 ± 3.90) than in adults (4.88 ± 3.24). The standardized TTP maps revealed dynamic improvement with an increase in the corresponding scores at the 1-, 3-, and 6-month postoperative follow-ups; the scores stabilized after 6 months. The mean improvement in the 6-month scores of the pediatric and adult groups was 4.15 ± 3.55 and 6.03 ± 3.04, respectively. The 6-month TTP score improvements were associated with Matsushima grades. If we took score improvement as the outcome, the preoperative TTP score was the only significant predictor in multivariable analysis.

CONCLUSIONS:

The standardized TTP maps and scoring system facilitated the quantification of the sequential perfusion changes during Moyamoya disease treatment. The preoperative perfusion status was the only predictor of indirect revascularization outcome.

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Percutaneous CT-Guided Skull Biopsy: Feasibility, Safety, and Diagnostic Yield [INTERVENTIONAL]

BACKGROUND AND PURPOSE:

Although percutaneous musculoskeletal biopsies are routinely performed in the axial and appendicular skeleton, there are no published data on the systematic evaluation of the feasibility, safety, and diagnostic accuracy of percutaneous skull biopsy. In certain clinical encounters such as patients with primary skull tumors or patients with known cancer and isolated skull lesions suspected of calvarial metastasis or synchronous primary tumor, percutaneous skull biopsy may be considered a viable option. The purpose of this study was to evaluate the feasibility, safety profile, and diagnostic yield of percutaneous CT-guided skull biopsy.

MATERIALS AND METHODS:

Percutaneous CT-guided skull biopsy was performed in 14 patients. Patient demographics, cancer history, indication for initial imaging, imaging technique of diagnosis, skull tumor anatomic location, and final histologic diagnosis were documented. Preprocedural imaging of each skull lesion was reviewed to determine tumor size and characteristics. Procedural notes were reviewed to determine the total conscious sedation time or anesthesia time, type of biopsy needle, and the number and length of obtained core specimens. Procedure-related complications were also documented according to the Society of Interventional Radiology classification.

RESULTS:

All CT-guided percutaneous skull biopsy procedures were performed as preoperatively planned and were technically successful. Procedures were performed with the patient under conscious sedation in 93% (13/14) of cases. Definitive histologic diagnosis was achieved in 86% (12/14) of cases. There were no acute or delayed procedure-related complications.

CONCLUSIONS:

The results of this retrospective initial study suggest that percutaneous CT-guided skull biopsy is feasible with an excellent safety profile, affords a high diagnostic yield for histologic characterization, and may obviate more invasive open skull biopsies.

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Sexual Dimorphism and Hemispheric Asymmetry of Hippocampal Volumetric Integrity in Normal Aging and Alzheimer Disease [ADULT BRAIN]

BACKGROUND AND PURPOSE:

Asymmetric atrophy of the hippocampus is an important clinical finding in normal aging and Alzheimer disease. In this study, we investigate the associations between the magnitude and asymmetry of hippocampal volumetric integrity and age, sex, and dementia severity.

MATERIALS AND METHODS:

We have recently developed a rapid fully automatic algorithm to measure the hippocampal parenchymal fraction, an index of hippocampal volumetric integrity on structural MR imaging of the brain. We applied this algorithm to measure the hippocampal parenchymal fraction bilaterally on 775 MR imaging volumes scanned from 198 volunteers in a publicly available data base. All subjects were right-handed and older than 60 years of age. Subjects were categorized as cognitively healthy (n = 98), with mild cognitive impairment (n = 70), or with mild/moderate Alzheimer disease (n = 30). We used linear mixed-effects models to analyze the hippocampal parenchymal fraction and its asymmetry with respect to age, sex, dementia severity, and intracranial volume.

RESULTS:

After controlling for age, sex, and intracranial volume, we found that the magnitude of the hippocampal parenchymal fraction decreased and its asymmetry increased significantly with dementia severity. Also, hippocampal parenchymal fraction asymmetry was significantly higher in men after controlling for all other variables, but there was no sex effect on hippocampal parenchymal fraction magnitude. The magnitude of the hippocampal parenchymal fraction decreased and its asymmetry increased significantly with age in subjects who were cognitively healthy, but associations with age were different in nature in the mild cognitive impairment and Alzheimer disease groups.

CONCLUSIONS:

Hippocampal atrophy progresses asymmetrically with age in cognitively healthy subjects. Hippocampal parenchymal fraction asymmetry is significantly higher in men than women and in mild cognitive impairment/Alzheimer disease relative to cognitively healthy individuals.

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Brain DSC MR Perfusion in Children: A Clinical Feasibility Study Using Different Technical Standards of Contrast Administration [FUNCTIONAL]

BACKGROUND AND PURPOSE:

Dynamic susceptibility contrast MR perfusion imaging has limited results in children due to difficulties in reproducing technical standards derived from adults. This prospective, multicenter study aimed to determine DSC feasibility and quality in children using custom administration of a standard dose of gadolinium.

MATERIALS AND METHODS:

Eighty-three consecutive children with brain tumors underwent DSC perfusion with a standard dose of gadobutrol administered by an automated power injector. The location and size of intravenous catheters and gadobutrol volume and flow rates were reported, and local and/or systemic adverse effects were recorded. DSC was qualitatively evaluated by CBV maps and signal intensity–time curves and quantitatively by the percentage of signal drop and full width at half-maximum, and the data were compared with the standards reported for adults. Quantitative data were grouped by flow rate, and differences among groups were assessed by analysis of covariance and tested for statistical significance with a t test.

RESULTS:

No local or systemic adverse events were recorded independent of catheter location (63 arm, 14 hand, 6 foot), size (24–18 ga), and flow rates (1–5 mL/s). High-quality CBV maps and signal intensity–time curves were achieved in all patients, and quantitative evaluations were equal or superior to those reported for adults. No significant differences (P ≥ .05) were identified among the higher-flow-rate groups in the quantitative data.

CONCLUSIONS:

A custom administration of a standard dose of gadobutrol allows safe and high-quality DSC MR perfusion imaging in children.

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A Review of Magnetic Particle Imaging and Perspectives on Neuroimaging [REVIEW ARTICLE]

SUMMARY:

Magnetic particle imaging is an emerging tomographic technique with the potential for simultaneous high-resolution, high-sensitivity, and real-time imaging. Magnetic particle imaging is based on the unique behavior of superparamagnetic iron oxide nanoparticles modeled by the Langevin theory, with the ability to track and quantify nanoparticle concentrations without tissue background noise. It is a promising new imaging technique for multiple applications, including vascular and perfusion imaging, oncology imaging, cell tracking, inflammation imaging, and trauma imaging. In particular, many neuroimaging applications may be enabled and enhanced with magnetic particle imaging. In this review, we will provide an overview of magnetic particle imaging principles and implementation, current applications, promising neuroimaging applications, and practical considerations.

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Renal Contrast on CT Myelography: Diagnostic Value in Patients with Spontaneous Intracranial Hypotension [SPINE]

BACKGROUND AND PURPOSE:

The significance of renal contrast on CT myelography is uncertain. This project examined different patient populations undergoing CT myelography for the presence of renal contrast to determine whether this finding is of diagnostic value in spontaneous intracranial hypotension.

MATERIALS AND METHODS:

Four groups of patients were analyzed for renal contrast on CT myelography. The control group underwent CT myelography for reasons other than spontaneous intracranial hypotension (n = 47). Patients in study group 1 had spontaneous intracranial hypotension but CT myelography negative for dural CSF leak and CSF venous fistula (n = 83). Patients in study group 2 had spontaneous intracranial hypotension and CT myelography positive for dural CSF leak (n = 44). Patients in study group 3 had spontaneous intracranial hypotension and CT myelography suggestive of CSF venous fistula due to a hyperdense paraspinal vein (n = 17, eleven surgically confirmed).

RESULTS:

Renal contrast was present on the initial CT myelography in 0/47 patients in the control group, 10/83 patients in group one, 1/44 patients in group 2, and 7/17 patients in group 3. Renal contrast on initial CT myelography in patients with suspected or surgically confirmed CSF venous fistula was significantly more likely than in patients with a dural CSF leak (P = .0003).

CONCLUSIONS:

Renal contrast on initial CT myelography was seen only in patients with spontaneous intracranial hypotension. This was more common in confirmed/suspected CSF venous fistulas compared with dural leaks. Early renal contrast in patients with spontaneous intracranial hypotension should prompt scrutiny for a hyperdense paraspinal vein, and, if none is found, potentially advanced diagnostic studies.

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MR Imaging Scoring System for White Matter Injury after Deep Medullary Vein Thrombosis and Infarction in Neonates [PEDIATRICS]

BACKGROUND AND PURPOSE:

Advanced imaging techniques have allowed earlier and more accurate detection of cerebral deep medullary vein thrombosis and infarction. Our objective was to develop an MR imaging scoring system to evaluate the severity of white matter injury in neonates with deep medullary vein thrombosis and infarction.

MATERIALS AND METHODS:

This was a retrospective study of infants born ≥32 weeks' gestation (2000–2016) diagnosed with deep medullary vein thrombosis and infarction on neuroimaging in the first 30 days of life. A 102-point deep medullary vein white matter injury global severity score was developed. MR images were scored by 2 pediatric radiologists. Subject clinical data and regional and global severity scores were recorded.

RESULTS:

Fifty-one patients (mean gestational age, 37.3 ± 2.2 weeks; mean birth weight, 3182 ± 720 g) were included with a mean age at diagnosis via MR imaging of postnatal day 10.1 ± 6.1. Global severity scores ranged from 1 to 53, with a median score of 11 (interquartile range, 5–25). Lesions were more common in the frontal and parietal regions and less common in the occipital and temporal regions. Fifty-five percent of the group had neonatal seizures. No difference in perinatal risk factors (gestational age, birthweight, 5-minute Apgar score, chorioamnionitis, delivery room resuscitation, ventilator, or inotrope requirement) was observed among severity score quartiles.

CONCLUSIONS:

An MR imaging scoring system provides a comprehensive and objective classification of WM injury after deep medullary vein thrombosis and infarction in late preterm and term neonates. The global severity score is independent of gestational age and other antenatal risk factors, consistent with presentation in previously healthy-appearing neonates.

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Asthma Undiagnosed in One in Five Urban Adolescents

Odds of being undiagnosed higher for girls, Asian - Americans versus white non - Hispanics (Source: Pulmonary Medicine News - Doctors Lounge)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RMLPl1

Asthma Undiagnosed in One in Five Urban Adolescents

Odds of being undiagnosed higher for girls, Asian - Americans versus white non - Hispanics (Source: Pulmonary Medicine News - Doctors Lounge)

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January is Thyroid Awareness Month

Thyroid Medication Among Most Prescribed in U.S.
Laura Rosbrow-Telem, Public News Service – MA

Dr. Elizabeth Pearce, president of the American Thyroid Association and a professor at Boston University's School of Medicine, says thyroid disorders, which affect the thyroid gland toward the bottom of the neck, particularly impact women, especially as they age.

Read Article…

The post January is Thyroid Awareness Month appeared first on American Thyroid Association.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RVehRB

Asthma Undiagnosed in One in Five Urban Adolescents

Odds of being undiagnosed higher for girls, Asian - Americans versus white non - Hispanics (Source: Pulmonary Medicine News - Doctors Lounge)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RMLPl1

January is Thyroid Awareness Month

Thyroid Medication Among Most Prescribed in U.S.
Laura Rosbrow-Telem, Public News Service – MA

Dr. Elizabeth Pearce, president of the American Thyroid Association and a professor at Boston University's School of Medicine, says thyroid disorders, which affect the thyroid gland toward the bottom of the neck, particularly impact women, especially as they age.

Read Article…

The post January is Thyroid Awareness Month appeared first on American Thyroid Association.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RVehRB

Asthma Undiagnosed in One in Five Urban Adolescents

Odds of being undiagnosed higher for girls, Asian - Americans versus white non - Hispanics (Source: Pulmonary Medicine News - Doctors Lounge)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RMLPl1

Turning immunity on and off

NIH Director ' s Wednesday Afternoon Lecture Series Dr. Hubbell uses biomaterials and protein engineering approaches to investigate topics in regenerative medicine and immunotherapeutics. In regenerative medicine, he focuses on biomaterial matrices that mimic the extracellular matrix and on growth factor - extracellular matrix interactions, working in a variety of animal models of regenerative medicine. In immunotherapeutics, he focuses on nanomaterials in vaccines that target lymphoid-resident antigen presenting cells and on protein engineering approaches to deliver antigen to the spleen and liver for inverse vaccines to induce tolerance to protein drugs and in autoimmunity. His interests are both basic and translational, having founded or co-founded five biomedical companies based on h...

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Division of Allergy, Immunology, and Transplantation Subcommittee - January 2019

Report from Division Director and Division StaffAir date: 1/28/2019 1:00:00 PM (Source: Videocast - All Events)

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Turning immunity on and off

NIH Director ' s Wednesday Afternoon Lecture Series Dr. Hubbell uses biomaterials and protein engineering approaches to investigate topics in regenerative medicine and immunotherapeutics. In regenerative medicine, he focuses on biomaterial matrices that mimic the extracellular matrix and on growth factor - extracellular matrix interactions, working in a variety of animal models of regenerative medicine. In immunotherapeutics, he focuses on nanomaterials in vaccines that target lymphoid-resident antigen presenting cells and on protein engineering approaches to deliver antigen to the spleen and liver for inverse vaccines to induce tolerance to protein drugs and in autoimmunity. His interests are both basic and translational, having founded or co-founded five biomedical companies based on h...

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Division of Allergy, Immunology, and Transplantation Subcommittee - January 2019

Report from Division Director and Division StaffAir date: 1/28/2019 1:00:00 PM (Source: Videocast - All Events)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HiWAHJ

January is Thyroid Awareness Month

Thyroid Medication Among Most Prescribed in U.S.
Laura Rosbrow-Telem, Public News Service – MA

Dr. Elizabeth Pearce, president of the American Thyroid Association and a professor at Boston University's School of Medicine, says thyroid disorders, which affect the thyroid gland toward the bottom of the neck, particularly impact women, especially as they age.

Read Article…

The post January is Thyroid Awareness Month appeared first on American Thyroid Association.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RVehRB

January is Thyroid Awareness Month

Thyroid Medication Among Most Prescribed in U.S.
Laura Rosbrow-Telem, Public News Service – MA

Dr. Elizabeth Pearce, president of the American Thyroid Association and a professor at Boston University's School of Medicine, says thyroid disorders, which affect the thyroid gland toward the bottom of the neck, particularly impact women, especially as they age.

Read Article…

The post January is Thyroid Awareness Month appeared first on American Thyroid Association.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RVehRB

Windgap Medical raises $12m for epinephrine auto-injector

Windgap Medical has raised $12 million from 106 investors as part of a $27 million round, according to a document filed with the SEC. The Watertown, Mass.-based company is developing an epinephrine auto-injector designed to treat severe allergic reactions. Get the full story at our sister site, Drug Delivery Business News. The post Windgap Medical raises $12m for epinephrine auto-injector appeared first on MassDevice. (Source: Mass Device)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DhCzx5

Sandoz launches PFS alternative to epinephrine auto-injector

Novartis (NYSE:NVS) division Sandoz said today that it launched its Symjepi epinephrine pre-filled syringe in the U.S. The company's product is designed as an alternative to epinephrine auto-injectors to treat emergency allergic reactions. Get the full story at our sister site, Drug Delivery Business News. The post Sandoz launches PFS alternative to epinephrine auto-injector appeared first on MassDevice. (Source: Mass Device)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TWC6pG

Relationship of Sociodemographic Factors and Outcomes in Functional Rhinoplasty

Facial plast Surg
DOI: 10.1055/s-0039-1677708

The objective of this article was to compare the effect of such sociodemographic factors as gender, age, marital status, employment status, race, and income on short- and long-term rhinoplasty outcomes using a validated disease-specific instrument—Nasal Obstruction Symptom Evaluation (NOSE) scale, as well as complication and revision rates. Patients who underwent a functional (+/− cosmetic) rhinoplasty with the senior author between January, 1 2012, and September 9, 2017, and had both a preoperative and at least one postoperative NOSE score, were included in the study. Sociodemographic variables of binary gender, age, marital status, employment status, race, and income based on zip code were collected. The primary outcomes were the differences between the preoperative and postoperative NOSE scores with short-term (less than 3 months) and longer-term (greater than 3 months) follow-up. Secondary outcomes were general complications and specifically revision surgery. Standard descriptive statistics, as well as univariable linear and logistic regressions, were conducted with each outcome measure. A total of 341 patients were included in this study. No individual patient-level variables were found to significantly affect the short- or longer-term average change in NOSE scores, although older age trended toward significance in longer-term average change in NOSE scores (p = 0.07). No factors significantly affected the rate of complications or revision surgery in this cohort. The authors found improvement in NOSE scores after rhinoplasty was not related to factors of age, gender, race, employment status, income, and marital status. This cohort also did not demonstrate differential rates in complications or revision surgery based on sociodemographic variables.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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The Effect of Minocycline on Fat Graft Survival and Apoptotic Pathway

Facial plast Surg
DOI: 10.1055/s-0039-1677709

Variable absorption rate is one of the biggest problems of fat grafting and one of the most important causes of fat graft volume loss is apoptosis. Minocycline is a tetracycline derivative and besides its antibacterial capacity, it has been widely using for anti-apoptotic effects. This study was designed to investigate the effect of minocycline on fat graft survival and adipocyte apoptosis. A total of two main and eight subgroups were designed and a total of 48 experimental animals, 6 in each group, were used. Fat grafts are obtained from Wistar albino rats and implanted to dorsal area of rats. Local and systemic minocycline was applied in the study groups. On the 9th day, apoptotic cells were detected by the terminal deoxynucleotidyl transferase dUTP nick end labeling method and on the 90th day morphologic characteristics and viability of adipocytes were evaluated using histologic and immunohistochemical methods and statistically compared. This study revealed that the fat grafts were bigger, and they kept their structures better and they were more vascular in the minocycline groups and apoptosis was significantly lower in the minocycline groups. The authors demonstrated that minocycline increases fat graft survival and statistical improvement in apoptosis inhibition via using minocycline therapy has been shown.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RUA7ET

Windgap Medical raises $12m for epinephrine auto-injector

Windgap Medical has raised $12 million from 106 investors as part of a $27 million round, according to a document filed with the SEC. The Watertown, Mass.-based company is developing an epinephrine auto-injector designed to treat severe allergic reactions. Get the full story at our sister site, Drug Delivery Business News. The post Windgap Medical raises $12m for epinephrine auto-injector appeared first on MassDevice. (Source: Mass Device)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DhCzx5

Sandoz launches PFS alternative to epinephrine auto-injector

Novartis (NYSE:NVS) division Sandoz said today that it launched its Symjepi epinephrine pre-filled syringe in the U.S. The company's product is designed as an alternative to epinephrine auto-injectors to treat emergency allergic reactions. Get the full story at our sister site, Drug Delivery Business News. The post Sandoz launches PFS alternative to epinephrine auto-injector appeared first on MassDevice. (Source: Mass Device)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TWC6pG

Relationship of Sociodemographic Factors and Outcomes in Functional Rhinoplasty

Facial plast Surg
DOI: 10.1055/s-0039-1677708

The objective of this article was to compare the effect of such sociodemographic factors as gender, age, marital status, employment status, race, and income on short- and long-term rhinoplasty outcomes using a validated disease-specific instrument—Nasal Obstruction Symptom Evaluation (NOSE) scale, as well as complication and revision rates. Patients who underwent a functional (+/− cosmetic) rhinoplasty with the senior author between January, 1 2012, and September 9, 2017, and had both a preoperative and at least one postoperative NOSE score, were included in the study. Sociodemographic variables of binary gender, age, marital status, employment status, race, and income based on zip code were collected. The primary outcomes were the differences between the preoperative and postoperative NOSE scores with short-term (less than 3 months) and longer-term (greater than 3 months) follow-up. Secondary outcomes were general complications and specifically revision surgery. Standard descriptive statistics, as well as univariable linear and logistic regressions, were conducted with each outcome measure. A total of 341 patients were included in this study. No individual patient-level variables were found to significantly affect the short- or longer-term average change in NOSE scores, although older age trended toward significance in longer-term average change in NOSE scores (p = 0.07). No factors significantly affected the rate of complications or revision surgery in this cohort. The authors found improvement in NOSE scores after rhinoplasty was not related to factors of age, gender, race, employment status, income, and marital status. This cohort also did not demonstrate differential rates in complications or revision surgery based on sociodemographic variables.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2HkauJv

The Effect of Minocycline on Fat Graft Survival and Apoptotic Pathway

Facial plast Surg
DOI: 10.1055/s-0039-1677709

Variable absorption rate is one of the biggest problems of fat grafting and one of the most important causes of fat graft volume loss is apoptosis. Minocycline is a tetracycline derivative and besides its antibacterial capacity, it has been widely using for anti-apoptotic effects. This study was designed to investigate the effect of minocycline on fat graft survival and adipocyte apoptosis. A total of two main and eight subgroups were designed and a total of 48 experimental animals, 6 in each group, were used. Fat grafts are obtained from Wistar albino rats and implanted to dorsal area of rats. Local and systemic minocycline was applied in the study groups. On the 9th day, apoptotic cells were detected by the terminal deoxynucleotidyl transferase dUTP nick end labeling method and on the 90th day morphologic characteristics and viability of adipocytes were evaluated using histologic and immunohistochemical methods and statistically compared. This study revealed that the fat grafts were bigger, and they kept their structures better and they were more vascular in the minocycline groups and apoptosis was significantly lower in the minocycline groups. The authors demonstrated that minocycline increases fat graft survival and statistical improvement in apoptosis inhibition via using minocycline therapy has been shown.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RUA7ET

Windgap Medical raises $12m for epinephrine auto-injector

Windgap Medical has raised $12 million from 106 investors as part of a $27 million round, according to a document filed with the SEC. The Watertown, Mass.-based company is developing an epinephrine auto-injector designed to treat severe allergic reactions. Get the full story at our sister site, Drug Delivery Business News. The post Windgap Medical raises $12m for epinephrine auto-injector appeared first on MassDevice. (Source: Mass Device)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DhCzx5

Sandoz launches PFS alternative to epinephrine auto-injector

Novartis (NYSE:NVS) division Sandoz said today that it launched its Symjepi epinephrine pre-filled syringe in the U.S. The company's product is designed as an alternative to epinephrine auto-injectors to treat emergency allergic reactions. Get the full story at our sister site, Drug Delivery Business News. The post Sandoz launches PFS alternative to epinephrine auto-injector appeared first on MassDevice. (Source: Mass Device)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TWC6pG

Windgap Medical raises $12m for epinephrine auto-injector

Windgap Medical has raised $12 million from 106 investors as part of a $27 million round, according to a document filed with the SEC. The Watertown, Mass.-based company is developing an epinephrine auto-injector designed to treat severe allergic reactions. Get the full story at our sister site, Drug Delivery Business News. The post Windgap Medical raises $12m for epinephrine auto-injector appeared first on MassDevice. (Source: Mass Device)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DhCzx5

Sandoz launches PFS alternative to epinephrine auto-injector

Novartis (NYSE:NVS) division Sandoz said today that it launched its Symjepi epinephrine pre-filled syringe in the U.S. The company's product is designed as an alternative to epinephrine auto-injectors to treat emergency allergic reactions. Get the full story at our sister site, Drug Delivery Business News. The post Sandoz launches PFS alternative to epinephrine auto-injector appeared first on MassDevice. (Source: Mass Device)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TWC6pG

Functional Reconstruction of Mandibular Segment Defects with Individual Preformed Reconstruction Plate and CTA-aided Iliac Crest Flap

With the development of imaging technology and computer-assisted surgery in oral and maxillofacial surgery, digital technology is widely used in vascularized bone flap grafts for mandible reconstruction. The aim of our study is to use digital technology throughout the treatment process to demonstrate that digital techniques can provide a reliable and accurate match between the mandible and the iliac crest flap to achieve functional reconstruction of mandibular segment defects.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SVU6Ae

Perioperative Management For the Cocaine-Positive Patient Undergoing Elective Surgery Under General Anesthesia

Cocaine use in the United States is widespread and on the rise.1,2 Due to the increased prevalence of cocaine use, it is likely that the oral and maxillofacial surgeon (OMS) will come across multiple instances of cocaine-positive patients presenting for elective surgery. Studies have already shown that many oral and maxillofacial surgery cases are cancelled due to the presence of cocaine metabolites in urine tests.1,3 Cocaine is a known risk factor for cardiovascular complications (eg, stroke, myocardial infarction, dysrhythmia, angina, hypertension, tachycardia, prolonged QT interval, coronary vasospasm, and aortic dissection)1-4, which in turn influences many providers to cancel elective surgery under general anesthesia.

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Developing HIV specific T Cells as a Cure Strategy Post BMT

Date: Wednesday, 01 23, 2019; Speaker: Catherine Bollard, Director, Center for Cancer& Immunology, Children's National HealthSystem; Building 33; 1N09 (Source: NIH Calendar of Events)

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Meta-Analysis: Vitamin D May Benefit Some COPD Patients (CME/CE)

(MedPage Today) -- Vitamin D pills almost halved exacerbation risk in vitamin D-deficient, COPD patients (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CrQAqd

Functional Reconstruction of Mandibular Segment Defects with Individual Preformed Reconstruction Plate and CTA-aided Iliac Crest Flap

With the development of imaging technology and computer-assisted surgery in oral and maxillofacial surgery, digital technology is widely used in vascularized bone flap grafts for mandible reconstruction. The aim of our study is to use digital technology throughout the treatment process to demonstrate that digital techniques can provide a reliable and accurate match between the mandible and the iliac crest flap to achieve functional reconstruction of mandibular segment defects.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SVU6Ae

Perioperative Management For the Cocaine-Positive Patient Undergoing Elective Surgery Under General Anesthesia

Cocaine use in the United States is widespread and on the rise.1,2 Due to the increased prevalence of cocaine use, it is likely that the oral and maxillofacial surgeon (OMS) will come across multiple instances of cocaine-positive patients presenting for elective surgery. Studies have already shown that many oral and maxillofacial surgery cases are cancelled due to the presence of cocaine metabolites in urine tests.1,3 Cocaine is a known risk factor for cardiovascular complications (eg, stroke, myocardial infarction, dysrhythmia, angina, hypertension, tachycardia, prolonged QT interval, coronary vasospasm, and aortic dissection)1-4, which in turn influences many providers to cancel elective surgery under general anesthesia.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ATHfHR

The Electronic Medical Record and Its Impact on Oral and Maxillofacial Surgery Training: Friend or Foe?

The United States healthcare industry has been said to be one of the world's largest, and most inefficient information enterprise. This has been partly attributed to the fact that medical records are stored on paper which in turn means that they cannot be used to coordinate interdisciplinary care as easily, routinely measure quality and record and reduce medical errors1. Electronic medical record (EMR) resources have been available for the past four decades, but recently are becoming more and more prevalent within different medical settings across the United States.

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Developing HIV specific T Cells as a Cure Strategy Post BMT

Date: Wednesday, 01 23, 2019; Speaker: Catherine Bollard, Director, Center for Cancer& Immunology, Children's National HealthSystem; Building 33; 1N09 (Source: NIH Calendar of Events)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2sAa0ot

Meta-Analysis: Vitamin D May Benefit Some COPD Patients (CME/CE)

(MedPage Today) -- Vitamin D pills almost halved exacerbation risk in vitamin D-deficient, COPD patients (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CrQAqd

The impact of implant abutment surface treatment with TiO2 on peri-implant levels of angiogenesis and bone-related markers: a randomized clinical trial

The goal of this randomized, blinded, split-mouth controlled clinical trial was to assess the influence of abutment surface treatment on tissue healing. Fifteen patients received two implants distributed randomly to two groups: test (TiO2 abutment surface), control (standard abutment surface). Levels of epidermal growth factor (EGF), bone morphogenetic protein 9 (BMP-9), endothelin 1 (ET-1), fibroblast growth factor (FGF), placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) were quantified in the peri-implant fluid after 3, 14, 30, and 60 days.

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Functional Reconstruction of Mandibular Segment Defects with Individual Preformed Reconstruction Plate and CTA-aided Iliac Crest Flap

With the development of imaging technology and computer-assisted surgery in oral and maxillofacial surgery, digital technology is widely used in vascularized bone flap grafts for mandible reconstruction. The aim of our study is to use digital technology throughout the treatment process to demonstrate that digital techniques can provide a reliable and accurate match between the mandible and the iliac crest flap to achieve functional reconstruction of mandibular segment defects.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SVU6Ae

Perioperative Management For the Cocaine-Positive Patient Undergoing Elective Surgery Under General Anesthesia

Cocaine use in the United States is widespread and on the rise.1,2 Due to the increased prevalence of cocaine use, it is likely that the oral and maxillofacial surgeon (OMS) will come across multiple instances of cocaine-positive patients presenting for elective surgery. Studies have already shown that many oral and maxillofacial surgery cases are cancelled due to the presence of cocaine metabolites in urine tests.1,3 Cocaine is a known risk factor for cardiovascular complications (eg, stroke, myocardial infarction, dysrhythmia, angina, hypertension, tachycardia, prolonged QT interval, coronary vasospasm, and aortic dissection)1-4, which in turn influences many providers to cancel elective surgery under general anesthesia.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ATHfHR

The Electronic Medical Record and Its Impact on Oral and Maxillofacial Surgery Training: Friend or Foe?

The United States healthcare industry has been said to be one of the world's largest, and most inefficient information enterprise. This has been partly attributed to the fact that medical records are stored on paper which in turn means that they cannot be used to coordinate interdisciplinary care as easily, routinely measure quality and record and reduce medical errors1. Electronic medical record (EMR) resources have been available for the past four decades, but recently are becoming more and more prevalent within different medical settings across the United States.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SZy27Z

The impact of implant abutment surface treatment with TiO2 on peri-implant levels of angiogenesis and bone-related markers: a randomized clinical trial

The goal of this randomized, blinded, split-mouth controlled clinical trial was to assess the influence of abutment surface treatment on tissue healing. Fifteen patients received two implants distributed randomly to two groups: test (TiO2 abutment surface), control (standard abutment surface). Levels of epidermal growth factor (EGF), bone morphogenetic protein 9 (BMP-9), endothelin 1 (ET-1), fibroblast growth factor (FGF), placental growth factor (PlGF), and vascular endothelial growth factor (VEGF) were quantified in the peri-implant fluid after 3, 14, 30, and 60 days.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CtCLYx

Functional Reconstruction of Mandibular Segment Defects with Individual Preformed Reconstruction Plate and CTA-aided Iliac Crest Flap

With the development of imaging technology and computer-assisted surgery in oral and maxillofacial surgery, digital technology is widely used in vascularized bone flap grafts for mandible reconstruction. The aim of our study is to use digital technology throughout the treatment process to demonstrate that digital techniques can provide a reliable and accurate match between the mandible and the iliac crest flap to achieve functional reconstruction of mandibular segment defects.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SVU6Ae

Perioperative Management For the Cocaine-Positive Patient Undergoing Elective Surgery Under General Anesthesia

Cocaine use in the United States is widespread and on the rise.1,2 Due to the increased prevalence of cocaine use, it is likely that the oral and maxillofacial surgeon (OMS) will come across multiple instances of cocaine-positive patients presenting for elective surgery. Studies have already shown that many oral and maxillofacial surgery cases are cancelled due to the presence of cocaine metabolites in urine tests.1,3 Cocaine is a known risk factor for cardiovascular complications (eg, stroke, myocardial infarction, dysrhythmia, angina, hypertension, tachycardia, prolonged QT interval, coronary vasospasm, and aortic dissection)1-4, which in turn influences many providers to cancel elective surgery under general anesthesia.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2ATHfHR

The Electronic Medical Record and Its Impact on Oral and Maxillofacial Surgery Training: Friend or Foe?

The United States healthcare industry has been said to be one of the world's largest, and most inefficient information enterprise. This has been partly attributed to the fact that medical records are stored on paper which in turn means that they cannot be used to coordinate interdisciplinary care as easily, routinely measure quality and record and reduce medical errors1. Electronic medical record (EMR) resources have been available for the past four decades, but recently are becoming more and more prevalent within different medical settings across the United States.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SZy27Z

Nasotracheal intubation-extubation-intubation and asleep-awake-asleep anesthesia technique for deep brain stimulation

Abstract

Background

The asleep-awake-asleep (AAA) technique and laryngeal mask airway (LMA) is a common general anesthesia technique for deep brain stimulation (DBS) surgery. However, the LMA is not always the ideal artificial airway. In this report, we presented our experiences with nasotracheal intubation-extubation-intubation (IEI) and AAA techniques in DBS surgery for Parkinson's disease (PD) patients to meet the needs of surgery and ensure patients' safety and comfort.

Case presentation

Three PD patients scheduled for DBS surgery had to receive general anesthesia for various reasons. For the first asleep stage, general anesthesia and nasotracheal intubation was completed with routine methods. During the awake stage, we pulled the nasotracheal tube back right above the epiglottis under fiberoptic bronchoscope (FOB) guidance for microelectrode recording (MER), macrostimulation testing and verbal communication. Once monitoring is completed, we induced anesthesia with rapid sequence induction and utilized the FOB to advance the nasotracheal tube into the trachea again. To minimize airway irritations during the process, we sprayed the airway with lidocaine before any manipulation. The neurophysiologists completed neuromoinitroing successfully and all three patients were satisfied with the anesthesia provided at follow-up.

Conclusion

Nasotracheal IEI and AAA anesthetic techniques should be considered as a viable option during DBS surgery.

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Nasotracheal intubation-extubation-intubation and asleep-awake-asleep anesthesia technique for deep brain stimulation

Abstract

Background

The asleep-awake-asleep (AAA) technique and laryngeal mask airway (LMA) is a common general anesthesia technique for deep brain stimulation (DBS) surgery. However, the LMA is not always the ideal artificial airway. In this report, we presented our experiences with nasotracheal intubation-extubation-intubation (IEI) and AAA techniques in DBS surgery for Parkinson's disease (PD) patients to meet the needs of surgery and ensure patients' safety and comfort.

Case presentation

Three PD patients scheduled for DBS surgery had to receive general anesthesia for various reasons. For the first asleep stage, general anesthesia and nasotracheal intubation was completed with routine methods. During the awake stage, we pulled the nasotracheal tube back right above the epiglottis under fiberoptic bronchoscope (FOB) guidance for microelectrode recording (MER), macrostimulation testing and verbal communication. Once monitoring is completed, we induced anesthesia with rapid sequence induction and utilized the FOB to advance the nasotracheal tube into the trachea again. To minimize airway irritations during the process, we sprayed the airway with lidocaine before any manipulation. The neurophysiologists completed neuromoinitroing successfully and all three patients were satisfied with the anesthesia provided at follow-up.

Conclusion

Nasotracheal IEI and AAA anesthetic techniques should be considered as a viable option during DBS surgery.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RA1uVp

Erector spinae plane catheter for neonatal thoracotomy: a potentially safer alternative to a thoracic epidural

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MlgSPK

Allergen challenge increases capsaicin evoked cough responses in allergic asthma

Changes in airway calibre and inflammation after allergen challenge in mild atopic asthmatics is associated with increased cough responses to inhaled capsaicin and spontaneous 24-hour coughing, implying neuronal sensitisation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DgTNKT

Hematopoietic stem cell transplantation for CD40 ligand deficiency: results from an EBMT/ESID-IEWP-SCETIDE-PIDTC Study

This manuscript reports the results of a worldwide survey of HSCT outcome in a large cohort of patients with CD40L deficiency. Key findings about survival and cure rate will be relevant to improve patients' management.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TULb28

Challenges in Assessing the Efficacy of Systemic Corticosteroids for Severe Wheezing Episodes in Preschool Children

This letter addresses the controversial issue of the use of oral corticosteroids during wheezing exacerbations in preschool-aged children by demonstrating findings of a prematurely terminated multi-center clinical trial, discussing lessons learned, and suggesting future directions.

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Gamma tocopherol effect on LPS-induced sputum neutrophilia is not modified by BMI or GSTM1 genotype

Gamma tocopherol may be beneficial as a primary or complementary therapeutic agent in conditions with neutrophilic airway inflammation. Its effects are not modified by BMI or GSTM1 genotype, allowing for its use in a broader population.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TZjIfQ

Hypoxia Enhances CD8+ Tc2 Dependent Airway Hyperresponsiveness and Inflammation Through Hypoxia Inducible Factor 1α

Hypoxia exposure amplifies CD8+ Tc2 differentiation with increased release of IL-13 in vitro and augmentation of lung allergic responses in vivo. The increases in Tc2 differentiation under hypoxia were shown to be dependent on HIF-1α.

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Vitamin D is no substitute for the sun

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Dgi6bT

Doctors explain misconceptions about penicillin allergy

(Reuters Health) - Most patients who report having a penicillin allergy are not really allergic to this highly effective antibiotic, and they may be missing out on the best treatment for their condition as a result, according to a new patient resource published in JAMA. (Source: Reuters: Health)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RAYpEm

Meta-Analysis: Vitamin D May Benefit Some COPD Patients (CME/CE)

(MedPage Today) -- Vitamin D pills almost halved exacerbation risk in vitamin D-deficient, COPD patients (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CrQAqd

Allergen challenge increases capsaicin evoked cough responses in allergic asthma

Changes in airway calibre and inflammation after allergen challenge in mild atopic asthmatics is associated with increased cough responses to inhaled capsaicin and spontaneous 24-hour coughing, implying neuronal sensitisation.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2DgTNKT

Hematopoietic stem cell transplantation for CD40 ligand deficiency: results from an EBMT/ESID-IEWP-SCETIDE-PIDTC Study

This manuscript reports the results of a worldwide survey of HSCT outcome in a large cohort of patients with CD40L deficiency. Key findings about survival and cure rate will be relevant to improve patients' management.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TULb28

Gamma tocopherol effect on LPS-induced sputum neutrophilia is not modified by BMI or GSTM1 genotype

Gamma tocopherol may be beneficial as a primary or complementary therapeutic agent in conditions with neutrophilic airway inflammation. Its effects are not modified by BMI or GSTM1 genotype, allowing for its use in a broader population.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TZjIfQ

One step forward, two steps back: The enigma of preschool wheeze

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TZjuW2

Double-strand break repair through homologous recombination in autosomal recessive BCL10 deficiency

DNA double-strand break (DSB) repair through homologous recombination from BCL10-/- patient is impaired. Given the relevance of DBS in the onset of cancer, it is important to highlight homologous recombination is BCL10-dependent in human fibroblasts.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TUSqHp

Meta-Analysis: Vitamin D May Benefit Some COPD Patients (CME/CE)

(MedPage Today) -- Vitamin D pills almost halved exacerbation risk in vitamin D-deficient, COPD patients (Source: MedPage Today Allergy)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CrQAqd

Doctors explain misconceptions about penicillin allergy

(Reuters Health) - Most patients who report having a penicillin allergy are not really allergic to this highly effective antibiotic, and they may be missing out on the best treatment for their condition as a result, according to a new patient resource published in JAMA. (Source: Reuters: Health)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RAYpEm

Aicardi syndrome: a case report

Discussion: through the established treatment, the child displayedmotor gain, cervical control, improvement of the respiratory condition, and no need forhospital admissions;these outcomescharacterizea good clinical evolution associated with the physiotherapeutic intervention focused on prevention and minimization of respiratory alterationsthatare frequently associated with morbidity and mortality in these cases. The results obtained point out the fundamental role of multidisciplinary intervention in coping with this condition.Resumo Introdu ção: a Síndrome de Aicardi (SA), caracteriza-se como uma síndrome rara identificada na presença das três características clássicas: agenesia de corpo caloso, lacunas coriorretinianas e espamos infantis. Descrição: a coleta de dados envolveu in...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RyPzY2

Cesarean section surgeries: the temporal evolution, epidemic tendency, the WHO proposals and recommendations, current doubts and challenges

Discussion: through the established treatment, the child displayedmotor gain, cervical control, improvement of the respiratory condition, and no need forhospital admissions;these outcomescharacterizea good clinical evolution associated with the physiotherapeutic intervention focused on prevention and minimization of respiratory alterationsthatare frequently associated with morbidity and mortality in these cases. The results obtained point out the fundamental role of multidisciplinary intervention in coping with this condition.Resumo Introdu ção: a Síndrome de Aicardi (SA), caracteriza-se como uma síndrome rara identificada na presença das três características clássicas: agenesia de corpo caloso, lacunas coriorretinianas e espamos infantis. Descrição: a coleta de dados envolveu in...

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Editorial Board

Publication date: January 2019Source: Speech Communication, Volume 106Author(s): (Source: Speech Communication)

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Mapping non-native pitch contours to meaning: Perceptual and experiential factors

Publication date: April 2019Source: Journal of Memory and Language, Volume 105Author(s): Jessica F. Hay, Ryan A. Cannistraci, Qian ZhaoAbstractInfants show interesting patterns of flexibility and constraint early in word learning. Here, we explore perceptual and experiential factors that drive associative learning of labels that differ in pitch contour. Contrary to the salience hypothesis proposed in Experiment 1, English-learning 14-month-olds failed to map acoustically distinctive level and dipping labels to novel referents, even though they discriminated the labels when no potential referents were present. Conversely, infants readily mapped the less distinctive rising and dipping labels. In Experiment 2, we found that the degree of pitch variation in labels also does not account for lea...

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Acknowledgment of Reviewers

Volume 15, Issue 1, January-March 2019, Page 102-102 . (Source: Language Learning and Development)

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Publications Received for Review.

Authors: PMID: 30645991 [PubMed - as supplied by publisher] (Source: Phonetica)

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Use of formant centralization ratio for vowel impairment detection in normal hearing and different degrees of hearing impairment.

CONCLUSIONS: The findings of this study showed that FCR was a more sensitive acoustic parameter than F2i/F2u ratio and VSA to distinguish speech of the HL groups from that of the normal group. Thus, FCR is considered to be applicable as an early objective measure of impaired vowel articulation in HL speakers. PMID: 30644324 [PubMed - as supplied by publisher] (Source: Logopedics, Phoniatrics, Vocology.)

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A review of virtual reality technologies in the field of communication disability: implications for practice and research.

CONCLUSIONS: Research employing VR is in its infancy in the field of speech-language pathology. Early evidence from other healthcare disciplines suggests that VR is an engaging means of delivering immersive and interactive training to build functional skills that can be generalized to the real world. While the introduction of new technology requires careful consideration of research ethics and patient safety, future VR communication research could proceed safely with adequate engagement of interdisciplinary teams and technology specialists. Implications for rehabilitation Immersive virtual reality may be used in rehabilitation to simulate natural environments to practice and develop communication skills. The sense of immersion that can be achieved using virtual reality may promote the gene...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RBp4Ba

Doctors explain misconceptions about penicillin allergy

(Reuters Health) - Most patients who report having a penicillin allergy are not really allergic to this highly effective antibiotic, and they may be missing out on the best treatment for their condition as a result, according to a new patient resource published in JAMA. (Source: Reuters: Health)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RAYpEm

Aicardi syndrome: a case report

Discussion: through the established treatment, the child displayedmotor gain, cervical control, improvement of the respiratory condition, and no need forhospital admissions;these outcomescharacterizea good clinical evolution associated with the physiotherapeutic intervention focused on prevention and minimization of respiratory alterationsthatare frequently associated with morbidity and mortality in these cases. The results obtained point out the fundamental role of multidisciplinary intervention in coping with this condition.Resumo Introdu ção: a Síndrome de Aicardi (SA), caracteriza-se como uma síndrome rara identificada na presença das três características clássicas: agenesia de corpo caloso, lacunas coriorretinianas e espamos infantis. Descrição: a coleta de dados envolveu in...

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2RyPzY2

Cesarean section surgeries: the temporal evolution, epidemic tendency, the WHO proposals and recommendations, current doubts and challenges

Discussion: through the established treatment, the child displayedmotor gain, cervical control, improvement of the respiratory condition, and no need forhospital admissions;these outcomescharacterizea good clinical evolution associated with the physiotherapeutic intervention focused on prevention and minimization of respiratory alterationsthatare frequently associated with morbidity and mortality in these cases. The results obtained point out the fundamental role of multidisciplinary intervention in coping with this condition.Resumo Introdu ção: a Síndrome de Aicardi (SA), caracteriza-se como uma síndrome rara identificada na presença das três características clássicas: agenesia de corpo caloso, lacunas coriorretinianas e espamos infantis. Descrição: a coleta de dados envolveu in...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CnYwbW

Are females and males equitably represented? A study of early readers

Publication date: February 2019Source: Linguistics and Education, Volume 49Author(s): Jackie F.K. Lee, Andy C.O. ChinAbstractEarly readers can play a significant role in the intergenerational transmission of gender roles. The present study examines how females and males are represented in selected early readers recommended by the Education Bureau of Hong Kong for the promotion of 'Reading to Learn' and 'Reading across the Curriculum'. The study used both manual and computational methods to examine how experiential and relational values are expressed through variables such as the ratio of female-to-male character types, the roles and activities depicted, character identification and the order of mention of males and females. The findings show that although the number of female human...

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Editorial Board

Publication date: January 2019Source: Speech Communication, Volume 106Author(s): (Source: Speech Communication)

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Screening and enrichment of high lipid producing microalgal consortia

Publication date: March 2019Source: Journal of Photochemistry and Photobiology B: Biology, Volume 192Author(s): Jyoti Sharma, Smita S. Kumar, Narsi R. Bishnoi, Arivalagan PugazhendhiAbstractLipid content is the main parameter for the evaluation of microalgae towards biodiesel production. The present study was aimed at the screening of desirable algal consortia based on lipid content for further processing into biofuel. Twenty different algal consortia were investigated for lipid content qualitatively by Nile Red and quantitatively by gravimetric method and FTIR. Nile Red is used as a fluorophore for physically characterizing the lipid body in algal cultures. The yellow fluorescence in all the samples confirmed the presence of lipid content when observed under a fluorescent microscope. Lipi...

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