Updated Date: Jan 30, 2019 EST (Source: DailyMed Drug Label Updates)
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Updated Date: Jan 30, 2019 EST (Source: DailyMed Drug Label Updates)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Secretion of cytoplasmic granules (ie, degranulation) and production of other mediators not stored in granules (eg, leukotrienes, prostaglandins, and diverse cytokines) by mast cells and basophils activated through Fc εRI play key roles in diverse IgE-mediated immune responses, including asthma, hay fever, food allergies, and anaphylaxis.1,2 In both mast cells and basophils, secretory granule structure is thought to reflect in part electrostatic complexes between proteases (positively charged) and proteoglycans (negatively charged), which associate with and thereby help store multiple bioactive molecules, including histamine and certain cytokines. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CSZhKC
Secretion of cytoplasmic granules (ie, degranulation) and production of other mediators not stored in granules (eg, leukotrienes, prostaglandins, and diverse cytokines) by mast cells and basophils activated through Fc εRI play key roles in diverse IgE-mediated immune responses, including asthma, hay fever, food allergies, and anaphylaxis.1,2 In both mast cells and basophils, secretory granule structure is thought to reflect in part electrostatic complexes between proteases (positively charged) and proteoglycans (negatively charged), which associate with and thereby help store multiple bioactive molecules, including histamine and certain cytokines. (Source: Journal of Allergy and Clinical Immunology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CSZhKC
The limitation of diagnosis of transition zone (TZ) prostate cancer (PCa) using subjective assessment of multiparametric (mp) MRI with PI‐RADS v2 is related to overlapping features between cancers and stromal benign prostatic hyperplasia (BPH) nodules, particularly in small lesions.
To evaluate modeling of quantitative apparent diffusion coefficient (ADC), texture, and shape features using logistic regression (LR) and support vector machine (SVM) models for the diagnosis of transition zone PCa.
Retrospective.
Ninety patients; 44 consecutive TZ PCa were compared with 61 consecutive BPH nodules (26 glandular/35 stromal).
3 T/T2‐weighted (T2W) fast spin‐echo, diffusion weighted imaging.
A radiologist manually segmented lesions on axial images for quantitative ADC (mean, 10th, 25th‐centile‐ADC), T2W‐shape (circularity, convexity) and T2W‐texture (kurtosis, skewness, entropy, run‐length nonuniformity [RLNU], gray‐level nonuniformity [GLNU]) analysis. A second radiologist segmented one‐fifth of randomly selected lesions to determine the reproducibility of measurements. The reference standard was histopathology for all lesions.
Quantitative features were selected a priori and were compared using univariate and multivariate analysis. LR and SVM models of statistically significant features were constructed and evaluated using receiver operator characteristic (ROC) analysis. Subgroup analysis of TZ PCa vs. only stromal BPH and in lesions measuring <15 mm was performed. Agreement in measurements was assessed using the Dice similarity coefficient (DSC).
Mean, 25th and 10th‐centile ADC, circularity, and texture (entropy, RLNU, GLNU) features differed between groups (P < 0.0001–0.0058); however, at multivariate analysis only circularity and ADC metrics (P < 0.001) remained significant. LR and SVM models were highly accurate for the diagnosis of TZ PCa (sensitivity/specificity/AUC): 93.2%/98.4%/0.989 and 93.2%/96.7%/0.949, respectively, with no significance difference between the LR and SVM models (P = 0.2271). Reproducibility of segmentation was excellent (DSC 0.84 tumors and 0.87 BPH). Subgroup analyses of TZ PCa vs. stromal BPH (AUC = 0.976) and in <15 mm lesions (AUC = 0.990) remained highly accurate.
LR and SVM models incorporating previously described quantitative ADC, shape and texture analysis features are highly accurate for the diagnosis of TZ PCa and remained accurate when comparing TZ PCa with stromal BPH and in smaller lesions.
Level of Evidence: 3
Technical Efficacy: Stage 2
J. Magn. Reson. Imaging 2019.
The limitation of diagnosis of transition zone (TZ) prostate cancer (PCa) using subjective assessment of multiparametric (mp) MRI with PI‐RADS v2 is related to overlapping features between cancers and stromal benign prostatic hyperplasia (BPH) nodules, particularly in small lesions.
To evaluate modeling of quantitative apparent diffusion coefficient (ADC), texture, and shape features using logistic regression (LR) and support vector machine (SVM) models for the diagnosis of transition zone PCa.
Retrospective.
Ninety patients; 44 consecutive TZ PCa were compared with 61 consecutive BPH nodules (26 glandular/35 stromal).
3 T/T2‐weighted (T2W) fast spin‐echo, diffusion weighted imaging.
A radiologist manually segmented lesions on axial images for quantitative ADC (mean, 10th, 25th‐centile‐ADC), T2W‐shape (circularity, convexity) and T2W‐texture (kurtosis, skewness, entropy, run‐length nonuniformity [RLNU], gray‐level nonuniformity [GLNU]) analysis. A second radiologist segmented one‐fifth of randomly selected lesions to determine the reproducibility of measurements. The reference standard was histopathology for all lesions.
Quantitative features were selected a priori and were compared using univariate and multivariate analysis. LR and SVM models of statistically significant features were constructed and evaluated using receiver operator characteristic (ROC) analysis. Subgroup analysis of TZ PCa vs. only stromal BPH and in lesions measuring <15 mm was performed. Agreement in measurements was assessed using the Dice similarity coefficient (DSC).
Mean, 25th and 10th‐centile ADC, circularity, and texture (entropy, RLNU, GLNU) features differed between groups (P < 0.0001–0.0058); however, at multivariate analysis only circularity and ADC metrics (P < 0.001) remained significant. LR and SVM models were highly accurate for the diagnosis of TZ PCa (sensitivity/specificity/AUC): 93.2%/98.4%/0.989 and 93.2%/96.7%/0.949, respectively, with no significance difference between the LR and SVM models (P = 0.2271). Reproducibility of segmentation was excellent (DSC 0.84 tumors and 0.87 BPH). Subgroup analyses of TZ PCa vs. stromal BPH (AUC = 0.976) and in <15 mm lesions (AUC = 0.990) remained highly accurate.
LR and SVM models incorporating previously described quantitative ADC, shape and texture analysis features are highly accurate for the diagnosis of TZ PCa and remained accurate when comparing TZ PCa with stromal BPH and in smaller lesions.
Level of Evidence: 3
Technical Efficacy: Stage 2
J. Magn. Reson. Imaging 2019.
Atopic dermatitis (AD) is a complex heterogeneous chronic inflammatory skin disease. Specific IgE antibodies against autoantigens have been observed in a subgroup of AD patients, however, little is known about IgG-auto-reactivity in AD. To investigate the presence of autoreactive IgG antibodies, we performed autoantibody profiling of IgG in patients with AD of different severities and in healthy controls (HC).
First, we performed an untargeted screening in plasma samples from 40 severe AD (sAD) patients and 40 HC towards 1152 protein fragments on planar antigen microarrays. Next, based on the findings and addition of more fragments, a targeted antigen suspension bead array was designed to profile a cohort of 50 sAD patients, 123 patients with moderate AD (mAD), and 84 HC against 148 protein fragments representing 96 unique proteins.
Forty-nine percent of the AD patients showed increased IgG-reactivity to any of the four antigens representing keratin associated protein 17-1 (KRTAP17-1), heat shock protein family A (Hsp70) member 4 (HSPA4), S100 calcium binding proteins A12 (S100A12), and Z (S100Z). The reactivity was more frequent in the sAD patients (66%) than in those with mAD (41%), whereas only present in 25% of the HC. IgG-reactivity to S100A12, a protein including an antimicrobial peptide, was only observed in AD patients (13/173).
Autoantibody profiling of IgG-reactivity using microarray technology revealed an autoantibody-based subgroup in patients with AD. The four identified autoantigens and especially S100A12 could, if characterized further, increase the understanding of different pathogenic mechanisms behind AD and thereby enable better treatment.
Atopic dermatitis (AD) is a complex heterogeneous chronic inflammatory skin disease. Specific IgE antibodies against autoantigens have been observed in a subgroup of AD patients, however, little is known about IgG-auto-reactivity in AD. To investigate the presence of autoreactive IgG antibodies, we performed autoantibody profiling of IgG in patients with AD of different severities and in healthy controls (HC).
First, we performed an untargeted screening in plasma samples from 40 severe AD (sAD) patients and 40 HC towards 1152 protein fragments on planar antigen microarrays. Next, based on the findings and addition of more fragments, a targeted antigen suspension bead array was designed to profile a cohort of 50 sAD patients, 123 patients with moderate AD (mAD), and 84 HC against 148 protein fragments representing 96 unique proteins.
Forty-nine percent of the AD patients showed increased IgG-reactivity to any of the four antigens representing keratin associated protein 17-1 (KRTAP17-1), heat shock protein family A (Hsp70) member 4 (HSPA4), S100 calcium binding proteins A12 (S100A12), and Z (S100Z). The reactivity was more frequent in the sAD patients (66%) than in those with mAD (41%), whereas only present in 25% of the HC. IgG-reactivity to S100A12, a protein including an antimicrobial peptide, was only observed in AD patients (13/173).
Autoantibody profiling of IgG-reactivity using microarray technology revealed an autoantibody-based subgroup in patients with AD. The four identified autoantigens and especially S100A12 could, if characterized further, increase the understanding of different pathogenic mechanisms behind AD and thereby enable better treatment.
In the midst of January's Consumer Electronics Show (CES)—an annual spectacle showcasing the latest and greatest (and some not-so-great) technologies set to transform our daily lives and society at large—ASHA came to Las Vegas espousing a different message than most. Via the Healthy Communication & Popular Technology Initiative, ASHA promoted balanced use of technology and the irreplaceable role of face-to-face interaction in children's communication, social and overall development, along with the critical need to practice safe listening. Surprisingly, reception for ASHA's message among the audience of tech enthusiasts was highly positive. Below are observations from the show, as well as opportunities for ASHA members to become trusted sources of advice—through media, publi...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bezxbt
In the midst of January's Consumer Electronics Show (CES)—an annual spectacle showcasing the latest and greatest (and some not-so-great) technologies set to transform our daily lives and society at large—ASHA came to Las Vegas espousing a different message than most. Via the Healthy Communication & Popular Technology Initiative, ASHA promoted balanced use of technology and the irreplaceable role of face-to-face interaction in children's communication, social and overall development, along with the critical need to practice safe listening. Surprisingly, reception for ASHA's message among the audience of tech enthusiasts was highly positive. Below are observations from the show, as well as opportunities for ASHA members to become trusted sources of advice—through media, publi...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bezxbt
In the midst of January's Consumer Electronics Show (CES)—an annual spectacle showcasing the latest and greatest (and some not-so-great) technologies set to transform our daily lives and society at large—ASHA came to Las Vegas espousing a different message than most. Via the Healthy Communication & Popular Technology Initiative, ASHA promoted balanced use of technology and the irreplaceable role of face-to-face interaction in children's communication, social and overall development, along with the critical need to practice safe listening. Surprisingly, reception for ASHA's message among the audience of tech enthusiasts was highly positive. Below are observations from the show, as well as opportunities for ASHA members to become trusted sources of advice—through media, publi...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
In the midst of January's Consumer Electronics Show (CES)—an annual spectacle showcasing the latest and greatest (and some not-so-great) technologies set to transform our daily lives and society at large—ASHA came to Las Vegas espousing a different message than most. Via the Healthy Communication & Popular Technology Initiative, ASHA promoted balanced use of technology and the irreplaceable role of face-to-face interaction in children's communication, social and overall development, along with the critical need to practice safe listening. Surprisingly, reception for ASHA's message among the audience of tech enthusiasts was highly positive. Below are observations from the show, as well as opportunities for ASHA members to become trusted sources of advice—through media, publi...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
In the midst of January's Consumer Electronics Show (CES)—an annual spectacle showcasing the latest and greatest (and some not-so-great) technologies set to transform our daily lives and society at large—ASHA came to Las Vegas espousing a different message than most. Via the Healthy Communication & Popular Technology Initiative, ASHA promoted balanced use of technology and the irreplaceable role of face-to-face interaction in children's communication, social and overall development, along with the critical need to practice safe listening. Surprisingly, reception for ASHA's message among the audience of tech enthusiasts was highly positive. Below are observations from the show, as well as opportunities for ASHA members to become trusted sources of advice—through media, publi...
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Grooming.Here is part of the scenario for language origins favored on this blog: long ago our ancestors began losing body hair with potentially ruinous dangers to the species. It reduced the ability to form bonds based on grooming and it made it difficult to move with a baby who, in previous generations, held on tightly to mama 's hair. The solution was bonding via babbling and sharing responsibility for the baby. For a long time, the human lineage made meaningless sounds that provided emotional ties, and eventually particularly sounds became associated with specific things or people.I defend this argument by pointing out that vocal-based bonding still precedes language today. Infants go through a period of babbling before they talk and sometimes their babbling becomes quite social. Yo...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TrPUbW
In the midst of January's Consumer Electronics Show (CES)—an annual spectacle showcasing the latest and greatest (and some not-so-great) technologies set to transform our daily lives and society at large—ASHA came to Las Vegas espousing a different message than most. Via the Healthy Communication & Popular Technology Initiative, ASHA promoted balanced use of technology and the irreplaceable role of face-to-face interaction in children's communication, social and overall development, along with the critical need to practice safe listening. Surprisingly, reception for ASHA's message among the audience of tech enthusiasts was highly positive. Below are observations from the show, as well as opportunities for ASHA members to become trusted sources of advice—through media, publi...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Grooming.Here is part of the scenario for language origins favored on this blog: long ago our ancestors began losing body hair with potentially ruinous dangers to the species. It reduced the ability to form bonds based on grooming and it made it difficult to move with a baby who, in previous generations, held on tightly to mama 's hair. The solution was bonding via babbling and sharing responsibility for the baby. For a long time, the human lineage made meaningless sounds that provided emotional ties, and eventually particularly sounds became associated with specific things or people.I defend this argument by pointing out that vocal-based bonding still precedes language today. Infants go through a period of babbling before they talk and sometimes their babbling becomes quite social. Yo...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TrPUbW
Ulcerated lesions of the oral cavity have many underlying etiologic factors, most commonly infection, immune related, traumatic, or neoplastic. A detailed patient history is critical in assessing ulcerative oral lesions and should include a complete medical and medication history; whether an inciting or triggering trauma, condition, or medication can be identified; the length of time the lesion has been present; the frequency of episodes in recurrent cases; the presence or absence of pain; and the growth of the lesion over time. For multiple or recurrent lesions the presence or history of ulcers on the skin, genital areas, or eyes should be evaluated along with any accompanying systemic symptoms such as fever, arthritis, or other signs of underlying systemic disease. Biopsy may be indicated in many ulcerative lesions of the oral cavity although some are more suitable for clinical diagnosis. Neoplastic ulcerated lesions are notorious in the oral cavity for their ability to mimic benign ulcerative lesions, highlighting the essential nature of biopsy to establish a diagnosis in cases that are not clinically identifiable or do not respond as expected to treatment. Adjunctive tests may be required for final diagnosis of some ulcerated lesions especially autoimmune lesions. Laboratory tests or evaluation to rule out systemic disease may be also required for recurrent or severe ulcerations especially when accompanied by other symptoms. This discussion will describe the clinical and histopathologic characteristics of a variety of ulcerated lesions found in the oral cavity.
Ulcerated lesions of the oral cavity have many underlying etiologic factors, most commonly infection, immune related, traumatic, or neoplastic. A detailed patient history is critical in assessing ulcerative oral lesions and should include a complete medical and medication history; whether an inciting or triggering trauma, condition, or medication can be identified; the length of time the lesion has been present; the frequency of episodes in recurrent cases; the presence or absence of pain; and the growth of the lesion over time. For multiple or recurrent lesions the presence or history of ulcers on the skin, genital areas, or eyes should be evaluated along with any accompanying systemic symptoms such as fever, arthritis, or other signs of underlying systemic disease. Biopsy may be indicated in many ulcerative lesions of the oral cavity although some are more suitable for clinical diagnosis. Neoplastic ulcerated lesions are notorious in the oral cavity for their ability to mimic benign ulcerative lesions, highlighting the essential nature of biopsy to establish a diagnosis in cases that are not clinically identifiable or do not respond as expected to treatment. Adjunctive tests may be required for final diagnosis of some ulcerated lesions especially autoimmune lesions. Laboratory tests or evaluation to rule out systemic disease may be also required for recurrent or severe ulcerations especially when accompanied by other symptoms. This discussion will describe the clinical and histopathologic characteristics of a variety of ulcerated lesions found in the oral cavity.
(Source: Dysphagia)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TiU8lU
(Source: Dysphagia)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TiU8lU
Funding Opportunity RFA-AI-19-011 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits applications developing computational models of immunity that advance understanding of the mechanisms required to induce and/or maintain protective immunity to infectious pathogens, other than HIV, and/or vaccines against such pathogens. The main goal of this FOA is to advance development and application of computational models of immunity that are refined through iterative immunological experimentation to validate and improve the utility and robustness of the computational models. Another goal of this FOA is to make the computational models and data developed under this initiative readily available to the broader research community for further refinement or ...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
Funding Opportunity RFA-AI-19-011 from the NIH Guide for Grants and Contracts. This Funding Opportunity Announcement (FOA) solicits applications developing computational models of immunity that advance understanding of the mechanisms required to induce and/or maintain protective immunity to infectious pathogens, other than HIV, and/or vaccines against such pathogens. The main goal of this FOA is to advance development and application of computational models of immunity that are refined through iterative immunological experimentation to validate and improve the utility and robustness of the computational models. Another goal of this FOA is to make the computational models and data developed under this initiative readily available to the broader research community for further refinement or ...
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
1. THYROID HORMONE THERAPY Taking levothyroxine with breakfast may be fine for many patients
Volume 6 Issue 11
Heather Hofflich, DO
90,612 views
2. THYROID NODULES Risk of thyroid cancer based on thyroid ultrasound findings
Volume 7 Issue 1
Jamshid Farahiti, MD
86,024 views
3. HYPOTHYROIDISM Desiccated thyroid extract vs Levothyroxine in the treatment of hypothyroidism
Volume 6 Issue 8
Angela M. Leung, MD, MSc
53,659 views
4. THYROID CANCER High risk of thyroid cancer in patients with multinodular goiter
Volume 6 Issue 11
Jamshid Farahiti, MD
46,359 views
5. HYPOTHYROIDISM When is the best time to take thyroid hormone?
Volume 4 Issue 5
Whitney Woodmansee, MD
46,413 views
6. THYROID AND PREGNANCY First Trimester TSH levels between 2.5 and 5.0 are associated with increased pregnancy loss
Volume 3 Issue 8
Whitney Woodmansee, MD
34,091 views
7. THYROID HORMONE TESTS Determination of optimal TSH ranges for reflex Free T4 testing
Volume 11 Issue 2
Whitney W. Woodmansee MD
22,787 views
8. HYPERTHYROIDISM Thyroid tests on newborns within the first five days will detect neonatal hyperthyroidism
Volume 7 Issue 7
Heather Hofflich, DO
21,568 views
9. THYROID AND PREGNANCY Low TSH levels early on in pregnancy may be normal
Volume 9 Issue 10
Alan P. Farwell, MD, FACE
21,047 views
10. THYROID AND PREGNANCY Increasing levothyroxine doses early in pregnancy is associated with a lower risk for pregnancy loss in hypothyroid women
Volume 9 Issue 10
Shirin Haddady, MD
20,502 views
The post Check out the ten Top-viewed articles in 2018 – Clinical Thyroidology for the Public appeared first on American Thyroid Association.
1. THYROID HORMONE THERAPY Taking levothyroxine with breakfast may be fine for many patients
Volume 6 Issue 11
Heather Hofflich, DO
90,612 views
2. THYROID NODULES Risk of thyroid cancer based on thyroid ultrasound findings
Volume 7 Issue 1
Jamshid Farahiti, MD
86,024 views
3. HYPOTHYROIDISM Desiccated thyroid extract vs Levothyroxine in the treatment of hypothyroidism
Volume 6 Issue 8
Angela M. Leung, MD, MSc
53,659 views
4. THYROID CANCER High risk of thyroid cancer in patients with multinodular goiter
Volume 6 Issue 11
Jamshid Farahiti, MD
46,359 views
5. HYPOTHYROIDISM When is the best time to take thyroid hormone?
Volume 4 Issue 5
Whitney Woodmansee, MD
46,413 views
6. THYROID AND PREGNANCY First Trimester TSH levels between 2.5 and 5.0 are associated with increased pregnancy loss
Volume 3 Issue 8
Whitney Woodmansee, MD
34,091 views
7. THYROID HORMONE TESTS Determination of optimal TSH ranges for reflex Free T4 testing
Volume 11 Issue 2
Whitney W. Woodmansee MD
22,787 views
8. HYPERTHYROIDISM Thyroid tests on newborns within the first five days will detect neonatal hyperthyroidism
Volume 7 Issue 7
Heather Hofflich, DO
21,568 views
9. THYROID AND PREGNANCY Low TSH levels early on in pregnancy may be normal
Volume 9 Issue 10
Alan P. Farwell, MD, FACE
21,047 views
10. THYROID AND PREGNANCY Increasing levothyroxine doses early in pregnancy is associated with a lower risk for pregnancy loss in hypothyroid women
Volume 9 Issue 10
Shirin Haddady, MD
20,502 views
The post Check out the ten Top-viewed articles in 2018 – Clinical Thyroidology for the Public appeared first on American Thyroid Association.
1. THYROID HORMONE THERAPY Taking levothyroxine with breakfast may be fine for many patients
Volume 6 Issue 11
Heather Hofflich, DO
90,612 views
2. THYROID NODULES Risk of thyroid cancer based on thyroid ultrasound findings
Volume 7 Issue 1
Jamshid Farahiti, MD
86,024 views
3. HYPOTHYROIDISM Desiccated thyroid extract vs Levothyroxine in the treatment of hypothyroidism
Volume 6 Issue 8
Angela M. Leung, MD, MSc
53,659 views
4. THYROID CANCER High risk of thyroid cancer in patients with multinodular goiter
Volume 6 Issue 11
Jamshid Farahiti, MD
46,359 views
5. HYPOTHYROIDISM When is the best time to take thyroid hormone?
Volume 4 Issue 5
Whitney Woodmansee, MD
46,413 views
6. THYROID AND PREGNANCY First Trimester TSH levels between 2.5 and 5.0 are associated with increased pregnancy loss
Volume 3 Issue 8
Whitney Woodmansee, MD
34,091 views
7. THYROID HORMONE TESTS Determination of optimal TSH ranges for reflex Free T4 testing
Volume 11 Issue 2
Whitney W. Woodmansee MD
22,787 views
8. HYPERTHYROIDISM Thyroid tests on newborns within the first five days will detect neonatal hyperthyroidism
Volume 7 Issue 7
Heather Hofflich, DO
21,568 views
9. THYROID AND PREGNANCY Low TSH levels early on in pregnancy may be normal
Volume 9 Issue 10
Alan P. Farwell, MD, FACE
21,047 views
10. THYROID AND PREGNANCY Increasing levothyroxine doses early in pregnancy is associated with a lower risk for pregnancy loss in hypothyroid women
Volume 9 Issue 10
Shirin Haddady, MD
20,502 views
The post Check out the ten Top-viewed articles in 2018 – Clinical Thyroidology for the Public appeared first on American Thyroid Association.
1. THYROID HORMONE THERAPY Taking levothyroxine with breakfast may be fine for many patients
Volume 6 Issue 11
Heather Hofflich, DO
90,612 views
2. THYROID NODULES Risk of thyroid cancer based on thyroid ultrasound findings
Volume 7 Issue 1
Jamshid Farahiti, MD
86,024 views
3. HYPOTHYROIDISM Desiccated thyroid extract vs Levothyroxine in the treatment of hypothyroidism
Volume 6 Issue 8
Angela M. Leung, MD, MSc
53,659 views
4. THYROID CANCER High risk of thyroid cancer in patients with multinodular goiter
Volume 6 Issue 11
Jamshid Farahiti, MD
46,359 views
5. HYPOTHYROIDISM When is the best time to take thyroid hormone?
Volume 4 Issue 5
Whitney Woodmansee, MD
46,413 views
6. THYROID AND PREGNANCY First Trimester TSH levels between 2.5 and 5.0 are associated with increased pregnancy loss
Volume 3 Issue 8
Whitney Woodmansee, MD
34,091 views
7. THYROID HORMONE TESTS Determination of optimal TSH ranges for reflex Free T4 testing
Volume 11 Issue 2
Whitney W. Woodmansee MD
22,787 views
8. HYPERTHYROIDISM Thyroid tests on newborns within the first five days will detect neonatal hyperthyroidism
Volume 7 Issue 7
Heather Hofflich, DO
21,568 views
9. THYROID AND PREGNANCY Low TSH levels early on in pregnancy may be normal
Volume 9 Issue 10
Alan P. Farwell, MD, FACE
21,047 views
10. THYROID AND PREGNANCY Increasing levothyroxine doses early in pregnancy is associated with a lower risk for pregnancy loss in hypothyroid women
Volume 9 Issue 10
Shirin Haddady, MD
20,502 views
The post Check out the ten Top-viewed articles in 2018 – Clinical Thyroidology for the Public appeared first on American Thyroid Association.
(NIH/National Institute of Allergy and Infectious Diseases) Scientists funded by the National Institutes of Health have developed a new assay to accurately and easily count the cells that comprise the HIV reservoir, the stubborn obstacle to an HIV cure. This advance will enable researchers who are trying to eliminate the HIV reservoir to clearly understand whether their strategies are working. The research was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of NIH. (Source: EurekAlert! - Infectious and Emerging Diseases)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
(NIH/National Institute of Allergy and Infectious Diseases) Scientists funded by the National Institutes of Health have developed a new assay to accurately and easily count the cells that comprise the HIV reservoir, the stubborn obstacle to an HIV cure. This advance will enable researchers who are trying to eliminate the HIV reservoir to clearly understand whether their strategies are working. The research was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of NIH. (Source: EurekAlert! - Infectious and Emerging Diseases)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
(NIH/National Institute of Allergy and Infectious Diseases) Scientists funded by the National Institutes of Health have developed a new assay to accurately and easily count the cells that comprise the HIV reservoir, the stubborn obstacle to an HIV cure. This advance will enable researchers who are trying to eliminate the HIV reservoir to clearly understand whether their strategies are working. The research was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of NIH. (Source: EurekAlert! - Infectious and Emerging Diseases)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
The possibility to obtain precise osteotomies without significant soft tissue damage represents a key point in modern approaches to rhinoplasty. In 2007, we first described the ultrasonic approach for percutaneous nasal bone osteotomies with minimal periosteal detachment.In this article, we retrospectively analyse the results of our piezosurgical rhinoplasty technique through our ten-year experience and describe the new perspectives of this technique.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S0mPr2
To present our experience with management of mandibular osteomyelitis with segmental resection, nerve preservation and immediate reconstruction with non-vascularized bone grafts.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CUmIDd
(NIH/National Institute of Allergy and Infectious Diseases) Scientists funded by the National Institutes of Health have developed a new assay to accurately and easily count the cells that comprise the HIV reservoir, the stubborn obstacle to an HIV cure. This advance will enable researchers who are trying to eliminate the HIV reservoir to clearly understand whether their strategies are working. The research was supported by the National Institute of Allergy and Infectious Diseases (NIAID), part of NIH. (Source: EurekAlert! - Infectious and Emerging Diseases)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
The possibility to obtain precise osteotomies without significant soft tissue damage represents a key point in modern approaches to rhinoplasty. In 2007, we first described the ultrasonic approach for percutaneous nasal bone osteotomies with minimal periosteal detachment.In this article, we retrospectively analyse the results of our piezosurgical rhinoplasty technique through our ten-year experience and describe the new perspectives of this technique.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S0mPr2
To present our experience with management of mandibular osteomyelitis with segmental resection, nerve preservation and immediate reconstruction with non-vascularized bone grafts.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2CUmIDd
The possibility to obtain precise osteotomies without significant soft tissue damage represents a key point in modern approaches to rhinoplasty. In 2007, we first described the ultrasonic approach for percutaneous nasal bone osteotomies with minimal periosteal detachment.In this article, we retrospectively analyse the results of our piezosurgical rhinoplasty technique through our ten-year experience and describe the new perspectives of this technique.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S0mPr2
The possibility to obtain precise osteotomies without significant soft tissue damage represents a key point in modern approaches to rhinoplasty. In 2007, we first described the ultrasonic approach for percutaneous nasal bone osteotomies with minimal periosteal detachment.In this article, we retrospectively analyse the results of our piezosurgical rhinoplasty technique through our ten-year experience and describe the new perspectives of this technique.
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2S0mPr2
To present our experience with management of mandibular osteomyelitis with segmental resection, nerve preservation and immediate reconstruction with non-vascularized bone grafts.
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Data from an 8-year study of 10,000 men aged 62 or older reveals a link between hearing loss and a markedly greater risk of subjective cognitive decline. (Source: Health News from Medical News Today)
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VANCOUVER, Wash. (AP) — Public health officials scrambling to contain a measles outbreak in the U.S. Northwest warned people to vaccinate their children Monday and worried that it could take months to contain the highly contagious viral illness due to a lower-than-normal vaccination rate at the epicenter of the crisis. The outbreak near Portland has sickened 35 people in Oregon and Washington since Jan. 1, with 11 more cases suspected. Most of the patients are children under 10, and one child has been hospitalized. Health officials say the outbreak is a textbook example of why it's critical to vaccinate against measles, which was eradicated in the U.S. after the vaccine was introduced in 1963. In recent years, however, the viral illness has popped up again from New York to California and...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GgA5ke
Data from an 8-year study of 10,000 men aged 62 or older reveals a link between hearing loss and a markedly greater risk of subjective cognitive decline. (Source: Health News from Medical News Today)
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VANCOUVER, Wash. (AP) — Public health officials scrambling to contain a measles outbreak in the U.S. Northwest warned people to vaccinate their children Monday and worried that it could take months to contain the highly contagious viral illness due to a lower-than-normal vaccination rate at the epicenter of the crisis. The outbreak near Portland has sickened 35 people in Oregon and Washington since Jan. 1, with 11 more cases suspected. Most of the patients are children under 10, and one child has been hospitalized. Health officials say the outbreak is a textbook example of why it's critical to vaccinate against measles, which was eradicated in the U.S. after the vaccine was introduced in 1963. In recent years, however, the viral illness has popped up again from New York to California and...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GgA5ke
Data from an 8-year study of 10,000 men aged 62 or older reveals a link between hearing loss and a markedly greater risk of subjective cognitive decline. (Source: Health News from Medical News Today)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
VANCOUVER, Wash. (AP) — Public health officials scrambling to contain a measles outbreak in the U.S. Northwest warned people to vaccinate their children Monday and worried that it could take months to contain the highly contagious viral illness due to a lower-than-normal vaccination rate at the epicenter of the crisis. The outbreak near Portland has sickened 35 people in Oregon and Washington since Jan. 1, with 11 more cases suspected. Most of the patients are children under 10, and one child has been hospitalized. Health officials say the outbreak is a textbook example of why it's critical to vaccinate against measles, which was eradicated in the U.S. after the vaccine was introduced in 1963. In recent years, however, the viral illness has popped up again from New York to California and...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2GgA5ke
Data from an 8-year study of 10,000 men aged 62 or older reveals a link between hearing loss and a markedly greater risk of subjective cognitive decline. (Source: Health News from Medical News Today)
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Authors: Carrol G, Conklin K Abstract Research into recurrent, highly conventionalized "formulaic" sequences has shown a processing advantage compared to "novel" (non-formulaic) language. Studies of individual types of formulaic sequence often acknowledge the contribution of specific factors, but little work exists to compare the processing of different types of phrases with fundamentally different properties. We use eye-tracking to compare the processing of three types of formulaic phrases-idioms, binomials, and collocations-and consider whether overall frequency can explain the advantage for all three, relative to control phrases. Results show an advantage, as evidenced through shorter reading times, for all three types. While overall phrase frequency contributes much of the proc...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SbmUaU
Authors: Baltazani M, Gryllia S, Arvaniti A Abstract We experimentally tested three hypotheses regarding the pragmatics of two tunes (one high-ending, one flat-ending) used with Greek wh-questions: (a) the high-ending tune is associated with information-seeking questions, while the flat-ending tune is also appropriate when wh-questions are not information-seeking, in which case their function can instead be akin to that of a statement; (b) the high-ending tune is more polite, and (c) more appropriate for contexts leading to information-seeking questions. The wh-questions used as experimental stimuli were elicited from four speakers in contexts likely to lead to either information-seeking or non-information-seeking uses. The speakers produced distinct tunes in response to the contex...
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Authors: Carrol G, Conklin K Abstract Research into recurrent, highly conventionalized "formulaic" sequences has shown a processing advantage compared to "novel" (non-formulaic) language. Studies of individual types of formulaic sequence often acknowledge the contribution of specific factors, but little work exists to compare the processing of different types of phrases with fundamentally different properties. We use eye-tracking to compare the processing of three types of formulaic phrases-idioms, binomials, and collocations-and consider whether overall frequency can explain the advantage for all three, relative to control phrases. Results show an advantage, as evidenced through shorter reading times, for all three types. While overall phrase frequency contributes much of the proc...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2SbmUaU
Authors: Baltazani M, Gryllia S, Arvaniti A Abstract We experimentally tested three hypotheses regarding the pragmatics of two tunes (one high-ending, one flat-ending) used with Greek wh-questions: (a) the high-ending tune is associated with information-seeking questions, while the flat-ending tune is also appropriate when wh-questions are not information-seeking, in which case their function can instead be akin to that of a statement; (b) the high-ending tune is more polite, and (c) more appropriate for contexts leading to information-seeking questions. The wh-questions used as experimental stimuli were elicited from four speakers in contexts likely to lead to either information-seeking or non-information-seeking uses. The speakers produced distinct tunes in response to the contex...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2UjBNVT
Date: Wednesday, 02 06, 2019; Speaker: Francisco Quintana; Building: Building 10 (Clinical Center); Lipsett Auditorium; Videocast Event (Source: NIH Calendar of Events)
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Date: Wednesday, 01 30, 2019; Speaker: Erin J. Adams; Building: Building 10 (Clinical Center); Lipsett Auditorium; Videocast Event (Source: NIH Calendar of Events)
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Date: Wednesday, 02 06, 2019; Speaker: Francisco Quintana; Building: Building 10 (Clinical Center); Lipsett Auditorium; Videocast Event (Source: NIH Calendar of Events)
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Date: Wednesday, 01 30, 2019; Speaker: Erin J. Adams; Building: Building 10 (Clinical Center); Lipsett Auditorium; Videocast Event (Source: NIH Calendar of Events)
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Connected hearing aid owners can now request a virtual consultation and receive a scheduling response within 24 to 48 hours. (Source: mobihealthnews)
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Connected hearing aid owners can now request a virtual consultation and receive a scheduling response within 24 to 48 hours. (Source: mobihealthnews)
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Connected hearing aid owners can now request a virtual consultation and receive a scheduling response within 24 to 48 hours. (Source: mobihealthnews)
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Connected hearing aid owners can now request a virtual consultation and receive a scheduling response within 24 to 48 hours. (Source: mobihealthnews)
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To find an optimal arc design for hybrid volumetric modulated arc therapy (H-VMAT), a combination of conventional 3DCRT and VMAT plans for left-sided whole breast radiation therapy.
A total of 26 left-sided early-stage breast cancer patients were selected for this study. To find the superior plan, H-VMAT with three different arc designs including, two partial arcs (2A), four partial arcs (4A) and four tangential arcs (TA) were created for each study case by combining 3DCRT and VMAT with 75% 3DCRT/25% VMAT dose proportion of prescription dose.
All H-VMAT plans achieved the expected target coverage. A higher conformity index and homogeneity index were achieved for 2A and 4A H-VMAT plans and significantly differ from TA H-VMAT (p < 0.003). The heart and ipsilateral lung dose parameters were comparable among all plans except heart V40Gy which was significantly less in 4A H-VMAT plan (p < 0.05). The contralateral lung, contralateral breast, spinal cord, normal tissue doses and MU were significantly less in TA H-VMAT (p < 0.03). The beam-on time was significantly less in 2A H-VMAT (p < 0.0001).
2A and 4A H-VMAT techniques are effective in improving the PTV dosimetric parameters as well as reducing the OAR doses. Further, 2A H-VMAT delivers less MU and beam-on time compared to 4A H-VMAT.
To find an optimal arc design for hybrid volumetric modulated arc therapy (H-VMAT), a combination of conventional 3DCRT and VMAT plans for left-sided whole breast radiation therapy.
A total of 26 left-sided early-stage breast cancer patients were selected for this study. To find the superior plan, H-VMAT with three different arc designs including, two partial arcs (2A), four partial arcs (4A) and four tangential arcs (TA) were created for each study case by combining 3DCRT and VMAT with 75% 3DCRT/25% VMAT dose proportion of prescription dose.
All H-VMAT plans achieved the expected target coverage. A higher conformity index and homogeneity index were achieved for 2A and 4A H-VMAT plans and significantly differ from TA H-VMAT (p < 0.003). The heart and ipsilateral lung dose parameters were comparable among all plans except heart V40Gy which was significantly less in 4A H-VMAT plan (p < 0.05). The contralateral lung, contralateral breast, spinal cord, normal tissue doses and MU were significantly less in TA H-VMAT (p < 0.03). The beam-on time was significantly less in 2A H-VMAT (p < 0.0001).
2A and 4A H-VMAT techniques are effective in improving the PTV dosimetric parameters as well as reducing the OAR doses. Further, 2A H-VMAT delivers less MU and beam-on time compared to 4A H-VMAT.
Publication date: Available online 30 January 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Cui-Ping Gong, Ying Luo, Ying-Ying PanAbstractWound dehiscence is a surgical complication and its management is inevitable because 25% to 35% of patients suffered from post laparotomy wound dehiscence. The excellent biodegradability and biocompatibility of chitosan and alginate have provided ample space for future developments in biomedical applications. Hence, the present work is directed towards the synthesis of robust biofilm made up of chitosan (CS), zinc oxide (ZnO) nanoparticles and Alginate (Alg). Chitosan and alginate were used for their pore forming ability, and ZnO is for its antibacterial action. The proposed biofilm was characterized with different character...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2sVuHv7
In conclusion, the findings showed the useful antioxidant, non-cytotoxic, antibacterial, and antifungal effects of A. Saralicum ethanolic extract.Graphical Abstract (Source: Journal of Photochemistry and Photobiology B: Biology)
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This study indicates that the human-induced pollution in coastal water, could have more severe impacts when combined with the stress induced by UVR. (Source: Journal of Photochemistry and Photobiology B: Biology)
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In this study, we revealed that the conversion of male gamete phototactic sign, positive to negative, was accelerated by mixing with female gametes. The supernatant after the centrifugation of female gamete suspension showed the same activity to change the phototactic sign, suggesting that a factor released from female gametes was responsible for the reaction. A known brown algal sex pheromone, ectocarpene, induced chemotaxis of male gametes of M. cylindricus. The addition of this compound induced the change of phototactic sign, clearly indicating that a sex pheromone is essential for the reversal. An inhibitor of phosphodiesterase, theophylline, inhibited the chemotaxis and phototactic sign reversion by a factor released from female gametes and ectocarpene. Measurements of cyclic nucleoti...
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. (Source: International Journal of Speech-Language Pathology)
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Authors: Rasmussen G, Andersen EM, Kristiansen ED PMID: 30693822 [PubMed - as supplied by publisher] (Source: Logopedics, Phoniatrics, Vocology.)
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. (Source: Aphasiology)
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CONCLUSIONS: Introducing an interactional perspective to self-directed speech and dialogue, this study provides new insights into the notion of a "good conversation" in dementia care. PMID: 30693814 [PubMed - as supplied by publisher] (Source: Logopedics, Phoniatrics, Vocology.)
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CONCLUSIONS: We argue that routine and ritual both provide constraints but also resources for PWDs to actively co-co-create new shared activities with co-present others, and we suggest that PWDs' possibilities for taking initiatives for activities during leisure time among other things rely on the routines that have already been established in interaction with care staff and others or on non-routine activities which PWDs may turn into routines as they re-establish them. PMID: 30693817 [PubMed - as supplied by publisher] (Source: Logopedics, Phoniatrics, Vocology.)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2sUffQ5
CONCLUSION: The study discusses how manipulation may be understood as care staff practices for making a residents' wishes fit the institutional constraints they are subjected to and for "doing what is best for the resident." PMID: 30693829 [PubMed - as supplied by publisher] (Source: Logopedics, Phoniatrics, Vocology.)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MLjJBK
Publication date: Available online 30 January 2019Source: Journal of Photochemistry and Photobiology B: BiologyAuthor(s): Cui-Ping Gong, Ying Luo, Ying-Ying PanAbstractWound dehiscence is a surgical complication and its management is inevitable because 25% to 35% of patients suffered from post laparotomy wound dehiscence. The excellent biodegradability and biocompatibility of chitosan and alginate have provided ample space for future developments in biomedical applications. Hence, the present work is directed towards the synthesis of robust biofilm made up of chitosan (CS), zinc oxide (ZnO) nanoparticles and Alginate (Alg). Chitosan and alginate were used for their pore forming ability, and ZnO is for its antibacterial action. The proposed biofilm was characterized with different character...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2sVuHv7
In conclusion, the findings showed the useful antioxidant, non-cytotoxic, antibacterial, and antifungal effects of A. Saralicum ethanolic extract.Graphical Abstract (Source: Journal of Photochemistry and Photobiology B: Biology)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
This study indicates that the human-induced pollution in coastal water, could have more severe impacts when combined with the stress induced by UVR. (Source: Journal of Photochemistry and Photobiology B: Biology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2sVuAzH
In this study, we revealed that the conversion of male gamete phototactic sign, positive to negative, was accelerated by mixing with female gametes. The supernatant after the centrifugation of female gamete suspension showed the same activity to change the phototactic sign, suggesting that a factor released from female gametes was responsible for the reaction. A known brown algal sex pheromone, ectocarpene, induced chemotaxis of male gametes of M. cylindricus. The addition of this compound induced the change of phototactic sign, clearly indicating that a sex pheromone is essential for the reversal. An inhibitor of phosphodiesterase, theophylline, inhibited the chemotaxis and phototactic sign reversion by a factor released from female gametes and ectocarpene. Measurements of cyclic nucleoti...
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MHfOFU
. (Source: International Journal of Speech-Language Pathology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2sVutUN
Authors: Rasmussen G, Andersen EM, Kristiansen ED PMID: 30693822 [PubMed - as supplied by publisher] (Source: Logopedics, Phoniatrics, Vocology.)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MEFG5n
. (Source: Aphasiology)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2sTwh0B
CONCLUSIONS: Introducing an interactional perspective to self-directed speech and dialogue, this study provides new insights into the notion of a "good conversation" in dementia care. PMID: 30693814 [PubMed - as supplied by publisher] (Source: Logopedics, Phoniatrics, Vocology.)
MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.
CONCLUSIONS: We argue that routine and ritual both provide constraints but also resources for PWDs to actively co-co-create new shared activities with co-present others, and we suggest that PWDs' possibilities for taking initiatives for activities during leisure time among other things rely on the routines that have already been established in interaction with care staff and others or on non-routine activities which PWDs may turn into routines as they re-establish them. PMID: 30693817 [PubMed - as supplied by publisher] (Source: Logopedics, Phoniatrics, Vocology.)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2sUffQ5
CONCLUSION: The study discusses how manipulation may be understood as care staff practices for making a residents' wishes fit the institutional constraints they are subjected to and for "doing what is best for the resident." PMID: 30693829 [PubMed - as supplied by publisher] (Source: Logopedics, Phoniatrics, Vocology.)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2MLjJBK
Our aim was to evaluate if epistaxis is directly associated with the etiology or pathophysiological mechanism which results in the syndrome itself or arises as a secondary effect.
We performed an extensive literature review of the web-based PubMed database from the National Library of Medicine to ascertain syndromes related to this condition. Etiology, pathophysiological mechanisms, occurrence, clinical features and management were noted for each of these syndromes.
Epistaxis is commonly seen in syndromes that are usually directly related to vascular abnormalities or coagulation defects. However, in some cases, it is not.
Since a number of these syndromes are rare and elaborate tests are not carried out in the absence of a positive family history or until other specific clinical features appear, a risk of underdiagnosis and the dilemma of whether epistaxis is specifically related to the syndrome or a secondary effect still remains.
Directional link between excessive screen time and lower scores in developmental tests Related items fromOnMedica Scotland reveals target of halving child obesity by 2030 Put families at heart of helping obese children Flu nasal spray fine for children with egg allergy Texting can improve flu jab uptake CCGs ' duties for children with disabilities (Source: OnMedica Latest News)
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Our aim was to evaluate if epistaxis is directly associated with the etiology or pathophysiological mechanism which results in the syndrome itself or arises as a secondary effect.
We performed an extensive literature review of the web-based PubMed database from the National Library of Medicine to ascertain syndromes related to this condition. Etiology, pathophysiological mechanisms, occurrence, clinical features and management were noted for each of these syndromes.
Epistaxis is commonly seen in syndromes that are usually directly related to vascular abnormalities or coagulation defects. However, in some cases, it is not.
Since a number of these syndromes are rare and elaborate tests are not carried out in the absence of a positive family history or until other specific clinical features appear, a risk of underdiagnosis and the dilemma of whether epistaxis is specifically related to the syndrome or a secondary effect still remains.
Directional link between excessive screen time and lower scores in developmental tests Related items fromOnMedica Scotland reveals target of halving child obesity by 2030 Put families at heart of helping obese children Flu nasal spray fine for children with egg allergy Texting can improve flu jab uptake CCGs ' duties for children with disabilities (Source: OnMedica Latest News)
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CONCLUSIONS: Adults with moderate-profound hearing loss, whose speech recognition has deteriorated, are no longer benefitting from HAs and fulfil defined criteria for straightforward CI, should be referred for formal CI candidacy evaluation. PMID: 30686138 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bd9Zvd
CONCLUSIONS: In order to enhance societal participation of people with deafblindness, a significant change in the focus of rehabilitation services is required which involves professionals viewing participation as both a means and an end outcome while designing interventions. PMID: 30686125 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TllsQz
CONCLUSIONS: Our data indicate that Atoh1 may have similar but partially different functions in the development of hair cells in the cochlea and vestibule. PMID: 30686130 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BbuLLE
CONCLUSIONS: Adults with moderate-profound hearing loss, whose speech recognition has deteriorated, are no longer benefitting from HAs and fulfil defined criteria for straightforward CI, should be referred for formal CI candidacy evaluation. PMID: 30686138 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2Bd9Zvd
CONCLUSIONS: In order to enhance societal participation of people with deafblindness, a significant change in the focus of rehabilitation services is required which involves professionals viewing participation as both a means and an end outcome while designing interventions. PMID: 30686125 [PubMed - as supplied by publisher] (Source: Disability and Rehabilitation)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2TllsQz
CONCLUSIONS: Our data indicate that Atoh1 may have similar but partially different functions in the development of hair cells in the cochlea and vestibule. PMID: 30686130 [PubMed - as supplied by publisher] (Source: Acta Oto-Laryngologica)
from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader http://bit.ly/2BbuLLE
The purpose of this study was to investigate the Gonial angle in relation to the position of the lingula using computerized image analysis to guide the oral surgeons to prevent injury to the inferior alveolar nerve and peripheral blood vessels during surgery.
We measured Gonial angle sizes of bilateral rami and the distances from the lingula tip to the mandibular notch (LN), the anterior (LA) and posterior (LP) margin of the mandibular ramus, the mandibular base (LB) and the occlusive plane (h) in 407 Chinese adults with CBCT.
In males, the mean distance of LN was 17.64 mm in the low Gonial angle group while 16.76 mm in the high Gonial angle group, which was significantly different between two groups (P < 0.001). The distance of LA in LGA group was obviously longer than that in HGA group (P < 0.001). The mean distance LP of men was 17.94 mm in LGA group while 16.9 mm in HGA group (P < 0.001). In females, the mean distance of LB in LGA group was 33.32 mm and 32.37 mm in HGA group (P < 0.01).
We discovered that the segment of the mandibular branch, between the mandibular lingula and the mandibular angle, was obviously smaller in the HGA group than that in the LGA group.
The purpose of this study was to investigate the Gonial angle in relation to the position of the lingula using computerized image analysis to guide the oral surgeons to prevent injury to the inferior alveolar nerve and peripheral blood vessels during surgery.
We measured Gonial angle sizes of bilateral rami and the distances from the lingula tip to the mandibular notch (LN), the anterior (LA) and posterior (LP) margin of the mandibular ramus, the mandibular base (LB) and the occlusive plane (h) in 407 Chinese adults with CBCT.
In males, the mean distance of LN was 17.64 mm in the low Gonial angle group while 16.76 mm in the high Gonial angle group, which was significantly different between two groups (P < 0.001). The distance of LA in LGA group was obviously longer than that in HGA group (P < 0.001). The mean distance LP of men was 17.94 mm in LGA group while 16.9 mm in HGA group (P < 0.001). In females, the mean distance of LB in LGA group was 33.32 mm and 32.37 mm in HGA group (P < 0.01).
We discovered that the segment of the mandibular branch, between the mandibular lingula and the mandibular angle, was obviously smaller in the HGA group than that in the LGA group.
Directional link between excessive screen time and lower scores in developmental tests Related items fromOnMedica Scotland reveals target of halving child obesity by 2030 Put families at heart of helping obese children Flu nasal spray fine for children with egg allergy Texting can improve flu jab uptake CCGs ' duties for children with disabilities (Source: OnMedica Latest News)
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Directional link between excessive screen time and lower scores in developmental tests Related items fromOnMedica Scotland reveals target of halving child obesity by 2030 Put families at heart of helping obese children Flu nasal spray fine for children with egg allergy Texting can improve flu jab uptake CCGs ' duties for children with disabilities (Source: OnMedica Latest News)
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to compare the radiographic marginal bone levels of implants placed in sites previously augmented with autogenous bone grafts and implants placed in native bone. Secondary outcomes included: implant survival, periodontal/peri‐implant parameters as well as short‐ and long‐term patient‐reported outcome measures.
The study was designed as a case‐control study including 38 patients equally distributed into two groups (previously augmented with autogenous bone blocks (AB) and implants placed in native bone (NB)). In total 67 implants were placed. Clinical, radiographic and patient‐reported outcome measures (PROMs) as well as complication rates were assessed based on a chart review and at a follow‐up examination (≧5 years after implant placement). Nonparametric mixed models were applied for the comparison of the two groups because of the clustered data. The data was analyzed descriptively, and p‐values were calculated using nonparametric mixed models to account for the clustered data.
The mean follow‐up time was 10.2 years (range 6‐13 years; AB) and 8.3 years (range 5‐16 years; NB). One implant was lost in group NB (97.5% survival rate) and none in group AB (100%). Following primary augmentation, six major complications (wound dehiscences, acute pulpitis, intra‐ and extraoral sensitivity disturbances) were observed at the donor sites. At time of implant placement, only minimal complications occurred and only in group NB. Median marginal bone levels at the follow‐up were significantly higher in group NB (1.15; Q1: 0.50 mm/Q3: 1.83 mm) than in group AB (1.58; Q1: 1.01 mm/Q3: 2.40 mm; p=0.0411). Probing depth, bleeding on probing and recession values were similar in both groups. PROMs revealed high visual analogue scale values (i.e. high satisfaction) for both procedures.
Dental implants placed in sites augmented with autogenous bone or in native bone revealed healthy peri‐implant tissues after 5‐16 years. Marginal bone levels were significantly higher for implant placed in native bone. Complications following primary augmentation encompassed every third patient but were mostly transient.
This article is protected by copyright. All rights reserved.
to compare the radiographic marginal bone levels of implants placed in sites previously augmented with autogenous bone grafts and implants placed in native bone. Secondary outcomes included: implant survival, periodontal/peri‐implant parameters as well as short‐ and long‐term patient‐reported outcome measures.
The study was designed as a case‐control study including 38 patients equally distributed into two groups (previously augmented with autogenous bone blocks (AB) and implants placed in native bone (NB)). In total 67 implants were placed. Clinical, radiographic and patient‐reported outcome measures (PROMs) as well as complication rates were assessed based on a chart review and at a follow‐up examination (≧5 years after implant placement). Nonparametric mixed models were applied for the comparison of the two groups because of the clustered data. The data was analyzed descriptively, and p‐values were calculated using nonparametric mixed models to account for the clustered data.
The mean follow‐up time was 10.2 years (range 6‐13 years; AB) and 8.3 years (range 5‐16 years; NB). One implant was lost in group NB (97.5% survival rate) and none in group AB (100%). Following primary augmentation, six major complications (wound dehiscences, acute pulpitis, intra‐ and extraoral sensitivity disturbances) were observed at the donor sites. At time of implant placement, only minimal complications occurred and only in group NB. Median marginal bone levels at the follow‐up were significantly higher in group NB (1.15; Q1: 0.50 mm/Q3: 1.83 mm) than in group AB (1.58; Q1: 1.01 mm/Q3: 2.40 mm; p=0.0411). Probing depth, bleeding on probing and recession values were similar in both groups. PROMs revealed high visual analogue scale values (i.e. high satisfaction) for both procedures.
Dental implants placed in sites augmented with autogenous bone or in native bone revealed healthy peri‐implant tissues after 5‐16 years. Marginal bone levels were significantly higher for implant placed in native bone. Complications following primary augmentation encompassed every third patient but were mostly transient.
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The association between diet and head and neck cancer (HNC) survival is unclear.
Cox proportional hazard models measured the association between fruit, vegetable, and deep‐fried food intake and HNC overall survival adjusting for clinical, social and lifestyle variables including smoking, alcohol, and HPV status.
Fruit and vegetable intake and improved survival were associated in minimally adjusted analyses. Following adjustment for smoking and alcohol consumption (fully adjusted analyses), the association with survival disappeared for fruit (HR 0.91, 95% CI 0.67, 1.23; P for trend = .55) and attenuated for vegetables (HR 0.79, 95% CI 0.61, 1.03; P for trend = .04). We observed no association between survival and deep‐fried food intake in minimally adjusted or fully adjusted analyses (HR 0.88 95% CI 0.72, 1.07; P for trend = .13).
Vegetable intake and HNC survival are modestly associated. There is some confounding by tobacco and alcohol consumption.
