Medicine by Alexandros G. Sfakianakis,Anapafseos 5 Agios Nikolaos 72100 Crete Greece,00302841026182,: 10/04/18

Πέμπτη 4 Οκτωβρίου 2018

Food‐induced fatal anaphylaxis: from epidemiological data to general prevention strategies

Clinical &Experimental Allergy, Volume 0, Issue ja, -Not available-.

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Concussion epidemiology in athletes who are deaf or hard-of-hearing compared with athletes who are hearing - Brancaleone MP, Clifton DR, Onate JA, Boucher LC.

OBJECTIVE: To compare the epidemiology of concussion between athletes who are deaf or hard-of-hearing (D/HoH) and athletes who are hearing. DESIGN: Descriptive epidemiology study. SETTING: Data were collected from 2 Division III athletic programs. ... (Source: SafetyLit)

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Panel Sheds Light on DBS Electrode Design Concerns

Traditionally there has always been a great deal of conversation surrounding deep brain stimulation (DBS) systems. However, this just hasnât been the case for one of the most important components of the technology â the electrode. A panel at MD&M Minneapolis, being moderated by Eric Sabelman, a Neurosurgery Bioengineer at Kaiser Permanente, could help change the conversation and put the focus on electrodes. The panel is titled Deep Brain Stimulation: How Will New Electrodes Improve Results? âThe particular reason I think for having a panel, is the electrode itself rarely gets a lot of attention in the professional society meetings,â Sabelman, told MD+DI. âHaving a panel of people that are knowled...

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Concussion epidemiology in athletes who are deaf or hard-of-hearing compared with athletes who are hearing - Brancaleone MP, Clifton DR, Onate JA, Boucher LC.

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Zimbabwe:Sign Language for HIV/Aids Counsellors

[The Herald] The National Aids Council, in conjunction with Government, recently conducted a training workshop for HIV and Aids counsellors for the deaf after it emerged that they were not easily accessing information regarding the infection and the disease. (Source: AllAfrica News: HIV-Aids and STDs)

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Deaf or Dead? The Unbearable Choice for some TB Patients

Phumeza Tisile is a student at the University of Cape Town and an advocate working to help eradicate TBBy Phumeza TisileCAPE TOWN, Oct 3 2018 (IPS)Like death, hearing loss is irreversible. I never imagined that I would have to choose between the two until seven years ago when I became infected with tuberculosis (TB), a contagious disease caused by an airborne bacterium. TB is curable, but some strains are resistant to first line treatment, which can be the beginning of a nightmare for the infected person, as I found out in 2010. I was in the first year of undergraduate studies at the Cape Peninsula University of Technology in South Africa. Life was normal. I had normal conversations with people. I listened to music and watched TV shows with no subtitles. I could hear.Things changed when I ...

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Turn up the volume: The latest in hearing aids

Two out of three people over age 70 have trouble hearing, but only about 20% of adults who have hearing loss actually use a hearing aid, for the most part because of costs related to the devices themselves and to testing and consultations with a doctor or audiologist. David Pogue checks out the latest advances in hearing aid technology that have reduced size and added unique features, and finds out what changes consumers can anticipate after Congress passed a bill allowing hearing aids to be sold over-the-counter. (Source: Health News: CBSNews.com)

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Listen Up, This Hearing Aid Stock Is Set To Take Off

One way to play the tech innovations for hearing aids. (Source: Forbes.com Healthcare News)

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Study Supports Oxygen Therapy for Sudden Hearing Loss

Title: Study Supports Oxygen Therapy for Sudden Hearing LossCategory: Health NewsCreated: 9/27/2018 12:00:00 AMLast Editorial Review: 9/28/2018 12:00:00 AM (Source: MedicineNet Hearing General)

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Concussion epidemiology in athletes who are deaf or hard-of-hearing compared with athletes who are hearing - Brancaleone MP, Clifton DR, Onate JA, Boucher LC.

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Listen Up, This Hearing Aid Stock Is Set To Take Off

One way to play the tech innovations for hearing aids. (Source: Forbes.com Healthcare News)

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Deaf or Dead? The Unbearable Choice for some TB Patients

Zimbabwe:Sign Language for HIV/Aids Counsellors

Turn up the volume: The latest in hearing aids

Study Supports Oxygen Therapy for Sudden Hearing Loss

Listen Up, This Hearing Aid Stock Is Set To Take Off

One way to play the tech innovations for hearing aids. (Source: Forbes.com Healthcare News)

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Study of Auditory Performance on Prosodic Tests in Cochlear Implanted Subjects Using a Fine Structure Strategy

Condition: Sensorineural Hearing Loss, Bilateral Intervention: Device: FineHearing strategy Sponsor: Med-El Elektromedizinische Geraete GmbH Not yet recruiting (Source: ClinicalTrials.gov)

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Optimization of Cochlear Implant MAP-parameters in Children

Conditions: Cochlear Implants; Evoked Potentials, Auditory; Child; Disabilities Hearing; Deafness; Hearing Intervention: Other: Re-programming of cochlear implant Sponsors: Göteborg University; Vastra Gotaland Region Not yet recruiting (Source: ClinicalTrials.gov)

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Clinical efficacy of sublingual immunotherapy is associated with restoration of steady-state serum lipocalin 2 after SLIT: a pilot study

ConclusionSerum LCN2 concentrations 9 months off-SLIT correlated with clinical reactivity in allergic patients. An increase in the LCN2 levels 9 months after HDM-SLIT was associated with a clinical benefit. Serum LCN2 may thus contribute to assess clinical reactivity in allergic patients.Trial registrationPart of the data were generated fromclinicaltrials.gov Identifier NCT01644617. (Source: World Allergy Organization Journal)

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Allergy diagnosis from symptoms to molecules, or from molecules to symptoms: a comparative clinical study

ConclusionsFor the diagnostic verification of clinically suspected allergy, the novel concept "from molecules to clinic" offers a reliable diagnostic workup in shorter time. Due to lower skin test numbers it is especially applicable for young children and seniors, in atopic patients, and whenever skin tests get difficult or unreliable. (Source: World Allergy Organization Journal)

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DYE-FREE CHILDRENS ALLERGY (Diphenhydramine Hydrochloride) Solution [Aurohealth LLC]

Updated Date: Sep 28, 2018 EST (Source: DailyMed Drug Label Updates)

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CHILDRENS COLD AND ALLERGY (Brompheniramine Maleate And Phenylephrine Hcl) Solution [Aurohealth LLC]

Updated Date: Sep 28, 2018 EST (Source: DailyMed Drug Label Updates)

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Concussion epidemiology in athletes who are deaf or hard-of-hearing compared with athletes who are hearing - Brancaleone MP, Clifton DR, Onate JA, Boucher LC.

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Panel Sheds Light on DBS Electrode Design Concerns

Deaf or Dead? The Unbearable Choice for some TB Patients

Zimbabwe:Sign Language for HIV/Aids Counsellors

Turn up the volume: The latest in hearing aids

Study Supports Oxygen Therapy for Sudden Hearing Loss

Listen Up, This Hearing Aid Stock Is Set To Take Off

One way to play the tech innovations for hearing aids. (Source: Forbes.com Healthcare News)

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Optimization of Cochlear Implant MAP-parameters in Children

DYE-FREE CHILDRENS ALLERGY (Diphenhydramine Hydrochloride) Solution [Aurohealth LLC]

Updated Date: Sep 28, 2018 EST (Source: DailyMed Drug Label Updates)

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ALL DAY ALLERGY RELIEF (Cetirizine Hcl) Tablet [McKesson (Health Mart)]

Updated Date: Sep 27, 2018 EST (Source: DailyMed Drug Label Updates)

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FLUAD vs. FLUZONE HD Influenza Vaccine in Residents of Long Term Care

Condition: Flu Interventions: Drug: Fluad Vaccine; Drug: Fluzone HD Vaccine Sponsors: David H. Canaday; Case Western Reserve University; US Department of Veterans Affairs; Brown University; National Institutes of Health (NIH); National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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Food Allergy Diagnostic Test Response to Previous Oral Challenge Response

Condition: Food Hypersensitivity Intervention: Other: Conjunctival Allergen Challenge Sponsor: ORA, Inc. Completed (Source: ClinicalTrials.gov)

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The Effect of Different Dental Implant Surface Characteristics on Immunological and Microbiological Parameters

Conditions: Peri-implant Mucositis; Peri-Implantitis Interventions: Other: PICF, Perio-paper®; Other: Subgingival Plaque, Hu-Friedy®; Other: Williams probe, PCPNU-15 Hu-Friedy®; Other: Demographic Sponsor: Necmettin Erbakan University Completed (Source: ClinicalTrials.gov)

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Immunological and Functional Characterization of Cellular Population CD45+ Infiltrating Human Glioblastoma

Condition: Glioblastoma Intervention: Other: no intervention Sponsor: Centre Hospitalier Universitaire, Amiens Recruiting (Source: ClinicalTrials.gov)

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Imaging Immune Activation in HIV by PET-MR

Condition: HIV Infections Intervention: Drug: [18F]F-AraG (2'-deoxy-2'-fluoro-9-β-D-arabinofuranosylguanine) Sponsors: University of California, San Francisco; National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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Study to Assess Tolerance of Traces in Peanut/Tree Nut Allergic Children.

Conditions: Food Allergy; Peanut Allergy; Tree Nut Allergy Intervention: Other: Oral food challenge to foods with traces Sponsor: University Hospital, Geneva Recruiting (Source: ClinicalTrials.gov)

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Evaluation of EB01 Cream for the Treatment of Chronic Allergic Contact Dermatitis

Condition: Allergic Contact Dermatitis Interventions: Drug: EB01 Cream Placebo; Drug: EB01 Cream 0.2%; Drug: EB01 Cream 1.0%; Drug: EB01 Cream 2.0% Sponsors: Edesa Biotech Inc.; Innovaderm Research Inc. Not yet recruiting (Source: ClinicalTrials.gov)

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Effect of Health Promotion on Allergic Rhinitis by Infrared-C Ray Irradiation

Condition: Allergic Rhinitis Interventions: Device: infrared-C ray irradiation; Device: eye mask; Drug: Xyzal Oral Product; Drug: Fluticasone Furoate Sponsors: Nanhua University; Buddhist Tzu Chi General Hospital; Solano Semiconductor Technology., LTD. Completed (Source: ClinicalTrials.gov)

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Genetic Factors and Immunological Determinism of Persistent Consequences of Chikungunya

Condition: Chikungunya Fever Interventions: Other: Quality of life survey; Genetic: Saliva collection; Genetic: Blood collection Sponsors: Centre Hospitalier Universitaire de la Réunion; Conservatoire national des Arts et Métiers Recruiting (Source: ClinicalTrials.gov)

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Imaging Immune Activation in HIV by PET-MR

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Study to Assess Tolerance of Traces in Peanut/Tree Nut Allergic Children.

Evaluation of EB01 Cream for the Treatment of Chronic Allergic Contact Dermatitis

Effect of Health Promotion on Allergic Rhinitis by Infrared-C Ray Irradiation

Psychoacoustic classification of persistent tinnitus

ConclusionClassifying persistent tinnitus as pure tone or noise, present in high or low frequency and establishing its different characteristics allow us to know its peculiarities and the effects of this symptom in patients' lives.ResumoIntroduçãoO zumbido é um sintoma de difícil tratamento, com respostas diferentes nos pacientes. É classificado de formas diversas, de acordo com a origem ou doenças associadas.ObjetivoPropor uma classificação única e mensurável do zumbido persistente, por meio da sua percepção como sons da natureza ou da vida cotidiana e da sua comparação com o tom puro ou o ruído, de pitch alto ou baixo, apresentados ao paciente pelos sons do audiômetro.MétodoParticiparam 110 pacientes adultos, de ambos os sexos, atendidos no Ambulatório de Zumbido, ten...

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Is there a best side for cochlear implants in post-lingual patients?

ConclusionThe cochlear implant in the ear with the worst auditory residue favors a bimodal hearing, which would allow the binaural summation, without compromising the improvement of the audiometric threshold and the speech perception.ResumoIntroduçãoO implante coclear é uma prótese sensorial capaz de restaurar a audição em pacientes com perda auditiva neurossensorial bilateral severa ou profunda.ObjetivoAvaliar se há um melhor lado para o implante coclear em pacientes pós-linguais.MétodoEstudo longitudinal retrospectivo; incluiu 40 indivíduos, de ambos os sexos, idade média de 47 anos, com perda auditiva pós-lingual, usuários de implante coclear unilateral por mais de 12 meses e menos de 24 meses, com perda auditiva assimétrica entre as orelhas (diferença de 10 dBNA, em pelo...

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Audiological outcomes in sudden sensorineural hearing loss with presumed inner ear hemorrhage

ConclusionsProfound sudden sensorineural hearing loss caused by inner ear hemorrhage often has an unsatisfactory prognosis. However, this cohort did experience partial audiological recovery with delayed onset. Immediate and effective intratympanic corticosteroid may have therapeutic potential for this intractable disease. (Source: American Journal of Otolaryngology)

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Management of spontaneous temporal bone cerebrospinal fluid leak: A 30-year experience

ConclusionThere is an increase in the incidence of spontaneous CSF leaks possibly associated with an increase in BMI in the United States over the last 30 years. (Source: American Journal of Otolaryngology)

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More than keratitis, ichthyosis, and deafness: multisystem effects of lethal GJB2 mutations

Infant death in KID syndrome is recognized; its association with specific genotypes and pathophysiology is inadequately understood. (Source: Journal of the American Academy of Dermatology)

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Unilateral congenital malformations of middle ear with intact external ear: a review of 64 cases

ConclusionUnilateral congenital middle ear malformations with intact external ear can be complex and diverse. Functional ossiculoplasty for patients with unilateral congenital middle ear malformations can achieve good hearing outcomes. (Source: European Archives of Oto-Rhino-Laryngology)

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American Sign Language Interpreters Perceptions of Barriers to Healthcare Communication in Deaf and Hard of Hearing Patients

AbstractCommunication barriers between healthcare providers and patients contribute to health disparities and the effectiveness of health promotion messages. This is especially true regarding communication between providers and deaf and hard of hearing (HOH) patients due to lack of understanding of cultural and linguistic differences, ineffectiveness of various means of communication and level of health literacy within that population. This research aimed to identify American Sign Language (ASL) interpreters ' perceptions of barriers to effective communication between deaf and HOH patients and healthcare providers. We conducted a survey of ASL interpreters attending the 2015 National Symposium on Healthcare Interpreting with an overall response rate of 25%. Results indicated a significan...

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The impact of rehabilitation on quality of life after hearing loss: a systematic review

ConclusionFrom these findings, we concluded that hearing rehabilitation does have a positive impact on quality of life after hearing loss. (Source: European Archives of Oto-Rhino-Laryngology)

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Psychoacoustic classification of persistent tinnitus

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Is there a best side for cochlear implants in post-lingual patients?

Audiological outcomes in sudden sensorineural hearing loss with presumed inner ear hemorrhage

Management of spontaneous temporal bone cerebrospinal fluid leak: A 30-year experience

American Sign Language Interpreters Perceptions of Barriers to Healthcare Communication in Deaf and Hard of Hearing Patients

The impact of rehabilitation on quality of life after hearing loss: a systematic review

ConclusionFrom these findings, we concluded that hearing rehabilitation does have a positive impact on quality of life after hearing loss. (Source: European Archives of Oto-Rhino-Laryngology)

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Interaural Time Difference Perception with a Cochlear Implant and a Normal Ear

AbstractCurrently there is a growing population of cochlear-implant (CI) users with (near) normal hearing in the non-implanted ear. This configuration is often called SSD (single-sided deafness) CI. The goal of the CI is often to improve spatial perception, so the question raises to what extent SSD CI listeners are sensitive to interaural time differences (ITDs). In a controlled lab setup, sensitivity to ITDs was investigated in 11 SSD CI listeners. The stimuli were 100-pps pulse trains on the CI side and band-limited click trains on the acoustic side. After determining level balance and the delay needed to achieve synchronous stimulation of the two ears, the just noticeable difference in ITD was measured using an adaptive procedure. Seven out of 11 listeners were sensitive to ITDs, with a...

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Association Between Type 2 Diabetes Mellitus and Hearing Loss Among Patients in a Coastal City of South India

AbstractDiabetes mellitus (DM) is a metabolic culprit known to perpetuate several disease processes. The relationship between hearing loss (HL) and type 2 DM (T2DM) remains unclear despite the vast volume of research devoted to this topic. We conducted this study with the aim to evaluate HL among T2DM patients and to assess the relationship between severity of HL, glycosylated hemoglobin (HbA1c) levels and duration of T2DM. Design: a time bound descriptive crosssectional study. Setting: tertiary care hospital of South India. Subjects: subjects with T2DM, aged from 40 to 60 years (excluding hypertension, chronic noise exposure and history of smoking or ototoxicity) were included. Methods: Non-random convenience sampling. Details were gathered using a self-administered, semistructured ques...

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Clinical profile of childhood blindness and inappropriate enrolment of children in schools for visually impaired in Uttar Pradesh, India

Conclusion: Schools for the blind should be screened routinely to reduce the incidence of misdiagnosed visual impairment. This will prevent inappropriate enrolment and will definitely help in reducing the social and economic burden of society and of the schools of blind too. (Source: Indian Journal of Ophthalmology)

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Punk-Rocker-Turned-Audiologist Protects Musicians ’ Hearing

Audiologist Anthony Kovacs understands the hearing dangers of being a musician. Before he began spending his days protecting peoples' hearing, he put his own at risk. Kovacs sang with punk band Shot Baker—he still performs and records with them occasionally—and worked at live music venues when he wasn't on stage. Now he focuses his full-time practice on treating people with tinnitus. He still goes to music festivals and performances, but usually as more than an audience member. Last month he took a group of audiology students from his alma mater—University of Northern Colorado—to the Bohemian Nights festival. The group spent their time fitting performers, stagehands, venue crew, sound engineers and others working the festival with custom earplugs. Working in an unregulated ind...

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Let me introduce you to zein

Zein is a protein in corn ("maize" outside the U.S.) that, if held side-by-side against the gliadin protein of wheat, rye, or barley, overlaps substantially in structure (i.e., amino acid sequence). In other words, the zein protein of corn resembles the gliadin protein of other grains—not identical but with overlapping similarities in structure. This should come as no surprise, as corn and other grains share evolutionary history as grasses, not to mention ongoing exchange of genetic material over eons, given the impressive promiscuity of grasses and their ability to share and combine genetic material. (Recall how 14-chromosome ancient einkorn wheat mated with various wild grasses over the last several thousand years to yield modern 42-chromosome Triticum aestivum wheat....

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Chronic Allograft Injury Common Among Pediatric Liver-transplant Recipients Chronic Allograft Injury Common Among Pediatric Liver-transplant Recipients

A substantial proportion of pediatric liver-transplant patients with normal liver tests have varying degrees of subclinical chronic allograft injury, according to new findings.Reuters Health Information (Source: Medscape Allergy Headlines)

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Childhood Secondhand Smoke Exposure Tied to Arthritis in Adulthood Childhood Secondhand Smoke Exposure Tied to Arthritis in Adulthood

Women exposed to secondhand smoke as children may be more likely to develop rheumatoid arthritis than people who didn't breathe cigarette fumes growing up, a French study suggests.Reuters Health Information (Source: Medscape Allergy Headlines)

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Guideline-Recommended Antibiotics Suffice to Treat CAP in Children Under Five Guideline-Recommended Antibiotics Suffice to Treat CAP in Children Under Five

Young children with community-acquired pneumonia (CAP) can be managed with guideline-recommended antibiotics, without additional diagnostics such as chest X-rays (CXRs) or complete blood counts (CBCs), researchers say.Reuters Health Information (Source: Medscape Allergy Headlines)

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Labeling Hospitalized Kids as Antibiotic-Allergic Tied to Worse Outcomes Labeling Hospitalized Kids as Antibiotic-Allergic Tied to Worse Outcomes

Pediatric inpatients labeled as allergic to antibiotics have worse clinical outcomes than hospitalized children without this label, new research from Australia suggests.Reuters Health Information (Source: Medscape Allergy Headlines)

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Let me introduce you to zein

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Chronic Allograft Injury Common Among Pediatric Liver-transplant Recipients Chronic Allograft Injury Common Among Pediatric Liver-transplant Recipients

Labeling Hospitalized Kids as Antibiotic-Allergic Tied to Worse Outcomes Labeling Hospitalized Kids as Antibiotic-Allergic Tied to Worse Outcomes

Low-Dose Oral Food Challenge with Hazelnut: Efficacy and Tolerability in Children

Conclusions: To our knowledge, this was the first study to assess the efficacy and tolerability of H-LDOFC in a pediatric population. Our study suggests that in children with HA, H-LDOFC is well accepted and safe because adverse reactions are mild and the majority are represented by localized symptoms (oral allergy syndrome) and efficient, especially in terms of improvement of quality of life. For these reasons it could be more extensively used in the treatment of HA.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

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Fric Test Revisited: A Suggestion for a New Scoring System and Its Correlation with Urticaria Control Test and Dermatology Life Quality Index

Conclusions: This new Fric scoring system allows comparison with other tools and shows moderate correlations with most of the tools. Using disease-specific tools is recommended since they provide a subjective evaluation of disease severity, QoL impairment, and disease control.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

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Sensitization to Common Aeroallergens in the Atopic Population of West Bengal, India: An Investigation by Skin Prick Test

Conclusion: Following the increasing trend, house dust mite sensitization still held the dominance like in any other Indian population reported earlier. This study would pave the way to construct a standard and minimal SPT panel for the atopic patients of eastern India.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

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Antihistamines: Recommended Dosage – Divergence between Clinical Practice and Guideline Recommendations

The updosing of second-generation antihistamines for chronic urticaria is based on inconsistent findings. Herein, we report data on the treatment of children with chronic spontaneous urticaria (CSU) unresponsive to single doses of second-generation H(1)-antihistamines in whom an increase in antihistamine was performed without improvement and with a high prevalence of adverse events. Thus, it appears that well-controlled, well-designed clinical trials are needed to clarify which nonsedating antihistamines should be used, in what dose, and for how long in patients not responding to the standard treatment, despite the improvement in health care that guidelines help to incorporate. Furthermore, a critical use of such guidelines should be done to improve the knowledge in CSU, especially in the ...

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Fric Test Revisited: A Suggestion for a New Scoring System and Its Correlation with Urticaria Control Test and Dermatology Life Quality Index

Sensitization to Common Aeroallergens in the Atopic Population of West Bengal, India: An Investigation by Skin Prick Test

Antihistamines: Recommended Dosage – Divergence between Clinical Practice and Guideline Recommendations

Deletions in < b > < i > SERPING1 < /i > < /b > Lead to Lower C1 Inhibitor Function: Lower C1 Inhibitor Function Can Predict Disease Severity

Conclusion: Deletion mutations may represent the most unfavorable effect on C1 inhibitor function. The earlier disease onset age could be a sign for lower C1 inhibitor function levels in adult life. C1q levels could also be low in C1-INH-HAE patients, as in acquired angioedema. Lower C1 inhibitor function can predict disease severity and may have negative impacts on the course of C1-INH-HAE.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

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Allergen Immunization Induces Major Changes in Microbiota Composition and Short-Chain Fatty Acid Production in Different Gut Segments in a Mouse Model of Lupine Food Allergy

Conclusions: Allergen immunization with CT in the present food allergy model induced profound changes in the microbiome composition and SCFA production. The result suggests that the colon may be the most sensitive gut segment for investigating changes in the gut microbiome.Int Arch Allergy Immunol (Source: International Archives of Allergy and Immunology)

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Albuminuria Linked to COPD

(MedPage Today) -- Findings suggest role for endothelial damage in the lung disease (Source: MedPage Today Allergy)

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UCLA researchers discover aggressive prostate and lung cancers are driven by common mechanisms

UCLA researchers have discovered a common process in the development of late-stage, small cell cancers of the prostate and lung. These shared molecular mechanisms could lead to the development of drugs to treat not just prostate and lung cancers, but small cell cancers of almost any organ.The key finding: Prostate and lung cells have very different patterns of gene expression when they 're healthy, but almost identical patterns when they transform into small cell cancers. The research suggests that different types of small cell tumors evolve similarly, even when they come from different organs.The study, led by Dr. Owen Witte, founding director of the UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and professor of microbiology, immunology and molecular g...

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Childhood Risk Profiles Affect Middle - Age Lung Function

Children with frequent asthma, allergies who smoke as adults are most vulnerable group (Source: Pulmonary Medicine News - Doctors Lounge)

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Chronic Allograft Injury Common Among Pediatric Liver-transplant Recipients Chronic Allograft Injury Common Among Pediatric Liver-transplant Recipients

Childhood Secondhand Smoke Exposure Tied to Arthritis in Adulthood Childhood Secondhand Smoke Exposure Tied to Arthritis in Adulthood

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FDA grants approval of Xolair (omalizumab) prefilled syringe formulation

Roche announced today that the U.S. Food and Drug Administration (FDA) has approved 75 mg/0.5 mL and 150 mg/1 mL single-dose prefilled syringes (PFS) for Xolair ® (omalizumab) as an additional formulation for both allergic asthma and chronic idiopathic urticaria (CIU) indications. (Source: Roche Investor Update)

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What is the Blood Culture Recovery Rate After Antibiotic Pretreatment?

Discussion Sepsis is an inflammatory response syndrome in the presence of an infection, it can be caused by bacteria, viruses or fungi. Bacteremia is the presence of bacteria in the blood. Studies from the US show an increased incidence of sepsis (0.56 to 0.89 cases/1000 children in all age groups) but a decreased fatality rate from 10.3% to 8.9%. The prevalence of severe sepsis in pediatric intensive care settings is reported in as many as 7.7% of admissions. Severe sepsis is more common when patients have co-morbities. Primary prevention includes immunization and appropriate precautions and procedures (i.e. catheter access) in hospitalized children or those with chronic medical needs. Prophylactic antibiotics for patients with neutropenia are also a secondary intervention. Sepsis can be...

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Were you breastfed? You'll earn more

Scientists at Queen's University Belfast, who led the study of 9,000 people, believe breastfeeding improves the development of the brain and reduces the risk of allergies and illness. (Source: the Mail online | Health)

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10 Year evaluation of patients with severe uncontrolled allergic asthma treated with Omalizumab.

Conference abstracts (Source: The Aspergillus Website - updates)

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UCLA researchers discover aggressive prostate and lung cancers are driven by common mechanisms

Guideline-Recommended Antibiotics Suffice to Treat CAP in Children Under Five Guideline-Recommended Antibiotics Suffice to Treat CAP in Children Under Five

Labeling Hospitalized Kids as Antibiotic-Allergic Tied to Worse Outcomes Labeling Hospitalized Kids as Antibiotic-Allergic Tied to Worse Outcomes

Physician experts highlight research ahead of Otolaryngology's Annual Meeting

(American Academy of Otolaryngology - Head and Neck Surgery) The latest research on ear health, head and neck cancer, sleep-disordered breathing, rhinology and allergy, facial plastics, laryngology and swallowing disorders, endocrine surgery, and other topics related to otolaryngology-head and neck surgery will be presented in Atlanta, Ga., October 7-10, during the 2018 Annual Meeting& OTO Experience of the American Academy of Otolaryngology-Head and Neck Surgery Foundation. (Source: EurekAlert! - Medicine and Health)

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Ocular involvement in atopic disease: a review

Purpose of review To provide a review of the potential sight-threatening sequelae associated with ocular involvement of atopic disease and to discuss the management of this chronic condition. Recent findings There has been a recognition that atopic keratoconjunctivitis (AKC) is a chronic, inflammatory and potentially blinding disease. Recent efforts have focused on steroid sparing, systemic T cell and calcineurin inhibitor medications for the treatment of severe disease. Summary Ocular involvement in atopic disease can have a variety of clinical manifestations. Progressive disease can be vision threatening, especially in younger patients. Prompt and effective treatment through a multidisciplinary approach, including ophthalmology, allergy and immunology and dermatology, can permit ...

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Chronic Allograft Injury Common Among Pediatric Liver-transplant Recipients Chronic Allograft Injury Common Among Pediatric Liver-transplant Recipients

The current status of the magnocellular theory of developmental dyslexia

Publication date: Available online 26 March 2018Source: NeuropsychologiaAuthor(s): John SteinAbstractSome people doubt that the concept of developmental dyslexia (DD) is useful at all because the phonological weaknesses seen in DD cannot be distinguished from those found in every person with poor reading skills, whatever their cause. Here I argue that true DD is characterised by poor temporal processing, hence impaired visual and auditory sequencing, that is caused by impaired development of transient/magnocellular (M-) systems throughout the brain. These deficits can be measured in order to distinguish the causes of the phonological weaknesses in DD from those causing similar deficits in other types of poor reading. Importantly this knowledge can be exploited to develop effective improvem...

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Childhood Secondhand Smoke Exposure Tied to Arthritis in Adulthood Childhood Secondhand Smoke Exposure Tied to Arthritis in Adulthood

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Subtractive proteomics and immunoinformatics revealed novel B-cell derived T-cell epitopes against Yersinia enterocolitica: An etiological agent of Yersiniosis

Publication date: December 2018Source: Microbial Pathogenesis, Volume 125Author(s): Qurat ul Ain, Sajjad Ahmad, Syed Sikander AzamAbstractYersinia enterocolitica is the third most common cause of gastrointestinal manifestations in Europe. Statistically, every year the pathogen accounts for 640 hospitalizations, 117,000 illnesses, and 35 deaths in the United States. The associated mortality rate of the pathogen is 50% and is virtually resistant to penicillin G, ampicillin and cephalotin. The development of new and effective therapeutic procedures is urgently needed to counter the multi-drug-resistant phenotypes imposed by the said pathogen. Based on subtractive reverse vaccinology and immunoinformatics approaches, we have successfully predicted novel antigenic peptide vaccine candidates aga...

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FDA grants approval of Xolair (omalizumab) prefilled syringe formulation

What is the Blood Culture Recovery Rate After Antibiotic Pretreatment?

Beating immune reactions for healthier heart valve implants

Existing data suggest that immune reactions reduce the lifespan of animal-derived heart valves implanted in cardiac patients. An EU-funded project discovered how to overcome this limitation, to produce valves with improved biocompatibility and novel immunological strategies that will benefit younger patients in particular. (Source: EUROPA - Research Information Centre)

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10 Year evaluation of patients with severe uncontrolled allergic asthma treated with Omalizumab.

Conference abstracts (Source: The Aspergillus Website - updates)

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Real-life experience of Omalizumab in adult Cystic Fibrosis patients with allergic severe asthma and Allergic Bronchopulmonary Aspergillosis

Conference abstracts (Source: The Aspergillus Website - updates)

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Labeling Hospitalized Kids as Antibiotic-Allergic Tied to Worse Outcomes Labeling Hospitalized Kids as Antibiotic-Allergic Tied to Worse Outcomes

Asthma and immunology: a call for papers for AAAAI

Publication date: Available online 3 October 2018Source: The Lancet Respiratory MedicineAuthor(s): Rachel Marshall (Source: The Lancet Respiratory Medicine)

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Ocular involvement in atopic disease: a review

Subtractive proteomics and immunoinformatics revealed novel B-cell derived T-cell epitopes against Yersinia enterocolitica: An etiological agent of Yersiniosis

Efficacy of house dust mite sublingual tablet in the treatment of allergic rhinoconjunctivitis: A randomized trial in a pediatric population

Pediatric Allergy and Immunology,Volume 0, Issue ja, -Not available-. (Source: Pediatric Allergy and Immunology)

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Highlights and recent developments in food and drug allergy, and anaphylaxis in EAACI journals (2017)

Predictive values of alpha ‐gal IgE levels and alpha‐gal IgE: Total IgE ratio and oral food challenge‐proven meat allergy in a population with a high prevalence of reported red meat allergy

Pediatric Allergy and Immunology, EarlyView. (Source: Pediatric Allergy and Immunology)

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Early childcare enrollment and childhood wheezing phenotypes

Sinus Surgery Procedure

Title: Sinus Surgery ProcedureCategory: Procedures and TestsCreated: 12/31/1997 12:00:00 AMLast Editorial Review: 10/2/2018 12:00:00 AM (Source: MedicineNet Allergies General)

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We All Carry a Personal Cloud of Germs, Chemicals

Title: We All Carry a Personal Cloud of Germs, ChemicalsCategory: Health NewsCreated: 9/20/2018 12:00:00 AMLast Editorial Review: 9/21/2018 12:00:00 AM (Source: MedicineNet Allergies General)

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Early childcare enrollment and childhood wheezing phenotypes

We All Carry a Personal Cloud of Germs, Chemicals

Epidemiology and Risk Factors of Asthma-COPD Overlap in Low- and Middle-Income Countries

Asthma-COPD Overlap is examined in a large, multinational cohort of adults across low- and middle-income settings. Risk factors prevalent in low- and middle-income countries are investigated and ACO is found to be common and severe. (Source: Journal of Allergy and Clinical Immunology)

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Continuing Medical Education Calendar

The following offer AMA PRA Category 1 Credits ™ and meet the ABAI requirements for MOC: (Source: Journal of Allergy and Clinical Immunology)

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Correction

As a follow-up to the article published in the May 2018 issue, "Short-term ibrutinib therapy suppresses skin test responses and eliminates IgE-mediated basophil activation in adults with peanut or tree nut allergy" (J Allergy Clin Immunol 2018;141:1914-6), the authors have provided an additional figure presenting an alternative format of data in the paper's original Fig 1. The authors note, "In presenting our work during talks, we have been asked more specifically about individuals' skin test responses before and during ibrutinib therapy, which we now realize is not easily discernible in the published version of Figure 1 because we regrettably did not include connecting lines between data points for each subject. (Source: Journal of Allergy and Clinical Immunology)

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Clockwork allergy: How the circadian clock underpins allergic reactions

Allergic disease is characterized by marked day-night changes in the clinical symptoms and laboratory parameters of allergy. Recent reports suggest that the circadian clock, which drives a biological rhythm with a periodicity of approximately 24 hours in behavior and physiology, underpins a time of day–dependent variation in allergic reactions. New studies also suggest that disruption of clock activity not only influences temporal variation but can also enhance the severity of allergic reactions and even increase susceptibility to aller gic disease. (Source: Journal of Allergy and Clinical Immunology)

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News Beyond Our Pages

Osteopontin might be associated with remodeling in asthmatic patients. Morimoto et al (Immunity 2018;49:134-50, e6; https://ift.tt/2QrYsNI) have identified an important role for amphiregulin-producing pathogenic memory TH2 (Tpath2) cells in this process. The epithelium-derived cytokine IL-33 induced amphiregulin-producing TH2 cells through its cell-surface receptor ST2. Amphiregulin led to reprogramming of eosinophils into an inflammatory state with enhanced secretion of the profibrotic protein osteopontin. (Source: Journal of Allergy and Clinical Immunology)

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The Editors' Choice

Early-life viral respiratory tract infections are associated with development of asthma and atopic disease. The mechanisms linking viral infections to postviral atopy are not understood. Using human samples and a mouse model, Cheung et al (p 1206) demonstrated an important role for a subset of neutrophils and leukotrienes in translation of viral respiratory tract infections into postviral atopic disease. (Source: Journal of Allergy and Clinical Immunology)

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Editorial Board

(Source: Journal of Allergy and Clinical Immunology)

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Cover 1

(Source: Journal of Allergy and Clinical Immunology)

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News & Notes

Registration and housing for the 2019 Annual Meeting is now open to AAAAI Fellows, with members gaining access beginning October 10. Visit annualmeeting.aaaai.org to register and select your hotel accommodations. (Source: Journal of Allergy and Clinical Immunology)

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A skewed pool of resident T cells triggers psoriasis-associated tissue responses in never-lesional psoriasis skin

In psoriasis patients, the skin that has not yet experienced the disease harbours resident T cells with the potential to drive psoriasiform tissue responses. (Source: Journal of Allergy and Clinical Immunology)

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Treatment of urticarial vasculitis: A systematic review

Urticarial vasculitis (UV) is a difficult-to-treat condition characterized by long-lasting urticarial rashes and histopathologic findings of leukocytoclastic vasculitis. Treatment is dictated by severity of skin and systemic involvement and the underlying systemic disease. This is a comprehensive systematic review of the efficacy of current UV treatment options. We searched for relevant studies in seven databases including MEDLINE, Scopus, and Web of Science. In total, 261 eligible studies and 789 unique UV patients were included in the systematic review. (Source: Journal of Allergy and Clinical Immunology)

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Continuing Medical Education Calendar

Loss-of-function mutations in CARD14 are associated with a severe variant of atopic dermatitis

Dominant gain-of-function mutations in CARD14, encoding a known regulator of NF- κB, cause psoriasis and related disorders. Here, the authors show that dominant negative mutations in the same gene result in severe atopic dermatitis and decreased NF-κB signaling. (Source: Journal of Allergy and Clinical Immunology)

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Correction

Advances in asthma in 2017: Mechanisms, biologics, and genetics

This review summarizes some of the most significant advances in asthma research over the past year. We first focus on novel discoveries in the mechanism of asthma development and exacerbation. This is followed by a discussion of potential new biomarkers, including the use of radiographic markers of disease. Several new biologics have become available to the clinician in the past year, and we summarize these advances and how they can influence the clinical delivery of asthma care. After this, important findings in the genetics of asthma and heterogeneity in phenotypes of the disease are explored, as is the role the environment plays in shaping the development and exacerbation of asthma. (Source: Journal of Allergy and Clinical Immunology)

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(Source: Journal of Allergy and Clinical Immunology)

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Anti –IL-5 treatments in patients with severe asthma by blood eosinophil thresholds: Indirect treatment comparison

Three anti –IL-5 pathway–directed therapies are approved for use in patients with severe eosinophilic asthma (SEA); however, no head-to-head comparison data are available. (Source: Journal of Allergy and Clinical Immunology)

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Clockwork allergy: How the circadian clock underpins allergic reactions

Regulatory T-cell deficiency and autoimmune skin disease: Beyond the scurfy mouse and immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome

Regulatory T (Treg) cells, which specifically express forkhead box P3 (Foxp3) as the master regulatory gene, are actively engaged in the maintenance of peripheral immune tolerance and prevention of autoimmunity.1,2 Scurfy mice and patients with immune dysregulation, polyendocrinopathy, enteropathy, X-linked (IPEX) syndrome have mutations in the Foxp3 gene and consequently lack functional Treg cells, developing a variety of autoimmune reactions in various tissues, including the skin.3 (Source: Journal of Allergy and Clinical Immunology)

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Brief Overview of This Month's JACI

(Source: Journal of Allergy and Clinical Immunology)

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The Editors' Choice

Editorial Board

(Source: Journal of Allergy and Clinical Immunology)

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News & Notes

Information for Readers

(Source: Journal of Allergy and Clinical Immunology)

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Unexpected Relevant Role of Gene Mosaicism in Primary Immunodeficiency Diseases

ADS revealed gene mosaicism in ≈25% of enrolled PID families. These data highlight the relevant role of mosaicism in PID, which may have serious consequences regarding patient's treatment and genetic counseling. (Source: Journal of Allergy and Clinical Immunology)

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ARIA Phase 4 (2018): Change management in allergic rhinitis and asthma multimorbidity using mobile technology

Allergic Rhinitis and its Impact on Asthma (ARIA) has evolved from a guideline using the best approach to integrated care pathways (ICPs) using mobile technology in AR and asthma multimorbidity. The proposed next phase of ARIA is Change Management (CM) with the aim of providing an active and healthy life to rhinitis sufferers and to those with asthma multimorbidity across the life cycle whatever their gender or socio-economic status in order to reduce health and social inequities incurred by the disease. (Source: Journal of Allergy and Clinical Immunology)

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A skewed pool of resident T cells triggers psoriasis-associated tissue responses in never-lesional psoriasis skin

Treatment of urticarial vasculitis: A systematic review

Loss-of-function mutations in CARD14 are associated with a severe variant of atopic dermatitis

Advances in asthma in 2017: Mechanisms, biologics, and genetics

Anti –IL-5 treatments in patients with severe asthma by blood eosinophil thresholds: Indirect treatment comparison

Regulatory T-cell deficiency and autoimmune skin disease: Beyond the scurfy mouse and immune dysregulation, polyendocrinopathy, enteropathy, X-linked syndrome

Congenital absence of the deep inferior epigastric system: a case report

Abstract

Preoperative computerised tomographic angiography (CTA) in free flap breast reconstruction outlines the deep inferior epigastric perforator (DIEP). It can identify a single or twin system, measure vessel calibre, and identify iatrogenic/congenital anatomical variations. Evidence of the effect of previous abdominal incisions on this vessel system remain inconclusive. We present the case of a congenital absence of the system identified from routine preoperative CTA. A 61-year-old female presented for immediate unilateral breast reconstruction following mastectomy for ductal carcinoma in situ. She previously had a right-sided Kocher's incision performed for an open cholecystectomy and a gridiron incision. Coincidentally, preoperative CTA demonstrated congenital absence of the left DIEP system, and marked atrophy of the upper right rectus abdominis (RA). As a result, the superior gluteal artery perforator (SGAP) flap was planned. Intraoperatively, a 1.318-kg SGAP was raised on three perforators and coupled to the internal mammary vessels. In the postoperative period, there were no complications. Preoperative CTA demonstrated multiple hazards in raising a DIEP flap, CTA permitted surgical planning, improving patient safety and surgical efficiency. Preoperative CTA identifies vessel abnormalities resulting from abdominal scarring. The rate of congenital anomalies is unknown. This incidental discovery highlights the role CTA has in reducing operative time, facilitating a successful free tissue transfer, therefore improving patient safety.

Level of Evidence: Level V, diagnostic study.

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Is there an order of loss of sounds in speakers with Parkinson's disease?

Authors: Read J, Miller N, Kitsou N Abstract Influential reports on speech changes in people with Parkinson's disease (PD; Logemann et al., 1978, 1981) reported a posterior to anterior pattern of loss of speech sound accuracy. These claims have never been examined. In a partial replication of Logemann et al.'s work, we examined whether posterior lingual sounds are most affected in people with Parkinson's disease, followed by anterior lingual sounds and then labial sounds. Ninety-nine people with PD (age: mean 70.7, SD 8.46; time since diagnosis: mean 6.97, SD 6.2) with mild to severe overall motor symptoms (Hoehn and Yahr stages 1-5, median 2.5) completed a diagnostic intelligibility test. This was scored by 60 listeners unfamiliar with PD and dysarthric speech. We calculated the p...

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Modifying Food Textures: Practices and Beliefs of Staff Involved in Nutrition Care.

Conclusions: Survey respondents conveyed generally positive attitudes and opinions about the use of texture-modified foods, and respondents perceived them to be easy to execute and beneficial to the nutritional well-being of patients. Survey findings clearly highlight the contributions of frontline staff in the service delivery of modified food textures. Consideration must be given to continued reliance on informal, limited instruction about texture-modified foods and possible implications for safe nutrition care. Both professional and frontline staff convey a willingness to customize or alter food textures and the belief that patients should be able to choose the level of texture modification that they want to eat. PMID: 30267081 [PubMed - as supplied by publisher] (Source: American J...

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Vessel Wall Enhancement in Treated Unruptured Aneurysms [LETTERS]

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Reply: [LETTERS]

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Methodologic Issues on Interrater Reliability Regarding Structural and DTI-Based Corticospinal Tract Asymmetry [LETTERS]

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Flow-Diversion Effect of LEO Stents: Aneurysm Occlusion and Flow Remodeling of Covered Side Branches and Perforators [INTERVENTIONAL]

BACKGROUND AND PURPOSE:

Flow diversion with intermediate-porosity stents (braided stents) has been recently reported for distally located small aneurysms. The aim of this study was to evaluate the flow-diversion effect of LEO stents on covered vessels and for aneurysms treated with sole stent-placement therapy.

MATERIALS AND METHODS:

We retrospectively evaluated the following outcomes: 1) remodeling of covered side branches and perforators (extra-aneurysmal flow remodeling), and 2) the occlusion rate of aneurysms treated with sole stent-placement therapy (intra-aneurysmal flow remodeling).

RESULTS:

Seventy-six patients with 98 covered vessels were studied. Overall, 89 covered arteries (91%) were normal, 7 showed narrowing (7%), and 2 (2%) were occluded (1 posterior communicating artery and 1 MCA) without related complications (mean DSA follow-up, 14 months). Univariate and multivariate analyses highlighted smoking (P = .03) and the length of follow-up (P = .002) as factors associated with arterial remodeling. Of the 17 Sylvian (lenticulostriate arteries) and 7 basilar perforators, 1 (4%) group of Sylvian perforators covered with double stents had asymptomatic remodeling. Ten aneurysms (mean size, 3.5 mm) were treated with LEO stents as stent monotherapy (5 recanalized after coiling and 5 directly treated with the LEO). Complete occlusion (Raymond-Roy I) was achieved in 70% of aneurysms (mean follow-up, 14 months). The Raymond-Roy I occlusion rate among recanalized aneurysms and those directly treated with LEO stents was 80% and 60%, respectively (P = .9).

CONCLUSIONS:

The rate of flow remodeling on the covered arteries and perforators was 9% and 4%, respectively, and was clinically irrelevant in all cases. Complete occlusion of aneurysms treated with sole stent-placement therapy was 70%. These data stress the flow-diversion properties of LEO stents.

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Subtraction CTA: An Alternative Imaging Option for the Follow-Up of Flow-Diverter-Treated Aneurysms? [INTERVENTIONAL]

BACKGROUND AND PURPOSE:

This was a pilot study to explore the diagnostic accuracy and safety of subtraction CTA combined with a single-energy metal artifact reduction algorithm (SEMAR) compared to DSA for the evaluation of intracranial aneurysm occlusion after flow diverter treatment.

MATERIALS AND METHODS:

We included patients treated with a flow diverter for an unruptured intracranial aneurysm between November 2015 and November 2016. The patient cohort comprised 2 groups: those who underwent follow-up imaging 1 month after flow-diverter treatment and those with a known residual intracranial aneurysm after flow diverter treatment who underwent imaging at regular follow-ups. Full-brain subtraction CTA was performed on a 320–detector row CT system. A low-dose non-enhanced volume acquisition was followed by a contrast-enhanced volume CTA. Iterative and noise-reduction filters, SEMAR, and ^SURESubtraction algorithms were applied. DSA was performed on a flat panel C-arm angiography system. Standard posteroanterior, lateral, 3D, and detailed 2D acquisitions were performed. Imaging was independently scored by 2 clinicians. Aneurysm occlusion (Raymond scale) was our primary outcome parameter.

RESULTS:

Thirteen intracranial aneurysms were evaluated with subtraction CTA and DSA. Nine aneurysm remnants were demonstrated by both subtraction CTA and DSA. The sensitivity and specificity of subtraction CTA for the detection of aneurysm occlusion were 100% (95% CI, 82.41%–100%) and 100% (95% CI, 67.55%–100%), respectively. Agreement between readers was perfect ( = 1.0). The smallest neck remnant detected on subtraction CTA was 1.2 mm. No complications occurred.

CONCLUSIONS:

Subtraction CTA with single-electron metal artifact reduction is effective in the reduction of metal artifacts of flow diverters and might therefore be a viable alternative in the assessment of intracranial aneurysm occlusion after flow diverter treatment.

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Fluoroscopically Guided Facet Injections: Comparison of Intra-Articular and Periarticular Steroid and Anesthetic Injection on Immediate and Short-Term Pain Relief [SPINE]

BACKGROUND AND PURPOSE:

The effectiveness of facet injections is unclear in the literature. Our objective was to determine the immediate and short-term efficacy of intra-articular and periarticular steroid/anesthetic injections for facet-mediated lumbar pain.

MATERIALS AND METHODS:

All outpatient fluoroscopically guided facet injections at a single institution during a 54-month period were retrospectively and independently reviewed by 2 musculoskeletal (MSK) trained radiologists. All intra-articular, all periarticular, and partial intra-/periarticular injection locations were determined. Periarticular and partial peri-/intra-articular injections were combined for analysis. Preinjection, immediate, and 1-week postinjection numeric pain scores, patient age, sex, anesthetic/steroid mixture, fluoroscopic time, and physician performing the procedure were recorded.

RESULTS:

Seventy-seven patients (mean age, 51.1 years) had 100 procedures with 205 total facet joints injected. All intra-articular, all periarticular, and partial peri-/intra-articular injections constituted 54%, 20%, and 26% of the cases, respectively. The immediate and 1-week postprocedural change in pain was –3.7 (95% CI, –4.5 to –2.8; P < .001) and –1.4 (95% CI, –2.2 to –0.6; P = .001) for the all intra-articular and –3.6 (95% CI, –4.4 to –2.9; P < .001) and –1.2 (95% CI, –1.9 to –0.4; P = .002) for the combined group. Changes in immediate pain were significantly associated with the prepain level (P < .001) and patient age (P = .024) but not with the anesthetic used. Analyses revealed no significant difference in pain reduction between the groups either immediately or 1 week postinjection. Intra-articular injections required less fluoroscopic time (geometric mean, 39 versus 52 seconds) (P = .005).

CONCLUSIONS:

Intra-articular and periarticular fluoroscopically guided facet injections provide statistically significant and similar pain relief both immediately and 1 week postinjection.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PdQyaC

Spinal Coccidioidomycosis: MR Imaging Findings in 41 Patients [SPINE]

BACKGROUND AND PURPOSE:

Coccidioides immitis is a dimorphic fungus endemic to the Southwest United States and Mexico, and at our institution, it is a relatively common pathogen presenting with a broad spectrum of associated spine diseases. We describe the various spinal manifestations resulting from coccidioidal infection and provide MR imaging examples from 41 pathologically proved cases.

MATERIALS AND METHODS:

Retrospective electronic medical record and PACS searches were performed. Patients found to have both MR imaging findings positive for infection and confirmative biopsy and/or CSF studies were included. Abnormal MR imaging findings were identified, categorized, and quantified. Patient demographics and associated intracranial involvement if present were also recorded.

RESULTS:

Forty-one patients were included. Positive findings were categorized as leptomeningeal enhancement (26 patients, 63%), arachnoiditis (22 patients, 54%), osteomyelitis-discitis (14 patients, 34%), cord edema (11 patients, 27%), and true syrinx (3 patients, 7%). Thirty patients had documented brain involvement (73%), most commonly in the form of basilar meningitis. Four patients were positive for HIV (10%). Fifteen patients had pulmonary manifestations at presentation (37%).

CONCLUSIONS:

C immitis results in various spinal manifestations, most commonly leptomeningeal enhancement and arachnoiditis/adhesive disease followed by osteomyelitis, which may resemble tuberculous or pyogenic infection on MR imaging.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2y1jTOZ

Impact of Ischemic Lesion Location on the mRS Score in Patients with Ischemic Stroke: A Voxel-Based Approach [ADULT BRAIN]

BACKGROUND AND PURPOSE:

Previous studies indicated that ischemic lesion volume might be a useful surrogate marker for functional outcome in ischemic stroke but should be considered in the context of lesion location. In contrast to previous studies using the ROI approach, which has several drawbacks, the present study aimed to measure the impact of ischemic lesion location on functional outcome using a more precise voxelwise approach.

MATERIALS AND METHODS:

Datasets of patients with acute ischemic strokes from the Multicenter Randomized Clinical Trial of Endovascular Therapy for Acute Ischemic Stroke in the Netherlands (MR CLEAN) were used. Primary outcome was functional outcome as assessed by the modified Rankin Scale 3 months after stroke. Ischemic lesion volume was determined on CT scans 3–9 days after stroke. Voxel-based lesion-symptom mapping techniques, including covariates that are known to be associated with functional outcome, were used to determine the impact of ischemic lesion location for outcome.

RESULTS:

Of the 500 patients in the MR CLEAN trial, 216 were included for analysis. The mean age was 63 years. Lesion-symptom mapping with inclusion of covariates revealed that especially left-hemispheric lesions in the deep periventricular white matter and adjacent internal capsule showed a great influence on functional outcome.

CONCLUSIONS:

Our study confirms that infarct location has an important impact on functional outcome of patients with stroke and should be considered in prediction models. After we adjusted for covariates, the left-hemispheric corticosubcortical fiber tracts seemed to be of higher functional importance compared with cortical lesions.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2P7DZh4

Do All Patients with Multiple Sclerosis Benefit from the Use of Contrast on Serial Follow-Up MR Imaging? A Retrospective Analysis [ADULT BRAIN]

BACKGROUND AND PURPOSE:

Patients with multiple sclerosis routinely have MR imaging with contrast every 6–12 months to assess response to medication. Multiple recent studies provide evidence of tissue deposition of MR imaging contrast agents, questioning the long-term safety of these agents. The goal of this retrospective image-analysis study was to determine whether contrast could be reserved for only those patients who show new MS lesions on follow-up examinations.

MATERIALS AND METHODS:

We retrospectively reviewed brain MRIs of 138 patients. To increase our sensitivity, we used a previously described computerized image-comparison software to evaluate the stability or progression of multiple sclerosis white matter lesions in noncontrast FLAIR sequences. We correlated these findings with evidence of contrast-enhancing lesions on the enhanced T1 sequence from the same scan.

RESULTS:

Thirty-three scans showed an increase in white matter lesion burden. Among those 33 patients, 14 examinations also demonstrated enhancing new lesions. While we found a single example of enhancement of a pre-existing white matter lesion that appeared unchanged in size, that same examination showed an overall increase in lesion burden with enhancement of other, new lesions. Thus, we found that all patients with enhancing lesions had evidence of progression on their noncontrast imaging.

CONCLUSIONS:

Because all enhancing lesions were associated with new lesions on unenhanced imaging and progression was only evident in 24% of patients, in patients with relapsing-remitting MS, it is reasonable to consider reserving contrast for only those patients with evidence of progression on noncontrast MR images.

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Flow-Diversion Effect of LEO Stents: Aneurysm Occlusion and Flow Remodeling of Covered Side Branches and Perforators [INTERVENTIONAL]

BACKGROUND AND PURPOSE:

MATERIALS AND METHODS:

RESULTS:

CONCLUSIONS:

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PcyU7k

Subtraction CTA: An Alternative Imaging Option for the Follow-Up of Flow-Diverter-Treated Aneurysms? [INTERVENTIONAL]

BACKGROUND AND PURPOSE:

MATERIALS AND METHODS:

RESULTS:

CONCLUSIONS:

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2y1blrA

Fluoroscopically Guided Facet Injections: Comparison of Intra-Articular and Periarticular Steroid and Anesthetic Injection on Immediate and Short-Term Pain Relief [SPINE]

BACKGROUND AND PURPOSE:

MATERIALS AND METHODS:

RESULTS:

CONCLUSIONS:

Intra-articular and periarticular fluoroscopically guided facet injections provide statistically significant and similar pain relief both immediately and 1 week postinjection.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2PdQyaC

Spinal Coccidioidomycosis: MR Imaging Findings in 41 Patients [SPINE]

BACKGROUND AND PURPOSE:

MATERIALS AND METHODS:

RESULTS:

CONCLUSIONS:

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2y1jTOZ

Πληροφορίες

Πέμπτη 4 Οκτωβρίου 2018