Improving the Results of Endonasal Dacryocystorhinostomy with Mitomycin C Application: A Prospective Case–Control Study

Abstract

Many surgical advancement paved to surgical success in endonasal endoscopic dacryocystorhinostomy. Mitomycin C is a systemic chemotherapeutic agent derived from Streptomyces caespitosus that inhibits the synthesis of DNA, cellular RNA, and protein by inhibiting the synthesis of collagen by fibroblasts. The objective of the study was to evaluate the advantage of mitomycin C in primary endoscopic endonasal dacryocystorhinostomy without stenting. Randomised case control design. Tertiary academic centre in central India. 112 patients who presented with epiphora and diagnosed as chronic dacryocystitis after syringing by ophthalmologist, were selected and randomised into two groups with or without mitomycin C intraoperative application. 112 eyes underwent endoscopic-dacryocystorhinostomy. Additional surgeries were done according to necessity. Mitomycin C was applied in concentration of 0.4 mg/dl for 5 min. Patients were followed up on OPD-basis at the end of 1st week, 1st month, 3rd month and over phone call at end of 1 year. Symptomatic improvement assessed by verbal enquiry and clinically by syringing by ophthalmologist. 8 patients underwent septal surgery in case group and 4 in control group along with 1 concha bullosa correction in the case group (p < 0.05). Nil intraoperative complications (p < 0.05) and nil postoperative complication noted (p < 0.05). Functional and anatomical patency found to be 100% at the end of 1st week in both groups, 96.5% at 3rd month in case group and 96.4% and 92.9% at 1 month and 3 month respectively in control group. Nasal endoscopy of all surgical failures showed restenosis in both case group and control group except 1 patient with granulation in control group. Eventhough intraoperative mitomycin C application is effective in increasing the success rate of endonasal DCR surgery in standard nasolacrimal duct obstruction, and with no significant complications from its use, the study did not show added benefit in the primary endoscopic endoscopic dacryocystorhinostomy without stenting.

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Mitomycin-C in Post-endoscopic Septoplasty Synechiae: Does it Really Helps?

Abstract

Endoscopic septoplasty has advantage of magnified image and access to posterior part of the septum. Synechiae formation is a common complication of this procedure. The incidence of adhesions rises particularly in cases of submucosal flap tears which is sometimes unavoidable during spurectomy. Various procedures like septal splints, nasal packings have been tried to reduce the incidence of adhesions. Recently mitomycin-C is being tried to decrease post operative adhesions after Functional Endoscopic Sinus Surgery, endoscopic Dacrocystorhinostomy, with varying degree of success. Mitomycin-C has got anti fibroblastic activity, which inhibits the fibroblasts without hampering epithelization. Eighty (80) Patients undergoing septoplasty and spurectomy were observed for any submucosal flap tear, and those developing flap tear were included in the study. The patients were divided into 2 groups of 40 each. In group-1 topical mitomycin (0.4 mg/ml) was applied at the raw area for 5 min, similarly normal saline was applied in group-2 (control).The aim of study was to evaluate the role of mitomycin-C in preventing post operative adhesions in Endoscopic septoplasty. Adhesion rate was calculated at 1 month, and compared using Chi square test. P value < 0.05 was considered significant. The adhesion rate at 1 month was 17.5% in group-1 and 45% in group-2 (P = 0.008). Incidence of adhesion decreased significantly in mitomycin-C treated group. Mitomycin-C can routinely be used in septoplasty to prevent post op adhesions, particularly in cases of submucosal flap tears/concurrent turbinate reduction procedures.

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Survival percentages of atraumatic restorative treatment (ART) restorations and sealants in posterior teeth: an updated systematic review and meta-analysis

Abstract

Objective

The aim of the present study is to update the results of two previous meta-analyses, published in 2006 and 2012, on the survival percentages of atraumatic restorative treatment (ART) restorations and ART sealants. The current meta-analysis includes Chinese publications not investigated before.

Materials and methods

Until February 2017, six databases were interrogated (two English, one Portuguese, one Spanish and two Chinese). Using six exclusion criteria, a group of six independent reviewers selected 43 publications from a total of 1958 potentially relevant studies retrieved. Confidence intervals and/or standard errors were calculated and the heterogeneity variance of the survival rates was estimated.

Results

The survival percentages and standard errors of single-surface and multiple-surface ART restorations in primary posterior teeth over the first 2 years were 94.3% (± 1.5) and 65.4% (± 3.9), respectively; for single-surface ART restorations in permanent posterior teeth over the first 3 years, they were 87.1% (± 3.2); and for multiple-surface ART restorations in permanent posterior teeth over the first 5 years, they were 77% (± 9.0). The mean annual dentine-carious-lesion-failure percentages in previously sealed pits and fissures using ART sealants in permanent posterior teeth over the first 3 and 5 years were 0.9 and 1.9%, respectively.

Conclusions

ART single-surface restorations presented high survival percentages in both primary and permanent posterior teeth, whilst ART multiple-surface restorations presented lower survival percentages. ART sealants presented a high-caries-preventive effect.

Clinical relevance

ART is an effective evidence-based option for treating and preventing carious lesions in primary and permanent posterior teeth.

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Improving the Results of Endonasal Dacryocystorhinostomy with Mitomycin C Application: A Prospective Case–Control Study

Abstract

Many surgical advancement paved to surgical success in endonasal endoscopic dacryocystorhinostomy. Mitomycin C is a systemic chemotherapeutic agent derived from Streptomyces caespitosus that inhibits the synthesis of DNA, cellular RNA, and protein by inhibiting the synthesis of collagen by fibroblasts. The objective of the study was to evaluate the advantage of mitomycin C in primary endoscopic endonasal dacryocystorhinostomy without stenting. Randomised case control design. Tertiary academic centre in central India. 112 patients who presented with epiphora and diagnosed as chronic dacryocystitis after syringing by ophthalmologist, were selected and randomised into two groups with or without mitomycin C intraoperative application. 112 eyes underwent endoscopic-dacryocystorhinostomy. Additional surgeries were done according to necessity. Mitomycin C was applied in concentration of 0.4 mg/dl for 5 min. Patients were followed up on OPD-basis at the end of 1st week, 1st month, 3rd month and over phone call at end of 1 year. Symptomatic improvement assessed by verbal enquiry and clinically by syringing by ophthalmologist. 8 patients underwent septal surgery in case group and 4 in control group along with 1 concha bullosa correction in the case group (p < 0.05). Nil intraoperative complications (p < 0.05) and nil postoperative complication noted (p < 0.05). Functional and anatomical patency found to be 100% at the end of 1st week in both groups, 96.5% at 3rd month in case group and 96.4% and 92.9% at 1 month and 3 month respectively in control group. Nasal endoscopy of all surgical failures showed restenosis in both case group and control group except 1 patient with granulation in control group. Eventhough intraoperative mitomycin C application is effective in increasing the success rate of endonasal DCR surgery in standard nasolacrimal duct obstruction, and with no significant complications from its use, the study did not show added benefit in the primary endoscopic endoscopic dacryocystorhinostomy without stenting.

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Mitomycin-C in Post-endoscopic Septoplasty Synechiae: Does it Really Helps?

Abstract

Endoscopic septoplasty has advantage of magnified image and access to posterior part of the septum. Synechiae formation is a common complication of this procedure. The incidence of adhesions rises particularly in cases of submucosal flap tears which is sometimes unavoidable during spurectomy. Various procedures like septal splints, nasal packings have been tried to reduce the incidence of adhesions. Recently mitomycin-C is being tried to decrease post operative adhesions after Functional Endoscopic Sinus Surgery, endoscopic Dacrocystorhinostomy, with varying degree of success. Mitomycin-C has got anti fibroblastic activity, which inhibits the fibroblasts without hampering epithelization. Eighty (80) Patients undergoing septoplasty and spurectomy were observed for any submucosal flap tear, and those developing flap tear were included in the study. The patients were divided into 2 groups of 40 each. In group-1 topical mitomycin (0.4 mg/ml) was applied at the raw area for 5 min, similarly normal saline was applied in group-2 (control).The aim of study was to evaluate the role of mitomycin-C in preventing post operative adhesions in Endoscopic septoplasty. Adhesion rate was calculated at 1 month, and compared using Chi square test. P value < 0.05 was considered significant. The adhesion rate at 1 month was 17.5% in group-1 and 45% in group-2 (P = 0.008). Incidence of adhesion decreased significantly in mitomycin-C treated group. Mitomycin-C can routinely be used in septoplasty to prevent post op adhesions, particularly in cases of submucosal flap tears/concurrent turbinate reduction procedures.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xvPdV2

Survival percentages of atraumatic restorative treatment (ART) restorations and sealants in posterior teeth: an updated systematic review and meta-analysis

Abstract

Objective

The aim of the present study is to update the results of two previous meta-analyses, published in 2006 and 2012, on the survival percentages of atraumatic restorative treatment (ART) restorations and ART sealants. The current meta-analysis includes Chinese publications not investigated before.

Materials and methods

Until February 2017, six databases were interrogated (two English, one Portuguese, one Spanish and two Chinese). Using six exclusion criteria, a group of six independent reviewers selected 43 publications from a total of 1958 potentially relevant studies retrieved. Confidence intervals and/or standard errors were calculated and the heterogeneity variance of the survival rates was estimated.

Results

The survival percentages and standard errors of single-surface and multiple-surface ART restorations in primary posterior teeth over the first 2 years were 94.3% (± 1.5) and 65.4% (± 3.9), respectively; for single-surface ART restorations in permanent posterior teeth over the first 3 years, they were 87.1% (± 3.2); and for multiple-surface ART restorations in permanent posterior teeth over the first 5 years, they were 77% (± 9.0). The mean annual dentine-carious-lesion-failure percentages in previously sealed pits and fissures using ART sealants in permanent posterior teeth over the first 3 and 5 years were 0.9 and 1.9%, respectively.

Conclusions

ART single-surface restorations presented high survival percentages in both primary and permanent posterior teeth, whilst ART multiple-surface restorations presented lower survival percentages. ART sealants presented a high-caries-preventive effect.

Clinical relevance

ART is an effective evidence-based option for treating and preventing carious lesions in primary and permanent posterior teeth.

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Seasonal variation of airborne allergenic fungal spores in ambient PM 10 —a study in Guwahati, the largest city of north-east India

AbstractFungal spores in ambient particulate matter (PM) is one of the major constituents which can adversely affect human health. For the first time, an investigation was conducted for 1  year at a residential region in north-east India to study the seasonal variation of PM10-associated fungal spore concentration and their diversity. Using fine particulate sampler, samples were collected at 12  h intervals for 1 week of every month during July 2016–June 2017. Twelve-hour averaged PM10 concentration was 79.74  μg/m3 and 103.47  μg/m3 during day and night time, respectively. Fungal spore concentration was 126 (54 –294) CFU/m3 during day time and 107 (55 to 161) CFU/m3 during night time. Seven individual genera of fungal spores, namelyAspergillus,Penicillium,Cladosporium,Fusarium,...

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Primary Surgical Treatment of Erythema Elevatum Diutinum

Erythema elevatum diutinum (EED) is a rare skin disease caused an Arthrus-type immunological  reaction to antigen with immune complex deposition in the cutaneous microvasculature, which leads to tissue damage secondary to the effects of complement and leukocytes. It presents as brown or red cutaneous nodules, papules, or plaques, often on the extensor surfaces of the hands, knees, or elbow s. Onset usually occurs in the fourth to sixth decades but possibly younger in patients with human immunodeficiency virus. (Source: The Journal of Hand Surgery)

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Seasonal variation of airborne allergenic fungal spores in ambient PM 10 —a study in Guwahati, the largest city of north-east India

AbstractFungal spores in ambient particulate matter (PM) is one of the major constituents which can adversely affect human health. For the first time, an investigation was conducted for 1  year at a residential region in north-east India to study the seasonal variation of PM10-associated fungal spore concentration and their diversity. Using fine particulate sampler, samples were collected at 12  h intervals for 1 week of every month during July 2016–June 2017. Twelve-hour averaged PM10 concentration was 79.74  μg/m3 and 103.47  μg/m3 during day and night time, respectively. Fungal spore concentration was 126 (54 –294) CFU/m3 during day time and 107 (55 to 161) CFU/m3 during night time. Seven individual genera of fungal spores, namelyAspergillus,Penicillium,Cladosporium,Fusarium,...

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Primary Surgical Treatment of Erythema Elevatum Diutinum

Erythema elevatum diutinum (EED) is a rare skin disease caused an Arthrus-type immunological  reaction to antigen with immune complex deposition in the cutaneous microvasculature, which leads to tissue damage secondary to the effects of complement and leukocytes. It presents as brown or red cutaneous nodules, papules, or plaques, often on the extensor surfaces of the hands, knees, or elbow s. Onset usually occurs in the fourth to sixth decades but possibly younger in patients with human immunodeficiency virus. (Source: The Journal of Hand Surgery)

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Man who was 'saved by recession' urges cancer checks

Man who was 'saved by recession' urges cancer checks  Irish ExaminerFull coverage

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Man who was 'saved by recession' urges cancer checks

Man who was 'saved by recession' urges cancer checks  Irish ExaminerFull coverage

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Nearly two dozen already registered for Colors of Cancer 5K Color Run and Walk

Nearly two dozen already registered for Colors of Cancer 5K Color Run and Walk  WV NewsFull coverage

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Nearly two dozen already registered for Colors of Cancer 5K Color Run and Walk

Nearly two dozen already registered for Colors of Cancer 5K Color Run and Walk  WV NewsFull coverage

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Evaluation of the eAdjust Application

Conditions:   Hearing Loss, Bilateral;   Hearing Loss, Sensorineural Intervention:   Device: eAdjust 0.2 hearing aid smartphone application (or app) Sponsors:   Nottingham University Hospitals NHS Trust;   Sonova AG;   University of Nottingham Recruiting (Source: ClinicalTrials.gov)

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Comparison of white and blue light assessment of the upper and lower palpebral conjunctiva

Papillary changes of the palpebral conjunctiva, often described as papillae, lid roughness, or giant papillary conjunctivitis (GPC), are morphological changes in the tissue which can occur in the upper and/or lower eyelid [1,2]. Though the aetiology is still unclear, papillary changes have been associated with ocular allergy and with contact lens wear [3]. The latter is often also referred to as contact lens induced papillary conjunctivitis (CLPC) [3], which can be either localized or general [3]. (Source: Contact Lens and Anterior Eye)

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Effect of Influenza Vaccination or Infection on the Development of Protective Immunity in Children

Conditions:   Influenza;   Influenza Immunisation Intervention:   Biological: Influenza Virus Quadrivalent Inactivated Vaccine Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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Effect of Health Promotion on Allergic Rhinitis by Infrared-C Ray Irradiation

Condition:   Allergic Rhinitis Interventions:   Device: infrared-C ray irradiation;   Device: eye mask;   Drug: Xyzal Oral Product;   Drug: Fluticasone Furoate Sponsors:   Nanhua University;   Buddhist Tzu Chi General Hospital;   Solano Semiconductor Technology., LTD. Completed (Source: ClinicalTrials.gov)

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Introduction and Maintenance of Still Eating Protein Blends in Support of Infant Nutritional Goals

Condition:   Food Allergy Intervention:   Dietary Supplement: Food Supplement Sponsor:   Northwestern University Completed (Source: ClinicalTrials.gov)

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Evaluation of the eAdjust Application

Conditions:   Hearing Loss, Bilateral;   Hearing Loss, Sensorineural Intervention:   Device: eAdjust 0.2 hearing aid smartphone application (or app) Sponsors:   Nottingham University Hospitals NHS Trust;   Sonova AG;   University of Nottingham Recruiting (Source: ClinicalTrials.gov)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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The PEBBLES Study - Testing a Strategy for Preventing Eczema and Food Allergy in High Risk Infants

Conditions:   Eczema;   Asthma;   Allergy;Food Intervention:   Drug: EpiCeram Sponsor:   University of Melbourne Recruiting (Source: ClinicalTrials.gov)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pj02Gj

Comparison of white and blue light assessment of the upper and lower palpebral conjunctiva

Papillary changes of the palpebral conjunctiva, often described as papillae, lid roughness, or giant papillary conjunctivitis (GPC), are morphological changes in the tissue which can occur in the upper and/or lower eyelid [1,2]. Though the aetiology is still unclear, papillary changes have been associated with ocular allergy and with contact lens wear [3]. The latter is often also referred to as contact lens induced papillary conjunctivitis (CLPC) [3], which can be either localized or general [3]. (Source: Contact Lens and Anterior Eye)

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Study Evaluating the Efficacy and Safety of Fexofenadine in Subjects Suffering From Seasonal Allergic Rhinitis in Presence of Pollutants

Condition:   Rhinitis Seasonal Interventions:   Drug: Fexofenadine M016455;   Drug: Placebo Sponsor:   Sanofi Not yet recruiting (Source: ClinicalTrials.gov)

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Effect of Influenza Vaccination or Infection on the Development of Protective Immunity in Children

Conditions:   Influenza;   Influenza Immunisation Intervention:   Biological: Influenza Virus Quadrivalent Inactivated Vaccine Sponsor:   National Institute of Allergy and Infectious Diseases (NIAID) Not yet recruiting (Source: ClinicalTrials.gov)

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Serum Immunologic Markers Levels in During the Delivery

Condition:   Immunologic Markers Intervention:   Diagnostic Test: Blood sampling Sponsor:   Brno University Hospital Not yet recruiting (Source: ClinicalTrials.gov)

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HIV Infection and Risk Related Coinfections/Comorbidities in Indonesia

Condition:   HIV Intervention:   Sponsors:   Ina-Respond;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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Introduction and Maintenance of Still Eating Protein Blends in Support of Infant Nutritional Goals

Condition:   Food Allergy Intervention:   Dietary Supplement: Food Supplement Sponsor:   Northwestern University Completed (Source: ClinicalTrials.gov)

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The PEBBLES Study - Testing a Strategy for Preventing Eczema and Food Allergy in High Risk Infants

Conditions:   Eczema;   Asthma;   Allergy;Food Intervention:   Drug: EpiCeram Sponsor:   University of Melbourne Recruiting (Source: ClinicalTrials.gov)

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Study Evaluating the Efficacy and Safety of Fexofenadine in Subjects Suffering From Seasonal Allergic Rhinitis in Presence of Pollutants

Condition:   Rhinitis Seasonal Interventions:   Drug: Fexofenadine M016455;   Drug: Placebo Sponsor:   Sanofi Not yet recruiting (Source: ClinicalTrials.gov)

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Serum Immunologic Markers Levels in During the Delivery

Condition:   Immunologic Markers Intervention:   Diagnostic Test: Blood sampling Sponsor:   Brno University Hospital Not yet recruiting (Source: ClinicalTrials.gov)

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HIV Infection and Risk Related Coinfections/Comorbidities in Indonesia

Condition:   HIV Intervention:   Sponsors:   Ina-Respond;   National Institute of Allergy and Infectious Diseases (NIAID) Recruiting (Source: ClinicalTrials.gov)

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Preventing and Managing Operating Room Fires in Otolaryngology —Head and Neck Surgery

Otolaryngologists are at high risk of surgical fire. During surgery in the head and neck region there is close proximity of 3 essential elements: an ignition source, a fuel, and an oxidizing agent. In this article, the authors highlight the scenarios where fire may occur and offer steps that surgeons can take to minimize risk for their patients. By understanding the elements of the fire triad, otolaryngologists can decrease the risk of surgical fire, through careful control of oxidizers, ignition sources, and potential fuels in the operating room. (Source: Otolaryngologic clinics of North America)

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Facial Palsy: Diagnostic and Therapeutic Management

Facial expression is an evolutionary adaption facilitating successful social interaction. Muscles of facial expression are pivotal to nonverbal communication, articulation, and corneal protection. Facial palsy results in functional, communicative, and social impairment with profound negative impact on quality of life and emotional well-being. Congenital absence or acute facial nerve insult results in flaccid paralysis. Ultimate recovery following facial nerve insult lies on a spectrum from persistence of dense paralysis to return of normal function; in between zonal permutations of varying degrees of static and kinetic hypoactivity and hyperactivity and synkinesis exist. (Source: Otolaryngologic clinics of North America)

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You ’re Never Fully Dressed Without a Smile

Whether we like it or not, judgments based on facial appearance play a powerful role in how we treat others and how we ourselves are treated. Psychologists have long known that attractive people achieve better outcomes in practically all walks of life. We have all heard, "You never get a second chance to make a first impression." What is striking is that the judgment during the first impression is made within 1/10th of one second.1 (Source: Otolaryngologic clinics of North America)

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Preventing and Managing Operating Room Fires in Otolaryngology —Head and Neck Surgery

Otolaryngologists are at high risk of surgical fire. During surgery in the head and neck region there is close proximity of 3 essential elements: an ignition source, a fuel, and an oxidizing agent. In this article, the authors highlight the scenarios where fire may occur and offer steps that surgeons can take to minimize risk for their patients. By understanding the elements of the fire triad, otolaryngologists can decrease the risk of surgical fire, through careful control of oxidizers, ignition sources, and potential fuels in the operating room. (Source: Otolaryngologic clinics of North America)

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Evaluation and Management of Facial Nerve Schwannoma

Facial nerve schwannomas are benign peripheral nerve sheath tumors that arise from Schwann cells, and most commonly present with facial paresis and/or hearing loss. Computed tomography and MRI are critical to diagnosis. Management decisions are based on tumor size, facial function, and hearing status. Observation is usually the best option in patients with good facial function. For patients with poor facial function, the authors favor surgical resection with facial reanimation. There is growing evidence to support radiation treatment in patients with progressively worsening moderate facial paresis and growing tumors. (Source: Otolaryngologic clinics of North America)

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Resident and Fellow Engagement in Safety and Quality

Beyond educational and institutional requirements, there is a need for trainees (residents and fellows) to learn patient safety and quality improvement skills in order to achieve the ultimate goal of providing better patient care. Key steps to engagement include creating a safety and quality culture, supporting faculty development, and selecting appropriate curricular resources. Efforts to align the goals and processes of the graduate medical education institution and teaching hospital can foster a unified mission. Faculty must be prepared to teach and reinforce these topics on a regular basis. Both didactic instruction and experiential learning are necessary components for trainee education. (Source: Otolaryngologic clinics of North America)

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Facial Palsy: Diagnostic and Therapeutic Management

Facial expression is an evolutionary adaption facilitating successful social interaction. Muscles of facial expression are pivotal to nonverbal communication, articulation, and corneal protection. Facial palsy results in functional, communicative, and social impairment with profound negative impact on quality of life and emotional well-being. Congenital absence or acute facial nerve insult results in flaccid paralysis. Ultimate recovery following facial nerve insult lies on a spectrum from persistence of dense paralysis to return of normal function; in between zonal permutations of varying degrees of static and kinetic hypoactivity and hyperactivity and synkinesis exist. (Source: Otolaryngologic clinics of North America)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NTx51H

You ’re Never Fully Dressed Without a Smile

Whether we like it or not, judgments based on facial appearance play a powerful role in how we treat others and how we ourselves are treated. Psychologists have long known that attractive people achieve better outcomes in practically all walks of life. We have all heard, "You never get a second chance to make a first impression." What is striking is that the judgment during the first impression is made within 1/10th of one second.1 (Source: Otolaryngologic clinics of North America)

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PDE3/4 Inhibitor Yields Symptom Relief in COPD

(MedPage Today) -- Tested as standalone, but potential role seen as add-on therapy (Source: MedPage Today Allergy)

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Access to Treatment for Head/Neck Cancer Patients Improved with Medicaid Expansion

Access to Treatment for Head/Neck Cancer Patients Improved with Medicaid Expansion  MedicalResearch.com (blog)Full coverage

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Impact of Polymer Bioconjugation on Protein Stability and Activity Investigated with Discrete Conjugates: Alternatives to PEGylation.

Authors: Morgenstern J, Gil Alvaradejo G, Bluthardt N, Beloqui A, Delaittre G, Hubbuch J Abstract Covalent attachment of synthetic polymers to proteins, known as protein-polymer conjugation, is currently one of the main approaches for improving the physicochemical properties of these biomolecules. The most commonly employed polymer is polyethylene glycol (PEG), as evidenced by extensive research and clinical track records for its use in biopharmaceuticals. However, the occurrence of allergic reactions or hypersensitivity and the discovery of PEG antibodies, on the one hand, and the rise of controlled polymerization techniques and novel monomers, on the other hand, have been driving the search for alternative polymers for bioconjugation. The present study describes the synthesis, pu...

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Impact of Polymer Bioconjugation on Protein Stability and Activity Investigated with Discrete Conjugates: Alternatives to PEGylation.

Authors: Morgenstern J, Gil Alvaradejo G, Bluthardt N, Beloqui A, Delaittre G, Hubbuch J Abstract Covalent attachment of synthetic polymers to proteins, known as protein-polymer conjugation, is currently one of the main approaches for improving the physicochemical properties of these biomolecules. The most commonly employed polymer is polyethylene glycol (PEG), as evidenced by extensive research and clinical track records for its use in biopharmaceuticals. However, the occurrence of allergic reactions or hypersensitivity and the discovery of PEG antibodies, on the one hand, and the rise of controlled polymerization techniques and novel monomers, on the other hand, have been driving the search for alternative polymers for bioconjugation. The present study describes the synthesis, pu...

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Johnson County kids share their own stories for Childhood Cancer Awareness Month

Johnson County kids share their own stories for Childhood Cancer Awareness Month  Fox 59Full coverage

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Thyroid Cancer 101

Thyroid Cancer 101  Newswise (press release)Full coverage

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Bone grafting in orthognathic surgery: a systematic review

Bone grafting has been used in orthognathic surgery to fill the gaps created by jaw repositioning, with the intention of improving healing and stability. Since the majority of orthognathic cases have a satisfactory result, the decision to graft or not is a clinical dilemma. A systematic review of the literature was performed on the use of bone grafts in orthognathic surgery. A search of PubMed, MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials yielded 1927 articles published up until 2018. (Source: International Journal of Oral and Maxillofacial Surgery)

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Describing the mandible in patients with craniofacial microsomia based on principal component analysis and thin plate spline video analysis

Craniofacial microsomia (CFM) is most often described as a unilateral malformation of derivatives of the first and second branchial arches. The mandible has been classified using several classification systems. However, all are based on two-dimensional imaging. The aim of this study was to mathematically describe the deformed mandible based on principal component analysis (PCA) in a three-dimensional way. This may aid in defining the flaws in existing surgical corrections of the mandible through the identification of the differences in shape compared with a normal mandible in a holistic view with the help of videos. (Source: International Journal of Oral and Maxillofacial Surgery)

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Johnson County kids share their own stories for Childhood Cancer Awareness Month

Johnson County kids share their own stories for Childhood Cancer Awareness Month  Fox 59Full coverage

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Thyroid Cancer 101

Thyroid Cancer 101  Newswise (press release)Full coverage

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Risk factors and prognosis for the primary intraosseous carcinoma of the jaw

Primary intraosseous carcinoma (PIOC) is a rare but aggressive type of odontogenic tumour arising within the jawbone. Diagnosis criteria and treatment strategy remain difficult and controversial. The present study aimed to clarify the clinicopathological features and determine prognostic factors in management of PIOC. A retrospective study of 30 patients with PIOC, treated at the Hospital of Stomatology of Sun Yat-sen University between 2009 and 2017, was conducted. Clinical, histopathological and treatment modality data were collected. (Source: International Journal of Oral and Maxillofacial Surgery)

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Bone grafting in orthognathic surgery: a systematic review

Bone grafting has been used in orthognathic surgery to fill the gaps created by jaw repositioning, with the intention of improving healing and stability. Since the majority of orthognathic cases have a satisfactory result, the decision to graft or not is a clinical dilemma. A systematic review of the literature was performed on the use of bone grafts in orthognathic surgery. A search of PubMed, MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials yielded 1927 articles published up until 2018. (Source: International Journal of Oral and Maxillofacial Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QIkLQd

Describing the mandible in patients with craniofacial microsomia based on principal component analysis and thin plate spline video analysis

Craniofacial microsomia (CFM) is most often described as a unilateral malformation of derivatives of the first and second branchial arches. The mandible has been classified using several classification systems. However, all are based on two-dimensional imaging. The aim of this study was to mathematically describe the deformed mandible based on principal component analysis (PCA) in a three-dimensional way. This may aid in defining the flaws in existing surgical corrections of the mandible through the identification of the differences in shape compared with a normal mandible in a holistic view with the help of videos. (Source: International Journal of Oral and Maxillofacial Surgery)

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NIH Research Festival - Plenary Session III

During this session, we will hear about the recent research advances in the areas of food and skin allergies, and virus pathogenesis and vaccine development.For more information go tohttps://researchfestival.nih.gov/2018/plenary-sessionsAir date: 9/14/2018 10:00:00 AM (Source: Videocast - All Events)

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NIH Research Festival - Plenary Session III

During this session, we will hear about the recent research advances in the areas of food and skin allergies, and virus pathogenesis and vaccine development.For more information go tohttps://researchfestival.nih.gov/2018/plenary-sessionsAir date: 9/14/2018 10:00:00 AM (Source: Videocast - All Events)

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PDE3/4 Inhibitor Yields Symptom Relief in COPD

(MedPage Today) -- Tested as standalone, but potential role seen as add-on therapy (Source: MedPage Today Allergy)

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PDE3/4 Inhibitor Yields Symptom Relief in COPD

(MedPage Today) -- Tested as standalone, but potential role seen as add-on therapy (Source: MedPage Today Allergy)

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Reduced CD8 + T cells infiltration can be associated to a malignant transformation in potentially malignant oral epithelial lesions

Abstract

Objective

The aim of this study was to evaluate the immunohistochemical expressions of PD1, CD4⁺, and CD8⁺ in premalignant lesions (OPML) that were transformed into oral squamous cell carcinoma OSCC (OPML-OSCC), in OSCC and also in premalignant lesions that were not transformed into OSCC (OPML-NOSSC).

Materials and methods

Retrospective analyses were performed in order to verify the demographic characteristics of the patients. CD4, CD8, and PD1 IMH studies were carried out on OPML and OSCC samples from 11 patients with OPML-OSCC and OPML, together with samples from 14 patients with OPML-NOSCC. The differences between OPML-OSCC and OPML-NOSCC were analyzed.

Results

Non-homogenous leukoplakia, together with the related oral subsite, and the lack of an exposure to tobacco, were all associated with malignant transformations. There were no statistical differences in the PD1 expression and the CD4⁺ cells in OPML-OSCC and OPML-NOSCC. A significant increment in the CD8⁺ cells was noted in the OPML that evolved into carcinomas when compared with OPML-NOSCC (p = 0.05), whereas there were higher CD8⁺ cells levels in the carcinomas when compared with the OPML that evolved into carcinomas (p = 0.027).

Conclusions

CD8⁺ cells infiltrate more in OPML-NOSCC than in OPML-OSCC. Carcinoma is more infiltrated by CD8⁺ cells than its associated OPML.

Clinical relevance

Understanding immunological factors associated with malignant transformation of oral premalignant lesions can open a new way to treat this disease.

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Reduced CD8 + T cells infiltration can be associated to a malignant transformation in potentially malignant oral epithelial lesions

Abstract

Objective

The aim of this study was to evaluate the immunohistochemical expressions of PD1, CD4⁺, and CD8⁺ in premalignant lesions (OPML) that were transformed into oral squamous cell carcinoma OSCC (OPML-OSCC), in OSCC and also in premalignant lesions that were not transformed into OSCC (OPML-NOSSC).

Materials and methods

Retrospective analyses were performed in order to verify the demographic characteristics of the patients. CD4, CD8, and PD1 IMH studies were carried out on OPML and OSCC samples from 11 patients with OPML-OSCC and OPML, together with samples from 14 patients with OPML-NOSCC. The differences between OPML-OSCC and OPML-NOSCC were analyzed.

Results

Non-homogenous leukoplakia, together with the related oral subsite, and the lack of an exposure to tobacco, were all associated with malignant transformations. There were no statistical differences in the PD1 expression and the CD4⁺ cells in OPML-OSCC and OPML-NOSCC. A significant increment in the CD8⁺ cells was noted in the OPML that evolved into carcinomas when compared with OPML-NOSCC (p = 0.05), whereas there were higher CD8⁺ cells levels in the carcinomas when compared with the OPML that evolved into carcinomas (p = 0.027).

Conclusions

CD8⁺ cells infiltrate more in OPML-NOSCC than in OPML-OSCC. Carcinoma is more infiltrated by CD8⁺ cells than its associated OPML.

Clinical relevance

Understanding immunological factors associated with malignant transformation of oral premalignant lesions can open a new way to treat this disease.

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Reduced CD8 + T cells infiltration can be associated to a malignant transformation in potentially malignant oral epithelial lesions

ConclusionsCD8+ cells infiltrate more in OPML-NOSCC than in OPML-OSCC. Carcinoma is more infiltrated by CD8+ cells than its associated OPML.Clinical relevanceUnderstanding immunological factors associated with malignant transformation of oral premalignant lesions can open a new way to treat this disease. (Source: Clinical Oral Investigations)

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Severe Bronchiolitis Profiles and Risk of Developing Recurrent Wheezing by Age 3 Years

Severe bronchiolitis profiles identified by a clustering approach were differentially associated with allergy and inflammatory biomarkers, nasopharyngeal microbiota profiles, and the risk of developing recurrent wheezing by age 3 years. (Source: Journal of Allergy and Clinical Immunology)

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Injury, dysbiosis and filaggrin deficiency drive skin inflammation via keratinocyte IL-1 α release

Our data demonstrate that injury and dysbiosis drive intracellular IL-1 α release from keratinocytes to mediate chronic inflammation in filaggrin-deficient mice. IL-1α and dysbiosis could represent therapeutic targets to reduce skin inflammation in atopic dermatitis. (Source: Journal of Allergy and Clinical Immunology)

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Reduced CD8 + T cells infiltration can be associated to a malignant transformation in potentially malignant oral epithelial lesions

ConclusionsCD8+ cells infiltrate more in OPML-NOSCC than in OPML-OSCC. Carcinoma is more infiltrated by CD8+ cells than its associated OPML.Clinical relevanceUnderstanding immunological factors associated with malignant transformation of oral premalignant lesions can open a new way to treat this disease. (Source: Clinical Oral Investigations)

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Fel d 1 and Fel d 4 levels in cat fur, saliva, and urine

Cats are popular household pets and commonly cause allergies. Several cat allergens have been identified, including Fel d 1, an uteroglobin. More commonly, animal allergens are lipocalins, and the cat lipocalin allergen Fel d 4 has been identified.1 (Source: Journal of Allergy and Clinical Immunology)

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Severe Bronchiolitis Profiles and Risk of Developing Recurrent Wheezing by Age 3 Years

Severe bronchiolitis profiles identified by a clustering approach were differentially associated with allergy and inflammatory biomarkers, nasopharyngeal microbiota profiles, and the risk of developing recurrent wheezing by age 3 years. (Source: Journal of Allergy and Clinical Immunology)

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Trans-maternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T-cells

Perinatal exposure to Helicobacter pylori or its immunomodulatory molecule VacA confers protection against allergic airway inflammation in mouse models. This protection is mediated by regulatory T-cells but is not indicative of generalized immunosuppression. (Source: Journal of Allergy and Clinical Immunology)

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Injury, dysbiosis and filaggrin deficiency drive skin inflammation via keratinocyte IL-1 α release

Our data demonstrate that injury and dysbiosis drive intracellular IL-1 α release from keratinocytes to mediate chronic inflammation in filaggrin-deficient mice. IL-1α and dysbiosis could represent therapeutic targets to reduce skin inflammation in atopic dermatitis. (Source: Journal of Allergy and Clinical Immunology)

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Fel d 1 and Fel d 4 levels in cat fur, saliva, and urine

Cats are popular household pets and commonly cause allergies. Several cat allergens have been identified, including Fel d 1, an uteroglobin. More commonly, animal allergens are lipocalins, and the cat lipocalin allergen Fel d 4 has been identified.1 (Source: Journal of Allergy and Clinical Immunology)

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PDE3/4 Inhibitor Yields Symptom Relief in COPD

(MedPage Today) -- Tested as standalone, but potential role seen as add-on therapy (Source: MedPage Today Allergy)

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Heterogenous treatment for anti-NMDAR encephalitis in children leads to different outcomes 6 –12 months after diagnosis

This study investigated outcomes from different treatments for anti-NMDAR encephalitis. Nineteen children in three treatments group: steroid alone, IVIG alone, and IVIG and steroid were reviewed. IVIG was administered to 13 (68%) and 6 (32%) only received steroids. Those receiving IVIG treatment with or without steroids had greater improvement in mRS at 6 (p  = 0.04) and 12 months (p = 0.03). (Source: Journal of Neuroimmunology)

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PDE3/4 Inhibitor Yields Symptom Relief in COPD

(MedPage Today) -- Tested as standalone, but potential role seen as add-on therapy (Source: MedPage Today Allergy)

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from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NnLyna

Injury, dysbiosis and filaggrin deficiency drive skin inflammation via keratinocyte IL-1 α release

Our data demonstrate that injury and dysbiosis drive intracellular IL-1 α release from keratinocytes to mediate chronic inflammation in filaggrin-deficient mice. IL-1α and dysbiosis could represent therapeutic targets to reduce skin inflammation in atopic dermatitis. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DbQ9UO

Severe Bronchiolitis Profiles and Risk of Developing Recurrent Wheezing by Age 3 Years

Severe bronchiolitis profiles identified by a clustering approach were differentially associated with allergy and inflammatory biomarkers, nasopharyngeal microbiota profiles, and the risk of developing recurrent wheezing by age 3 years. (Source: Journal of Allergy and Clinical Immunology)

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Heterogenous treatment for anti-NMDAR encephalitis in children leads to different outcomes 6 –12 months after diagnosis

This study investigated outcomes from different treatments for anti-NMDAR encephalitis. Nineteen children in three treatments group: steroid alone, IVIG alone, and IVIG and steroid were reviewed. IVIG was administered to 13 (68%) and 6 (32%) only received steroids. Those receiving IVIG treatment with or without steroids had greater improvement in mRS at 6 (p  = 0.04) and 12 months (p = 0.03). (Source: Journal of Neuroimmunology)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

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Trans-maternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T-cells

Perinatal exposure to Helicobacter pylori or its immunomodulatory molecule VacA confers protection against allergic airway inflammation in mouse models. This protection is mediated by regulatory T-cells but is not indicative of generalized immunosuppression. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2D8kkMs

Injury, dysbiosis and filaggrin deficiency drive skin inflammation via keratinocyte IL-1 α release

Our data demonstrate that injury and dysbiosis drive intracellular IL-1 α release from keratinocytes to mediate chronic inflammation in filaggrin-deficient mice. IL-1α and dysbiosis could represent therapeutic targets to reduce skin inflammation in atopic dermatitis. (Source: Journal of Allergy and Clinical Immunology)

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Periostin and Dipeptidyl Peptidase-4

Periostin and dipeptidyl peptidase-4 (DPP-4) are proteins induced by type 2 cytokines interleukin (IL)-4 and IL-13 and show increased expression in asthma and diseases with type 2 inflammation, including atopic dermatitis and chronic rhinosinusitis. Both proteins can also be induced by other stimuli, such as profibrotic factors, which may confound their specificity as biomarkers of IL-13 pathway activation and type 2 –driven disease. DPP-4 is important in glucose metabolism; therefore, serum concentrations may be confounded by the presence of concomitant metabolic disease. This review evaluates the potential of these biomarkers for anti–IL-13–directed therapy in asthma and diseases with type 2 inflammation . (Source: Immunology and Allergy Clinics of North America)

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Severe Bronchiolitis Profiles and Risk of Developing Recurrent Wheezing by Age 3 Years

Severe bronchiolitis profiles identified by a clustering approach were differentially associated with allergy and inflammatory biomarkers, nasopharyngeal microbiota profiles, and the risk of developing recurrent wheezing by age 3 years. (Source: Journal of Allergy and Clinical Immunology)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NnAoyH

Trans-maternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T-cells

Perinatal exposure to Helicobacter pylori or its immunomodulatory molecule VacA confers protection against allergic airway inflammation in mouse models. This protection is mediated by regulatory T-cells but is not indicative of generalized immunosuppression. (Source: Journal of Allergy and Clinical Immunology)

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Periostin and Dipeptidyl Peptidase-4

Periostin and dipeptidyl peptidase-4 (DPP-4) are proteins induced by type 2 cytokines interleukin (IL)-4 and IL-13 and show increased expression in asthma and diseases with type 2 inflammation, including atopic dermatitis and chronic rhinosinusitis. Both proteins can also be induced by other stimuli, such as profibrotic factors, which may confound their specificity as biomarkers of IL-13 pathway activation and type 2 –driven disease. DPP-4 is important in glucose metabolism; therefore, serum concentrations may be confounded by the presence of concomitant metabolic disease. This review evaluates the potential of these biomarkers for anti–IL-13–directed therapy in asthma and diseases with type 2 inflammation . (Source: Immunology and Allergy Clinics of North America)

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The Extended Purse-String Rhytidectomy

Facial plast Surg
DOI: 10.1055/s-0038-1672176

Facelifts remain a critical part of a facial plastic surgeon's cosmetic practice. Techniques continue to evolve, while at the same time patients demand less invasive procedures with less morbidity. The authors present a facelift plication technique using wide purse-string sutures placed into the superficial musculoaponeurotic system and platysma. This is a retrospective review with a level of evidence 3 set at a medical spa and tertiary referral center designed to assess a purse-string suture technique using an inner followed by an outer purse-string, with refinements being made during the timeframe of the review. One hundred and eighteen patients were reviewed and 95 were included in the study given the inclusion criteria of a minimum of 1-year follow-up. Based on the subjective judgment of the primary surgeon, 37 patients were found to have excellent results, while 43 patients were judged as having good results. The judgment was based on the physical exam improvement of the aging aspects of the patient, and patient satisfaction. Ten patients displayed fair results (the patients were marginally happy), and five patients were noted to have poor results (they were notably unhappy). Complications included eight hematomas, five patients with prominent scars, and one patient with skin loss in the temple region. There were no cases of facial nerve injury. The extended purse-string rhytidectomy is a good alternative to traditional facelift techniques. This offers a plication method that results in the vertical vector that is now considered of paramount importance with all facelifts. The authors feel that it is a valuable tool that can be considered in most patients presenting for aging face surgery.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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A 2-Year Follow-up Study of an Absorbable Implant to Treat Nasal Valve Collapse

Facial plast Surg
DOI: 10.1055/s-0038-1672213

The safety and effectiveness of an absorbable implant for lateral cartilage support have been recently demonstrated in subjects with nasal valve collapse (NVC) at 12 months postprocedure. This follow-up study aimed to assess whether the safety and effectiveness of the implant persist in these patients for 24 months after the procedure. Thirty subjects with Nasal Obstruction Symptom Evaluation (NOSE) score ≥ 55 and isolated NVC were treated; 14 cases were performed in an operating suite under general anesthesia and 16 cases were performed in a clinic-based setting under local anesthesia. The implant, a polylactic acid copolymer, was placed with a delivery tool within the nasal wall to provide lateral cartilage support. Subjects were followed up through 24 months postprocedure. Fifty-six implants were placed in 30 subjects. The mean preoperative NOSE score was 76.7 ± 14.8, with a range of 55 to 100. At 24 months, the mean score was 32.0 ± 29.3, reflecting an average within-patient reduction of −44.0 ± 31.1 points. There were no device-related adverse events in the 12 to 24 months period. There were five subjects who exited the study prior to the 24-month follow-up. Four of the five subjects who exited were elected for further intervention and one subject was lost to follow-up. This study demonstrates safety of an absorbable implant for lateral nasal wall support and symptom improvement in some subjects with NVC at 24 months postprocedure.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2POVJxO

The Extended Purse-String Rhytidectomy

Facial plast Surg
DOI: 10.1055/s-0038-1672176

Facelifts remain a critical part of a facial plastic surgeon's cosmetic practice. Techniques continue to evolve, while at the same time patients demand less invasive procedures with less morbidity. The authors present a facelift plication technique using wide purse-string sutures placed into the superficial musculoaponeurotic system and platysma. This is a retrospective review with a level of evidence 3 set at a medical spa and tertiary referral center designed to assess a purse-string suture technique using an inner followed by an outer purse-string, with refinements being made during the timeframe of the review. One hundred and eighteen patients were reviewed and 95 were included in the study given the inclusion criteria of a minimum of 1-year follow-up. Based on the subjective judgment of the primary surgeon, 37 patients were found to have excellent results, while 43 patients were judged as having good results. The judgment was based on the physical exam improvement of the aging aspects of the patient, and patient satisfaction. Ten patients displayed fair results (the patients were marginally happy), and five patients were noted to have poor results (they were notably unhappy). Complications included eight hematomas, five patients with prominent scars, and one patient with skin loss in the temple region. There were no cases of facial nerve injury. The extended purse-string rhytidectomy is a good alternative to traditional facelift techniques. This offers a plication method that results in the vertical vector that is now considered of paramount importance with all facelifts. The authors feel that it is a valuable tool that can be considered in most patients presenting for aging face surgery.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2xl6hhm

A 2-Year Follow-up Study of an Absorbable Implant to Treat Nasal Valve Collapse

Facial plast Surg
DOI: 10.1055/s-0038-1672213

The safety and effectiveness of an absorbable implant for lateral cartilage support have been recently demonstrated in subjects with nasal valve collapse (NVC) at 12 months postprocedure. This follow-up study aimed to assess whether the safety and effectiveness of the implant persist in these patients for 24 months after the procedure. Thirty subjects with Nasal Obstruction Symptom Evaluation (NOSE) score ≥ 55 and isolated NVC were treated; 14 cases were performed in an operating suite under general anesthesia and 16 cases were performed in a clinic-based setting under local anesthesia. The implant, a polylactic acid copolymer, was placed with a delivery tool within the nasal wall to provide lateral cartilage support. Subjects were followed up through 24 months postprocedure. Fifty-six implants were placed in 30 subjects. The mean preoperative NOSE score was 76.7 ± 14.8, with a range of 55 to 100. At 24 months, the mean score was 32.0 ± 29.3, reflecting an average within-patient reduction of −44.0 ± 31.1 points. There were no device-related adverse events in the 12 to 24 months period. There were five subjects who exited the study prior to the 24-month follow-up. Four of the five subjects who exited were elected for further intervention and one subject was lost to follow-up. This study demonstrates safety of an absorbable implant for lateral nasal wall support and symptom improvement in some subjects with NVC at 24 months postprocedure.
[...]

Thieme Medical Publishers 333 Seventh Avenue, New York, NY 10001, USA.

Article in Thieme eJournals:
Table of contents  |  Abstract  |  Full text

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Alcohol in Any Amount Found Unsafe; Linked to 3 Million Deaths a Year: Global Study

Alcohol in Any Amount Found Unsafe; Linked to 3 Million Deaths a Year: Global Study  Insurance JournalFull coverage

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Alcohol in Any Amount Found Unsafe; Linked to 3 Million Deaths a Year: Global Study

Alcohol in Any Amount Found Unsafe; Linked to 3 Million Deaths a Year: Global Study  Insurance JournalFull coverage

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Head and Neck Cancer Treatment Market Research, Growth Opportunities, Analysis and Forecasts Report 2017-2021

Head and Neck Cancer Treatment Market Research, Growth Opportunities, Analysis and Forecasts Report 2017-2021  Our Market ResearchFull coverage

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Head and Neck Cancer Treatment Market Research, Growth Opportunities, Analysis and Forecasts Report 2017-2021

Head and Neck Cancer Treatment Market Research, Growth Opportunities, Analysis and Forecasts Report 2017-2021  Our Market ResearchFull coverage

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Delray throat cancer survivor to perform concert in Boca on Saturday

Delray throat cancer survivor to perform concert in Boca on Saturday  MyPalmBeachPostFull coverage

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Going gluten free in non-celiac autoimmune diseases: the missing ingredient.

Authors: Lerner A, Matthias T PMID: 30220227 [PubMed - as supplied by publisher] (Source: Expert Review of Clinical Immunology)

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Golimumab in the treatment of psoriatic arthritis.

Authors: Love TJ, Kavanaugh A Abstract INTRODUCTION: Psoriatic arthritis is an inflammatory arthritis that can be aggressive and destructive, resulting in significant morbidity. While many new agents have been approved for the treatment of psoriatic arthritis over the past decade, TNF inhibitors remain an anchor treatment, in part based on extensive clinical experience. Recently, the TNF inhibitor golimumab was approved for intravenous use in psoriatic arthritis. Areas covered: This expert review presents an overview of the currently available treatment options for psoriatic arthritis with a focus on the evidence from clinical trials supporting the use of golimumab in psoriatic arthritis. This information is placed in context with recent advances in the understanding of psoriatic a...

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Maillard reaction with ribose, galacto-oligosaccharide or chitosan-oligosaccharide reduced the allergenicity of shrimp tropomyosin by inducing conformational changes

Publication date: 15 February 2019Source: Food Chemistry, Volume 274Author(s): Linglin Fu, Chong Wang, Jinbao Wang, Saiqiao Ni, Yanbo WangAbstractTropomyosin (TM), the predominant shellfish allergen, has induced severe food allergy worldwide, but efficient prevention and cure measures are limited nowadays. In the present study, we introduced an approach to eliminate Penaeus chinensis TM by Maillard reaction with reducing sugars including ribose, galacto-oligosaccharide (GOS) and chitosan-oligosaccharide (COS), which reduced the allergenicity by up to 60%. We also evaluated the conformational changes of TM during reaction by far-UV circular dichroism, and found the reaction-induced alternation from α-helix to β-sheet. We further determined the effect of Maillard reaction on TM allergenic ...

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Comparative characterization of two galectins excreted-secreted from intestine-dwelling parasitic versus free-living females of the soil-transmitted nematode Strongyloides

Publication date: October 2018Source: Molecular and Biochemical Parasitology, Volume 225Author(s): Dana Ditgen, Emmanuela M. Anandarajah, Anika Reinhardt, Abuelhassan Elshazly Younis, Susanne Witt, Jan Hansmann, Eva Lorenz, Marisela García-Hernández, Daniela Paclik, Hanns Soblik, Abbas Jolodar, Peter H. Seeberger, Eva Liebau, Norbert W. BrattigAbstractHelminths are complex pathogens that ensure their long-term survival by influencing the immune responses of their host. Excretory/secretory products (ESP) can exert immunoregulatory effects which foster parasite survival. Galectins represent a widespread group of β-galactoside-binding proteins which are involved in a multitude of biological processes operative in parasite-host interaction. We had earlier identified seven galectins in Stron...

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Use of Pipeline Endovascular Device in Patients with Nickel Allergies

Metal allergies affect a significant portion of the population; intracranial flow diverters contain many of the most commonly allergenic metals. Prior literature has suggested patch testing for all patients with documented or suspected metal allergies prior to intracranial flow diverter placement, however there remains a paucity of reports of patients with documented metal allergies undergoing intracranial flow diversion. (Source: World Neurosurgery)

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Delray throat cancer survivor to perform concert in Boca on Saturday

Delray throat cancer survivor to perform concert in Boca on Saturday  MyPalmBeachPostFull coverage

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Going gluten free in non-celiac autoimmune diseases: the missing ingredient.

Authors: Lerner A, Matthias T PMID: 30220227 [PubMed - as supplied by publisher] (Source: Expert Review of Clinical Immunology)

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Golimumab in the treatment of psoriatic arthritis.

Authors: Love TJ, Kavanaugh A Abstract INTRODUCTION: Psoriatic arthritis is an inflammatory arthritis that can be aggressive and destructive, resulting in significant morbidity. While many new agents have been approved for the treatment of psoriatic arthritis over the past decade, TNF inhibitors remain an anchor treatment, in part based on extensive clinical experience. Recently, the TNF inhibitor golimumab was approved for intravenous use in psoriatic arthritis. Areas covered: This expert review presents an overview of the currently available treatment options for psoriatic arthritis with a focus on the evidence from clinical trials supporting the use of golimumab in psoriatic arthritis. This information is placed in context with recent advances in the understanding of psoriatic a...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NUAOfj

Maillard reaction with ribose, galacto-oligosaccharide or chitosan-oligosaccharide reduced the allergenicity of shrimp tropomyosin by inducing conformational changes

Publication date: 15 February 2019Source: Food Chemistry, Volume 274Author(s): Linglin Fu, Chong Wang, Jinbao Wang, Saiqiao Ni, Yanbo WangAbstractTropomyosin (TM), the predominant shellfish allergen, has induced severe food allergy worldwide, but efficient prevention and cure measures are limited nowadays. In the present study, we introduced an approach to eliminate Penaeus chinensis TM by Maillard reaction with reducing sugars including ribose, galacto-oligosaccharide (GOS) and chitosan-oligosaccharide (COS), which reduced the allergenicity by up to 60%. We also evaluated the conformational changes of TM during reaction by far-UV circular dichroism, and found the reaction-induced alternation from α-helix to β-sheet. We further determined the effect of Maillard reaction on TM allergenic ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OAJvsc

Comparative characterization of two galectins excreted-secreted from intestine-dwelling parasitic versus free-living females of the soil-transmitted nematode Strongyloides

Publication date: October 2018Source: Molecular and Biochemical Parasitology, Volume 225Author(s): Dana Ditgen, Emmanuela M. Anandarajah, Anika Reinhardt, Abuelhassan Elshazly Younis, Susanne Witt, Jan Hansmann, Eva Lorenz, Marisela García-Hernández, Daniela Paclik, Hanns Soblik, Abbas Jolodar, Peter H. Seeberger, Eva Liebau, Norbert W. BrattigAbstractHelminths are complex pathogens that ensure their long-term survival by influencing the immune responses of their host. Excretory/secretory products (ESP) can exert immunoregulatory effects which foster parasite survival. Galectins represent a widespread group of β-galactoside-binding proteins which are involved in a multitude of biological processes operative in parasite-host interaction. We had earlier identified seven galectins in Stron...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NVwn42

Use of Pipeline Endovascular Device in Patients with Nickel Allergies

Metal allergies affect a significant portion of the population; intracranial flow diverters contain many of the most commonly allergenic metals. Prior literature has suggested patch testing for all patients with documented or suspected metal allergies prior to intracranial flow diverter placement, however there remains a paucity of reports of patients with documented metal allergies undergoing intracranial flow diversion. (Source: World Neurosurgery)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2OCZ8iP

“How Important are Letters of Recommendation? A Survey of Oral and Maxillofacial Surgery Residency Program Directors”

Letters of recommendation are currently a part of the application process for residencies in oral and maxillofacial surgery. However, the value placed on the information contained in such letters by program directors is unclear. The purpose of this study was to determine what role letters of recommendation play in decision-making process.

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“How Important are Letters of Recommendation? A Survey of Oral and Maxillofacial Surgery Residency Program Directors”

Letters of recommendation are currently a part of the application process for residencies in oral and maxillofacial surgery. However, the value placed on the information contained in such letters by program directors is unclear. The purpose of this study was to determine what role letters of recommendation play in decision-making process.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nj2LxX

A multi-group approach to examining language development in at-risk learners.

Authors: Delcenserie A, Genesee F, Trudeau N, Champoux F Abstract A battery of standardized language tests and control measures was administered to three groups of at-risk language learners - internationally adopted children, deaf children with cochlear implants, and children with specific language impairment - and to groups of second-language learners and typically developing monolingual children. All children were acquiring French, were matched on age, gender, and socioeconomic status, and were between age 5;0 and 7;3 at the time of testing. Differences between the at-risk and not-at-risk groups were evident in all domains of language testing. The children with SLI or CIs scored significantly lower than the IA children and all three at-risk groups scored lower than the monolingua...

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Improving vaccination uptake in pediatric Cochlear implant recipients

An Infectious Disease vaccine specialist joined our institution 's Cochlear Implant Team in 2010 in order to address the high percentage of non-compliance to immunization prior to surgery identified previously ... (Source: Journal of Otolaryngology - Head and Neck Surgery)

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Screening of Hearing in Newborn Infants: Follow-Up and Outcome After 40930 Births in Babol, Northern Iran.

CONCLUSION: It is recommended that all newborns undergo hearing screening test before hospital discharge, and those with impairment receive supportive measures from 3 months of age, and be re-examined at 12 months of age. PMID: 30221527 [PubMed - in process] (Source: Archives of Iranian Medicine)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MKOCEB

A multi-group approach to examining language development in at-risk learners.

Authors: Delcenserie A, Genesee F, Trudeau N, Champoux F Abstract A battery of standardized language tests and control measures was administered to three groups of at-risk language learners - internationally adopted children, deaf children with cochlear implants, and children with specific language impairment - and to groups of second-language learners and typically developing monolingual children. All children were acquiring French, were matched on age, gender, and socioeconomic status, and were between age 5;0 and 7;3 at the time of testing. Differences between the at-risk and not-at-risk groups were evident in all domains of language testing. The children with SLI or CIs scored significantly lower than the IA children and all three at-risk groups scored lower than the monolingua...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MJavEo

Improving vaccination uptake in pediatric Cochlear implant recipients

An Infectious Disease vaccine specialist joined our institution 's Cochlear Implant Team in 2010 in order to address the high percentage of non-compliance to immunization prior to surgery identified previously ... (Source: Journal of Otolaryngology - Head and Neck Surgery)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pkXTKa

Screening of Hearing in Newborn Infants: Follow-Up and Outcome After 40930 Births in Babol, Northern Iran.

CONCLUSION: It is recommended that all newborns undergo hearing screening test before hospital discharge, and those with impairment receive supportive measures from 3 months of age, and be re-examined at 12 months of age. PMID: 30221527 [PubMed - in process] (Source: Archives of Iranian Medicine)

MedWorm Message: If you are looking to buy something in the January Sales please visit TheJanuarySales.com for a directory of all the best sales in the UK. Any income gained via affiliate links keeps MedWorm running.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MKOCEB

Risk factors and prognosis for the primary intraosseous carcinoma of the jaw

Primary intraosseous carcinoma (PIOC) is a rare but aggressive type of odontogenic tumour arising within the jawbone. Diagnosis criteria and treatment strategy remain difficult and controversial. The present study aimed to clarify the clinicopathological features and determine prognostic factors in management of PIOC. A retrospective study of 30 patients with PIOC, treated at the Hospital of Stomatology of Sun Yat-sen University between 2009 and 2017, was conducted. Clinical, histopathological and treatment modality data were collected.

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Risk factors and prognosis for the primary intraosseous carcinoma of the jaw

Primary intraosseous carcinoma (PIOC) is a rare but aggressive type of odontogenic tumour arising within the jawbone. Diagnosis criteria and treatment strategy remain difficult and controversial. The present study aimed to clarify the clinicopathological features and determine prognostic factors in management of PIOC. A retrospective study of 30 patients with PIOC, treated at the Hospital of Stomatology of Sun Yat-sen University between 2009 and 2017, was conducted. Clinical, histopathological and treatment modality data were collected.

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Bone grafting in orthognathic surgery: a systematic review

Bone grafting has been used in orthognathic surgery to fill the gaps created by jaw repositioning, with the intention of improving healing and stability. Since the majority of orthognathic cases have a satisfactory result, the decision to graft or not is a clinical dilemma. A systematic review of the literature was performed on the use of bone grafts in orthognathic surgery. A search of PubMed, MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials yielded 1927 articles published up until 2018.

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Bone grafting in orthognathic surgery: a systematic review

Bone grafting has been used in orthognathic surgery to fill the gaps created by jaw repositioning, with the intention of improving healing and stability. Since the majority of orthognathic cases have a satisfactory result, the decision to graft or not is a clinical dilemma. A systematic review of the literature was performed on the use of bone grafts in orthognathic surgery. A search of PubMed, MEDLINE, Embase, and the Cochrane Central Register of Controlled Trials yielded 1927 articles published up until 2018.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2NVNWkn

Long-term postoperative control of eosinophilic chronic rhinosinusitis recurrence by inserting a steroid-eluting, sinus-bioabsorbable device reduces the dosage of oral steroid

We employed a steroid-eluting, sinus-bioabsorbable device for local treatment after surgery for eosinophilic chronic rhinosinusitis (ECRS). One year later, we investigated its efficacy in suppressing recurrence and reducing the use of oral steroids.

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High-resolution repertoire analysis reveals a major bystander activation of Tfh and Tfr cells [Immunology and Inflammation]

T follicular helper (Tfh) and regulatory (Tfr) cells are terminally differentiated cells found in germinal centers (GCs), specialized secondary lymphoid organ structures dedicated to antibody production. As such, follicular T (Tfol) cells are supposed to be specific for immunizing antigens, which has been reported for Tfh cells but is debated... (Source: Proceedings of the National Academy of Sciences)

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Chemokine receptors CCR2 and CX3CR1 regulate viral encephalitis-induced hippocampal damage but not seizures [Immunology and Inflammation]

Viral encephalitis is a major risk factor for the development of seizures, epilepsy, and hippocampal damage with associated cognitive impairment, markedly reducing quality of life in survivors. The mechanisms underlying seizures and hippocampal neurodegeneration developing during and after viral encephalitis are only incompletely understood, hampering the development of preventive treatments.... (Source: Proceedings of the National Academy of Sciences)

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Trans-maternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T-cells

Perinatal exposure to Helicobacter pylori or its immunomodulatory molecule VacA confers protection against allergic airway inflammation in mouse models. This protection is mediated by regulatory T-cells but is not indicative of generalized immunosuppression.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2D7kCU0

Long-term postoperative control of eosinophilic chronic rhinosinusitis recurrence by inserting a steroid-eluting, sinus-bioabsorbable device reduces the dosage of oral steroid

We employed a steroid-eluting, sinus-bioabsorbable device for local treatment after surgery for eosinophilic chronic rhinosinusitis (ECRS). One year later, we investigated its efficacy in suppressing recurrence and reducing the use of oral steroids.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2QF7xnk

Injury, dysbiosis and filaggrin deficiency drive skin inflammation via keratinocyte IL-1α release

Our data demonstrate that injury and dysbiosis drive intracellular IL-1α release from keratinocytes to mediate chronic inflammation in filaggrin-deficient mice. IL-1α and dysbiosis could represent therapeutic targets to reduce skin inflammation in atopic dermatitis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DgDOhQ

High-resolution repertoire analysis reveals a major bystander activation of Tfh and Tfr cells [Immunology and Inflammation]

T follicular helper (Tfh) and regulatory (Tfr) cells are terminally differentiated cells found in germinal centers (GCs), specialized secondary lymphoid organ structures dedicated to antibody production. As such, follicular T (Tfol) cells are supposed to be specific for immunizing antigens, which has been reported for Tfh cells but is debated... (Source: Proceedings of the National Academy of Sciences)

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Lack of Sprouty 1 and 2 enhances survival of effector CD8+ T cells and yields more protective memory cells [Immunology and Inflammation]

Identifying novel pathways that promote robust function and longevity of cytotoxic T cells has promising potential for immunotherapeutic strategies to combat cancer and chronic infections. We show that sprouty 1 and 2 (Spry1/2) molecules regulate the survival and function of memory CD8+ T cells. Spry1/2 double-knockout (DKO) ovalbumin (OVA)-specific CD8+... (Source: Proceedings of the National Academy of Sciences)

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Chemokine receptors CCR2 and CX3CR1 regulate viral encephalitis-induced hippocampal damage but not seizures [Immunology and Inflammation]

Viral encephalitis is a major risk factor for the development of seizures, epilepsy, and hippocampal damage with associated cognitive impairment, markedly reducing quality of life in survivors. The mechanisms underlying seizures and hippocampal neurodegeneration developing during and after viral encephalitis are only incompletely understood, hampering the development of preventive treatments.... (Source: Proceedings of the National Academy of Sciences)

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Sprouty branches out to control T cell memory [Immunology and Inflammation]

CD8+ T cells provide critical immune protection against infections and cancer. Upon T cell receptor (TCR) recognition of a cognate antigen–MHC I complex and costimulatory signals presented by dendritic cells, quiescent CD8+ T cells undergo activation, leading to proliferation and effector responses that mediate clearance of pathogen-infected cells or cancer.... (Source: Proceedings of the National Academy of Sciences)

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Trans-maternal Helicobacter pylori exposure reduces allergic airway inflammation in offspring through regulatory T-cells

Perinatal exposure to Helicobacter pylori or its immunomodulatory molecule VacA confers protection against allergic airway inflammation in mouse models. This protection is mediated by regulatory T-cells but is not indicative of generalized immunosuppression.

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Severe Bronchiolitis Profiles and Risk of Developing Recurrent Wheezing by Age 3 Years

Severe bronchiolitis profiles identified by a clustering approach were differentially associated with allergy and inflammatory biomarkers, nasopharyngeal microbiota profiles, and the risk of developing recurrent wheezing by age 3 years.

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Injury, dysbiosis and filaggrin deficiency drive skin inflammation via keratinocyte IL-1α release

Our data demonstrate that injury and dysbiosis drive intracellular IL-1α release from keratinocytes to mediate chronic inflammation in filaggrin-deficient mice. IL-1α and dysbiosis could represent therapeutic targets to reduce skin inflammation in atopic dermatitis.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2DgDOhQ

Access to Treatment for Head/Neck Cancer Patients Improved with Medicaid Expansion

Access to Treatment for Head/Neck Cancer Patients Improved with Medicaid Expansion  MedicalResearch.com (blog)Full coverage

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“How Important are Letters of Recommendation? A Survey of Oral and Maxillofacial Surgery Residency Program Directors”

Letters of recommendation are currently a part of the application process for residencies in oral and maxillofacial surgery. However, the value placed on the information contained in such letters by program directors is unclear. The purpose of this study was to determine what role letters of recommendation play in decision-making process.

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Access to Treatment for Head/Neck Cancer Patients Improved with Medicaid Expansion

Access to Treatment for Head/Neck Cancer Patients Improved with Medicaid Expansion  MedicalResearch.com (blog)Full coverage

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“How Important are Letters of Recommendation? A Survey of Oral and Maxillofacial Surgery Residency Program Directors”

Letters of recommendation are currently a part of the application process for residencies in oral and maxillofacial surgery. However, the value placed on the information contained in such letters by program directors is unclear. The purpose of this study was to determine what role letters of recommendation play in decision-making process.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2Nj2LxX

FIERCE for a cure: Natick boot camp raises money for cancer research

FIERCE for a cure: Natick boot camp raises money for cancer research  Milford Daily NewsFull coverage

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FIERCE for a cure: Natick boot camp raises money for cancer research

FIERCE for a cure: Natick boot camp raises money for cancer research  Milford Daily NewsFull coverage

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Drug Prices Increase More Than Expected After Shortages

Expected price increase 20 percent for all drugs after shortage versus 9 percent in absence of shortage (Source: Pulmonary Medicine News - Doctors Lounge)

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Compliance With Requirement to Report Results on EUCTR Is Poor

Half of trials on European Union Clinical Trials Register are non - compliant with requirements (Source: Pulmonary Medicine News - Doctors Lounge)

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Researchers find adult stem cell characteristics in aggressive cancers from different tissues

UCLA researchers have discovered  genetic similarities between the adult stem cells responsible for maintaining and repairing epithelial tissues — which line all of the organs and cavities inside the body — and the cells that drive aggressive epithelial cancers. Their findings could bring about a better understanding of how ag gressive, treatment-resistant cancers develop and progress, and could eventually lead to new drugs for a range of advanced epithelial cancers such as lung, prostate and bladder cancers. The study, led by senior authors Owen Witte and Thomas Graeber, both of the  UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and Jonsson Comprehensive Cancer Center, was published in the  journal Cell Reports.Epithelial cancers account for ...

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Feds fund $3.5M for Durham firm's yellow fever treatment

A Durham pharmaceutical company has received $3.5 million from a federal agency to support clinical trials for a drug to treat people with yellow fever. For BioCryst Pharmaceuticals, the latest funds from the National Institute of Allergy and Infectious Diseases (NIAID) for galidesivir brings development contract funding to a total of $43 million.   BioCryst saw success during its Phase 1 trials; healthy patients tolerated the drug and found it to be safe. In animal studies, galidesivir showed… (Source: bizjournals.com Health Care:Physician Practices headlines)

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Drug Prices Increase More Than Expected After Shortages

Expected price increase 20 percent for all drugs after shortage versus 9 percent in absence of shortage (Source: Pulmonary Medicine News - Doctors Lounge)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

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Compliance With Requirement to Report Results on EUCTR Is Poor

Half of trials on European Union Clinical Trials Register are non - compliant with requirements (Source: Pulmonary Medicine News - Doctors Lounge)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pmd8m1

Researchers find adult stem cell characteristics in aggressive cancers from different tissues

UCLA researchers have discovered  genetic similarities between the adult stem cells responsible for maintaining and repairing epithelial tissues — which line all of the organs and cavities inside the body — and the cells that drive aggressive epithelial cancers. Their findings could bring about a better understanding of how ag gressive, treatment-resistant cancers develop and progress, and could eventually lead to new drugs for a range of advanced epithelial cancers such as lung, prostate and bladder cancers. The study, led by senior authors Owen Witte and Thomas Graeber, both of the  UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and Jonsson Comprehensive Cancer Center, was published in the  journal Cell Reports.Epithelial cancers account for ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MJTwld

Feds fund $3.5M for Durham firm's yellow fever treatment

A Durham pharmaceutical company has received $3.5 million from a federal agency to support clinical trials for a drug to treat people with yellow fever. For BioCryst Pharmaceuticals, the latest funds from the National Institute of Allergy and Infectious Diseases (NIAID) for galidesivir brings development contract funding to a total of $43 million.   BioCryst saw success during its Phase 1 trials; healthy patients tolerated the drug and found it to be safe. In animal studies, galidesivir showed… (Source: bizjournals.com Health Care:Physician Practices headlines)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2plnXF8

Drug Prices Increase More Than Expected After Shortages

Expected price increase 20 percent for all drugs after shortage versus 9 percent in absence of shortage (Source: Pulmonary Medicine News - Doctors Lounge)

MedWorm Message: Have you tried our new medical search engine? More powerful than before. Log on with your social media account. 100% free.

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MJ5QCj

Compliance With Requirement to Report Results on EUCTR Is Poor

Half of trials on European Union Clinical Trials Register are non - compliant with requirements (Source: Pulmonary Medicine News - Doctors Lounge)

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2pmd8m1

Researchers find adult stem cell characteristics in aggressive cancers from different tissues

UCLA researchers have discovered  genetic similarities between the adult stem cells responsible for maintaining and repairing epithelial tissues — which line all of the organs and cavities inside the body — and the cells that drive aggressive epithelial cancers. Their findings could bring about a better understanding of how ag gressive, treatment-resistant cancers develop and progress, and could eventually lead to new drugs for a range of advanced epithelial cancers such as lung, prostate and bladder cancers. The study, led by senior authors Owen Witte and Thomas Graeber, both of the  UCLA Eli and Edythe Broad Center of Regenerative Medicine and Stem Cell Research and Jonsson Comprehensive Cancer Center, was published in the  journal Cell Reports.Epithelial cancers account for ...

from #Head and Neck by Sfakianakis via simeraentaxei on Inoreader https://ift.tt/2MJTwld